{"id":"https://openalex.org/W2064686844","doi":"https://doi.org/10.1186/1752-0509-5-76","title":"Network-based scoring system for genome-scale metabolic reconstructions","display_name":"Network-based scoring system for genome-scale metabolic reconstructions","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2064686844","doi":"https://doi.org/10.1186/1752-0509-5-76","mag":"2064686844","pmid":"https://pubmed.ncbi.nlm.nih.gov/21595941"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-76","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-76","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-76","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-76","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030951161","display_name":"M. \u00c1ngeles Serrano","orcid":"https://orcid.org/0000-0001-8779-5931"},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"M \u00c1ngeles Serrano","raw_affiliation_strings":["Departament de Qu\u00edmica F\u00edsica, Universitat de Barcelona, Mart\u00ed i Franqu\u00e8s 1, Barcelona, 08028, Spain. marian.serrano@ub.edu","Departament de Qu\u00edmica F\u00edsica Universitat de Barcelona Barcelona Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departament de Qu\u00edmica F\u00edsica, Universitat de Barcelona, Mart\u00ed i Franqu\u00e8s 1, Barcelona, 08028, Spain. marian.serrano@ub.edu","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Departament de Qu\u00edmica F\u00edsica Universitat de Barcelona Barcelona Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016938143","display_name":"Francesc Sagu\u00e9s","orcid":"https://orcid.org/0000-0002-2956-5676"},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francesc Sagu\u00e9s","raw_affiliation_strings":["Departament de Qu\u00edmica F\u00edsica, Universitat de Barcelona, Mart\u00ed i Franqu\u00e8s 1, Barcelona, 08028, Spain","Departament de Qu\u00edmica F\u00edsica Universitat de Barcelona Barcelona Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departament de Qu\u00edmica F\u00edsica, Universitat de Barcelona, Mart\u00ed i Franqu\u00e8s 1, Barcelona, 08028, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Departament de Qu\u00edmica F\u00edsica Universitat de Barcelona Barcelona Spain","institution_ids":["https://openalex.org/I71999127"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030951161"],"corresponding_institution_ids":["https://openalex.org/I71999127"],"apc_list":null,"apc_paid":{"value":1460,"currency":"EUR","value_usd":1574},"fwci":0.3992,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.62606777,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"5","issue":"1","first_page":"76","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.942799985408783,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.942799985408783,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.8140157461166382},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.608241856098175},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5076707601547241},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.4886179566383362},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.45567354559898376},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4371546506881714},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20762154459953308},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1270107626914978},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.0889638364315033}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.8140157461166382},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.608241856098175},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5076707601547241},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.4886179566383362},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.45567354559898376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4371546506881714},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20762154459953308},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1270107626914978},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0889638364315033},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-5-76","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-76","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-76","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:21595941","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21595941","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:diposit.ub.edu:2445/21445","is_oa":true,"landing_page_url":"https://hdl.handle.net/2445/21445","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Articles publicats en revistes (Ci\u00e8ncia dels Materials i Qu\u00edmica