{"id":"https://openalex.org/W2016664053","doi":"https://doi.org/10.1186/1752-0509-5-s1-s16","title":"Network screening of Goto-Kakizaki rat liver microarray data during diabetic progression","display_name":"Network screening of Goto-Kakizaki rat liver microarray data during diabetic progression","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2016664053","doi":"https://doi.org/10.1186/1752-0509-5-s1-s16","mag":"2016664053","pmid":"https://pubmed.ncbi.nlm.nih.gov/21689475"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-s1-s16","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-s1-s16","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-S1-S16","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"conference-abstract","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-S1-S16","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111576556","display_name":"Huarong Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huarong Zhou","raw_affiliation_strings":["Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. hrzhou@sibs.ac.cn","Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. hrzhou@sibs.ac.cn","institution_ids":["https://openalex.org/I4210106477"]},{"raw_affiliation_string":"Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007377061","display_name":"Shigeru Saito","orcid":"https://orcid.org/0000-0002-8708-9102"},"institutions":[{"id":"https://openalex.org/I3005327000","display_name":"Institute for Infocomm Research","ror":"https://ror.org/053rfa017","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I3005327000","https://openalex.org/I91275662"]},{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP","SG"],"is_corresponding":false,"raw_author_name":"Shigeru Saito","raw_affiliation_strings":["Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, 135-0064, Japan","INFOCOM Corporation, Tokyo, 150-0001, Japan","Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, 135-0064, Japan","institution_ids":["https://openalex.org/I73613424"]},{"raw_affiliation_string":"INFOCOM Corporation, Tokyo, 150-0001, Japan","institution_ids":["https://openalex.org/I3005327000"]},{"raw_affiliation_string":"Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I73613424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001095645","display_name":"Guanying Piao","orcid":null},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210103894","display_name":"Hefei National Center for Physical Sciences at Nanoscale","ror":"https://ror.org/01jeedh73","country_code":"CN","type":"facility","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366","https://openalex.org/I4210103894"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanying Piao","raw_affiliation_strings":["Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China","Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, China","Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China","institution_ids":["https://openalex.org/I126520041","https://openalex.org/I4210103894"]},{"raw_affiliation_string":"Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"raw_affiliation_string":"Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, China","institution_ids":["https://openalex.org/I126520041","https://openalex.org/I4210103894"]},{"raw_affiliation_string":"Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109218292","display_name":"Zhi-Ping Liu","orcid":"https://orcid.org/0000-0002-2437-3536"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Ping Liu","raw_affiliation_strings":["Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"raw_affiliation_string":"Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101451440","display_name":"Jiguang Wang","orcid":"https://orcid.org/0000-0002-6923-4097"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiguang Wang","raw_affiliation_strings":["Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"raw_affiliation_string":"Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045840721","display_name":"Katsuhisa Horimoto","orcid":"https://orcid.org/0000-0002-8328-6694"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["CN","JP"],"is_corresponding":true,"raw_author_name":"Katsuhisa Horimoto","raw_affiliation_strings":["Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, 135-0064, Japan","Institute of Systems Biology, Shanghai University, Shanghai, 200444, China","Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan","Institute of Systems Biology, Shanghai University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, 135-0064, Japan","institution_ids":["https://openalex.org/I73613424"]},{"raw_affiliation_string":"Institute of Systems Biology, Shanghai University, Shanghai, 200444, China","institution_ids":["https://openalex.org/I113940042"]},{"raw_affiliation_string":"Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I73613424"]},{"raw_affiliation_string":"Institute of Systems Biology, Shanghai University, Shanghai, China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012283696","display_name":"Luonan Chen","orcid":"https://orcid.org/0000-0002-3960-0068"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["CN","JP"],"is_corresponding":true,"raw_author_name":"Luonan Chen","raw_affiliation_strings":["Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, 135-0064, Japan","Institute of Systems Biology, Shanghai University, Shanghai, 200444, China","Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan","Institute of Systems Biology, Shanghai University, Shanghai, China","Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, 135-0064, Japan","institution_ids":["https://openalex.org/I73613424"]},{"raw_affiliation_string":"Institute of Systems Biology, Shanghai University, Shanghai, 200444, China","institution_ids":["https://openalex.org/I113940042"]},{"raw_affiliation_string":"Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"raw_affiliation_string":"Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I73613424"]},{"raw_affiliation_string":"Institute