{"id":"https://openalex.org/W2148165054","doi":"https://doi.org/10.1186/1752-0509-5-178","title":"Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation","display_name":"Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation","publication_year":2011,"publication_date":"2011-10-28","ids":{"openalex":"https://openalex.org/W2148165054","doi":"https://doi.org/10.1186/1752-0509-5-178","mag":"2148165054","pmid":"https://pubmed.ncbi.nlm.nih.gov/22034949"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-178","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-178","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-178","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-178","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056948879","display_name":"Gaby Wangorsch","orcid":"https://orcid.org/0000-0003-3200-5394"},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gaby Wangorsch","raw_affiliation_strings":["Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, Germany","Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, Am Hubland, 97074, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, Am Hubland, 97074, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077575730","display_name":"Elke Butt","orcid":"https://orcid.org/0000-0002-0429-3918"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elke Butt","raw_affiliation_strings":["Institute for Clinical Biochemistry & Pathobiochemistry, Gromb\u00fchlstra\u00dfe 12, 97080, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Biochemistry & Pathobiochemistry, Gromb\u00fchlstra\u00dfe 12, 97080, W\u00fcrzburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000906656","display_name":"Regina Mark","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Regina Mark","raw_affiliation_strings":["Institute for Clinical Biochemistry & Pathobiochemistry, Gromb\u00fchlstra\u00dfe 12, 97080, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Biochemistry & Pathobiochemistry, Gromb\u00fchlstra\u00dfe 12, 97080, W\u00fcrzburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074740596","display_name":"Katharina Hubertus","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katharina Hubertus","raw_affiliation_strings":["Institute for Clinical Biochemistry & Pathobiochemistry, Gromb\u00fchlstra\u00dfe 12, 97080, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Biochemistry & Pathobiochemistry, Gromb\u00fchlstra\u00dfe 12, 97080, W\u00fcrzburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070564162","display_name":"J\u00f6rg Geiger","orcid":"https://orcid.org/0000-0002-7689-531X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J\u00f6rg Geiger","raw_affiliation_strings":["Institute for Clinical Biochemistry & Pathobiochemistry, Gromb\u00fchlstra\u00dfe 12, 97080, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Biochemistry & Pathobiochemistry, Gromb\u00fchlstra\u00dfe 12, 97080, W\u00fcrzburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086202312","display_name":"Thomas Dandekar","orcid":"https://orcid.org/0000-0003-1886-7625"},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas Dandekar","raw_affiliation_strings":["Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, Am Hubland, 97074, W\u00fcrzburg, Germany","European Molecular Biology Laboratory (EMBL), Postfach 102209, 69012, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, Am Hubland, 97074, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"European Molecular Biology Laboratory (EMBL), Postfach 102209, 69012, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210153543"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070610653","display_name":"Marcus Dittrich","orcid":"https://orcid.org/0000-0002-7726-5491"},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcus Dittrich","raw_affiliation_strings":["Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, Am Hubland, 97074, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, Am Hubland, 97074, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086202312"],"corresponding_institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210153543"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":1256,"currency":"EUR","value_usd":1354},"fwci":2.3121,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.88911413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"178","last_page":"178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.9668999910354614,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.9668999910354614,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.830909252166748},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6711111664772034},{"id":"https://openalex.org/keywords/modulation","display_name":"Modulation (music)","score":0.602013349533081},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4747343957424164},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.43732383847236633},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.42512246966362},{"id":"https://openalex.org/keywords/platelet","display_name":"Platelet","score":0.4226579964160919},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.37494468688964844},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.37378764152526855},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.36465781927108765},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3409053087234497},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.24496346712112427},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.23430058360099792},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.09175068140029907}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.830909252166748},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6711111664772034},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.602013349533081},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4747343957424164},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43732383847236633},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42512246966362},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4226579964160919},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37494468688964844},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37378764152526855},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36465781927108765},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3409053087234497},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24496346712112427},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.23430058360099792},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09175068140029907},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-5-178","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-178","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-178","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:22034949","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22034949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:europepmc.org:2252464","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3247139","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:opus.bibliothek.uni-wuerzburg.de:5972","is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-69145","pdf_url":null,"source":{"id":"https://openalex.org/S4306401635","display_name":"Online Publication Service of W\u00fcrzburg University (W\u00fcrzburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I25974101","host_organization_name":"University of W\u00fcrzburg","host_organization_lineage":["https://openalex.org/I25974101"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-178","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-178","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-178","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.49000000953674316,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1336006094","display_name":null,"funder_award_id":"TP-A2","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2598214052","display_name":null,"funder_award_id":"0315395D","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G653862013","display_name":null,"funder_award_id":"SFB\u00a0688","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2148165054.pdf","grobid_xml":"https://content.openalex.org/works/W2148165054.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W52033219","https://openalex.org/W1482785943","https://openalex.org/W1526841021","https://openalex.org/W1550053345","https://openalex.org/W1566938829","https://openalex.org/W1581415510","https://openalex.org/W1641228030","https://openalex.org/W1819958631","https://openalex.org/W1920444087","https://openalex.org/W1937193746","https://openalex.org/W1963851797","https://openalex.org/W1966533959","https://openalex.org/W1975906565","https://openalex.org/W1979679214","https://openalex.org/W1995457482","https://openalex.org/W2005253053","https://openalex.org/W2008844408","https://openalex.org/W2009373717","https://openalex.org/W2010601590","https://openalex.org/W2014261859","https://openalex.org/W2019750186","https://openalex.org/W2019783790","https://openalex.org/W2028876959","https://openalex.org/W2029690794","https://openalex.org/W2030883334","https://openalex.org/W2033258166","https://openalex.org/W2036540567","https://openalex.org/W2037925074","https://openalex.org/W2040072601","https://openalex.org/W2051072298","https://openalex.org/W2054139090","https://openalex.org/W2067738389","https://openalex.org/W2071467620","https://openalex.org/W2079515620","https://openalex.org/W2082988800","https://openalex.org/W2084548757","https://openalex.org/W2086948789","https://openalex.org/W2091287127","https://openalex.org/W2097414678","https://openalex.org/W2103838923","https://openalex.org/W2104208015","https://openalex.org/W2104849069","https://openalex.org/W2111541126","https://openalex.org/W2116924861","https://openalex.org/W2118462346","https://openalex.org/W2121316694","https://openalex.org/W2121619203","https://openalex.org/W2123845517","https://openalex.org/W2135847472","https://openalex.org/W2138571254","https://openalex.org/W2139065317","https://openalex.org/W2139322721","https://openalex.org/W2141421288","https://openalex.org/W2143894094","https://openalex.org/W2148309043","https://openalex.org/W2152150730","https