{"id":"https://openalex.org/W2044349720","doi":"https://doi.org/10.1186/1752-0509-6-149","title":"Modeling and analysis of flux distributions in the two branches of the phosphotransferase system in Pseudomonas putida","display_name":"Modeling and analysis of flux distributions in the two branches of the phosphotransferase system in Pseudomonas putida","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2044349720","doi":"https://doi.org/10.1186/1752-0509-6-149","mag":"2044349720","pmid":"https://pubmed.ncbi.nlm.nih.gov/23216700"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-6-149","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-149","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-149","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-149","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040121825","display_name":"Andreas Kremling","orcid":"https://orcid.org/0000-0001-9533-6786"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Andreas Kremling","raw_affiliation_strings":["Fachgebiet Systembiotechnologie, Technische Universit\u00e4t M\u00fcnchen, Garching b, M\u00fcnchen, Germany. a.kremling@lrz.tu-muenchen.de","Fachgebiet Systembiotechnologie, Technische Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fachgebiet Systembiotechnologie, Technische Universit\u00e4t M\u00fcnchen, Garching b, M\u00fcnchen, Germany. a.kremling@lrz.tu-muenchen.de","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Fachgebiet Systembiotechnologie, Technische Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040048649","display_name":"Katharina Pfl\u00fcger\u2010Grau","orcid":"https://orcid.org/0000-0002-8334-353X"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina Pfl\u00fcger-Grau","raw_affiliation_strings":["Fachgebiet Systembiotechnologie, Technische Universit\u00e4t M\u00fcnchen, Garching b., M\u00fcnchen, Germany","Fachgebiet Systembiotechnologie, Technische Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fachgebiet Systembiotechnologie, Technische Universit\u00e4t M\u00fcnchen, Garching b., M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Fachgebiet Systembiotechnologie, Technische Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032152872","display_name":"Max Chavarr\u00eda","orcid":"https://orcid.org/0000-0001-5901-3576"},"institutions":[{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Max Chavarr\u00eda","raw_affiliation_strings":["Systems Biology Program, Centro Nacional de Biotecnolog\u00eda-CSIC, Campus Cantoblanco, Madrid, Spain","Systems Biology Program, Centro Nacional de Biotecnolog\u00eda-CSIC, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Program, Centro Nacional de Biotecnolog\u00eda-CSIC, Campus Cantoblanco, Madrid, Spain","institution_ids":["https://openalex.org/I4210104776"]},{"raw_affiliation_string":"Systems Biology Program, Centro Nacional de Biotecnolog\u00eda-CSIC, Madrid, Spain","institution_ids":["https://openalex.org/I4210104776"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066986229","display_name":"Jacek Pucha\u0142ka","orcid":null},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jacek Puchalka","raw_affiliation_strings":["Helmholtz Center for Infection Research, Braunschweig, Germany","Present address: University Children\u2019s Hospital, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz Center for Infection Research, Braunschweig, Germany","institution_ids":["https://openalex.org/I4210124929"]},{"raw_affiliation_string":"Present address: University Children\u2019s Hospital, Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039324414","display_name":"V\u00edtor A. P. Martins dos Santos","orcid":"https://orcid.org/0000-0002-2352-9017"},"institutions":[{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Vitor Martins dos Santos","raw_affiliation_strings":["Wageningen University & Research centre, Agrotechnology & Food Sciences, Wageningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wageningen University & Research centre, Agrotechnology & Food Sciences, Wageningen, Netherlands","institution_ids":["https://openalex.org/I913481162"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088742946","display_name":"V\u0131\u0301ctor de Lorenzo","orcid":"https://orcid.org/0000-0002-6041-2731"},"institutions":[{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"V\u00edctor de Lorenzo","raw_affiliation_strings":["Systems Biology Program, Centro Nacional de Biotecnologa-CSIC, Campus Cantoblanco, Madrid, Spain","Systems Biology Program, Centro Nacional de Biotecnolog\u00eda-CSIC, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Program, Centro Nacional de Biotecnologa-CSIC, Campus Cantoblanco, Madrid, Spain","institution_ids":["https://openalex.org/I4210104776"]},{"raw_affiliation_string":"Systems Biology Program, Centro Nacional de Biotecnolog\u00eda-CSIC, Madrid, Spain","institution_ids":["https://openalex.org/I4210104776"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5040121825"],"corresponding_institution_ids":["https://openalex.org/I62916508"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.75,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.73745362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"6","issue":"1","first_page":"149","last_page":"149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudomonas-putida","display_name":"Pseudomonas