{"id":"https://openalex.org/W2010217915","doi":"https://doi.org/10.1186/1752-0509-5-195","title":"Model-based clustering reveals vitamin D dependent multi-centrality hubs in a network of vitamin-related proteins","display_name":"Model-based clustering reveals vitamin D dependent multi-centrality hubs in a network of vitamin-related proteins","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2010217915","doi":"https://doi.org/10.1186/1752-0509-5-195","mag":"2010217915","pmid":"https://pubmed.ncbi.nlm.nih.gov/22136443"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-195","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-195","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-195","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-195","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101655330","display_name":"Thanh-Phuong Nguyen","orcid":"https://orcid.org/0000-0003-3817-5183"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I2802934434","display_name":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology","ror":"https://ror.org/04kcgyj43","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I1290206253","https://openalex.org/I193223587","https://openalex.org/I2802934434","https://openalex.org/I4210164937"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Thanh-Phuong Nguyen","raw_affiliation_strings":["The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Piazza Manifattura 1, 38068 Rovereto (Trento), Italy","The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Piazza Manifattura 1, 38068 Rovereto (Trento), Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]},{"raw_affiliation_string":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085009979","display_name":"Marco Scotti","orcid":"https://orcid.org/0000-0002-0775-6148"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I2802934434","display_name":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology","ror":"https://ror.org/04kcgyj43","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I1290206253","https://openalex.org/I193223587","https://openalex.org/I2802934434","https://openalex.org/I4210164937"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Scotti","raw_affiliation_strings":["The Microsoft Research -University of Trento Centre for Computational and Systems Biology (COSBI), Piazza Manifattura 1, 38068 Rovereto (Trento), Italy","The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Microsoft Research -University of Trento Centre for Computational and Systems Biology (COSBI), Piazza Manifattura 1, 38068 Rovereto (Trento), Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]},{"raw_affiliation_string":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031554670","display_name":"Melissa J. Morine","orcid":null},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I2802934434","display_name":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology","ror":"https://ror.org/04kcgyj43","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I1290206253","https://openalex.org/I193223587","https://openalex.org/I2802934434","https://openalex.org/I4210164937"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Melissa J Morine","raw_affiliation_strings":["The Microsoft Research -University of Trento Centre for Computational and Systems Biology (COSBI), Piazza Manifattura 1, 38068 Rovereto (Trento), Italy","The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Microsoft Research -University of Trento Centre for Computational and Systems Biology (COSBI), Piazza Manifattura 1, 38068 Rovereto (Trento), Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]},{"raw_affiliation_string":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028775661","display_name":"Corrado Priami","orcid":"https://orcid.org/0000-0002-3261-6235"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I2802934434","display_name":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology","ror":"https://ror.org/04kcgyj43","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I1290206253","https://openalex.org/I193223587","https://openalex.org/I2802934434","https://openalex.org/I4210164937"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Corrado Priami","raw_affiliation_strings":["The Microsoft Research -University of Trento Centre for Computational and Systems Biology (COSBI), Piazza Manifattura 1, 38068 Rovereto (Trento), Italy","Department of Information Engineering and Computer Science, University of Trento, Povo, Italy","The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Microsoft Research -University of Trento Centre for Computational and Systems Biology (COSBI), Piazza Manifattura 1, 38068 Rovereto (Trento), Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]},{"raw_affiliation_string":"Department of Information Engineering and Computer Science, University of