{"id":"https://openalex.org/W2058474593","doi":"https://doi.org/10.1186/1752-0509-5-46","title":"Predictive integration of gene functional similarity and co-expression defines treatment response of endothelial progenitor cells","display_name":"Predictive integration of gene functional similarity and co-expression defines treatment response of endothelial progenitor cells","publication_year":2011,"publication_date":"2011-03-30","ids":{"openalex":"https://openalex.org/W2058474593","doi":"https://doi.org/10.1186/1752-0509-5-46","mag":"2058474593","pmid":"https://pubmed.ncbi.nlm.nih.gov/21447198"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-46","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-46","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-46","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-46","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050612781","display_name":"Francisco Azuaje","orcid":"https://orcid.org/0000-0002-9207-9072"},"institutions":[{"id":"https://openalex.org/I4210144605","display_name":"Laboratoire National de Sant\u00e9","ror":"https://ror.org/04y798z66","country_code":"LU","type":"facility","lineage":["https://openalex.org/I4210144605"]}],"countries":["LU"],"is_corresponding":true,"raw_author_name":"Francisco J Azuaje","raw_affiliation_strings":["Laboratory of Cardiovascular Research, Centre de Recherche Public-Sant\u00e9, L-1150, Luxembourg. Francisco.Azuaje@crp-sante.lu","Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Research, Centre de Recherche Public-Sant\u00e9, L-1150, Luxembourg. Francisco.Azuaje@crp-sante.lu","institution_ids":["https://openalex.org/I4210144605"]},{"raw_affiliation_string":"Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg","institution_ids":["https://openalex.org/I4210144605"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100379058","display_name":"Haiying Wang","orcid":"https://orcid.org/0000-0001-8358-9065"},"institutions":[{"id":"https://openalex.org/I138801177","display_name":"University of Ulster","ror":"https://ror.org/01yp9g959","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Haiying Wang","raw_affiliation_strings":["School of Computing and Mathematics, Computer Science Research Institute, University of Ulster, Newtownabbey, BT37 0QB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing and Mathematics, Computer Science Research Institute, University of Ulster, Newtownabbey, BT37 0QB, UK","institution_ids":["https://openalex.org/I138801177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024401909","display_name":"Huiru Zheng","orcid":"https://orcid.org/0000-0001-7648-8709"},"institutions":[{"id":"https://openalex.org/I138801177","display_name":"University of Ulster","ror":"https://ror.org/01yp9g959","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Huiru Zheng","raw_affiliation_strings":["School of Computing and Mathematics, Computer Science Research Institute, University of Ulster, Newtownabbey, BT37 0QB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing and Mathematics, Computer Science Research Institute, University of Ulster, Newtownabbey, BT37 0QB, UK","institution_ids":["https://openalex.org/I138801177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039139051","display_name":"Fr\u00e9d\u00e9rique L\u00e9onard","orcid":null},"institutions":[{"id":"https://openalex.org/I4210144605","display_name":"Laboratoire National de Sant\u00e9","ror":"https://ror.org/04y798z66","country_code":"LU","type":"facility","lineage":["https://openalex.org/I4210144605"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9rique L\u00e9onard","raw_affiliation_strings":["Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg","institution_ids":["https://openalex.org/I4210144605"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018638151","display_name":"Magali Rolland-Turner","orcid":null},"institutions":[{"id":"https://openalex.org/I4210144605","display_name":"Laboratoire National de Sant\u00e9","ror":"https://ror.org/04y798z66","country_code":"LU","type":"facility","lineage":["https://openalex.org/I4210144605"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Magali Rolland-Turner","raw_affiliation_strings":["Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg","institution_ids":["https://openalex.org/I4210144605"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100388566","display_name":"Lu Zhang","orcid":"https://orcid.org/0000-0001-7141-6730"},"institutions":[{"id":"https://openalex.org/I4210144605","display_name":"Laboratoire National de Sant\u00e9","ror":"https://ror.org/04y798z66","country_code":"LU","type":"facility","lineage":["https://openalex.org/I4210144605"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Lu Zhang","raw_affiliation_strings":["Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg","institution_ids":["https://openalex.org/I4210144605"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052329481","display_name":"Yvan Devaux","orcid":"https://orcid.org/0000-0002-5321-8543"},"institutions":[{"id":"https://openalex.org/I4210144605","display_name":"Laboratoire National de Sant\u00e9","ror":"https://ror.org/04y798z66","country_code":"LU","type":"facility","lineage":["https://openalex.org/I4210144605"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Yvan Devaux","raw_affiliation_strings":["Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg","institution_ids":["https://openalex.org/I4210144605"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103518794","display_name":"Daniel