of Systems Biology, Shanghai University, Shanghai, China","institution_ids":["https://openalex.org/I113940042"]},{"raw_affiliation_string":"Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5012283696","https://openalex.org/A5045840721","https://openalex.org/A5111576556"],"corresponding_institution_ids":["https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I73613424"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":null,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"Suppl 1","first_page":"S16","last_page":"S16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.3504999876022339,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.3504999876022339,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.06279999762773514,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.05770000070333481,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.7251604199409485},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.7026195526123047},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.6622177362442017},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.6520084142684937},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5327261686325073},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4842495620250702},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4632725715637207},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.441896915435791},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.42426687479019165},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3955903649330139},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.35954487323760986},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.34597116708755493},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3144344687461853},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.2578592300415039},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.22713804244995117},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19278469681739807}],"concepts":[{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.7251604199409485},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.7026195526123047},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6622177362442017},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.6520084142684937},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5327261686325073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4842495620250702},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4632725715637207},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.441896915435791},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42426687479019165},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3955903649330139},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35954487323760986},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.34597116708755493},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3144344687461853},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2578592300415039},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22713804244995117},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19278469681739807}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-5-s1-s16","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-s1-s16","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-S1-S16","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:21689475","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21689475","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:3121116","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3121116","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:repository.hkust.edu.hk:1783.1-81511","is_oa":false,"landing_page_url":"http://repository.hkust.edu.hk/ir/Record/1783.1-81511","pdf_url":null,"source":{"id":"https://openalex.org/S4306401796","display_name":"Rare & Special e-Zone (The Hong Kong University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I200769079","host_organization_name":"Hong Kong University of Science and Technology","host_organization_lineage":["https://openalex.org/I200769079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-s1-s16","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-s1-s16","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-S1-S16","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1828425977","display_name":null,"funder_award_id":"973 Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3042681841","display_name":null,"funder_award_id":"2011CB504003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G404715356","display_name":null,"funder_award_id":"91029301","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G5019685449","display_name":null,"funder_award_id":"973Program","funder_id":"https://openalex.org/F4320327563","funder_display_name":"Major State Basic Research Development Program of China"},{"id":"https://openalex.org/G5800477032","display_name":null,"funder_award_id":"61072149","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5987144200","display_name":null,"funder_award_id":"2009CSP002","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G6495355840","display_name":null,"funder_award_id":"2009CSP002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6844234221","display_name":null,"funder_award_id":"2011CB504003","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8426690845","display_name":null,"funder_award_id":"91029301","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8957980045","display_name":null,"funder_award_id":"91029301","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320309612","display_name":"Natural Science Foundation of Shanghai","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320321530","display_name":"Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences","ror":"https://ror.org/011rf9d86"},{"id":"https://openalex.org/F4320327563","display_name":"Major State Basic Research Development Program of China","ror":null},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016664053.pdf","grobid_xml":"https://content.openalex.org/works/W2016664053.