{"id":"https://openalex.org/W2059241142","doi":"https://doi.org/10.1186/1752-0509-5-5","title":"SPABBATS: A pathway-discovery method based on Boolean satisfiability that facilitates the characterization of suppressor mutants","display_name":"SPABBATS: A pathway-discovery method based on Boolean satisfiability that facilitates the characterization of suppressor mutants","publication_year":2011,"publication_date":"2011-01-11","ids":{"openalex":"https://openalex.org/W2059241142","doi":"https://doi.org/10.1186/1752-0509-5-5","mag":"2059241142","pmid":"https://pubmed.ncbi.nlm.nih.gov/21219666"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029265039","display_name":"Lope A. Fl\u00f3rez","orcid":null},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lope A Fl\u00f3rez","raw_affiliation_strings":["Department of General Microbiology, Georg-August-University of G\u00f6ttingen, Germany","Department of General Microbiology, Georg-August-University of G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Microbiology, Georg-August-University of G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]},{"raw_affiliation_string":"Department of General Microbiology, Georg-August-University of G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055408509","display_name":"Katrin Gunka","orcid":null},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katrin Gunka","raw_affiliation_strings":["Department of General Microbiology, Georg-August-University of G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Microbiology, Georg-August-University of G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059399309","display_name":"Rafael Polan\u00eda","orcid":"https://orcid.org/0000-0002-6176-6806"},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rafael Polan\u00eda","raw_affiliation_strings":["Department of Clinical Neurophysiology, Georg-August-University of G\u00f6ttingen, G\u00f6ttingen, Germany","Department of Clinical Neurophysiology, Georg\u2010August\u2010University of G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neurophysiology, Georg-August-University of G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]},{"raw_affiliation_string":"Department of Clinical Neurophysiology, Georg\u2010August\u2010University of G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004620625","display_name":"Stefan Tholen","orcid":"https://orcid.org/0009-0008-4746-2356"},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Tholen","raw_affiliation_strings":["Department of General Microbiology, Georg-August-University of G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Microbiology, Georg-August-University of G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006672133","display_name":"J\u00f6rg St\u00fclke","orcid":"https://orcid.org/0000-0001-5881-5390"},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"J\u00f6rg St\u00fclke","raw_affiliation_strings":["Department of General Microbiology, Georg-August-University of G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Microbiology, Georg-August-University of G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006672133"],"corresponding_institution_ids":["https://openalex.org/I74656192"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":1.1217,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.76276336,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"5","issue":"1","first_page":"5","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.648364782333374},{"id":"https://openalex.org/keywords/suppressor","display_name":"Suppressor","score":0.6160447597503662},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6111487746238708},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.6076404452323914},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.5718445777893066},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5276447534561157},{"id":"https://openalex.org/keywords/boolean-network","display_name":"Boolean network","score":0.5209737420082092},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.4840649664402008},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.44369104504585266},{"id":"https://openalex.org/keywords/satisfiability","display_name":"Satisfiability","score":0.42231547832489014},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4207336902618408},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3970273435115814},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3082091510295868},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.2669143080711365},{"id":"https://openalex.org/keywords/boolean-function","display_name":"Boolean function","score":0.22040554881095886},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.19299748539924622}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.648364782333374},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.6160447597503662},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6111487746238708},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.6076404452323914},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.5718445777893066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5276447534561157},{"id":"https://openalex.org/C134444547","wikidata":"https://www.wikidata.org/wiki/Q585230","display_name":"Boolean network","level":3,"score":0.5209737420082092},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4840649664402008},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.44369104504585266},{"id":"https://openalex.org/C168773769","wikidata":"https://www.wikidata.org/wiki/Q1350299","display_name":"Satisfiability","level":2,"score":0.42231547832489014},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4207336902618408},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3970273435115814},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3082091510295868},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.2669143080711365},{"id":"https://openalex.org/C187455244","wikidata":"https://www.wikidata.org/wiki/Q942353","display_name":"Boolean function","level":2,"score":0.22040554881095886},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.19299748539924622}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005969","descriptor_name":"Glutamate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005969","descriptor_name":"Glutamate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005969","descriptor_name":"Glutamate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008128","descriptor_name":"Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008128","descriptor_name":"Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008128","descriptor_name":"Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013489","descriptor_name":"Suppression, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013489","descriptor_name":"Suppression, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013489","descriptor_name":"Suppression, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1186/1752-0509-5-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:21219666","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21219666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":"Journal Article"},{"id":"pmh:oai:www.zora.uzh.ch:84622","is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/84622/1/Florez_et_al_SPABBATS.