R. Wagner","orcid":null},"institutions":[{"id":"https://openalex.org/I4210144605","display_name":"Laboratoire National de Sant\u00e9","ror":"https://ror.org/04y798z66","country_code":"LU","type":"facility","lineage":["https://openalex.org/I4210144605"]},{"id":"https://openalex.org/I162487826","display_name":"Centre Hospitalier de Luxembourg","ror":"https://ror.org/03xq7w797","country_code":"LU","type":"healthcare","lineage":["https://openalex.org/I162487826"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Daniel R Wagner","raw_affiliation_strings":["Division of Cardiology, Centre Hospitalier, L-1210, Luxembourg","Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Centre Hospitalier, L-1210, Luxembourg","institution_ids":["https://openalex.org/I162487826"]},{"raw_affiliation_string":"Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg","institution_ids":["https://openalex.org/I4210144605"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5050612781"],"corresponding_institution_ids":["https://openalex.org/I4210144605"],"apc_list":null,"apc_paid":null,"fwci":0.6651,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.68685831,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"5","issue":"1","first_page":"46","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.3476000130176544,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.3476000130176544,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.0763000026345253,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.06030000001192093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.5927358865737915},{"id":"https://openalex.org/keywords/progenitor-cell","display_name":"Progenitor cell","score":0.5803430080413818},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.544731855392456},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5312725305557251},{"id":"https://openalex.org/keywords/data-integration","display_name":"Data integration","score":0.5282499194145203},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.4835905432701111},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4481474757194519},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.42204374074935913},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.38987791538238525},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.36647284030914307},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3259197771549225},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3074018955230713},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2920435070991516},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.28852641582489014},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.27612459659576416},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11626532673835754}],"concepts":[{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.5927358865737915},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5803430080413818},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.544731855392456},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5312725305557251},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.5282499194145203},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4835905432701111},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4481474757194519},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.42204374074935913},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38987791538238525},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36647284030914307},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3259197771549225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3074018955230713},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2920435070991516},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.28852641582489014},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.27612459659576416},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11626532673835754},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019742","descriptor_name":"Chemokines, CC","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019742","descriptor_name":"Chemokines, CC","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019742","descriptor_name":"Chemokines, CC","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-5-46","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-46","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-46","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:21447198","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21447198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:f949a4dea5f247f285c4a3bad053b31d","is_oa":false,"landing_page_url":"https://doaj.org/article/f949a4dea5f247f285c4a3bad053b31d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 5, Iss 1, p 46 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2088825","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3080295","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-46","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-46","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-46","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6499999761581421,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320859","display_name":"Ulster University","ror":"https://ror.org/01yp9g959"},{"id":"https://openalex.org/F4320321038","display_name":"Fonds National de la Recherche Luxembourg","ror":"https://ror.org/039z13y21"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2058474593.pdf","grobid_xml":"https://content.openalex.org/works/W2058474593.