{"id":"https://openalex.org/W2168942083","doi":"https://doi.org/10.1186/1752-0509-5-175","title":"Compartmentation of glycogen metabolism revealed from 13C isotopologue distributions","display_name":"Compartmentation of glycogen metabolism revealed from 13C isotopologue distributions","publication_year":2011,"publication_date":"2011-10-28","ids":{"openalex":"https://openalex.org/W2168942083","doi":"https://doi.org/10.1186/1752-0509-5-175","mag":"2168942083","pmid":"https://pubmed.ncbi.nlm.nih.gov/22034837"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-175","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-175","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-175","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-175","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019443273","display_name":"Igor Mar\u00edn de Mas","orcid":"https://orcid.org/0000-0003-2925-8155"},"institutions":[{"id":"https://openalex.org/I4210115203","display_name":"Cl\u00ednica Diagonal","ror":"https://ror.org/023j0b748","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115203"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Igor Marin de Mas","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Av Diagonal 643, 08028 Barcelona, Spain","Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Av Diagonal 643, 08028, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Av Diagonal 643, 08028 Barcelona, Spain","institution_ids":["https://openalex.org/I4210115203","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Av Diagonal 643, 08028, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009596579","display_name":"Vitaly A. Selivanov","orcid":"https://orcid.org/0000-0002-7937-9249"},"institutions":[{"id":"https://openalex.org/I4210120482","display_name":"Physico-Technical Institute","ror":"https://ror.org/02jj4k517","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I4210096333","https://openalex.org/I4210119369","https://openalex.org/I4210120482"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES","RU"],"is_corresponding":true,"raw_author_name":"Vitaly A Selivanov","raw_affiliation_strings":["A.N.Belozersky Institute of Physico-Chemical Biology, MSU, Moscow, 199899, Russia","Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Av Diagonal 643, 08028, Barcelona, Spain","Institute of Biomedicine of Universitat de Barcelona (IBUB) and CSIC-Associated Unit, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.N.Belozersky Institute of Physico-Chemical Biology, MSU, Moscow, 199899, Russia","institution_ids":["https://openalex.org/I4210120482"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Av Diagonal 643, 08028, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Institute of Biomedicine of Universitat de Barcelona (IBUB) and CSIC-Associated Unit, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006364089","display_name":"Silvia Mar\u00edn","orcid":"https://orcid.org/0000-0003-0693-2207"},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Silvia Marin","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Av Diagonal 643, 08028, Barcelona, Spain","Institute of Biomedicine of Universitat de Barcelona (IBUB) and CSIC-Associated Unit, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Av Diagonal 643, 08028, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Institute of Biomedicine of Universitat de Barcelona (IBUB) and CSIC-Associated Unit, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042593224","display_name":"Josep Roca","orcid":"https://orcid.org/0000-0003-4768-8722"},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210160192","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Josep Roca","raw_affiliation_strings":["Hospital Cl\u00ednic, IDIBAPS, CIBERES; Universitat de Barcelona, Barcelona, 08028, Spain","Hospital Cl\u00ednic, IDIBAPS, CIBERES","Universitat de Barcelona, Barcelona, 08028, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednic, IDIBAPS, CIBERES; Universitat de Barcelona, Barcelona, 08028, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Hospital Cl\u00ednic, IDIBAPS, CIBERES","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192"]},{"raw_affiliation_string":"Universitat de Barcelona, Barcelona, 08028, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083895460","display_name":"Matej Ore\u0161i\u010d","orcid":"https://orcid.org/0000-0002-2856-9165"},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Matej Ore\u0161i\u010d","raw_affiliation_strings":["Technical Research Centre of Finland, Espoo, and Institute for Molecular Medicine, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technical Research Centre of Finland, Espoo, and Institute for Molecular Medicine, Helsinki, Finland","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083106002","display_name":"Loranne