{"id":"https://openalex.org/W2114334846","doi":"https://doi.org/10.1186/1752-0509-6-117","title":"Integrated network analysis reveals a novel role for the cell cycle in 2009 pandemic influenza virus-induced inflammation in macaque lungs","display_name":"Integrated network analysis reveals a novel role for the cell cycle in 2009 pandemic influenza virus-induced inflammation in macaque lungs","publication_year":2012,"publication_date":"2012-08-31","ids":{"openalex":"https://openalex.org/W2114334846","doi":"https://doi.org/10.1186/1752-0509-6-117","mag":"2114334846","pmid":"https://pubmed.ncbi.nlm.nih.gov/22937776"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-6-117","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-117","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-117","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-117","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011546242","display_name":"Jason E. Shoemaker","orcid":"https://orcid.org/0000-0003-3315-7103"},"institutions":[{"id":"https://openalex.org/I4210158720","display_name":"Social Insurance Saitama Chuo Hospital","ror":"https://ror.org/04vqzd428","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210132540","https://openalex.org/I4210158720"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jason E Shoemaker","raw_affiliation_strings":["ERATO Infection-Induced Host Responses Project, Saitama, 332-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ERATO Infection-Induced Host Responses Project, Saitama, 332-0012, Japan","institution_ids":["https://openalex.org/I4210158720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112679419","display_name":"Satoshi Fukuyama","orcid":null},"institutions":[{"id":"https://openalex.org/I4210158720","display_name":"Social Insurance Saitama Chuo Hospital","ror":"https://ror.org/04vqzd428","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210132540","https://openalex.org/I4210158720"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Fukuyama","raw_affiliation_strings":["ERATO Infection-Induced Host Responses Project, Saitama, 332-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ERATO Infection-Induced Host Responses Project, Saitama, 332-0012, Japan","institution_ids":["https://openalex.org/I4210158720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033752290","display_name":"Amie J. Eisfeld","orcid":"https://orcid.org/0000-0003-2231-3107"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amie J Eisfeld","raw_affiliation_strings":["School of Veterinary Medicine, Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine, Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031034213","display_name":"Yukiko Muramoto","orcid":"https://orcid.org/0000-0002-8706-3113"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yukiko Muramoto","raw_affiliation_strings":["Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103503588","display_name":"Shinji Watanabe","orcid":null},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210158720","display_name":"Social Insurance Saitama Chuo Hospital","ror":"https://ror.org/04vqzd428","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210132540","https://openalex.org/I4210158720"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Shinji Watanabe","raw_affiliation_strings":["ERATO Infection-Induced Host Responses Project, Saitama, 332-0012, Japan","School of Veterinary Medicine, Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ERATO Infection-Induced Host Responses Project, Saitama, 332-0012, Japan","institution_ids":["https://openalex.org/I4210158720"]},{"raw_affiliation_string":"School of Veterinary Medicine, Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114833713","display_name":"Tokiko Watanabe","orcid":"https://orcid.org/0000-0002-8242-7539"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210158720","display_name":"Social Insurance Saitama Chuo Hospital","ror":"https://ror.org/04vqzd428","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210132540","https://openalex.org/I4210158720"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Tokiko Watanabe","raw_affiliation_strings":["ERATO Infection-Induced Host Responses Project, Saitama, 332-0012, Japan","School of Veterinary Medicine, Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ERATO Infection-Induced Host Responses Project, Saitama, 332-0012, Japan","institution_ids":["https://openalex.org/I4210158720"]},{"raw_affiliation_string":"School of Veterinary Medicine, Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101616697","display_name":"Yukiko Matsuoka","orcid":"https://orcid.org/0000-0002-5171-9096"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210118579","display_name":"Systems Biology Institute","ror":"https://ror.org/02c7akf81","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4210118579"]},{"id":"https://openalex.org/I4210158720","display_name":"Social Insurance Saitama Chuo Hospital","ror":"https://ror.org/04vqzd428","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210132540","https://openalex.org/I4210158720"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Yukiko Matsuoka","raw_affiliation_strings":["ERATO Infection-Induced Host Responses