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W19051162","https://openalex.org/W1647729745","https://openalex.org/W1966094414","https://openalex.org/W1967879212","https://openalex.org/W1976246270","https://openalex.org/W1978414516","https://openalex.org/W1979103623","https://openalex.org/W1985213868","https://openalex.org/W1993677879","https://openalex.org/W2002024777","https://openalex.org/W2009255619","https://openalex.org/W2016703670","https://openalex.org/W2030998114","https://openalex.org/W2046747076","https://openalex.org/W2049436815","https://openalex.org/W2057545775","https://openalex.org/W2076535906","https://openalex.org/W2084168100","https://openalex.org/W2096150327","https://openalex.org/W2096169903","https://openalex.org/W2096939566","https://openalex.org/W2102557353","https://openalex.org/W2107922629","https://openalex.org/W2118221286","https://openalex.org/W2121168048","https://openalex.org/W2124396531","https://openalex.org/W2125050685","https://openalex.org/W2130687290","https://openalex.org/W2131822674","https://openalex.org/W2135893370","https://openalex.org/W2138912059","https://openalex.org/W2139070508","https://openalex.org/W2141432425","https://openalex.org/W2141837666","https://openalex.org/W2145029433","https://openalex.org/W2150671144","https://openalex.org/W2157795344","https://openalex.org/W2158197251","https://openalex.org/W2158217645","https://openalex.org/W2158285228","https://openalex.org/W2159241859","https://openalex.org/W2159675211","https://openalex.org/W2163087495","https://openalex.org/W2165253681","https://openalex.org/W2166525781","https://openalex.org/W2168264491","https://openalex.org/W2916767477","https://openalex.org/W2917375902","https://openalex.org/W4285719527","https://openalex.org/W4294107304"],"related_works":["https://openalex.org/W2053081898","https://openalex.org/W2091029514","https://openalex.org/W2283234068","https://openalex.org/W2392243736","https://openalex.org/W2374633941","https://openalex.org/W2063301313","https://openalex.org/W86652014","https://openalex.org/W2096566481","https://openalex.org/W2389212772","https://openalex.org/W2091674433"],"abstract_inverted_index":{"BACKGROUND:":[0],"Endothelial":[1],"progenitor":[2],"cells":[3],"(EPCs)":[4],"have":[5],"been":[6],"implicated":[7],"in":[8,24,86,215,236],"different":[9],"processes":[10],"crucial":[11],"to":[12,51,56,79,103,135,163,233,270,297],"vasculature":[13],"repair,":[14],"which":[15,219],"may":[16],"offer":[17,183],"the":[18,53,64,145,165,189,197,224,228,248,261,272,282],"basis":[19],"for":[20,167,275],"new":[21,105,177,244,288],"therapeutic":[22],"strategies":[23],"cardiovascular":[25],"disease.":[26],"Despite":[27],"advances":[28],"facilitated":[29],"by":[30,157,204],"functional":[31,73,98,120],"genomics,":[32],"there":[33],"is":[34],"a":[35,59,243,268],"lack":[36],"of":[37,40,44,67,83,92,147,223,227,250,263,285],"systems-level":[38,65,283],"understanding":[39],"treatment":[41,106,235],"response":[42,55,85,107],"mechanisms":[43],"EPCs.":[45,87,286],"In":[46],"this":[47],"research":[48],"we":[49,76,210],"aimed":[50],"characterize":[52],"EPCs":[54,117,237],"adenosine":[57],"(Ado),":[58],"cardioprotective":[60],"factor,":[61],"based":[62,143,246],"on":[63,144,247],"integration":[66,91],"gene":[68,93,206,251],"expression":[69,94,110,207],"data":[70,95,111,253],"and":[71,96,115,119,137,159,254],"prior":[72],"knowledge.":[74],"Specifically,":[75],"set":[77],"out":[78],"identify":[80,104],"novel":[81],"biosignatures":[82,180],"Ado-treatment":[84],"RESULTS:":[88],"The":[89,152,171,278,287],"predictive":[90,290],"standardized":[97],"similarity":[99,121,128,256],"information":[100,131],"enabled":[101,133],"us":[102,134],"biosignatures.":[108,170,277],"Gene":[109,125],"originated":[112],"from":[113],"Ado-treated":[114],"-untreated":[116],"samples,":[118],"was":[122],"estimated":[123],"with":[124,242],"Ontology":[126],"(GO)-based":[127],"information.":[129,257],"These":[130],"sources":[132],"implement":[136],"evaluate":[138],"an":[139,212],"integrated":[140,173],"prediction":[141],"approach":[142,292],"concept":[146],"k-nearest":[148],"neighbours":[149],"learning":[150],"(kNN).":[151],"method":[153,245],"can":[154,182,200,238,293],"be":[155,239,295],"executed":[156],"expert-":[158],"data-driven":[160],"input":[161],"queries":[162,266],"guide":[164,271],"search":[166,274],"biologically":[168],"meaningful":[169],"resulting":[172],"kNN":[174],"system":[175],"identified":[176],"candidate":[178,276],"EPC":[179],"that":[181,196],"high":[184],"classification":[185],"performance":[186],"(areas":[187],"under":[188],"operating":[190],"characteristic":[191],"curve>0.8).":[192],"We":[193],"also":[194,259,294],"showed":[195],"proposed":[198,279],"models":[199],"outperform":[201],"those":[202],"discovered":[203],"standard":[205],"analysis.":[208],"Furthermore,":[209],"report":[211],"initial":[213],"independent":[214],"vitro":[216],"experimental":[217],"follow-up,":[218],"provides":[220],"additional":[221],"evidence":[222],"potential":[225],"validity":[226],"top":[229],"biosignature.":[230],"CONCLUSION:":[231],"Response":[232],"Ado":[234],"accurately":[240],"characterized":[241],"combination":[249],"co-expression":[252],"GO-based":[255],"It":[258],"exploits":[260],"incorporation":[262],"human":[264],"expert-driven":[265],"as":[267],"strategy":[269],"automated":[273],"biosignature":[280],"improves":[281],"characterization":[284,300],"integrative":[289],"modeling":[291],"applied":[296],"other":[298],"phenotype":[299],"or":[301],"biomarker":[302],"discovery":[303],"problems.":[304]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}