Agius","orcid":"https://orcid.org/0000-0002-6419-6503"},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Loranne Agius","raw_affiliation_strings":["Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089973047","display_name":"Marta Cascante","orcid":"https://orcid.org/0000-0002-2062-4633"},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Marta Cascante","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Av Diagonal 643, 08028, Barcelona, Spain","Institute of Biomedicine of Universitat de Barcelona (IBUB) and CSIC-Associated Unit, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Av Diagonal 643, 08028, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Institute of Biomedicine of Universitat de Barcelona (IBUB) and CSIC-Associated Unit, Spain","institution_ids":["https://openalex.org/I71999127"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5009596579","https://openalex.org/A5089973047"],"corresponding_institution_ids":["https://openalex.org/I4210120482","https://openalex.org/I71999127"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.8516,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.72262659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"5","issue":"1","first_page":"175","last_page":"175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.450300008058548,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.450300008058548,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.2475000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0868000015616417,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-flux-analysis","display_name":"Metabolic flux analysis","score":0.8094531297683716},{"id":"https://openalex.org/keywords/hexose","display_name":"Hexose","score":0.6618844270706177},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.6187529563903809},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.5491292476654053},{"id":"https://openalex.org/keywords/glycogen","display_name":"Glycogen","score":0.5239981412887573},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.5007522106170654},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.5004382133483887},{"id":"https://openalex.org/keywords/isotope","display_name":"Isotope","score":0.47369837760925293},{"id":"https://openalex.org/keywords/isotopologue","display_name":"Isotopologue","score":0.46465247869491577},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.4642314314842224},{"id":"https://openalex.org/keywords/isotopic-labeling","display_name":"Isotopic labeling","score":0.4629462957382202},{"id":"https://openalex.org/keywords/pentose-phosphate-pathway","display_name":"Pentose phosphate pathway","score":0.4589858949184418},{"id":"https://openalex.org/keywords/isotopomers","display_name":"Isotopomers","score":0.423289954662323},{"id":"https://openalex.org/keywords/metabolome","display_name":"Metabolome","score":0.41639912128448486},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4027455747127533},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4005450904369354},{"id":"https://openalex.org/keywords/glycolysis","display_name":"Glycolysis","score":0.3608675003051758},{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.20854449272155762},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.18508851528167725},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.07597872614860535}],"concepts":[{"id":"https://openalex.org/C160941953","wikidata":"https://www.wikidata.org/wiki/Q6822342","display_name":"Metabolic flux analysis","level":3,"score":0.8094531297683716},{"id":"https://openalex.org/C2776393687","wikidata":"https://www.wikidata.org/wiki/Q339725","display_name":"Hexose","level":3,"score":0.6618844270706177},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.6187529563903809},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5491292476654053},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.5239981412887573},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5007522106170654},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5004382133483887},{"id":"https://openalex.org/C164304813","wikidata":"https://www.wikidata.org/wiki/Q25276","display_name":"Isotope","level":2,"score":0.47369837760925293},{"id":"https://openalex.org/C13934619","wikidata":"https://www.wikidata.org/wiki/Q2198720","display_name":"Isotopologue","level":3,"score":0.46465247869491577},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.4642314314842224},{"id":"https://openalex.org/C36674120","wikidata":"https://www.wikidata.org/wiki/Q370228","display_name":"Isotopic labeling","level":2,"score":0.4629462957382202},{"id":"https://openalex.org/C3409486","wikidata":"https://www.wikidata.org/wiki/Q827489","display_name":"Pentose phosphate