Project, Saitama, 332-0012, Japan","School of Veterinary Medicine, Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, Madison, WI, USA","The Systems Biology Institute, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ERATO Infection-Induced Host Responses Project, Saitama, 332-0012, Japan","institution_ids":["https://openalex.org/I4210158720"]},{"raw_affiliation_string":"School of Veterinary Medicine, Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"The Systems Biology Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4210118579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086835862","display_name":"Hiroaki Kitano","orcid":"https://orcid.org/0000-0002-3589-1953"},"institutions":[{"id":"https://openalex.org/I142637625","display_name":"Okinawa Institute of Science and Technology Graduate University","ror":"https://ror.org/02qg15b79","country_code":"JP","type":"education","lineage":["https://openalex.org/I142637625"]},{"id":"https://openalex.org/I4210118579","display_name":"Systems Biology Institute","ror":"https://ror.org/02c7akf81","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4210118579"]},{"id":"https://openalex.org/I4210122684","display_name":"Sony Computer Science Laboratories","ror":"https://ror.org/02nc46417","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210122684"]},{"id":"https://openalex.org/I4210158720","display_name":"Social Insurance Saitama Chuo Hospital","ror":"https://ror.org/04vqzd428","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210132540","https://openalex.org/I4210158720"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroaki Kitano","raw_affiliation_strings":["Division of Systems Biology, Cancer Institute, Tokyo, Japan","ERATO Infection-Induced Host Responses Project, Saitama, 332-0012, Japan","Okinawa Institute of Science and Technology, Okinawa, Japan","Sony Computer Science Laboratories, Inc, Tokyo, Japan","The Systems Biology Institute, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Systems Biology, Cancer Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4210118579"]},{"raw_affiliation_string":"ERATO Infection-Induced Host Responses Project, Saitama, 332-0012, Japan","institution_ids":["https://openalex.org/I4210158720"]},{"raw_affiliation_string":"Okinawa Institute of Science and Technology, Okinawa, Japan","institution_ids":["https://openalex.org/I142637625"]},{"raw_affiliation_string":"Sony Computer Science Laboratories, Inc, Tokyo, Japan","institution_ids":["https://openalex.org/I4210122684"]},{"raw_affiliation_string":"The Systems Biology Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4210118579"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076363097","display_name":"Yoshihiro Kawaoka","orcid":"https://orcid.org/0000-0001-5061-8296"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]},{"id":"https://openalex.org/I4210086300","display_name":"National Institute of Infectious Diseases","ror":"https://ror.org/001ggbx22","country_code":"JP","type":"government","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210086300"]},{"id":"https://openalex.org/I4210158720","display_name":"Social Insurance Saitama Chuo Hospital","ror":"https://ror.org/04vqzd428","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210132540","https://openalex.org/I4210158720"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"Yoshihiro Kawaoka","raw_affiliation_strings":["Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan","Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan","ERATO Infection-Induced Host Responses Project, Saitama, 332-0012, Japan","International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan","School of Veterinary Medicine, Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan","institution_ids":["https://openalex.org/I161296585","https://openalex.org/I4210086300"]},{"raw_affiliation_string":"Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan","institution_ids":[]},{"raw_affiliation_string":"ERATO Infection-Induced Host Responses Project, Saitama, 332-0012, Japan","institution_ids":["https://openalex.org/I4210158720"]},{"raw_affiliation_string":"International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan","institution_ids":["https://openalex.org/I161296585","https://openalex.org/I4210086300"]},{"raw_affiliation_string":"School of Veterinary Medicine, Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5076363097","https://openalex.org/A5086835862"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I142637625","https://openalex.org/I161296585","https://openalex.org/I4210086300","https://openalex.org/I4210118579","https://openalex.org/I4210122684","https://openalex.org/I4210158720"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":1.0459,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.74971217,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"6","issue":"1","first_page":"117","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6769999861717224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6769999861717224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.1143999993801117,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.03519999980926514,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7335101962089539},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.7138311266899109},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"Influenza