putida","score":0.7516926527023315},{"id":"https://openalex.org/keywords/phosphotransferase","display_name":"Phosphotransferase","score":0.717296838760376},{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.5903581380844116},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.5897731184959412},{"id":"https://openalex.org/keywords/flux-balance-analysis","display_name":"Flux balance analysis","score":0.5252261161804199},{"id":"https://openalex.org/keywords/fructose","display_name":"Fructose","score":0.5142630934715271},{"id":"https://openalex.org/keywords/pep-group-translocation","display_name":"PEP group translocation","score":0.5052083134651184},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.47663959860801697},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4195367097854614},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.39079412817955017},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.36208850145339966},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.34702521562576294},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.2486647665500641},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.16043215990066528},{"id":"https://openalex.org/keywords/phosphoenolpyruvate-carboxykinase","display_name":"Phosphoenolpyruvate carboxykinase","score":0.10954254865646362}],"concepts":[{"id":"https://openalex.org/C2780543182","wikidata":"https://www.wikidata.org/wiki/Q2738168","display_name":"Pseudomonas putida","level":3,"score":0.7516926527023315},{"id":"https://openalex.org/C2777504003","wikidata":"https://www.wikidata.org/wiki/Q3381520","display_name":"Phosphotransferase","level":3,"score":0.717296838760376},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.5903581380844116},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.5897731184959412},{"id":"https://openalex.org/C167091322","wikidata":"https://www.wikidata.org/wiki/Q5463029","display_name":"Flux balance analysis","level":2,"score":0.5252261161804199},{"id":"https://openalex.org/C2776970464","wikidata":"https://www.wikidata.org/wiki/Q122043","display_name":"Fructose","level":2,"score":0.5142630934715271},{"id":"https://openalex.org/C45656491","wikidata":"https://www.wikidata.org/wiki/Q1538418","display_name":"PEP group translocation","level":4,"score":0.5052083134651184},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47663959860801697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4195367097854614},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.39079412817955017},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36208850145339966},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34702521562576294},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2486647665500641},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.16043215990066528},{"id":"https://openalex.org/C143937172","wikidata":"https://www.wikidata.org/wiki/Q303568","display_name":"Phosphoenolpyruvate carboxykinase","level":3,"score":0.10954254865646362},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010728","descriptor_name":"Phosphoenolpyruvate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010728","descriptor_name":"Phosphoenolpyruvate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010728","descriptor_name":"Phosphoenolpyruvate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010731","descriptor_name":"Phosphoenolpyruvate Sugar Phosphotransferase System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010731","descriptor_name":"Phosphoenolpyruvate Sugar Phosphotransferase System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010731","descriptor_name":"Phosphoenolpyruvate Sugar Phosphotransferase System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016958","descriptor_name":"Pseudomonas putida","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D016958","descriptor_name":"Pseudomonas putida","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D016958","descriptor_name":"Pseudomonas putida","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D016958","descriptor_name":"Pseudomonas putida","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016958","descriptor_name":"Pseudomonas putida","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016958","descriptor_name":"Pseudomonas putida","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019289","descriptor_name":"Pyruvic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019289","descriptor_name":"Pyruvic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019289","descriptor_name":"Pyruvic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-6-149","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-149","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-149","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:23216700","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23216700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:library.wur.nl:wurpubs/432263","is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/modeling-and-analysis-of-flux-distributions-in-the-two-branches-o","pdf_url":null,"source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ISSN: 