F\u00edsica)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:recercat.cat:2072/179385","is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/21445","pdf_url":null,"source":{"id":"https://openalex.org/S4306402147","display_name":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:98481fed48fa48538dd29cb6e61effeb","is_oa":false,"landing_page_url":"https://doaj.org/article/98481fed48fa48538dd29cb6e61effeb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 5, Iss 1, p 76 (2011)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3113238","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3113238","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-76","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-76","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-76","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320335162","display_name":"Departament d'Universitats, Recerca i Societat de la Informaci\u00f3","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2064686844.pdf","grobid_xml":"https://content.openalex.org/works/W2064686844.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W166161619","https://openalex.org/W1529898704","https://openalex.org/W1544632947","https://openalex.org/W1666636243","https://openalex.org/W1814099126","https://openalex.org/W1966692814","https://openalex.org/W1983202741","https://openalex.org/W1992015378","https://openalex.org/W1994321911","https://openalex.org/W2004258751","https://openalex.org/W2017099446","https://openalex.org/W2017202214","https://openalex.org/W2017987256","https://openalex.org/W2018045523","https://openalex.org/W2053906518","https://openalex.org/W2064446502","https://openalex.org/W2075283200","https://openalex.org/W2085993965","https://openalex.org/W2094399313","https://openalex.org/W2098824895","https://openalex.org/W2099913238","https://openalex.org/W2100380298","https://openalex.org/W2101267973","https://openalex.org/W2108859156","https://openalex.org/W2110017370","https://openalex.org/W2111823238","https://openalex.org/W2113654464","https://openalex.org/W2142522788","https://openalex.org/W2144885342","https://openalex.org/W2146564314","https://openalex.org/W2148604310","https://openalex.org/W2148606196","https://openalex.org/W2157082398","https://openalex.org/W2157825442","https://openalex.org/W2158698691","https://openalex.org/W2163480486","https://openalex.org/W2169015768","https://openalex.org/W2170427655","https://openalex.org/W3103786587","https://openalex.org/W3106353906"],"related_works":["https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W1971568933","https://openalex.org/W5284979","https://openalex.org/W4245853730"],"abstract_inverted_index":{"BACKGROUND:":[0],"Network":[1],"reconstructions":[2],"at":[3,168],"the":[4,24,28,52,82,100,110,125,178],"cell":[5],"level":[6],"are":[7,16,38],"a":[8,75,86,90,162],"major":[9],"development":[10],"in":[11,130],"Systems":[12],"Biology.":[13],"However,":[14],"we":[15,73,96],"far":[17],"from":[18],"fully":[19],"exploiting":[20],"its":[21],"potentialities.":[22],"Often,":[23],"incremental":[25],"complexity":[26],"of":[27,45,65,85,102,127,156,165,174,181],"pursued":[29],"systems":[30],"overrides":[31],"experimental":[32,66,150],"capabilities,":[33],"or":[34,68,145,171],"increasingly":[35],"sophisticated":[36],"protocols":[37],"underutilized":[39],"to":[40,62,99,109,112,123],"merely":[41],"refine":[42],"confidence":[43,55],"levels":[44,173],"already":[46],"established":[47],"interactions.":[48],"For":[49],"metabolic":[50,87],"networks,":[51],"currently":[53],"employed":[54],"scoring":[56,78,135],"system":[57,79,136],"rates":[58],"reactions":[59,140],"discretely":[60],"according":[61],"nested":[63],"categories":[64],"evidence":[67],"model-based":[69],"likelihood.":[70],"RESULTS:":[71],"Here,":[72],"propose":[74],"complementary":[76],"network-based":[77,134],"that":[80,141],"exploits":[81],"statistical":[83],"regularities":[84],"network":[88],"as":[89],"bipartite":[91],"graph.":[92],"As":[93],"an":[94],"illustration,":[95],"apply":[97],"it":[98],"metabolism":[101],"Escherichia":[103],"coli.":[104],"The":[105],"model":[106],"is":[107],"adjusted":[108],"observations":[111],"derive":[113],"connection":[114],"probabilities":[115],"between":[116],"individual":[117],"metabolite-reaction":[118],"pairs":[119],"and,":[120],"after":[121],"validation,":[122],"assess":[124],"reliability":[126],"each":[128],"reaction":[129],"probabilistic":[131],"terms.":[132],"This":[133],"uncovers":[137],"very":[138],"specific":[139],"could":[142],"be":[143],"functionally":[144],"evolutionary":[146],"important,":[147],"identifies":[148],"prominent":[149],"targets,":[151],"and":[152],"enables":[153],"further":[154],"confirmation":[155],"modeling":[157],"results.":[158],"CONCLUSIONS:":[159],"We":[160],"foresee":[161],"wide":[163],"range":[164],"potential":[166],"applications":[167],"different":[169],"sub-cellular":[170],"supra-cellular":[172],"biological":[175,183],"interactions":[176],"given":[177],"natural":[179],"bipartivity":[180],"many":[182],"networks.":[184]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}