{"id":"https://openalex.org/W2104335693","doi":"https://doi.org/10.1186/1752-0509-5-204","title":"Heterogeneity reduces sensitivity of cell death for TNF-Stimuli","display_name":"Heterogeneity reduces sensitivity of cell death for TNF-Stimuli","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2104335693","doi":"https://doi.org/10.1186/1752-0509-5-204","mag":"2104335693","pmid":"https://pubmed.ncbi.nlm.nih.gov/22204418"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-204","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-204","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-204","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-204","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076462688","display_name":"Monica Schliemann","orcid":"https://orcid.org/0000-0002-3714-1523"},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke University Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Monica Schliemann","raw_affiliation_strings":["Institute for Automation Engineering, Laboratory for Systems Theory and Automatic Control, Otto-von-Guericke University Magdeburg, Germany","Institute for Automation Engineering, Laboratory for Systems Theory and Automatic Control, Otto-von-Guericke University Magdeburg, , Germany"],"affiliations":[{"raw_affiliation_string":"Institute for Automation Engineering, Laboratory for Systems Theory and Automatic Control, Otto-von-Guericke University Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]},{"raw_affiliation_string":"Institute for Automation Engineering, Laboratory for Systems Theory and Automatic Control, Otto-von-Guericke University Magdeburg, , Germany","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076279419","display_name":"Eric Bullinger","orcid":"https://orcid.org/0000-0002-8889-8286"},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Eric Bullinger","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, Institut Montefiore, Universit\u00e9 de Li\u00e8ge, Belgium","Department of Electrical Engineering and Computer Science, Institut Montefiore, Universit\u00e9 de Li\u00e8ge, , Belgium"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Institut Montefiore, Universit\u00e9 de Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Institut Montefiore, Universit\u00e9 de Li\u00e8ge, , Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028716413","display_name":"Steffen Borchers","orcid":null},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke University Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Steffen Borchers","raw_affiliation_strings":["Institute for Automation Engineering, Laboratory for Systems Theory and Automatic Control, Otto-von-Guericke University Magdeburg, Germany","Institute for Automation Engineering, Laboratory for Systems Theory and Automatic Control, Otto-von-Guericke University Magdeburg, , Germany"],"affiliations":[{"raw_affiliation_string":"Institute for Automation Engineering, Laboratory for Systems Theory and Automatic Control, Otto-von-Guericke University Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]},{"raw_affiliation_string":"Institute for Automation Engineering, Laboratory for Systems Theory and Automatic Control, Otto-von-Guericke University Magdeburg, , Germany","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001090900","display_name":"Frank Allg\u00f6wer","orcid":"https://orcid.org/0000-0002-3702-3658"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Allg\u00f6wer","raw_affiliation_strings":["Institute for Systems Theory and Automatic Control, University of Stuttgart, Germany","Institute for Systems Theory and Automatic Control University of Stuttgart Germany"],"affiliations":[{"raw_affiliation_string":"Institute for Systems Theory and Automatic Control, University of Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"Institute for Systems Theory and Automatic Control University of Stuttgart Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040485515","display_name":"Rolf Findeisen","orcid":"https://orcid.org/0000-0002-9112-5946"},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke University Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rolf Findeisen","raw_affiliation_strings":["Institute for Automation Engineering, Laboratory for Systems Theory and Automatic Control, Otto-von-Guericke University Magdeburg, Germany","Institute for Automation Engineering, Laboratory for Systems Theory and Automatic Control, Otto-von-Guericke University Magdeburg, , Germany"],"affiliations":[{"raw_affiliation_string":"Institute for Automation Engineering, Laboratory for Systems Theory and Automatic Control, Otto-von-Guericke University Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]},{"raw_affiliation_string":"Institute for Automation Engineering, Laboratory for Systems Theory and Automatic Control, Otto-von-Guericke University Magdeburg, , Germany","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056350199","display_name":"Peter Scheurich","orcid":null},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Scheurich","raw_affiliation_strings":["Institute of Cell Biology and Immunology, University of Stuttgart, Germany","Institute of Cell Biology and Immunology, University of Stuttgart, , Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Cell Biology and Immunology, University of Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"Institute of Cell Biology and Immunology, University of Stuttgart, , Germany","institution_ids":["https://openalex.org/I100066346"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5076462688"],"corresponding_institution_ids":["https://openalex.org/I95793202"],"apc_list":null,"apc_paid":null,"fwci":2.1344,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.87386801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"204","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9908000230789185,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6323440074920654},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"Programmed cell death","score":0.609961211681366},{"id":"https://openalex.org/keywords/tumor-necrosis-factor-alpha","display_name":"Tumor necrosis factor alpha","score":0.5907628536224365},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5767515301704407},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5578258037567139},{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.5366482138633728},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.4805893898010254},{"id":"https://openalex.org/keywords/proinflammatory-cytokine","display_name":"Proinflammatory cytokine","score":0.4595782458782196},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.45886725187301636},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.45096638798713684},{"id":"https://openalex.org/keywords/cytokine","display_name":"Cytokine","score":0.4342520833015442},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"Cell fate