Trento, Povo, Italy","institution_ids":["https://openalex.org/I193223587"]},{"raw_affiliation_string":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7869,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.70272353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"5","issue":"1","first_page":"195","last_page":"195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.5483999848365784,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.5483999848365784,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.15600000321865082,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.9055488109588623},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.7282572984695435},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.7085204720497131},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.621025025844574},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5736961364746094},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.543612003326416},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.4762808680534363},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.4619498550891876},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.45764559507369995},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.4544253349304199},{"id":"https://openalex.org/keywords/vitamin-d-and-neurology","display_name":"Vitamin D and neurology","score":0.4535079002380371},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38593706488609314},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.32206833362579346},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22635817527770996},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.22554969787597656},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.17565405368804932},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11481338739395142}],"concepts":[{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.9055488109588623},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.7282572984695435},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.7085204720497131},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.621025025844574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5736961364746094},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.543612003326416},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4762808680534363},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.4619498550891876},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.45764559507369995},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.4544253349304199},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.4535079002380371},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38593706488609314},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32206833362579346},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22635817527770996},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.22554969787597656},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17565405368804932},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11481338739395142},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-5-195","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-195","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-195","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:22136443","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22136443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:arpi.unipi.it:11568/881822","is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/881822","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unitn.it:11572/90440","is_oa":false,"landing_page_url":"http://hdl.handle.net/11572/90440","pdf_url":null,"source":{"id":"https://openalex.org/S4377196320","display_name":"Iris (University of Trento)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I193223587","host_organization_name":"University of Trento","host_organization_lineage":["https://openalex.org/I193223587"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:orbilu.uni.lu:10993/21701","is_oa":true,"landing_page_url":"https://orbilu.uni.lu/handle/10993/21701","pdf_url":null,"source":{"id":"https://openalex.org/S4306401815","display_name":"Open Repository and Bibliography (University of Luxembourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I186903577","host_organization_name":"University of Luxembourg","host_organization_lineage":["https://openalex.org/I186903577"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:3264545","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3264545","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-195","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-195","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-195","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.6800000071525574,"id":"https://metadata.un.org/sdg/2"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010217915.pdf","grobid_xml":"https://content.openalex.org/works/W2010217915.