{"id":"https://openalex.org/W2043705808","doi":"https://doi.org/10.1186/1752-0509-5-s2-s12","title":"Drug-drug relationship based on target information: application to drug target identification","display_name":"Drug-drug relationship based on target information: application to drug target identification","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2043705808","doi":"https://doi.org/10.1186/1752-0509-5-s2-s12","mag":"2043705808","pmid":"https://pubmed.ncbi.nlm.nih.gov/22784569"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-s2-s12","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-s2-s12","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-S2-S12","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"conference-abstract","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-S2-S12","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006597552","display_name":"Keunwan Park","orcid":"https://orcid.org/0000-0002-8783-9495"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I4210101891","display_name":"Korea Institute of Brain Science","ror":"https://ror.org/017stnw60","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210101891"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Keunwan Park","raw_affiliation_strings":["Department of Bio and Brain Engineering, KAIST, 373-1, Guseong-dong, Yuseong-gu, Daejeon, 305-701, Republic of Korea","Department of Bio and Brain Engineering, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bio and Brain Engineering, KAIST, 373-1, Guseong-dong, Yuseong-gu, Daejeon, 305-701, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Department of Bio and Brain Engineering, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I4210101891"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071721971","display_name":"Dongsup Kim","orcid":"https://orcid.org/0000-0002-5916-6799"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I4210101891","display_name":"Korea Institute of Brain Science","ror":"https://ror.org/017stnw60","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210101891"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Dongsup Kim","raw_affiliation_strings":["Department of Bio and Brain Engineering, KAIST, 373-1, Guseong-dong, Yuseong-gu, Daejeon, 305-701, Republic of Korea","Department of Bio and Brain Engineering, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bio and Brain Engineering, KAIST, 373-1, Guseong-dong, Yuseong-gu, Daejeon, 305-701, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Department of Bio and Brain Engineering, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I4210101891"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071721971"],"corresponding_institution_ids":["https://openalex.org/I157485424","https://openalex.org/I4210101891"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":null,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"Suppl 2","first_page":"S12","last_page":"S12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9805999994277954,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9805999994277954,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.8015614151954651},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.5862962007522583},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5508230328559875},{"id":"https://openalex.org/keywords/drug-target","display_name":"Drug target","score":0.5432804822921753},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5159333348274231},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.47951391339302063},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4641937017440796},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.444450318813324},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.4217385947704315},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2558196187019348},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.23410949110984802},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.20351237058639526},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18496784567832947}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.8015614151954651},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.5862962007522583},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5508230328559875},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.5432804822921753},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5159333348274231},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.47951391339302063},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4641937017440796},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.444450318813324},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.4217385947704315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2558196187019348},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.23410949110984802},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.20351237058639526},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18496784567832947},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-5-s2-s12","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-s2-s12","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-S2-S12","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:22784569","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22784569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:3287478","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3287478","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-s2-s12","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-s2-s12","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-S2-S12","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322091","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883"},{"id":"https://openalex.org/F4320322105","display_name":"Korea Institute of Science and Technology Information","ror":"https://ror.org/01k4yrm29"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2043705808.pdf","grobid_xml":"https://content.openalex.org/works/W2043705808.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1544009106","https://openalex.org/W1581314429","https://openalex.org/W1822144788","https://openalex.org/W1965440813","https://openalex.org/W1970202530","https://openalex.org/W1972935024","https://openalex.org/W1974037865","https://openalex.org/W1983434083","https://openalex.org/W2012949016","https://openalex.org/W2021083597","https://openalex.org/W2026910177","https://openalex.org/W2031159640","https://openalex.org/W2041928013","https://openalex.org/W2050934134","https://openalex.org/W2060899114","https://openalex.org/W2066688904","https://openalex.org/W2081050523","https://openalex.org/W2089589794","https://openalex.org/W2096729078","https://openalex.org/W2125253492","https://openalex.org/W2129448726","https://openalex.org/W2137052779","https://openalex.org/W2138512826","https://openalex.org/W2150065588","https://openalex.org/W2150472473","https://openalex.org/W2154896031","https://openalex.org/W2159887157","https://openalex.org/W2170146596","https://openalex.org/W2911964244","https://openalex.org/W2949243165","https://openalex.org/W2952213121"],"related_works":["https://openalex.org/W2553548503","https://openalex.org/W3045995536","https://openalex.org/W2226749982","https://openalex.org/W1967404732","https://openalex.org/W1989543759","https://openalex.org/W4310831746","https://openalex.org/W4386507285","https://openalex.org/W4379010217","https://openalex.org/W3206915023","https://openalex.org/W2035359345"],"abstract_inverted_index":{"BACKGROUND:":[0],"Drugs":[1],"that":[2,201],"bind":[3],"to":[4,43,58,100,105,154,207],"common":[5,107,163],"targets":[6],"likely":[7],"exert":[8],"similar":[9],"activities.":[10,30],"In":[11,109],"this":[12,32],"target-centric":[13],"view,":[14],"the":[15,24,36,64,77,112,115,127,149,160,166,202],"inclusion":[16],"of":[17,41,114,137,148,162,178,197],"richer":[18],"target":[19,61],"information":[20,62],"may":[21],"better":[22],"represent":[23],"relationships":[25],"between":[26],"drugs":[27],"and":[28,81,95,158,181],"their":[29,82],"Under":[31],"assumption,":[33],"we":[34],"expanded":[35],"\"common":[37],"binding":[38],"rule\"":[39],"assumption":[40],"QSAR":[42],"create":[44],"a":[45,106,121,182],"new":[46],"drug-drug":[47,65,116,143],"relationship":[48,66,117],"score":[49,151],"(DRS).":[50],"METHOD:":[51],"Our":[52],"method":[53,188,199],"uses":[54],"various":[55],"chemical":[56,138],"features":[57,139],"encode":[59],"drug":[60,69,79,102,168,191],"into":[63,73],"information.":[67],"Specifically,":[68],"pairs":[70,103],"were":[71,98,152],"transformed":[72],"numerical":[74],"vectors":[75],"containing":[76],"basal":[78],"properties":[80],"differences.":[83],"After":[84],"that,":[85],"machine":[86,132],"learning":[87,133],"techniques":[88,134],"such":[89,211],"as":[90,120,212],"data":[91],"cleaning,":[92],"dimension":[93],"reduction,":[94],"ensemble":[96],"classifier":[97],"used":[99,206],"prioritize":[101],"bound":[104],"target.":[108],"other":[110],"words,":[111],"estimation":[113],"is":[118,200],"restated":[119],"large-scale":[122],"classification":[123],"problem,":[124],"which":[125],"provides":[126],"framework":[128],"for":[129,140,165,173,189],"using":[130],"state-of-the-art":[131],"with":[135,185],"thousands":[136],"newly":[141],"defining":[142],"relationships.":[144],"CONCLUSIONS:":[145],"Various":[146],"aspects":[147],"presented":[150],"examined":[153],"determine":[155],"its":[156],"reliability":[157],"usefulness:":[159],"abundance":[161],"domains":[164],"predicted":[167],"pairs,":[169],"c.a.":[170],"80%":[171],"coverage":[172],"known":[174],"targets,":[175,180],"successful":[176],"identifications":[177],"unknown":[179],"meaningful":[183],"correlation":[184],"another":[186],"cutting-edge":[187],"analyzing":[190],"similarities.":[192],"The":[193],"most":[194],"significant":[195],"strength":[196],"our":[198],"DRS":[203],"can":[204],"be":[205],"describe":[208],"phenotypic":[209],"similarities,":[210],"pharmacological":[213],"effects.":[214]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}