A virus","score":0.5705970525741577},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.5545651912689209},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.5510866045951843},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.5134573578834534},{"id":"https://openalex.org/keywords/macaque","display_name":"Macaque","score":0.5124814510345459},{"id":"https://openalex.org/keywords/inflammation","display_name":"Inflammation","score":0.4834238290786743},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.4252150058746338},{"id":"https://openalex.org/keywords/pandemic","display_name":"Pandemic","score":0.4135389029979706},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.41268014907836914},{"id":"https://openalex.org/keywords/viral-entry","display_name":"Viral entry","score":0.41045185923576355},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.30173563957214355},{"id":"https://openalex.org/keywords/viral-replication","display_name":"Viral replication","score":0.28124308586120605},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2738580107688904},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.21138295531272888},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.17841535806655884},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17537623643875122},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.15367302298545837},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.1121944785118103},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.09220927953720093}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7335101962089539},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7138311266899109},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.5705970525741577},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5545651912689209},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5510866045951843},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5134573578834534},{"id":"https://openalex.org/C2778950215","wikidata":"https://www.wikidata.org/wiki/Q177601","display_name":"Macaque","level":2,"score":0.5124814510345459},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4834238290786743},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4252150058746338},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.4135389029979706},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.41268014907836914},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.41045185923576355},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.30173563957214355},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.28124308586120605},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2738580107688904},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.21138295531272888},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17841535806655884},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17537623643875122},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15367302298545837},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1121944785118103},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.09220927953720093},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008251","descriptor_name":"Macaca","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008251","descriptor_name":"Macaca","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008251","descriptor_name":"Macaca","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020170","descriptor_name":"Caspase 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020170","descriptor_name":"Caspase 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020170","descriptor_name":"Caspase 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-6-117","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-117","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-117","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:22937776","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22937776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:3b81c7cf094849f1a40da32da54b51e8","is_oa":false,"landing_page_url":"https://doaj.org/article/3b81c7cf094849f1a40da32da54b51e8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 6, Iss 1, p 117 (2012)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3481363","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3481363","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-6-117","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-117","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-117","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8799999952316284}],"awards":[{"id":"https://openalex.org/G2791241728","display_name":"Novel influenza A virus proteins translated from PA mRNA","funder_award_id":"24780296","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7900981282","display_name":null,"funder_award_id":"22136001","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320338112","display_name":"Exploratory Research for Advanced Technology","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2114334846.pdf","grobid_xml":"https://content.openalex.org/works/W2114334846.