{"id":"https://openalex.org/W2147005351","doi":"https://doi.org/10.1186/1752-0509-6-138","title":"A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen","display_name":"A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2147005351","doi":"https://doi.org/10.1186/1752-0509-6-138","mag":"2147005351","pmid":"https://pubmed.ncbi.nlm.nih.gov/23134774"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-6-138","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-138","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-138","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-138","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111461452","display_name":"Galina Lebedeva","orcid":null},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Galina Lebedeva","raw_affiliation_strings":["Centre for Synthetic and Systems Biology, University of Edinburgh, CH Waddington Building, the Kings Buildings, Mayfield Road, EH9 3JD, Edinburgh, UK. galina.lebedeva@ed.ac.uk","Centre for Synthetic and Systems Biology, University of Edinburgh, Edinburgh, UK"],"affiliations":[{"raw_affiliation_string":"Centre for Synthetic and Systems Biology, University of Edinburgh, CH Waddington Building, the Kings Buildings, Mayfield Road, EH9 3JD, Edinburgh, UK. galina.lebedeva@ed.ac.uk","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Centre for Synthetic and Systems Biology, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102136521","display_name":"Azusa Yamaguchi","orcid":null},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Azusa Yamaguchi","raw_affiliation_strings":["School of Informatics, University of Edinburgh, 10 Crichton Street, Edinburgh, UK","School of Informatics, University of Edinburgh, Edinburgh UK"],"affiliations":[{"raw_affiliation_string":"School of Informatics, University of Edinburgh, 10 Crichton Street, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"School of Informatics, University of Edinburgh, Edinburgh UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013140743","display_name":"Simon P. Langdon","orcid":"https://orcid.org/0000-0002-7200-9237"},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon P Langdon","raw_affiliation_strings":["Division of Pathology, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK","Division of Pathology, IGMM, University of Edinburgh, Edinburgh, UK"],"affiliations":[{"raw_affiliation_string":"Division of Pathology, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK","institution_ids":["https://openalex.org/I2800150677","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Division of Pathology, IGMM, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041891186","display_name":"Kenneth G. MacLeod","orcid":"https://orcid.org/0000-0002-6016-0837"},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kenneth Macleod","raw_affiliation_strings":["Division of Pathology, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK","Division of Pathology, IGMM, University of Edinburgh, Edinburgh, UK"],"affiliations":[{"raw_affiliation_string":"Division of Pathology, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK","institution_ids":["https://openalex.org/I2800150677","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Division of Pathology, IGMM, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064922783","display_name":"David J. Harrison","orcid":"https://orcid.org/0000-0001-9041-9988"},"institutions":[{"id":"https://openalex.org/I16835326","display_name":"University of St Andrews","ror":"https://ror.org/02wn5qz54","country_code":"GB","type":"education","lineage":["https://openalex.org/I16835326"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J Harrison","raw_affiliation_strings":["Medical and Biological Sciences Building, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9TF, UK","Medical and Biological Sciences Building, University of St Andrews, Fife, UK"],"affiliations":[{"raw_affiliation_string":"Medical and Biological Sciences Building, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9TF, UK","institution_ids":["https://openalex.org/I16835326"]},{"raw_affiliation_string":"Medical and Biological Sciences Building, University of St Andrews, Fife, UK","institution_ids":["https://openalex.org/I16835326"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5111461452"],"corresponding_institution_ids":["https://openalex.org/I98677209"],"apc_list":null,"apc_paid":null,"fwci":1.4493,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.8363326,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"6","issue":"1","first_page":"138","last_page":"138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9751999974250793,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9660999774932861,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tamoxifen","display_name":"Tamoxifen","score":0.9171916246414185},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"Estrogen receptor","score":0.6824092268943787},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-modulator","display_name":"Selective estrogen receptor modulator","score":0.5718128085136414},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"Estrogen receptor alpha","score":0.5206915140151978},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.502213716506958},{"id":"https://openalex.org/keywords/estrogen","display_name":"Estrogen","score":0.46239954233169556},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.4374191164970398},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4238021969795227},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.41823810338974},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3673642575740814},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.32733118534088135},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3004492521286011},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.2639944553375244},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.2127288281917572},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.19284185767173767},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17835566401481628}],"concepts":[{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.9171916246414185},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6824092268943787},{"id":"https://openalex.org/C2777944059","wikidata":"https://www.wikidata.org/wiki/Q903917","display_name":"Selective estrogen receptor modulator","level":5,"score":0.5718128085136414},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.5206915140151978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.502213716506958},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.46239954233169556},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4374191164970398},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4238021969795227},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41823810338974},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3673642575740814},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32733118534088135},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3004492521286011},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.2639944553375244},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2127288281917572},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19284185767173767},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17835566401481628}],"mesh":[{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-6-138","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-138","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-138","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:23134774","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23134774","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pure.ed.ac.uk:openaire/8196451a-0c79-44b3-88e9-79033761b61d","is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/8196451a-0c79-44b3-88e9-79033761b61d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lebedeva, G, Yamaguchi, A, Langdon, S