{"id":"https://openalex.org/W2130960804","doi":"https://doi.org/10.1186/1752-0509-5-88","title":"Systematic quantitative characterization of cellular responses induced by multiple signals","display_name":"Systematic quantitative characterization of cellular responses induced by multiple signals","publication_year":2011,"publication_date":"2011-05-30","ids":{"openalex":"https://openalex.org/W2130960804","doi":"https://doi.org/10.1186/1752-0509-5-88","mag":"2130960804","pmid":"https://pubmed.ncbi.nlm.nih.gov/21624115"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-88","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-88","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-88","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-88","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085289470","display_name":"Ibrahim Al\u2010Shyoukh","orcid":null},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ibrahim Al-Shyoukh","raw_affiliation_strings":["Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA 90095, USA","Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108096446","display_name":"Fuqu Yu","orcid":null},"institutions":[{"id":"https://openalex.org/I1330063522","display_name":"Johnson & Johnson (United States)","ror":"https://ror.org/03qd7mz70","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fuqu Yu","raw_affiliation_strings":["Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA, 90095, USA","Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, USA","Johnson & Johnson Pharmaceutical Research & Development LLC, San Diego, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Johnson & Johnson Pharmaceutical Research & Development LLC, San Diego, USA","institution_ids":["https://openalex.org/I1330063522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101779768","display_name":"Jiaying Feng","orcid":"https://orcid.org/0000-0002-6984-8080"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiaying Feng","raw_affiliation_strings":["Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA, 90095, USA","Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111592231","display_name":"Karen Yan","orcid":null},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Yan","raw_affiliation_strings":["Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA, 90095, USA","Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111763986","display_name":"Steven M. Dubinett","orcid":null},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Dubinett","raw_affiliation_strings":["Department of Medicine, University of California at Los Angeles, Los Angeles, CA, 90095, USA","Department of Medicine, University of California at Los Angeles,Los Angeles,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California at Los Angeles, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Medicine, University of California at Los Angeles,Los Angeles,USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009767255","display_name":"Chih\u2010Ming Ho","orcid":"https://orcid.org/0000-0001-7369-5446"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chih-Ming Ho","raw_affiliation_strings":["Department of Mechanical and Aerospace Engineering, University of California at Los Angeles, Los Angeles, CA, 90095, USA","Department of Mechanical and Aerospace Engineering, University of California at Los Angeles, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, University of California at Los Angeles, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, University of California at Los Angeles, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028973855","display_name":"Jeff S. Shamma","orcid":"https://orcid.org/0000-0001-5638-9551"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff S Shamma","raw_affiliation_strings":["School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA","[School of Electrical, and Computer Engineering, Georgia Institute of Technology, Atlanta, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"[School of Electrical, and Computer Engineering, Georgia Institute of Technology, Atlanta, USA]","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029398617","display_name":"Ren Sun","orcid":"https://orcid.org/0000-0002-8628-7019"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ren Sun","raw_affiliation_strings":["Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA, 90095, USA","Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5029398617"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":2.1291,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.87475831,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"88","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.8253999948501587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.8253999948501587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.05889999866485596,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.03440000116825104,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.7438502311706543},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.7072277665138245},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.6129580736160278},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6058251857757568},{"id":"https://openalex.org/keywords/signal","display_name":"SIGNAL (programming language)","score":0.502877414226532},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.39895492792129517},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3844274878501892},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3331175148487091},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32106053829193115},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31506800651550293}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.7438502311706543},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.7072277665138245},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.6129580736160278},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6058251857757568},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.502877414226532},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39895492792129517},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3844274878501892},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3331175148487091},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32106053829193115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31506800651550293},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1186/1752-0509-5-88","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-88","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-88","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:21624115","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21624115","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:3e968cfb2e2542f7b85833bdb0887e5f","is_oa":false,"landing_page_url":"https://doaj.org/article/3e968cfb2e2542f7b85833bdb0887e5f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 5, Iss 1, p 88 (2011)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt43v9c0h6","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/43v9c0h6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, vol 5","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt75m4n89v","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/75m4n89v","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, vol 5, iss 1","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3138445","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3138445","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:qt43v9c0h6","is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/43v9c0h6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Al-Shyoukh, I; Yu, F; Feng, J; Yan, K; Dubinett, S; Ho, CM; \u00c2\u00a0et al.