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W408793434","https://openalex.org/W633291512","https://openalex.org/W1500657154","https://openalex.org/W1549774650","https://openalex.org/W1928424447","https://openalex.org/W1977633287","https://openalex.org/W1980740451","https://openalex.org/W1981052578","https://openalex.org/W1990183405","https://openalex.org/W1998083587","https://openalex.org/W2000944510","https://openalex.org/W2007437829","https://openalex.org/W2014694767","https://openalex.org/W2022986290","https://openalex.org/W2025143098","https://openalex.org/W2027435290","https://openalex.org/W2027547437","https://openalex.org/W2033123284","https://openalex.org/W2035614767","https://openalex.org/W2056576390","https://openalex.org/W2061674320","https://openalex.org/W2065599173","https://openalex.org/W2069711307","https://openalex.org/W2079160762","https://openalex.org/W2084753433","https://openalex.org/W2088781656","https://openalex.org/W2094382067","https://openalex.org/W2097213953","https://openalex.org/W2104562247","https://openalex.org/W2104691673","https://openalex.org/W2112082957","https://openalex.org/W2130410032","https://openalex.org/W2131884064","https://openalex.org/W2146348844","https://openalex.org/W2147987672","https://openalex.org/W2152525973","https://openalex.org/W2154947819","https://openalex.org/W2155583793","https://openalex.org/W2158925425","https://openalex.org/W2167826316","https://openalex.org/W2170061704","https://openalex.org/W2316858638","https://openalex.org/W2502908839","https://openalex.org/W4238798265","https://openalex.org/W4239679102"],"related_works":["https://openalex.org/W1983994322","https://openalex.org/W2998765584","https://openalex.org/W2053053668","https://openalex.org/W2415025170","https://openalex.org/W74695042","https://openalex.org/W1531528770","https://openalex.org/W3032874291","https://openalex.org/W4250790143","https://openalex.org/W2986501422","https://openalex.org/W2945809197"],"abstract_inverted_index":{"BACKGROUND:":[0],"Type":[1],"2":[2],"diabetes":[3,77,229,298,322],"mellitus":[4],"(T2DM)":[5],"is":[6,46,65,78,194,288,331],"a":[7,18,24,58,67,73,81,89],"complex":[8,337],"systemic":[9],"disease,":[10],"with":[11,186],"significant":[12,101],"disorders":[13],"of":[14,30,52,62,76,99,182,208,226,295,308,346],"metabolism.":[15],"The":[16,205],"liver,":[17],"central":[19],"energy":[20],"metabolic":[21],"organ,":[22],"plays":[23],"critical":[25,318],"role":[26],"in":[27,105,122,143,149,191,223,230,263,277,299,320],"the":[28,50,63,97,106,150,154,161,166,174,180,187,198,202,209,212,215,219,224,231,289,300,309,321,344,353],"development":[29],"diabetes.":[31],"Although":[32],"gene":[33,55,83],"expression":[34,56],"levels":[35],"are":[36,157,238,254],"able":[37,332],"to":[38,48,57,85,92,109,196,279,333,351],"be":[39,86],"measured":[40,190,216],"via":[41],"microarray":[42,135,188],"since":[43],"1996,":[44],"it":[45],"difficult":[47],"evaluate":[49,93],"contributions":[51],"one":[53],"altered":[54,252],"specific":[59,74],"disease.":[60],"One":[61],"reasons":[64],"that":[66,328],"whole":[68],"network":[69,90,117,120,147,185,220,292,329,347],"picture":[70,91],"responsible":[71],"for":[72],"phase":[75],"missing,":[79],"while":[80],"single":[82,360],"has":[84],"put":[87],"into":[88],"its":[94],"importance.":[95],"In":[96],"aim":[98],"identifying":[100],"transcriptional":[102,167],"regulatory":[103,116,141,155,184],"networks":[104,142,156,200,213],"liver":[107,134],"contributing":[108],"diabetes,":[110,341],"we":[111],"have":[112,314],"performed":[113],"comprehensive":[114,206,291],"active":[115,140,199,239],"survey":[118,207],"by":[119,146,159,218],"screening":[121,148,221,293,330],"4":[123,261],"weeks":[124,262],"(w),":[125],"8-12":[126],"w,":[127],"and":[128,169,173,178,214,251,256,271,342],"18-20":[129],"w":[130],"Goto-Kakizaki":[131],"(GK)":[132],"rat":[133,145,193,233,302],"data.":[136],"RESULTS:":[137],"We":[138],"identify":[139],"GK":[144,192,232,264,301],"following":[151],"procedure.":[152],"First,":[153],"compiled":[158],"using":[160],"known":[162],"binary":[163],"relationships":[164],"between":[165,211],"factors":[168],"their":[170],"regulated":[171],"genes":[172],"biological":[175],"classification":[176],"scheme,":[177],"second,":[179],"consistency":[181,210],"each":[183],"data":[189,217,307],"estimated":[195],"detect":[197],"under":[201],"corresponding":[203],"conditions.":[204],"approach":[222,350],"case":[225],"non-insulin":[227,296],"dependent":[228,297],"reveals:":[234],"1.":[235],"More":[236],"pathways":[237,313],"during":[240],"inter-middle":[241],"stage":[242],"diabetes;":[243],"2.":[244],"Inflammation,":[245],"hypoxia,":[246],"increased":[247],"apoptosis,":[248],"decreased":[249],"proliferation,":[250],"metabolism":[253],"characteristics":[255],"display":[257],"as":[258,260,340],"early":[259],"strain;":[265],"3.":[266],"Diabetes":[267],"progression":[268],"accompanies":[269],"insults":[270],"compensations;":[272],"4.":[273],"Nuclear":[274],"receptors":[275],"work":[276],"concert":[278],"maintain":[280],"normal":[281],"glycemic":[282],"robustness":[283],"system.":[284],"CONCLUSION:":[285],"Notably":[286],"this":[287],"first":[290],"study":[294],"based":[303],"on":[304],"high":[305],"throughput":[306],"liver.":[310],"Several":[311],"important":[312],"been":[315],"revealed":[316],"playing":[317],"roles":[319],"progression.":[323],"Our":[324],"findings":[325],"also":[326],"implicate":[327],"help":[334],"us":[335],"understand":[336],"disease":[338],"such":[339],"demonstrate":[343],"power":[345],"systems":[348],"biology":[349],"elucidate":[352],"essential":[354],"mechanisms":[355],"which":[356],"would":[357],"escape":[358],"conventional":[359],"gene-based":[361],"analysis.":[362]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":4}],"updated_date":"2026-08-06T08:24:18.245995","created_date":"2025-10-10T00:00:00"}