pathway","level":4,"score":0.4589858949184418},{"id":"https://openalex.org/C127124265","wikidata":"https://www.wikidata.org/wiki/Q2100870","display_name":"Isotopomers","level":3,"score":0.423289954662323},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.41639912128448486},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4027455747127533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4005450904369354},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.3608675003051758},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.20854449272155762},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.18508851528167725},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07597872614860535},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-5-175","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-175","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-175","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:22034837","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22034837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:diposit.ub.edu:2445/24345","is_oa":true,"landing_page_url":"https://hdl.handle.net/2445/24345","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Articles publicats en revistes (Bioqu\u00edmica i Biomedicina Molecular)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.recercat.cat:2072/183656","is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/24345","pdf_url":null,"source":{"id":"https://openalex.org/S4306402147","display_name":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:5c7450b71b054a7b88c6cb4d00e6df2b","is_oa":false,"landing_page_url":"https://doaj.org/article/5c7450b71b054a7b88c6cb4d00e6df2b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 5, Iss 1, p 175 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2303642","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3292525","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-175","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-175","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-175","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16","score":0.5899999737739563}],"awards":[{"id":"https://openalex.org/G1616315867","display_name":null,"funder_award_id":"SAF2011-25726","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G1770074201","display_name":null,"funder_award_id":"2009SGR1308","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"},{"id":"https://openalex.org/G1952936224","display_name":null,"funder_award_id":"RD06/0020","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G2898191549","display_name":null,"funder_award_id":"RD06/0020/0046","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G2974580625","display_name":"DIAbetes type 1 PRediction, Early Pathogenesis and Prevention","funder_award_id":"202013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3170664214","display_name":null,"funder_award_id":"RD06/0020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G824650583","display_name":"Modelling and simulation environment for systems medicine\\n(Chronic obstructive pulmonary disease -COPD- as a use case)","funder_award_id":"270086","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"},{"id":"https://openalex.org/F4320322121","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320323428","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57"},{"id":"https://openalex.org/F4320334830","display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","ror":"https://ror.org/01n4pqe45"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338366","display_name":"FP7 Food, Agriculture and Fisheries, Biotechnology","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2168942083.pdf","grobid_xml":"https://content.openalex.org/works/W2168942083.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W259067892","https://openalex.org/W1498391596","https://openalex.org/W1517125074","https://openalex.org/W1540937567","https://openalex.org/W1569813716","https://openalex.org/W1581816464","https://openalex.org/W1602530349","https://openalex.org/W1723714747","https://openalex.org/W1966869097","https://openalex.org/W1975110556","https://openalex.org/W1984555524","https://openalex.org/W1986712983","https://openalex.org/W1989538987","https://openalex.org/W1992170087","https://openalex.org/W1992812133","https://openalex.org/W1995238008","https://openalex.org/W2005739770","https://openalex.org/W2007892976","https://openalex.org/W2008087600","https://openalex.org/W2010679017","https://openalex.org/W2017951535","https://openalex.org/W2030396954","https://openalex.org/W2030708049","https://openalex.org/W2035649591","https://openalex.org/W2043276874","https://openalex.org/W2052102985","https://openalex.org/W2058830090","https://openalex.org