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W73518508","https://openalex.org/W229097380","https://openalex.org/W289419902","https://openalex.org/W601753206","https://openalex.org/W950821216","https://openalex.org/W1563558118","https://openalex.org/W1965749318","https://openalex.org/W1971788485","https://openalex.org/W1982485436","https://openalex.org/W1986017734","https://openalex.org/W1987508755","https://openalex.org/W1994651468","https://openalex.org/W2001054969","https://openalex.org/W2006683252","https://openalex.org/W2011832962","https://openalex.org/W2016728733","https://openalex.org/W2018939748","https://openalex.org/W2031321774","https://openalex.org/W2031981194","https://openalex.org/W2036709589","https://openalex.org/W2038177382","https://openalex.org/W2043824066","https://openalex.org/W2047693963","https://openalex.org/W2052068288","https://openalex.org/W2056944867","https://openalex.org/W2061901927","https://openalex.org/W2072602645","https://openalex.org/W2072999569","https://openalex.org/W2076922381","https://openalex.org/W2077159940","https://openalex.org/W2082649645","https://openalex.org/W2082948758","https://openalex.org/W2083962905","https://openalex.org/W2085560238","https://openalex.org/W2087194317","https://openalex.org/W2090386832","https://openalex.org/W2094781659","https://openalex.org/W2095958938","https://openalex.org/W2099126603","https://openalex.org/W2108825111","https://openalex.org/W2112947018","https://openalex.org/W2118794217","https://openalex.org/W2118964707","https://openalex.org/W2121751202","https://openalex.org/W2126001334","https://openalex.org/W2130527237","https://openalex.org/W2130790725","https://openalex.org/W2143351258","https://openalex.org/W2144014661","https://openalex.org/W2144675138","https://openalex.org/W2152285853","https://openalex.org/W2154645767","https://openalex.org/W2155216078","https://openalex.org/W2155823086","https://openalex.org/W2156737316","https://openalex.org/W2159675211","https://openalex.org/W2161062388","https://openalex.org/W2163329495","https://openalex.org/W2163480486","https://openalex.org/W2164301360","https://openalex.org/W2324588294","https://openalex.org/W2410767510","https://openalex.org/W4255486652","https://openalex.org/W4292692520"],"related_works":["https://openalex.org/W2158714033","https://openalex.org/W4229728790","https://openalex.org/W4386628104","https://openalex.org/W2800059693","https://openalex.org/W78967844","https://openalex.org/W3213185671","https://openalex.org/W4206945140","https://openalex.org/W2509687359","https://openalex.org/W2127864418","https://openalex.org/W2023465156"],"abstract_inverted_index":{"BACKGROUND:":[0],"Nutritional":[1],"systems":[2,48],"biology":[3],"offers":[4],"the":[5,17,22,26,99,116,119,160,168,176,182,206,219],"potential":[6,249],"for":[7,12,36,82],"comprehensive":[8],"predictions":[9],"that":[10,137],"account":[11],"all":[13],"metabolic":[14],"changes":[15],"with":[16,111],"intricate":[18],"biological":[19],"organization":[20],"and":[21,70,126,141,149,192,203,236,244],"multitudinous":[23],"interactions":[24,100],"between":[25],"cellular":[27],"proteins.":[28,104,157,189],"Protein-protein":[29],"interaction":[30,59,72],"(PPI)":[31],"networks":[32,51],"can":[33],"be":[34],"used":[35],"an":[37,75,79],"integrative":[38],"description":[39],"of":[40,57,101,118,134,159,165,175,185,222],"molecular":[41],"processes.":[42],"Although":[43],"widely":[44],"adopted":[45],"in":[46,180,198],"nutritional":[47],"biology,":[49],"these":[50,156],"typically":[52],"encompass":[53],"a":[54,93,132,163,170,199],"single":[55],"category":[56],"functional":[58,71],"(i.e.,":[60],"metabolic,":[61],"regulatory":[62],"or":[63,65],"signaling)":[64],"nutrient.":[66,224],"Incorporating":[67],"multiple":[68],"nutrients":[69],"categories":[73],"under":[74],"integrated":[76,226],"framework":[77],"represents":[78],"informative":[80],"approach":[81,227],"gaining":[83],"system":[84,148,243],"level":[85],"insight":[86],"on":[87],"nutrient":[88],"metabolism.":[89],"RESULTS:":[90],"We":[91,130],"constructed":[92],"multi-level":[94],"PPI":[95,201],"network":[96,202,216,229],"starting":[97],"from":[98],"200":[102],"vitamin-related":[103],"Its":[105],"final":[106],"size":[107],"was":[108],"1,657":[109],"proteins,":[110],"2,700":[112],"interactions.":[113],"To":[114],"characterize":[115],"role":[117],"proteins":[120,136,211],"we":[121],"computed":[122],"6":[123],"centrality":[124,207],"indices":[125],"applied":[127],"model-based":[128,193],"clustering.":[129],"detected":[131],"subgroup":[133],"22":[135,186],"were":[138,152,212],"highly":[139],"central":[140,188],"significantly":[142],"related":[143,240],"to":[144,228,241,254],"vitamin":[145,200,252],"D.":[146],"Immune":[147],"cancer-related":[150],"processes":[151,246],"strongly":[153,213],"represented":[154,214],"among":[155,167,205,215],"Clustering":[158],"centralities":[161,177],"revealed":[162,195],"degree":[164],"redundancy":[166],"indices;":[169],"repeated":[171],"analysis":[172],"using":[173],"subsets":[174],"performed":[178],"well":[179],"identifying":[181],"original":[183],"set":[184],"most":[187],"CONCLUSIONS:":[190],"Hierarchical":[191],"clustering":[194],"multi-centrality":[196],"hubs":[197],"redundancies":[204],"indices.":[208],"Vitamin":[209],"D-related":[210],"hubs,":[217],"highlighting":[218],"pervasive":[220],"effects":[221],"this":[223],"Our":[225],"construction":[230],"identified":[231],"promiscuous":[232],"transcription":[233],"factors,":[234],"cytokines":[235],"enzymes":[237],"-":[238,247],"primarily":[239],"immune":[242],"cancer":[245],"representing":[248],"gatekeepers":[250],"linking":[251],"intake":[253],"disease.":[255]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}