determination","score":0.4210112392902374},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.41915449500083923},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3272045850753784},{"id":"https://openalex.org/keywords/caspase","display_name":"Caspase","score":0.3131362199783325},{"id":"https://openalex.org/keywords/inflammation","display_name":"Inflammation","score":0.2897750735282898},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.20322173833847046},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11981335282325745},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.1156466007232666},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.11301222443580627},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10030156373977661}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6323440074920654},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.609961211681366},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5907628536224365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5767515301704407},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5578258037567139},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.5366482138633728},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4805893898010254},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4595782458782196},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.45886725187301636},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.45096638798713684},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4342520833015442},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.4210112392902374},{"id":"https://openalex.org/C33195913","wikidata":"https://www.wikidata.org/wiki/Q20970121","display_name":"XIAP","level":5,"score":0.41915449500083923},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3272045850753784},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.3131362199783325},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2897750735282898},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.20322173833847046},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11981335282325745},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.1156466007232666},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11301222443580627},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10030156373977661},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047888","descriptor_name":"Receptors, Tumor Necrosis Factor, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047888","descriptor_name":"Receptors, Tumor Necrosis Factor, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047888","descriptor_name":"Receptors, Tumor Necrosis Factor, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-5-204","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-204","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-204","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:22204418","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22204418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:9b7cf284d57349bfaf1a58476b1b5cfb","is_oa":true,"landing_page_url":"https://doaj.org/article/9b7cf284d57349bfaf1a58476b1b5cfb","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 5, Iss 1, p 204 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2318595","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3313907","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/106900","is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/106900","pdf_url":null,"source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, 5, 204 (2011-12-28)","raw_type":"peer reviewed"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-204","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-204","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-204","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3718516188","display_name":null,"funder_award_id":"405/1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5106512922","display_name":null,"funder_award_id":"Deutsche Forschungsgemeinschaft (DFG","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6024419964","display_name":null,"funder_award_id":"Deutsche Forschungsgemeinschaft (DFG)","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6052429835","display_name":null,"funder_award_id":"(DFG)","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320325850","display_name":"Universit\u00e4t Stuttgart","ror":"https://ror.org/04vnq7t77"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104335693.pdf","grobid_xml":"https://content.openalex.org/works/W2104335693.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W185620062","https://openalex.org/W1481859923","https://openalex.org/W1674561526","https://openalex.org/W1904436122","https://openalex.org/W1964136077","https://openalex.org/W1965322366","https://openalex.org/W1968295892","https://openalex.org/W1973109581","https://openalex.org/W1976712056","https://openalex.org/W1988666714","https://openalex.org/W1991865867","https://openalex.org/W1994375291","https://openalex.org/W1994874844","https://openalex.org/W1996676269","https://openalex.org/W1999014427","https://openalex.org/W2007827117","https://openalex.org/W2020787191","https://openalex.org/W2030221255","https://openalex.org/W2040544940","https://openalex.org/W2042087846","https://openalex.org/W2048987027","https://openalex.org/W2050826226","https://openalex.org/W2050866010","https://openalex.org/W2052853635","https://openalex.org/W2055913285","https://openalex.org/W2074982435","https://openalex.org/W2086255604","https://openalex.org/W2087668188","https://openalex.org/W2088516779","https://openalex.org/W2099312222","https://openalex.org/W2106097745","https://openalex.org/W2109719547","https://openalex.org/W2111510713","https://openalex.org/W2114727688","https://openalex.org/W2120951438","https://openalex.org/W2129297473","https://openalex.org/W2140662159","https://openalex.org/W2152585118","https://openalex.org/W2154335467","https://openalex.org/W2165516338","https://openalex.org/W2412424452","https://openalex.org/W2478238109","https://openalex.org/W4251104453"],"related_works":["https://openalex.org/W3175553808","https://openalex.org/W2071300214","https://openalex.org/W2771646924","https://openalex.org/W2069557611","https://openalex.org/W2083350896","https://openalex.org/W2005531064","https://openalex.org/W2145006562","https://openalex.org/W2001919785","https://openalex.org/W1480706353","https://openalex.org/W2605624004"],"abstract_inverted_index":{"Cell":[0],"ensemble":[1],"modeling":[2],"of":[3,21,54,62,72,77],"a":[4,9],"heterogeneous":[5],"cell":[6,56,64],"population":[7,65],"including":[8],"global":[10,59],"sensitivity":[11,60],"analysis":[12,61],"presented":[13],"here":[14],"allowed":[15],"us":[16],"to":[17,33,47],"illuminate":[18],"the":[19,22,35,43,52,55,63,75],"role":[20],"different":[23],"elements":[24],"and":[25,39],"parameters":[26],"on":[27],"apoptotic":[28],"signaling.":[29],"The":[30,58],"receptors":[31],"serve":[32],"transmit":[34],"external":[36],"stimulus;":[37],"procaspases":[38],"their":[40],"inhibitors":[41],"control":[42],"switching":[44],"from":[45],"life":[46],"death,":[48],"while":[49],"NF-\u03baB":[50],"enhances":[51],"heterogeneity":[53],"population.":[57],"model":[66],"further":[67],"revealed":[68],"an":[69],"unexpected":[70],"impact":[71],"heterogeneity,":[73],"i.e.":[74],"reduction":[76],"parametric":[78],"sensitivity.":[79]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