/W2063809107","https://openalex.org/W2068330660","https://openalex.org/W2068722248","https://openalex.org/W2071987890","https://openalex.org/W2072925078","https://openalex.org/W2077592317","https://openalex.org/W2090386962","https://openalex.org/W2110585845","https://openalex.org/W2111602998","https://openalex.org/W2112963260","https://openalex.org/W2114572250","https://openalex.org/W2115026369","https://openalex.org/W2115198483","https://openalex.org/W2115338353","https://openalex.org/W2122055675","https://openalex.org/W2125595015","https://openalex.org/W2130784515","https://openalex.org/W2140614065","https://openalex.org/W2147288861","https://openalex.org/W2148622754","https://openalex.org/W2153892445","https://openalex.org/W2158713438","https://openalex.org/W2161304688","https://openalex.org/W2284158363","https://openalex.org/W2326605204","https://openalex.org/W2432517183","https://openalex.org/W2517175497","https://openalex.org/W3097169496","https://openalex.org/W4318598267"],"related_works":["https://openalex.org/W1989966971","https://openalex.org/W2321376996","https://openalex.org/W2096016195","https://openalex.org/W4322212194","https://openalex.org/W3027897936","https://openalex.org/W2095203814","https://openalex.org/W2996888210","https://openalex.org/W2568719136","https://openalex.org/W2041987999","https://openalex.org/W2062870685"],"abstract_inverted_index":{"BACKGROUND:":[0],"Stable":[1],"isotope":[2,113],"tracers":[3],"are":[4],"used":[5],"to":[6,54,177,252],"assess":[7],"metabolic":[8,89,101,204,215,244,254],"flux":[9,188],"profiles":[10],"in":[11,25,87,115,129,144,165,203,206,225,281],"living":[12],"cells.":[13,208],"The":[14,76,148,210,231,256],"existing":[15],"methods":[16],"of":[17,33,36,44,64,70,83,127,132,161,170,181,201,212,214,233,241,243,258,265,275,278,291,295],"measurement":[18],"average":[19,71],"out":[20],"the":[21,28,31,42,62,68,81,96,105,130,179,192,199,219,263,273,285,289],"isotopic":[22,72,84,168],"isomer":[23,73,85],"distribution":[24,86,222,264,287],"metabolites":[26,65,269],"throughout":[27],"cell,":[29],"whereas":[30],"knowledge":[32],"compartmental":[34],"organization":[35],"analyzed":[37,100],"pathways":[38],"is":[39,48,236,270,299],"crucial":[40],"for":[41,107],"evaluation":[43,242],"true":[45],"fluxes.":[46],"That":[47],"why":[49],"we":[50],"accepted":[51,193],"a":[52,56,152,166,228,239,292],"challenge":[53],"create":[55],"software":[57,77],"tool":[58],"that":[59,195,262,298],"allows":[60],"deciphering":[61],"compartmentation":[63,213],"based":[66,217],"on":[67,218],"analysis":[69,211,257],"distribution.":[74],"RESULTS:":[75],"Isodyn,":[78],"which":[79],"simulates":[80],"dynamics":[82],"central":[88],"pathways,":[90],"was":[91,175,223],"supplemented":[92],"by":[93,104,122],"algorithms":[94],"facilitating":[95],"transition":[97],"between":[98],"various":[99],"schemes,":[102],"and":[103,119,138],"tools":[106],"model":[108,194],"discrimination.":[109],"It":[110],"simulated":[111],"13C":[112,221],"distributions":[114],"glucose,":[116],"lactate,":[117],"glutamate":[118],"glycogen,":[120],"measured":[121,220,266],"mass":[123],"spectrometry":[124],"after":[125],"incubation":[126],"hepatocytes":[128],"presence":[131,290],"only":[133],"labeled":[134],"glucose":[135,137,145,268],"or":[136,146,158],"lactate":[139],"together":[140],"(with":[141],"label":[142],"either":[143,151],"lactate).":[147],"simulations":[149],"assumed":[150],"single":[153],"intracellular":[154],"hexose":[155,162,279,296],"phosphate":[156],"pool,":[157],"also":[159],"channeling":[160],"phosphates":[163,280,297],"resulting":[164],"different":[167],"composition":[169],"glycogen.":[171],"Model":[172],"discrimination":[173],"test":[174],"applied":[176],"check":[178],"consistency":[180],"both":[182],"models":[183],"with":[184,191,272],"experimental":[185,259],"data.":[186],"Metabolic":[187],"profiles,":[189],"evaluated":[190],"assumes":[196],"channeling,":[197],"revealed":[198,261],"range":[200],"changes":[202],"fluxes":[205],"liver":[207],"CONCLUSIONS:":[209],"networks":[216],"included":[224],"Isodyn":[226],"as":[227],"routine":[229],"procedure.":[230],"advantage":[232],"this":[234],"implementation":[235],"that,":[237],"being":[238],"part":[240],"fluxes,":[245],"it":[246],"does":[247],"not":[248],"require":[249],"additional":[250],"experiments":[251],"study":[253],"compartmentation.":[255],"data":[260],"13C-labeled":[267],"inconsistent":[271],"idea":[274],"perfect":[276],"mixing":[277],"cytosol.":[282],"In":[283],"contrast,":[284],"observed":[286],"indicates":[288],"separate":[293],"pool":[294],"channeled":[300],"towards":[301],"glycogen":[302],"synthesis.":[303]},"counts_by_year":[{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-25T09:21:30.201066","created_date":"2025-10-10T00:00:00"}