P, Macleod, K & Harrison, D J 2012, 'A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen', BMC Systems Biology, vol. 6, no. 1, pp. 138. https://doi.org/10.1186/1752-0509-6-138","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:7805a14c7b804db7a70aefc75466209b","is_oa":true,"landing_page_url":"https://doaj.org/article/7805a14c7b804db7a70aefc75466209b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 6, Iss 1, p 138 (2012)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2576197","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3573949","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:research-repository.st-andrews.ac.uk:10023/3887","is_oa":true,"landing_page_url":"https://hdl.handle.net/10023/3887","pdf_url":null,"source":{"id":"https://openalex.org/S4306400230","display_name":"St Andrews Research Repository (St Andrews Research Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I16835326","host_organization_name":"University of St Andrews","host_organization_lineage":["https://openalex.org/I16835326"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-6-138","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-138","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-138","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2080879326","display_name":null,"funder_award_id":"D019621","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2160003213","display_name":null,"funder_award_id":"BB/D019621/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2425203025","display_name":null,"funder_award_id":"BB/D019621/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4370143863","display_name":null,"funder_award_id":"BB/D019621","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5670658412","display_name":null,"funder_award_id":"EPSRC","funder_id":"https://openalex.org/F4320320064","funder_display_name":"Scottish Funding Council"},{"id":"https://openalex.org/G922893353","display_name":"Centre for Systems Biology at Edinburgh","funder_award_id":"BB/D019621/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320320064","display_name":"Scottish Funding Council","ror":"https://ror.org/056bwcz71"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147005351.pdf","grobid_xml":"https://content.openalex.org/works/W2147005351.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W63802623","https://openalex.org/W1212251450","https://openalex.org/W1502739652","https://openalex.org/W1757178672","https://openalex.org/W1919924887","https://openalex.org/W1966216790","https://openalex.org/W1967005047","https://openalex.org/W1969083682","https://openalex.org/W1980040001","https://openalex.org/W1980970062","https://openalex.org/W1982057320","https://openalex.org/W1997007589","https://openalex.org/W1999999697","https://openalex.org/W2000262653","https://openalex.org/W2005524843","https://openalex.org/W2012773975","https://openalex.org/W2013322816","https://openalex.org/W2013788592","https://openalex.org/W2019816105","https://openalex.org/W2022121555","https://openalex.org/W2023660072","https://openalex.org/W2026408020","https://openalex.org/W2026927522","https://openalex.org/W2029653181","https://openalex.org/W2033458863","https://openalex.org/W2035059302","https://openalex.org/W2038208040","https://openalex.org/W2039576757","https://openalex.org/W2041002275","https://openalex.org/W2041022431","https://openalex.org/W2042124938","https://openalex.org/W2045389096","https://openalex.org/W2051582399","https://openalex.org/W2051950850","https://openalex.org/W2052024663","https://openalex.org/W2052369163","https://openalex.org/W2055862445","https://openalex.org/W2056299617","https://openalex.org/W2059354961","https://openalex.org/W2059832897","https://openalex.org/W2061671852","https://openalex.org/W2064469818","https://openalex.org/W2066441904","https://openalex.org/W2069103780","https://openalex.org/W2072835427","https://openalex.org/W2074046037","https://openalex.org/W2076941162","https://openalex.org/W2079543349","https://openalex.org/W2087377669","https://openalex.org/W2096248361","https://openalex.org/W2097947745","https://openalex.org/W2101738855","https://openalex.org/W2104159099","https://openalex.org/W2105379381","https://openalex.org/W2105598902","https://openalex.org/W2109388713","https://openalex.org/W2122833634","https://openalex.org/W2127997722","https://openalex.org/W2128551987","https://openalex.org/W2130235602","https://openalex.org/W2133473049","https://openalex.org/W2139657953","https://openalex.org/W2143185770","https://openalex.org/W2150081723","https://openalex.org/W2152803686","https://openalex.org/W2152856165","https://openalex.org/W2155803397","https://openalex.org/W2155826575","https://openalex.org/W2164871552","https://openalex.org/W2165626744","https://openalex.org/W2166751342","https://openalex.org/W2167371528","https://openalex.org/W2169318796","https://openalex.org/W2187452737","https://openalex.org/W2216423518","https://openalex.org/W2419060838","https://openalex.org/W4235921732"],"related_works":["https://openalex.org/W2897518628","https://openalex.org/W2394521252","https://openalex.org/W2005957565","https://openalex.org/W1853105055","https://openalex.org/W2415102313","https://openalex.org/W3209895153","https://openalex.org/W145065296","https://openalex.org/W2364285896","https://openalex.org/W2413892742","https://openalex.org/W200925908"],"abstract_inverted_index":{"We":[0],"established":[1],"a":[2,36],"minimal":[3],"mechanistic":[4],"model":[5],"of":[6,24,35,45,54,63,70,73],"ER-dependent":[7],"gene":[8],"expression,":[9],"that":[10,32,48],"predicts":[11],"complex":[12],"non-linear":[13],"effects":[14,53],"in":[15,20,75],"transcriptional":[16],"response":[17],"to":[18,51],"tamoxifen":[19],"the":[21,33,58,61,71],"broad":[22],"range":[23],"biologically":[25],"plausible":[26],"parameter":[27],"values.":[28],"Our":[29],"findings":[30],"suggest":[31],"outcome":[34],"SERM's":[37],"action":[38],"is":[39],"defined":[40],"by":[41],"several":[42],"key":[43],"components":[44],"cellular":[46],"micro-environment,":[47],"may":[49],"contribute":[50],"cell-type-specific":[52],"SERMs":[55,74],"and":[56],"justify":[57],"need":[59],"for":[60,66],"development":[62],"combinatorial":[64],"biomarkers":[65],"more":[67],"accurate":[68],"prediction":[69],"efficacy":[72],"specific":[76],"cell":[77],"types.":[78]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