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/84622/1/Florez_et_al_SPABBATS.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Fl\u00f3rez, Lope A; Gunka, Katrin; Polania, Rafael; Tholen, Stefan; St\u00fclke, J\u00f6rg (2011). SPABBATS: A pathway-discovery method based on Boolean satisfiability that facilitates the characterization of suppressor mutants. BMC Systems Biology, 5:5.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3024933","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3024933","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:freidok.uni-freiburg.de:268351","is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/268351","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC systems biology. - 5, 5 (2011) , ISSN: 1752-0509","raw_type":"article"},{"id":"pmh:oai:goescholar:1/7228","is_oa":true,"landing_page_url":"http://resolver.sub.uni-goettingen.de/purl?gs-1/7228","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journalArticle"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/24070","is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gs-1/7228","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal_article"},{"id":"doi:10.5167/uzh-84622","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-84622","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Decent work and economic growth","score":0.5099999904632568,"id":"https://metadata.un.org/sdg/8"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306814","display_name":"Rose Foundation for Communities and the Environment","ror":"https://ror.org/0145pgy59"},{"id":"https://openalex.org/F4320321870","display_name":"Georg-August-Universit\u00e4t G\u00f6ttingen","ror":"https://ror.org/01y9bpm73"},{"id":"https://openalex.org/F4320329143","display_name":"Stiftung der Deutschen Wirtschaft","ror":"https://ror.org/00xwjya15"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2059241142.pdf","grobid_xml":"https://content.openalex.org/works/W2059241142.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1487827847","https://openalex.org/W1574161662","https://openalex.org/W1625145405","https://openalex.org/W1756965619","https://openalex.org/W1820142000","https://openalex.org/W1865283356","https://openalex.org/W1925095676","https://openalex.org/W2003293212","https://openalex.org/W2004678782","https://openalex.org/W2011665940","https://openalex.org/W2029595333","https://openalex.org/W2055074525","https://openalex.org/W2059718816","https://openalex.org/W2069676430","https://openalex.org/W2070756319","https://openalex.org/W2078355959","https://openalex.org/W2079531107","https://openalex.org/W2082093843","https://openalex.org/W2083011190","https://openalex.org/W2085182533","https://openalex.org/W2086248824","https://openalex.org/W2094764358","https://openalex.org/W2097189192","https://openalex.org/W2098922751","https://openalex.org/W2100637096","https://openalex.org/W2108047199","https://openalex.org/W2111086098","https://openalex.org/W2112388284","https://openalex.org/W2115029043","https://openalex.org/W2126705194","https://openalex.org/W2127844534","https://openalex.org/W2134668325","https://openalex.org/W2143841383","https://openalex.org/W2144634347","https://openalex.org/W2159890578","https://openalex.org/W2162459693","https://openalex.org/W2163850966","https://openalex.org/W2171993994","https://openalex.org/W2314225431","https://openalex.org/W2323778292"],"related_works":["https://openalex.org/W2786774244","https://openalex.org/W2135851057","https://openalex.org/W2097189192","https://openalex.org/W2119866908","https://openalex.org/W2155261113","https://openalex.org/W2406248618","https://openalex.org/W3211329625","https://openalex.org/W1989168955","https://openalex.org/W2149033595","https://openalex.org/W2059241142"],"abstract_inverted_index":{"BACKGROUND:":[0],"Several":[1],"computational":[2],"methods":[3,19],"exist":[4],"to":[5,23,48,145,163,181,204],"suggest":[6],"rational":[7],"genetic":[8,26],"interventions":[9],"that":[10,65],"improve":[11],"the":[12,29,32,50,92,97,120,123,127,130,134,165,169,175,189],"productivity":[13],"of":[14,28,40,87,94,116,122,133,168,178,191],"industrial":[15],"strains.":[16],"Nonetheless,":[17],"these":[18],"are":[20],"less":[21],"effective":[22],"predict":[24],"possible":[25],"responses":[27],"strain":[30],"after":[31],"intervention.":[33,52],"This":[34],"problem":[35],"requires":[36],"a":[37,76,114,200],"better":[38],"understanding":[39],"potential":[41],"alternative":[42,67,158],"metabolic":[43,68,182,192],"and":[44,72,139,195],"regulatory":[45],"pathways":[46,69,80,102,159,207],"able":[47,144],"counteract":[49],"targeted":[51],"RESULTS:":[53],"Here":[54],"we":[55,112],"present":[56],"SPABBATS,":[57],"an":[58],"algorithm":[59],"based":[60],"on":[61,147],"Boolean":[62],"satisfiability":[63],"(SAT)":[64],"computes":[66],"between":[70],"input":[71],"output":[73],"species":[74],"in":[75,85,96,199],"reconstructed":[77],"network.":[78],"The":[79],"can":[81,196],"be":[82,197],"constructed":[83],"iteratively":[84],"order":[86],"increasing":[88],"complexity.":[89],"SPABBATS":[90,173],"allows":[91],"accumulation":[93],"intermediates":[95],"pathways,":[98],"which":[99,160],"permits":[100],"discovering":[101],"missed":[103],"by":[104],"most":[105],"traditional":[106],"pathway":[107],"analysis":[108],"methods.":[109],"In":[110],"addition,":[111],"provide":[113],"proof":[115],"concept":[117],"experiment":[118],"for":[119,129,188],"validity":[121],"algorithm.":[124],"We":[125],"deleted":[126],"genes":[128],"glutamate":[131,148],"dehydrogenases":[132],"Gram-positive":[135],"bacterium":[136],"Bacillus":[137],"subtilis":[138],"isolated":[140],"suppressor":[141,170,193],"mutant":[142],"strains":[143],"grow":[146],"as":[149],"single":[150],"carbon":[151],"source.":[152],"Our":[153],"SAT":[154,179],"approach":[155],"proposed":[156],"candidate":[157],"were":[161],"decisive":[162],"pinpoint":[164],"exact":[166],"mutation":[167],"strain.":[171],"CONCLUSIONS:":[172],"is":[174,185],"first":[176],"application":[177],"techniques":[180],"problems.":[183],"It":[184],"particularly":[186],"useful":[187],"characterization":[190],"mutants":[194],"used":[198],"synthetic":[201],"biology":[202],"setting":[203],"design":[205],"new":[206],"with":[208],"specific":[209],"input-output":[210],"requirements.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-08-22T07:34:49.880490","created_date":"2025-10-10T00:00:00"}
