{"id":"https://openalex.org/W2072510115","doi":"https://doi.org/10.1186/1752-0509-5-199","title":"Regulatory coordination of clustered microRNAs based on microRNA-transcription factor regulatory network","display_name":"Regulatory coordination of clustered microRNAs based on microRNA-transcription factor regulatory network","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2072510115","doi":"https://doi.org/10.1186/1752-0509-5-199","mag":"2072510115","pmid":"https://pubmed.ncbi.nlm.nih.gov/22176772"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-199","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-199","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-199","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-199","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100346127","display_name":"Jin Wang","orcid":"https://orcid.org/0000-0001-9969-3094"},"institutions":[{"id":"https://openalex.org/I4210160211","display_name":"Pharmaceutical Biotechnology (Czechia)","ror":"https://ror.org/051tvr365","country_code":"CZ","type":"company","lineage":["https://openalex.org/I4210160211"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jin Wang","raw_affiliation_strings":["The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology","institution_ids":["https://openalex.org/I4210160211","https://openalex.org/I4391768045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074217468","display_name":"Martin Haubrock","orcid":"https://orcid.org/0000-0001-5292-4561"},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Haubrock","raw_affiliation_strings":["Department of Bioinformatics, Medical School, Georg August University of G\u00f6ttingen, Goldschmidtstrasse 1, D-37077, G\u00f6ttingen, Germany","Department of Bioinformatics, Medical School, Georg August University of G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Medical School, Georg August University of G\u00f6ttingen, Goldschmidtstrasse 1, D-37077, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]},{"raw_affiliation_string":"Department of Bioinformatics, Medical School, Georg August University of G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kun-Ming Cao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210160211","display_name":"Pharmaceutical Biotechnology (Czechia)","ror":"https://ror.org/051tvr365","country_code":"CZ","type":"company","lineage":["https://openalex.org/I4210160211"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Kun-Ming Cao","raw_affiliation_strings":["The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, Norway","The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, Norway","institution_ids":[]},{"raw_affiliation_string":"The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology","institution_ids":["https://openalex.org/I4210160211","https://openalex.org/I4391768045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083553317","display_name":"Xu Hua","orcid":"https://orcid.org/0000-0002-9775-4129"},"institutions":[{"id":"https://openalex.org/I4210160211","display_name":"Pharmaceutical Biotechnology (Czechia)","ror":"https://ror.org/051tvr365","country_code":"CZ","type":"company","lineage":["https://openalex.org/I4210160211"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Xu Hua","raw_affiliation_strings":["The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, Norway","The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, Norway","institution_ids":[]},{"raw_affiliation_string":"The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology","institution_ids":["https://openalex.org/I4210160211","https://openalex.org/I4391768045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112212826","display_name":"Chen\u2010Yu Zhang","orcid":"https://orcid.org/0000-0002-7329-7162"},"institutions":[{"id":"https://openalex.org/I4210160211","display_name":"Pharmaceutical Biotechnology (Czechia)","ror":"https://ror.org/051tvr365","country_code":"CZ","type":"company","lineage":["https://openalex.org/I4210160211"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Chen-Yu Zhang","raw_affiliation_strings":["The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, Norway","The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, Norway","institution_ids":[]},{"raw_affiliation_string":"The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology","institution_ids":["https://openalex.org/I4210160211","https://openalex.org/I4391768045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029172959","display_name":"Edgar Wingender","orcid":"https://orcid.org/0000-0002-7729-8453"},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Edgar Wingender","raw_affiliation_strings":["Department of Bioinformatics, Medical School, Georg August University of G\u00f6ttingen, Goldschmidtstrasse 1, D-37077, G\u00f6ttingen, Germany","Department of Bioinformatics, Medical School, Georg August University of G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Medical School, Georg August University of G\u00f6ttingen, Goldschmidtstrasse 1, D-37077, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]},{"raw_affiliation_string":"Department