1752-0509","raw_type":"Article/Letter to editor"},{"id":"pmh:oai:europepmc.org:2565769","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3562155","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:digital.csic.es:10261/65584","is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/65584","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Art\u00edculo"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1129789","is_oa":true,"landing_page_url":"http://mediatum.ub.tum.de/node?id=1129789","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-6-149","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-149","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-149","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.4699999988079071}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2044349720.pdf","grobid_xml":"https://content.openalex.org/works/W2044349720.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W112642569","https://openalex.org/W1502464218","https://openalex.org/W1546783991","https://openalex.org/W1570648636","https://openalex.org/W1692352656","https://openalex.org/W1924508503","https://openalex.org/W1971767514","https://openalex.org/W1995972929","https://openalex.org/W1996912752","https://openalex.org/W2011432458","https://openalex.org/W2012531533","https://openalex.org/W2021185868","https://openalex.org/W2031361744","https://openalex.org/W2050138011","https://openalex.org/W2051840094","https://openalex.org/W2054920102","https://openalex.org/W2064225836","https://openalex.org/W2064547428","https://openalex.org/W2065492641","https://openalex.org/W2069836703","https://openalex.org/W2071681271","https://openalex.org/W2079178430","https://openalex.org/W2079673773","https://openalex.org/W2083011190","https://openalex.org/W2091035438","https://openalex.org/W2092268570","https://openalex.org/W2105013618","https://openalex.org/W2111421616","https://openalex.org/W2119719542","https://openalex.org/W2123856846","https://openalex.org/W2133808275","https://openalex.org/W2138672920","https://openalex.org/W2139542233","https://openalex.org/W2160904340","https://openalex.org/W2166374078","https://openalex.org/W2167492238","https://openalex.org/W4327847579"],"related_works":["https://openalex.org/W2216617737","https://openalex.org/W2913500940","https://openalex.org/W2123159138","https://openalex.org/W1652028037","https://openalex.org/W2006276480","https://openalex.org/W1976727723","https://openalex.org/W2145658523","https://openalex.org/W1585151690","https://openalex.org/W2033434138","https://openalex.org/W1574593925"],"abstract_inverted_index":{"BACKGROUND:":[0],"Signal":[1],"transduction":[2],"plays":[3],"a":[4,27,33,54,70,196,210],"fundamental":[5],"role":[6,80,198],"in":[7,23],"the":[8,20,38,41,50,74,78,82,95,99,107,130,134,139,144,150,167,172,176,180,186,190,200,204],"understanding":[9],"of":[10,40,81,98,101,103,106,129,133,149,166,179,189,199,203],"cellular":[11],"physiology.":[12],"The":[13],"bacterial":[14],"phosphotransferase":[15],"system":[16],"(PTS)":[17],"together":[18],"with":[19,60],"PEP/pyruvate":[21],"node":[22],"central":[24,42],"metabolism":[25],"represents":[26],"signaling":[28],"unit":[29],"that":[30,163],"acts":[31],"as":[32,209],"sensory":[34],"element":[35],"and":[36,53,114,141,206],"measures":[37],"activity":[39],"metabolism.":[43],"Pseudomonas":[44],"putida":[45],"possesses":[46],"two":[47,75],"PTS":[48,108,173,205],"branches,":[49],"C-branch":[51],"(PTSFru)":[52],"second":[55,187,201],"branch":[56,188,202],"(PTSNtr),":[57],"which":[58],"communicate":[59],"each":[61],"other":[62],"by":[63,185],"phosphate":[64],"exchange.":[65],"Recent":[66],"experimental":[67,214],"results":[68],"showed":[69],"cross":[71],"talk":[72],"between":[73],"branches.":[76],"However,":[77],"functional":[79],"crosstalk":[83],"remains":[84],"open.":[85],"RESULTS:":[86],"A":[87],"mathematical":[88],"model":[89],"was":[90,124],"set":[91],"up":[92],"to":[93,126],"describe":[94],"available":[96],"data":[97,119],"state":[100],"phosphorylation":[102],"PtsN,":[104],"one":[105],"proteins,":[109],"for":[110,212],"different":[111,115],"environmental":[112],"conditions":[113],"strain":[116,153,170],"variants.":[117],"Additionally,":[118],"from":[120],"flux":[121,145],"balance":[122],"analysis":[123],"used":[125],"determine":[127],"some":[128],"kinetic":[131],"parameters":[132],"involved":[135],"reactions.":[136],"Based":[137],"on":[138,154,171],"calculated":[140],"estimated":[142],"parameters,":[143],"distribution":[146],"during":[147,164],"growth":[148,165],"wild":[151,168],"type":[152,169],"fructose":[155],"could":[156],"be":[157],"determined.":[158],"CONCLUSION:":[159],"Our":[160],"calculations":[161],"show":[162],"substrate":[174],"fructose,":[175],"major":[177],"part":[178],"phosphoryl":[181],"groups":[182],"is":[183],"provided":[184],"PTS.":[191],"This":[192],"theoretical":[193],"finding":[194],"indicates":[195],"new":[197],"will":[207],"serve":[208],"basis":[211],"further":[213],"studies.":[215]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}