(2011). Systematic quantitative characterization of cellular responses induced by multiple signals. BMC Systems Biology, 5. doi: 10.1186/1752-0509-5-88. UCLA: Retrieved from: http://www.escholarship.org/uc/item/43v9c0h6","raw_type":"article"},{"id":"pmh:qt75m4n89v","is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/75m4n89v","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Al-Shyoukh, Ibrahim; Yu, Fuqu; Feng, Jiaying; Yan, Karen; Dubinett, Steven; Ho, Chih-Ming; \u00c2\u00a0et al.(2011). Systematic quantitative characterization of cellular responses induced by multiple signals. BMC Systems Biology, 5(1), 88. doi: http://dx.doi.org/10.1186/1752-0509-5-88. Retrieved from: http://www.escholarship.org/uc/item/75m4n89v","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-88","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-88","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-88","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1406605075","display_name":null,"funder_award_id":"CA091791","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2629826732","display_name":null,"funder_award_id":"CA127042","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4194318513","display_name":null,"funder_award_id":"CA091791","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4998467921","display_name":null,"funder_award_id":"PN2 EY018228","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5327184411","display_name":null,"funder_award_id":"ECS-0501394","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7816589994","display_name":"Distributed Adaptive Systems: Feedback Control with Evolutionary Games","funder_award_id":"0501394","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8375188409","display_name":null,"funder_award_id":"PN2 EY018228","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306844","display_name":"Stop Cancer","ror":"https://ror.org/05dvmdf20"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2130960804.pdf","grobid_xml":"https://content.openalex.org/works/W2130960804.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1512072225","https://openalex.org/W1823937713","https://openalex.org/W1913622281","https://openalex.org/W1977863938","https://openalex.org/W1984227596","https://openalex.org/W1986557818","https://openalex.org/W1989053944","https://openalex.org/W2002016471","https://openalex.org/W2009608050","https://openalex.org/W2011912935","https://openalex.org/W2012927388","https://openalex.org/W2014390307","https://openalex.org/W2036583593","https://openalex.org/W2049940009","https://openalex.org/W2050343160","https://openalex.org/W2050375893","https://openalex.org/W2063046703","https://openalex.org/W2069466022","https://openalex.org/W2072462334","https://openalex.org/W2078857595","https://openalex.org/W2080364776","https://openalex.org/W2093472160","https://openalex.org/W2099208166","https://openalex.org/W2100755177","https://openalex.org/W2103638131","https://openalex.org/W2105572154","https://openalex.org/W2109444989","https://openalex.org/W2111289335","https://openalex.org/W2120627772","https://openalex.org/W2124872014","https://openalex.org/W2126060435","https://openalex.org/W2141805227","https://openalex.org/W2142148616","https://openalex.org/W2144362977","https://openalex.org/W2144370915","https://openalex.org/W2146878279","https://openalex.org/W2148138104","https://openalex.org/W2148254543","https://openalex.org/W2154364421","https://openalex.org/W2156761481","https://openalex.org/W2162944858","https://openalex.org/W2331782240","https://openalex.org/W2913066018","https://openalex.org/W3101756747","https://openalex.org/W4211151736","https://openalex.org/W4233484125","https://openalex.org/W4240237951","https://openalex.org/W4248510537","https://openalex.org/W4253794406","https://openalex.org/W4285719527","https://openalex.org/W4299583927"],"related_works":["https://openalex.org/W2158714033","https://openalex.org/W4386628104","https://openalex.org/W78967844","https://openalex.org/W3213185671","https://openalex.org/W4206945140","https://openalex.org/W2509687359","https://openalex.org/W4212865750","https://openalex.org/W2015238087","https://openalex.org/W2362023034","https://openalex.org/W2063941210"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cells":[1],"constantly":[2],"sense":[3],"many":[4],"internal":[5],"and":[6,9,25,50,56,186,200,207,210],"environmental":[7],"signals":[8,49],"respond":[10],"through":[11],"their":[12,51],"complex":[13],"signaling":[14,169,178],"network,":[15],"leading":[16],"to":[17,34,39,62,116],"particular":[18],"biological":[19,81,96],"outcomes.":[20],"However,":[21],"a":[22,31,58,105,108,117],"systematic":[23,76],"characterization":[24,77],"optimization":[26],"of":[27,48,78,88,112,123,131,137,143,153,158,167,176,197],"multi-signal":[28,79],"responses":[29,122],"remains":[30],"pressing":[32],"challenge":[33],"traditional":[35],"experimental":[36],"approaches":[37],"due":[38],"the":[40,45,100,121,128,141,147,151,159,172,177,184,216],"arising":[41],"complexity":[42],"associated":[43],"with":[44,183,221],"increasing":[46,127],"number":[47],"intensities.":[52],"RESULTS:":[53],"We":[54],"established":[55],"validated":[57],"data-driven":[59],"mathematical":[60,71],"approach":[61,85,148,163,193],"systematically":[63],"characterize":[64],"signal-response":[65],"relationships.":[66],"Our":[67],"results":[68,101],"demonstrate":[69],"how":[70],"learning":[72],"algorithms":[73],"can":[74,92,114,194],"enable":[75],"induced":[80],"activities.":[82],"The":[83,134,162],"proposed":[84],"enables":[86,149,165],"identification":[87,166],"input":[89],"combinations":[90,139],"that":[91],"result":[93],"in":[94,120],"desired":[95],"responses.":[97],"In":[98],"retrospect,":[99],"show":[102],"that,":[103],"unlike":[104],"single":[106],"drug,":[107],"properly":[109],"chosen":[110],"combination":[111,203],"drugs":[113],"lead":[115],"significant":[118],"difference":[119],"different":[124],"cell":[125],"types,":[126],"differential":[129],"targeting":[130],"certain":[132],"combinations.":[133],"successful":[135],"validation":[136],"identified":[138,180],"demonstrates":[140],"power":[142],"this":[144],"approach.":[145],"Moreover,":[146],"examining":[150],"efficacy":[152],"all":[154],"lower":[155],"order":[156],"mixtures":[157],"tested":[160],"signals.":[161,174,223],"also":[164],"system-level":[168],"interactions":[170,179,189,214],"between":[171],"applied":[173],"Many":[175],"were":[181],"consistent":[182],"literature,":[185],"other":[187,208],"unknown":[188],"emerged.":[190],"CONCLUSIONS:":[191],"This":[192],"facilitate":[195],"development":[196],"systems":[198],"biology":[199],"optimal":[201],"drug":[202],"therapies":[204],"for":[205,211],"cancer":[206],"diseases":[209],"understanding":[212],"key":[213],"within":[215],"cellular":[217],"network":[218],"upon":[219],"treatment":[220],"multiple":[222]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}
