{"id":"https://openalex.org/W1990368500","doi":"https://doi.org/10.1186/1752-0509-5-59","title":"Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis","display_name":"Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis","publication_year":2011,"publication_date":"2011-05-02","ids":{"openalex":"https://openalex.org/W1990368500","doi":"https://doi.org/10.1186/1752-0509-5-59","mag":"1990368500","pmid":"https://pubmed.ncbi.nlm.nih.gov/21535871"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-59","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-59","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-59","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-59","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080191241","display_name":"Prakash Vempati","orcid":null},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prakash Vempati","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA","Dept. of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]},{"raw_affiliation_string":"Dept. of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, USA","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030268482","display_name":"Aleksander S. Popel","orcid":"https://orcid.org/0000-0002-6706-9235"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleksander S Popel","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA","Dept. of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]},{"raw_affiliation_string":"Dept. of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, USA","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045576072","display_name":"Feilim Mac Gabhann","orcid":"https://orcid.org/0000-0003-3481-7740"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feilim Mac Gabhann","raw_affiliation_strings":["Institute for Computational Medicine and Department of Biomedical Engineering,  Johns Hopkins University, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Computational Medicine and Department of Biomedical Engineering,  Johns Hopkins University, Baltimore, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3952,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.88660458,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"59","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.944100022315979,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.944100022315979,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiogenesis","display_name":"Angiogenesis","score":0.7514848709106445},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"Vascular endothelial growth factor","score":0.6498559713363647},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6455667018890381},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"Extracellular matrix","score":0.5503456592559814},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.535633385181427},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor-a","display_name":"Vascular endothelial growth factor A","score":0.4455288350582123},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.36876192688941956},{"id":"https://openalex.org/keywords/vegf-receptors","display_name":"VEGF receptors","score":0.2092786729335785},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.18427184224128723}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7514848709106445},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.6498559713363647},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6455667018890381},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5503456592559814},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.535633385181427},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.4455288350582123},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36876192688941956},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.2092786729335785},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.18427184224128723}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003201","descriptor_name":"Computers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003201","descriptor_name":"Computers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003201","descriptor_name":"Computers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-5-59","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-59","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-59","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:21535871","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21535871","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:30e64af9318745509e236b235f5787c1","is_oa":false,"landing_page_url":"https://doaj.org/article/30e64af9318745509e236b235f5787c1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 5, Iss 1, p 59 (2011)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3113235","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3113235","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-59","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-59","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-59","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1183629664","display_name":null,"funder_award_id":"CA143868","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G276844601","display_name":null,"funder_award_id":"R33 HL087351","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3276941632","display_name":null,"funder_award_id":"R01 CA138264","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3446200926","display_name":null,"funder_award_id":"CA138264","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3937042154","display_name":null,"funder_award_id":"R01 CA138264","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5274348335","display_name":null,"funder_award_id":"R01 HL101200","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6024433419","display_name":null,"funder_award_id":"R00 HL093219","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6813494030","display_name":null,"funder_award_id":"U54 CA143868","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7512071930","display_name":null,"funder_award_id":"R00 HL093219","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7584011625","display_name":null,"funder_award_id":"R01 HL101200","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7602040823","display_name":null,"funder_award_id":"U54 CA143868","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990368500.pdf","grobid_xml":"https://content.openalex.org/works/W1990368500.