{"id":"https://openalex.org/W1971515286","doi":"https://doi.org/10.1186/1752-0509-5-64","title":"Thermodynamically consistent model calibration in chemical kinetics","display_name":"Thermodynamically consistent model calibration in chemical kinetics","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1971515286","doi":"https://doi.org/10.1186/1752-0509-5-64","mag":"1971515286","pmid":"https://pubmed.ncbi.nlm.nih.gov/21548948"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-64","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-64","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-64","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-64","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039319315","display_name":"Garrett Jenkinson","orcid":"https://orcid.org/0000-0003-2548-098X"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garrett Jenkinson","raw_affiliation_strings":["Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, MD 21218, USA. goutsias@jhu.edu","Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, MD 21218, USA. goutsias@jhu.edu","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040506666","display_name":"John Goutsias","orcid":"https://orcid.org/0000-0002-0192-3857"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Goutsias","raw_affiliation_strings":["Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.4868,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.6147089,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"5","issue":"1","first_page":"64","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.680899977684021,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.680899977684021,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.18979999423027039,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sbml","display_name":"SBML","score":0.6018285155296326},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6008810997009277},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.5653563737869263},{"id":"https://openalex.org/keywords/cascade","display_name":"Cascade","score":0.5613366961479187},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.561104416847229},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.506492018699646},{"id":"https://openalex.org/keywords/calibration","display_name":"Calibration","score":0.47257840633392334},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4530576765537262},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4476836025714874},{"id":"https://openalex.org/keywords/matlab","display_name":"MATLAB","score":0.42380475997924805},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.3958038091659546},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.38007429242134094},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.35172802209854126},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2504928708076477},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.23432621359825134},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.23192769289016724},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.1772284209728241}],"concepts":[{"id":"https://openalex.org/C87186988","wikidata":"https://www.wikidata.org/wiki/Q452197","display_name":"SBML","level":4,"score":0.6018285155296326},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6008810997009277},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5653563737869263},{"id":"https://openalex.org/C34146451","wikidata":"https://www.wikidata.org/wiki/Q5048094","display_name":"Cascade","level":2,"score":0.5613366961479187},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.561104416847229},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.506492018699646},{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.47257840633392334},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4530576765537262},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4476836025714874},{"id":"https://openalex.org/C2780365114","wikidata":"https://www.wikidata.org/wiki/Q169478","display_name":"MATLAB","level":2,"score":0.42380475997924805},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.3958038091659546},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.38007429242134094},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.35172802209854126},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2504928708076477},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23432621359825134},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.23192769289016724},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1772284209728241},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C45874996","wikidata":"https://www.wikidata.org/wiki/Q37045","display_name":"Markup language","level":3,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C8797682","wikidata":"https://www.wikidata.org/wiki/Q2115","display_name":"XML","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-5-64","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-64","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-64","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:21548948","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21548948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:89ef29a97156472e8d31371db13f1c5b","is_oa":false,"landing_page_url":"https://doaj.org/article/89ef29a97156472e8d31371db13f1c5b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 5, Iss 1, p 64 (2011)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3117730","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3117730","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-64","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-64","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-64","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320333566","display_name":"National Defense Science and Engineering Graduate","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1971515286.pdf","grobid_xml":"https://content.openalex.org/works/W1971515286.