of Bioinformatics, Medical School, Georg August University of G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101638808","display_name":"Jie Li","orcid":"https://orcid.org/0000-0002-2335-582X"},"institutions":[{"id":"https://openalex.org/I4210160211","display_name":"Pharmaceutical Biotechnology (Czechia)","ror":"https://ror.org/051tvr365","country_code":"CZ","type":"company","lineage":["https://openalex.org/I4210160211"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Jie Li","raw_affiliation_strings":["The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, Norway","The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, Norway","institution_ids":[]},{"raw_affiliation_string":"The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology","institution_ids":["https://openalex.org/I4210160211","https://openalex.org/I4391768045"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029172959","https://openalex.org/A5101638808","https://openalex.org/A5112212826"],"corresponding_institution_ids":["https://openalex.org/I4210160211","https://openalex.org/I4391768045","https://openalex.org/I74656192"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":2.2651,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.8788836,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"199","last_page":"199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9635999798774719,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9635999798774719,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8288012742996216},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6990450024604797},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.6040762066841125},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6032088994979858},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5969853401184082},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.5920989513397217},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.567632794380188},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5452984571456909},{"id":"https://openalex.org/keywords/regulatory-sequence","display_name":"Regulatory sequence","score":0.4490342140197754},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"Transcriptional regulation","score":0.42384809255599976},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4111189544200897},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3658927083015442}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8288012742996216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6990450024604797},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6040762066841125},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6032088994979858},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5969853401184082},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5920989513397217},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.567632794380188},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5452984571456909},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.4490342140197754},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.42384809255599976},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4111189544200897},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3658927083015442}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-5-199","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-199","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-199","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:22176772","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22176772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:4cbbf34a39fe495593a4e042fc1b04b7","is_oa":false,"landing_page_url":"https://doaj.org/article/4cbbf34a39fe495593a4e042fc1b04b7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 5, Iss 1, p 199 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2269557","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3262773","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:goescholar:1/7063","is_oa":true,"landing_page_url":"http://resolver.sub.uni-goettingen.de/purl?gs-1/7063","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journalArticle"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/21316","is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gs-1/7063","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal_article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-199","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-199","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-199","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G556581983","display_name":null,"funder_award_id":"30890044","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8313887831","display_name":null,"funder_award_id":"2007CB814806","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2072510115.pdf","grobid_xml":"https://content.openalex.org/works/W2072510115.