://openalex.org/W2158622495","https://openalex.org/W2160234311","https://openalex.org/W2161829561","https://openalex.org/W2163208338","https://openalex.org/W2165982972","https://openalex.org/W2166071821","https://openalex.org/W2169638476","https://openalex.org/W2797028157","https://openalex.org/W3116530612","https://openalex.org/W4247867842"],"related_works":["https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W2101501829","https://openalex.org/W2985427592","https://openalex.org/W2003194288","https://openalex.org/W2060263731","https://openalex.org/W391093122","https://openalex.org/W4361305867","https://openalex.org/W1521239975","https://openalex.org/W2113159581"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hemostasis":[1],"is":[2,21,36,72,189,303],"a":[3,161,213,306,334],"critical":[4],"and":[5,30,45,59,92,104,140,157,177,221,234,240,245,259,282,329,343,362],"active":[6],"function":[7],"of":[8,17,22,28,82,87,94,97,109,122,224,296,314,324,339],"the":[9,15,80,106,172,178,196,266,297,322],"blood":[10],"mediated":[11],"by":[12,145,191],"platelets.":[13],"Therefore,":[14],"prevention":[16],"pathological":[18],"platelet":[19,34,56,77,357],"aggregation":[20],"great":[23],"importance":[24],"as":[25,27,133,135,204,272,274,309,311],"well":[26,134,205,273,310],"pharmaceutical":[29],"medical":[31],"interest.":[32],"Endogenous":[33],"inhibition":[35],"predominantly":[37],"based":[38],"on":[39,356],"cyclic":[40,47,83,130,249,317,340],"nucleotides":[41],"(cAMP,":[42],"cGMP)":[43],"elevation":[44],"subsequent":[46],"nucleotide-dependent":[48],"protein":[49,60,261],"kinase":[50],"(PKA,":[51,263],"PKG)":[52,264],"activation.":[53,78],"In":[54],"turn,":[55],"phosphodiesterases":[57],"(PDEs)":[58],"phosphatases":[61],"counterbalance":[62],"their":[63,158],"activity.":[64],"This":[65],"main":[66],"inhibitory":[67,316],"pathway":[68,123,299],"in":[69,167,195,265,305,336],"human":[70],"platelets":[71,168],"crucial":[73],"for":[74,113,182,257],"countervailing":[75],"unwanted":[76],"Consequently,":[79],"regulators":[81],"nucleotide":[84,131,250,318,341],"signaling":[85,103,132,138,166,251,298,342,346],"are":[86,237],"particular":[88],"interest":[89],"to":[90,129,136,171],"pharmacology":[91],"therapeutics":[93],"atherothrombosis.":[95],"Modeling":[96],"pharmacodynamics":[98],"allows":[99],"understanding":[100],"this":[101,315],"intricate":[102],"supports":[105],"precise":[107],"description":[108],"these":[110],"pivotal":[111],"targets":[112],"pharmacological":[114,227],"modulation.":[115],"RESULTS:":[116],"We":[117],"modeled":[118],"dynamically":[119],"concentration-dependent":[120],"responses":[121],"effectors":[124],"(inhibitors,":[125],"activators,":[126],"drug":[127,231,280,353],"combinations)":[128],"downstream":[137],"events":[139,252],"verified":[141],"resulting":[142,277],"model":[143,176,216,338],"predictions":[144,289],"experimental":[146,325],"data.":[147],"Experiments":[148],"with":[149,217],"various":[150],"cAMP":[151,165,193,275],"affecting":[152],"compounds":[153],"including":[154,242,359],"anti-platelet":[155],"drugs":[156],"combinations":[159],"revealed":[160],"high":[162],"fidelity,":[163],"fine-tuned":[164,307],"without":[169],"cross-talk":[170],"cGMP":[173],"pathway.":[174,319],"The":[175],"data":[179],"provide":[180],"evidence":[181],"two":[183],"independent":[184],"feedback":[185],"loops:":[186],"PKA,":[187],"which":[188],"activated":[190],"elevated":[192],"levels":[194,276],"platelet,":[197],"subsequently":[198],"inhibits":[199],"adenylyl":[200],"cyclase":[201],"(AC)":[202],"but":[203],"activates":[206],"PDE3.":[207],"By":[208],"multi-experiment":[209],"fitting,":[210],"we":[211,332],"established":[212,333],"comprehensive":[214],"dynamic":[215,335],"one":[218],"predictive,":[219],"optimized":[220],"validated":[222],"set":[223],"parameters.":[225],"Different":[226],"conditions":[228],"(inhibition,":[229],"activation,":[230],"combinations,":[232],"permanent":[233],"transient":[235],"perturbations)":[236],"successfully":[238,351],"tested":[239],"simulated,":[241],"statistical":[243],"validation":[244],"sensitivity":[246,295],"analysis.":[247],"Downstream":[248],"target":[253],"different":[254,279],"phosphorylation":[255,271],"sites":[256],"cAMP-":[258],"cGMP-dependent":[260],"kinases":[262],"vasodilator-stimulated":[267],"phosphoprotein":[268],"(VASP).":[269],"VASP":[270],"from":[278],"strengths":[281],"combined":[283],"stimulants":[284],"were":[285,290],"quantitatively":[286],"modeled.":[287],"These":[288],"again":[291],"experimentally":[292],"validated.":[293],"High":[294],"at":[300],"low":[301],"concentrations":[302],"involved":[304],"balance":[308],"stable":[312],"activation":[313],"CONCLUSIONS:":[320],"On":[321],"basis":[323],"data,":[326],"literature":[327],"mining":[328],"database":[330],"screening":[331],"silico":[337],"probed":[344],"its":[345],"sensitivity.":[347],"Thoroughly":[348],"validated,":[349],"it":[350],"predicts":[352],"combination":[354],"effects":[355],"function,":[358],"synergism,":[360],"antagonism":[361],"regulatory":[363],"loops.":[364]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}