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1484198052","https://openalex.org/W1558903631","https://openalex.org/W1592132377","https://openalex.org/W1797657318","https://openalex.org/W1970185852","https://openalex.org/W1982258483","https://openalex.org/W1986015734","https://openalex.org/W1997288147","https://openalex.org/W2000014382","https://openalex.org/W2003501808","https://openalex.org/W2024060531","https://openalex.org/W2024985960","https://openalex.org/W2042943648","https://openalex.org/W2063366436","https://openalex.org/W2071629571","https://openalex.org/W2075161553","https://openalex.org/W2075260598","https://openalex.org/W2081580266","https://openalex.org/W2104370351","https://openalex.org/W2114124738","https://openalex.org/W2122105924","https://openalex.org/W2122284068","https://openalex.org/W2131416923","https://openalex.org/W2149325066","https://openalex.org/W2161304688","https://openalex.org/W2170484057","https://openalex.org/W2181692905","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2150908245","https://openalex.org/W2211443823","https://openalex.org/W2097410126","https://openalex.org/W2136043941","https://openalex.org/W2043776573","https://openalex.org/W2735157934","https://openalex.org/W3080133182","https://openalex.org/W1869813392","https://openalex.org/W2026725606","https://openalex.org/W2020641517"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,98],"dynamics":[2],"of":[3,13,66,92,132,136,148,158,215,231,241,255,278],"biochemical":[4,28,95,217,238],"reaction":[5,21,29,96,218,239],"systems":[6,30],"are":[7,53],"constrained":[8,108],"by":[9],"the":[10,20,43,90,102,129,137,143,156,169,184,195,212,253,276],"fundamental":[11],"laws":[12],"thermodynamics,":[14],"which":[15],"impose":[16],"well-defined":[17],"relationships":[18],"among":[19],"rate":[22],"constants":[23],"characterizing":[24],"these":[25,153],"systems.":[26,219],"Constructing":[27],"from":[31,177],"experimental":[32],"observations":[33],"often":[34],"leads":[35],"to":[36,60,84,225,247,274],"parameter":[37,232],"values":[38,88,127,210,233,251],"that":[39,52,79,111],"do":[40],"not":[41,54],"satisfy":[42],"necessary":[44],"thermodynamic":[45,113,150],"constraints.":[46],"This":[47],"can":[48,80,174,191,221,260,272],"result":[49],"in":[50,194],"models":[51,240],"physically":[55,208],"realizable":[56],"and":[57,145,155,203,267,271],"may":[58],"lead":[59],"inaccurate,":[61],"or":[62],"even":[63],"erroneous,":[64],"descriptions":[65],"cellular":[67,242],"function.":[68],"RESULTS:":[69],"We":[70],"introduce":[71],"a":[72,107,133,201,227],"thermodynamically":[73,86,125,185,228,236,249],"consistent":[74,229],"model":[75,103,135,190],"calibration":[76,104],"(TCMC)":[77],"method":[78,100,160,205],"be":[81,175,192,222],"effectively":[82,223],"used":[83,224],"provide":[85,261],"feasible":[87,126,186,250],"for":[89,128,161,206,211,234,252],"parameters":[91,131,154,214,254],"an":[93],"open":[94,216],"system.":[97],"proposed":[99],"formulates":[101],"problem":[105,110,277],"as":[106,244,246],"optimization":[109],"takes":[112],"constraints":[114,151],"(and,":[115],"if":[116],"desired,":[117],"additional":[118],"non-thermodynamic":[119],"constraints)":[120],"into":[121],"account.":[122],"By":[123],"calculating":[124],"kinetic":[130,213],"well-known":[134],"EGF/ERK":[138,187],"signaling":[139,188],"cascade,":[140],"we":[141],"demonstrate":[142],"qualitative":[144],"quantitative":[146],"significance":[147],"imposing":[149],"on":[152],"effectiveness":[157],"our":[159],"accomplishing":[162],"this":[163],"important":[164],"task.":[165],"MATLAB":[166],"software,":[167],"using":[168],"Systems":[170],"Biology":[171],"Toolbox":[172],"2.1,":[173],"accessed":[176],"http://www.cis.jhu.edu/~goutsias/CSS":[178],"lab/software.html.":[179],"An":[180],"SBML":[181],"file":[182],"containing":[183],"cascade":[189],"found":[193],"BioModels":[196],"database.":[197],"CONCLUSIONS:":[198],"TCMC":[199,259],"is":[200],"simple":[202],"flexible":[204],"obtaining":[207],"plausible":[209],"It":[220],"recalculate":[226],"set":[230],"existing":[235],"infeasible":[237],"function":[243],"well":[245],"estimate":[248],"new":[256],"models.":[257],"Furthermore,":[258],"dimensionality":[262],"reduction,":[263],"better":[264],"estimation":[265],"performance,":[266],"lower":[268],"computational":[269],"complexity,":[270],"help":[273],"alleviate":[275],"data":[279],"overfitting.":[280]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}