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1973676791","https://openalex.org/W1979268646","https://openalex.org/W1980389572","https://openalex.org/W2000904576","https://openalex.org/W2001475320","https://openalex.org/W2006348395","https://openalex.org/W2014946489","https://openalex.org/W2017199818","https://openalex.org/W2018045523","https://openalex.org/W2035459770","https://openalex.org/W2040851473","https://openalex.org/W2050869737","https://openalex.org/W2059357290","https://openalex.org/W2061672799","https://openalex.org/W2063144561","https://openalex.org/W2070571588","https://openalex.org/W2070692423","https://openalex.org/W2075329854","https://openalex.org/W2081931663","https://openalex.org/W2103017472","https://openalex.org/W2107506912","https://openalex.org/W2112192177","https://openalex.org/W2115093090","https://openalex.org/W2117391818","https://openalex.org/W2122683221","https://openalex.org/W2128674168","https://openalex.org/W2133763262","https://openalex.org/W2136850043","https://openalex.org/W2139791626","https://openalex.org/W2140446903","https://openalex.org/W2141655062","https://openalex.org/W2151912077","https://openalex.org/W2158381555","https://openalex.org/W2159675211","https://openalex.org/W2161149887","https://openalex.org/W2163199119","https://openalex.org/W2166898290","https://openalex.org/W2170952313","https://openalex.org/W2171230529","https://openalex.org/W4237011200","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2049907435","https://openalex.org/W2010571965","https://openalex.org/W2034377088","https://openalex.org/W2912720016","https://openalex.org/W2002709996","https://openalex.org/W3128451840","https://openalex.org/W2277277196","https://openalex.org/W2043274041","https://openalex.org/W2620422757","https://openalex.org/W2056161765"],"abstract_inverted_index":{"BACKGROUND:":[0],"MicroRNA":[1],"(miRNA)":[2],"is":[3,75,185,208,268,285],"a":[4,54,101,170,180,211,226,229,309],"class":[5],"of":[6,9,27,108,118,126,135,194,232,243,266,282,290,314,320],"small":[7],"RNAs":[8],"~22nt":[10],"which":[11,168],"play":[12],"essential":[13],"roles":[14,319],"in":[15,163,251,275,327],"many":[16],"crucial":[17],"biological":[18,173,328],"processes":[19],"and":[20,41,95,99,130,237,323],"numerous":[21],"human":[22],"diseases":[23],"at":[24,214],"post-transcriptional":[25],"level":[26],"gene":[28,73,277],"expression.":[29],"It":[30],"has":[31],"been":[32],"revealed":[33],"that":[34,86,113,123,132,184,207,258],"miRNA":[35,119,227,292],"genes":[36,249,257],"tend":[37,159],"to":[38,156,160,271],"be":[39,161],"clustered,":[40],"the":[42,64,81,88,105,127,140,145,153,164,176,191,195,199,219,222,245,254,272,276,288,291,303,321,324],"miRNAs":[43,66,94,125,134,147,154,178,201,267,296,305,326],"organized":[44],"into":[45],"one":[46,157],"cluster":[47,158],"are":[48,115],"usually":[49],"transcribed":[50],"coordinately.":[51],"This":[52],"implies":[53],"coordinated":[55,150,196,223,273],"regulation":[56,151,189,193,212,220,239,274,300],"mode":[57],"exerted":[58],"by":[59,187,210,225],"clustered":[60,65,109],"miRNAs.":[61,110],"However,":[62,175],"how":[63],"coordinate":[67,298],"their":[68,299],"regulations":[69],"on":[70,104,221,287],"large":[71],"scale":[72],"expression":[74],"still":[76],"unclear.":[77],"RESULTS:":[78],"We":[79,111],"constructed":[80],"miRNA-transcription":[82],"factor":[83],"regulatory":[84,106,182,205,278,283,315],"network":[85,166],"contains":[87],"interactions":[89],"between":[90],"transcription":[91],"factors":[92],"(TFs),":[93],"non-TF":[96],"protein-coding":[97],"genes,":[98,244],"made":[100],"genome-wide":[102],"study":[103],"coordination":[107,183,206,284,316],"found":[112],"there":[114],"two":[116,233],"types":[117],"clusters,":[120],"i.e.":[121],"homo-clusters":[122],"contain":[124,133],"same":[128,165],"family":[129],"hetero-clusters":[131],"various":[136],"families.":[137],"In":[138],"general,":[139],"homo-clustered":[141,177,295,322],"as":[142,144],"well":[143],"hetero-clustered":[146,200,304,325],"both":[148],"exhibit":[149],"since":[152],"belonging":[155],"involved":[162,250],"module,":[167],"performs":[169],"relatively":[171],"isolated":[172],"function.":[174],"show":[179,202],"direct":[181,192,236],"realized":[186,209],"one-step":[188],"(i.e.":[190],"targets),":[197],"whereas":[198],"an":[203],"indirect":[204,238],"comprising":[213],"least":[215],"three":[216],"steps":[217],"(e.g.":[218],"targets":[224],"through":[228],"sequential":[230],"action":[231],"TFs).":[234],"The":[235,263,280,294,311],"target":[240],"different":[241],"categories":[242],"former":[246],"predominantly":[247],"regulating":[248],"emergent":[252],"responses,":[253],"latter":[255],"targeting":[256],"imply":[259],"long-term":[260],"effects.":[261],"CONCLUSION:":[262],"genomic":[264],"clustering":[265],"closely":[269],"related":[270],"network.":[279],"pattern":[281,313],"dependent":[286],"composition":[289],"cluster.":[293],"mainly":[297],"rapidly,":[301],"while":[302],"exert":[306],"control":[307],"with":[308],"delay.":[310],"diverse":[312],"suggests":[317],"distinct":[318],"processes.":[329]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":6}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