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W6853850","https://openalex.org/W63970443","https://openalex.org/W1505566296","https://openalex.org/W1509421499","https://openalex.org/W1559694381","https://openalex.org/W1589410278","https://openalex.org/W1968541274","https://openalex.org/W1975296966","https://openalex.org/W1993728991","https://openalex.org/W2022979064","https://openalex.org/W2029232440","https://openalex.org/W2033279040","https://openalex.org/W2034246340","https://openalex.org/W2046208657","https://openalex.org/W2046533318","https://openalex.org/W2048045157","https://openalex.org/W2056446653","https://openalex.org/W2061200010","https://openalex.org/W2061904548","https://openalex.org/W2062254269","https://openalex.org/W2067340289","https://openalex.org/W2072602645","https://openalex.org/W2073234751","https://openalex.org/W2073716990","https://openalex.org/W2084624202","https://openalex.org/W2084639277","https://openalex.org/W2091849628","https://openalex.org/W2097795961","https://openalex.org/W2098349861","https://openalex.org/W2098881474","https://openalex.org/W2111307294","https://openalex.org/W2114381883","https://openalex.org/W2119394949","https://openalex.org/W2125268207","https://openalex.org/W2130014663","https://openalex.org/W2130790725","https://openalex.org/W2139372108","https://openalex.org/W2140612509","https://openalex.org/W2156140162","https://openalex.org/W2156613610","https://openalex.org/W2158217645","https://openalex.org/W2162080474","https://openalex.org/W2166655109","https://openalex.org/W2169336597","https://openalex.org/W2312463092","https://openalex.org/W2508794604","https://openalex.org/W4238581030","https://openalex.org/W4292196572","https://openalex.org/W4313306023"],"related_works":["https://openalex.org/W2080953535","https://openalex.org/W2090251528","https://openalex.org/W2162191803","https://openalex.org/W1820808323","https://openalex.org/W2147629250","https://openalex.org/W2400613564","https://openalex.org/W2016052042","https://openalex.org/W4283802257","https://openalex.org/W2772479624","https://openalex.org/W3211148092"],"abstract_inverted_index":{"BACKGROUND:":[0],"Annually,":[1],"influenza":[2,21,51,65,82],"A":[3],"viruses":[4],"circulate":[5],"the":[6,37,61,73,165,181,185,213],"world":[7],"causing":[8],"wide-spread":[9],"sickness,":[10],"economic":[11],"loss,":[12],"and":[13,108,117,127,151,158,208],"death.":[14],"One":[15],"way":[16],"to":[17,26,50,79,93,132,234],"better":[18],"defend":[19],"against":[20,236],"virus-induced":[22],"disease":[23],"may":[24],"be":[25],"develop":[27],"novel":[28,112],"host-based":[29],"therapies,":[30],"targeted":[31],"at":[32],"mitigating":[33],"viral":[34,145],"pathogenesis":[35],"through":[36],"management":[38],"of":[39,75,187],"virus-dysregulated":[40],"host":[41,48,95,138],"functions.":[42],"However,":[43],"mechanisms":[44],"that":[45,60,98,180],"govern":[46],"aberrant":[47],"responses":[49],"virus":[52,64,83,194,215],"infection":[53],"remain":[54],"incompletely":[55],"understood.":[56],"We":[57],"previously":[58],"showed":[59],"pandemic":[62],"H1N1":[63],"A/California/04/2009":[66],"(H1N1;":[67,86],"CA04)":[68],"has":[69],"enhanced":[70,144,182],"pathogenicity":[71],"in":[72,104,155,172,212],"lungs":[74],"cynomolgus":[76],"macaques":[77],"relative":[78],"a":[80,111,134,160,188,200,217],"seasonal":[81],"isolate":[84],"(A/Kawasaki/UTK-4/2009":[85],"KUTK4)).":[87],"RESULTS:":[88],"Here,":[89],"we":[90,109,198],"used":[91],"microarrays":[92],"identify":[94,199],"gene":[96],"sequences":[97],"were":[99],"highly":[100],"differentially":[101,136],"expressed":[102],"(DE)":[103],"CA04-infected":[105,156],"macaque":[106],"lungs,":[107,157],"employed":[110],"strategy":[113],"-":[114,131],"combining":[115],"functional":[116],"pathway":[118],"enrichment":[119,125],"analyses,":[120],"transcription":[121,170],"factor":[122,171],"binding":[123],"site":[124],"analysis":[126],"protein-protein":[128],"interaction":[129],"data":[130],"create":[133],"CA04":[135],"regulated":[137],"response":[139],"network.":[140],"This":[141,224],"network":[142],"describes":[143],"RNA":[146],"sensing,":[147],"immune":[148,190,205],"cell":[149,152,206],"signaling":[150,207],"cycle":[153],"arrest":[154],"highlights":[159],"novel,":[161],"putative":[162],"role":[163],"for":[164,229],"MYC-associated":[166],"zinc":[167],"finger":[168],"(MAZ)":[169],"regulating":[173],"these":[174],"processes.":[175],"CONCLUSIONS:":[176],"Our":[177],"findings":[178],"suggest":[179],"pathology":[183],"is":[184,210],"result":[186],"prolonged":[189],"response,":[191],"despite":[192],"successful":[193],"clearance.":[195],"Most":[196],"interesting,":[197],"mechanism":[201],"which":[202],"normally":[203],"suppresses":[204],"inflammation":[209],"ineffective":[211],"pH1N1":[214],"infection;":[216],"dyregulatory":[218],"event":[219],"also":[220],"associated":[221],"with":[222],"arthritis.":[223],"dysregulation":[225],"offers":[226],"several":[227],"opportunities":[228],"developing":[230],"strain-independent,":[231],"immunomodulatory":[232],"therapies":[233],"protect":[235],"future":[237],"pandemics.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