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W1488792046","https://openalex.org/W1495287184","https://openalex.org/W1508824327","https://openalex.org/W1543694381","https://openalex.org/W1554144288","https://openalex.org/W1566965859","https://openalex.org/W1574172480","https://openalex.org/W1574498833","https://openalex.org/W1624346216","https://openalex.org/W1937444536","https://openalex.org/W1965558704","https://openalex.org/W1968504912","https://openalex.org/W1969103696","https://openalex.org/W1971747634","https://openalex.org/W1975911973","https://openalex.org/W1976553848","https://openalex.org/W1977909615","https://openalex.org/W1979292005","https://openalex.org/W1981520514","https://openalex.org/W1986308750","https://openalex.org/W1987644022","https://openalex.org/W1988688040","https://openalex.org/W1991205575","https://openalex.org/W1991362893","https://openalex.org/W1992557354","https://openalex.org/W1993050497","https://openalex.org/W1994322982","https://openalex.org/W1995840246","https://openalex.org/W1996736210","https://openalex.org/W1998767340","https://openalex.org/W2001277825","https://openalex.org/W2002396741","https://openalex.org/W2002823287","https://openalex.org/W2003617951","https://openalex.org/W2004127276","https://openalex.org/W2008518743","https://openalex.org/W2012576713","https://openalex.org/W2017516431","https://openalex.org/W2018964420","https://openalex.org/W2020373346","https://openalex.org/W2022130011","https://openalex.org/W2024327925","https://openalex.org/W2027220430","https://openalex.org/W2030615367","https://openalex.org/W2032511198","https://openalex.org/W2034982562","https://openalex.org/W2037921918","https://openalex.org/W2038408091","https://openalex.org/W2041820816","https://openalex.org/W2046445865","https://openalex.org/W2049408374","https://openalex.org/W2051399767","https://openalex.org/W2054241501","https://openalex.org/W2056146626","https://openalex.org/W2056518174","https://openalex.org/W2058177351","https://openalex.org/W2062805975","https://openalex.org/W2067817921","https://openalex.org/W2075749165","https://openalex.org/W2081399416","https://openalex.org/W2082191890","https://openalex.org/W2086400832","https://openalex.org/W2087271480","https://openalex.org/W2090295661","https://openalex.org/W2093036411","https://openalex.org/W2095227131","https://openalex.org/W2100152476","https://openalex.org/W2100627342","https://openalex.org/W2106986641","https://openalex.org/W2107583561","https://openalex.org/W2109065012","https://openalex.org/W2112078298","https://openalex.org/W2112251383","https://openalex.org/W2114070475","https://openalex.org/W2114257111","https://openalex.org/W2115167653","https://openalex.org/W2115892984","https://openalex.org/W2116715149","https://openalex.org/W2121195075","https://openalex.org/W2121243662","https://openalex.org/W2127997127","https://openalex.org/W2132761658","https://openalex.org/W2135925543","https://openalex.org/W2138318533","https://openalex.org/W2138392373","https://openalex.org/W2141863235","https://openalex.org/W2143229014","https://openalex.org/W2143843964","https://openalex.org/W2146293179","https://openalex.org/W2158739925","https://openalex.org/W2158820988","https://openalex.org/W2160518321","https://openalex.org/W2163170931","https://openalex.org/W2165651944","https://openalex.org/W2166869712","https://openalex.org/W2186252333","https://openalex.org/W4235948748","https://openalex.org/W4251795098","https://openalex.org/W4285719527","https://openalex.org/W4388243180"],"related_works":["https://openalex.org/W2102113319","https://openalex.org/W4385622875","https://openalex.org/W3174992774","https://openalex.org/W2052861245","https://openalex.org/W2151772280","https://openalex.org/W2034393061","https://openalex.org/W1997324775","https://openalex.org/W2139412046","https://openalex.org/W2011095792","https://openalex.org/W2161808292"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"spatial":[2],"distribution":[3,183],"of":[4,15,37,110,120,152,180,212,220,249,276,284,287],"vascular":[5,16,231,236],"endothelial":[6,129],"growth":[7],"factor":[8],"A":[9,195],"(VEGF)":[10],"is":[11,167,198],"an":[12,128,173],"important":[13],"mediator":[14],"patterning.":[17],"Previous":[18],"experimental":[19],"studies":[20],"in":[21,46,55,61,74,123,135,143,157,172,229,261,279],"the":[22,35,47,124,144,150,181,210,217,221,246,250],"mouse":[23,145],"hindbrain":[24],"and":[25,59,81,114,191,282],"retina":[26],"have":[27,87],"suggested":[28],"that":[29,89,133,199,235],"VEGF":[30,38,57,80,96,111,121,138,156,166,182,222,251,259,267,280,288],"alternative":[31],"splicing,":[32],"which":[33],"controls":[34],"ability":[36,151,211],"to":[39,41,154,184,206,215,227],"bind":[40],"heparan":[42],"sulfate":[43],"proteoglycans":[44],"(HSPGs)":[45],"extracellular":[48,125],"matrix":[49,67],"(ECM),":[50],"plays":[51,70],"a":[52,71,105,163,186,204,213,262,270],"key":[53],"role":[54,73],"controlling":[56],"diffusion":[58],"gradients":[60,99],"tissues.":[62],"Conversely,":[63],"proteolysis":[64],"notably":[65],"by":[66,77,245,257],"metalloproteinases":[68],"(MMPs),":[69],"critical":[72],"pathological":[75,158],"situations":[76],"releasing":[78],"matrix-sequestered":[79],"modulating":[82],"angiogenesis.":[83],"However,":[84],"computational":[85],"models":[86,119],"predicted":[88,241],"HSPG":[90],"binding":[91,190],"alone":[92],"does":[93],"not":[94],"affect":[95],"localization":[97,136],"or":[98,170,253],"at":[100,242,254],"steady":[101],"state.":[102],"RESULTS:":[103],"Using":[104],"3D":[106],"molecular-detailed":[107],"reaction-diffusion":[108],"model":[109,164,226],"ligand-receptor":[112],"kinetics":[113],"transport,":[115],"we":[116],"test":[117],"alternate":[118],"transport":[122],"environment":[126],"surrounding":[127],"sprout.":[130],"We":[131,176],"show":[132],"differences":[134],"between":[137],"isoforms,":[139],"as":[140,147,149,203],"observed":[141],"experimentally":[142],"hindbrain,":[146],"well":[148],"proteases":[153,285],"redistribute":[155],"situations,":[159],"are":[160,238],"consistent":[161],"with":[162],"where":[165],"endogenously":[168],"cleared":[169],"degraded":[171],"isoform-specific":[174],"manner.":[175,264],"use":[177],"our":[178,225],"predictions":[179],"quantify":[185],"tip":[187],"cell's":[188],"receptor":[189],"gradient":[192],"sensing":[193],"capacity.":[194],"novel":[196],"prediction":[197],"neuropilin-1,":[200],"despite":[201],"functioning":[202],"coreceptor":[205],"VEGF\u2081\u2086\u2085-VEGFR2":[207],"binding,":[208],"reduces":[209],"cell":[214],"gauge":[216],"relative":[218],"steepness":[219],"distribution.":[223],"Comparing":[224],"available":[228],"vivo":[230],"patterning":[232,281],"data":[233],"suggests":[234],"phenotypes":[237],"most":[239],"consistently":[240],"short":[243],"range":[244,256],"soluble":[247],"fraction":[248],"distributions,":[252],"longer":[255],"matrix-bound":[258],"detected":[260],"filopodia-dependent":[263],"CONCLUSIONS:":[265],"Isoform-specific":[266],"degradation":[268],"provides":[269],"possible":[271],"explanation":[272],"for":[273],"numerous":[274],"examples":[275,283],"isoform":[277],"specificity":[278],"relocation":[286],"upon":[289],"release.":[290]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-06-25T08:15:23.626066","created_date":"2025-10-10T00:00:00"}
