{"id":"https://openalex.org/W2047158621","doi":"https://doi.org/10.1186/1752-0509-5-173","title":"An in silico approach combined with in vivo experiments enables the identification of a new protein whose overexpression can compensate for specific respiratory defects in Saccharomyces cerevisiae","display_name":"An in silico approach combined with in vivo experiments enables the identification of a new protein whose overexpression can compensate for specific respiratory defects in Saccharomyces cerevisiae","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2047158621","doi":"https://doi.org/10.1186/1752-0509-5-173","mag":"2047158621","pmid":"https://pubmed.ncbi.nlm.nih.gov/22027258"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-173","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-173","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-173","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-173","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105399350","display_name":"Annie Glatigny","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Annie Glatigny","raw_affiliation_strings":["CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, UPR3404, FRC3115, 91198 Gif-sur-Yvette, France. glatigny@cgm.cnrs-gif.fr","CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire Gif\u2010sur\u2010Yvette France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, UPR3404, FRC3115, 91198 Gif-sur-Yvette, France. glatigny@cgm.cnrs-gif.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560"]},{"raw_affiliation_string":"CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire Gif\u2010sur\u2010Yvette France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077425545","display_name":"Lise Mathieu","orcid":null},"institutions":[{"id":"https://openalex.org/I195731000","display_name":"Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines","ror":"https://ror.org/03mkjjy25","country_code":"FR","type":"education","lineage":["https://openalex.org/I195731000","https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lise Mathieu","raw_affiliation_strings":["UVSQ, 55 avenue de Paris, 78035, Versailles, France","UVSQ, 55 avenue de Paris, Versailles, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UVSQ, 55 avenue de Paris, 78035, Versailles, France","institution_ids":["https://openalex.org/I195731000"]},{"raw_affiliation_string":"UVSQ, 55 avenue de Paris, Versailles, France","institution_ids":["https://openalex.org/I195731000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110210431","display_name":"C.J. Herbert","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christopher J Herbert","raw_affiliation_strings":["CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, UPR3404, FRC3115, 91198, Gif-sur-Yvette, France","CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire Gif\u2010sur\u2010Yvette France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, UPR3404, FRC3115, 91198, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560"]},{"raw_affiliation_string":"CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire Gif\u2010sur\u2010Yvette France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110289036","display_name":"Genevi\u00e8ve Dujardin","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Genevi\u00e8ve Dujardin","raw_affiliation_strings":["CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, UPR3404, FRC3115, 91198, Gif-sur-Yvette, France","CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire Gif\u2010sur\u2010Yvette France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, UPR3404, FRC3115, 91198, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560"]},{"raw_affiliation_string":"CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire Gif\u2010sur\u2010Yvette France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079591293","display_name":"Brigitte Meunier","orcid":"https://orcid.org/0000-0002-6988-4663"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Brigitte Meunier","raw_affiliation_strings":["CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, UPR3404, FRC3115, 91198, Gif-sur-Yvette, France","CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire Gif\u2010sur\u2010Yvette France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, UPR3404, FRC3115, 91198, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560"]},{"raw_affiliation_string":"CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire Gif\u2010sur\u2010Yvette France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005312459","display_name":"Marie-H\u00e9l\u00e8ne Mucchielli-Giorgi","orcid":"https://orcid.org/0000-0002-4747-2561"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-H\u00e9l\u00e8ne Mucchielli-Giorgi","raw_affiliation_strings":["CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, UPR3404, FRC3115, 91198, Gif-sur-Yvette, France","Universit\u00e9 Pierre et Marie Curie- Paris 6, 75005, Paris, France","CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Gif-sur-Yvette, France","Universit\u00e9 Pierre et Marie Curie- Paris 6, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, UPR3404, FRC3115, 91198, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560"]},{"raw_affiliation_string":"Universit\u00e9 Pierre et Marie Curie- Paris 6, 75005, Paris, France","institution_ids":["https://openalex.org/I39804081"]},{"raw_affiliation_string":"CNRS, Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560"]},{"raw_affiliation_string":"Universit\u00e9 Pierre et Marie Curie- Paris 6, Paris, France","institution_ids":["https://openalex.org/I39804081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5105399350"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.4867,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.62629756,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"5","issue":"1","first_page":"173","last_page":"173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.4722000062465668,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.4722000062465668,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.07000000029802322,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.03139999881386757,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biogenesis","display_name":"Biogenesis","score":0.7166967391967773},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6644739508628845},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5789041519165039},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5770112872123718},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.525340735912323},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.482769638299942},{"id":"https://openalex.org/keywords/protein-subunit","display_name":"Protein subunit","score":0.4779125154018402},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.36189889907836914},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.31372565031051636},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2695869207382202}],"concepts":[{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.7166967391967773},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6644739508628845},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5789041519165039},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5770112872123718},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.525340735912323},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.482769638299942},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4779125154018402},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36189889907836914},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31372565031051636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2695869207382202}],"mesh":[{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-5-173","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-173","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-173","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:22027258","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22027258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:HAL:hal-04419134v1","is_oa":true,"landing_page_url":"https://hal.science/hal-04419134","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, 2011, 5 (1), pp.173. ⟨10.1186/1752-0509-5-173⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:02eb98289f9f4455bc1bf489c9645992","is_oa":false,"landing_page_url":"https://doaj.org/article/02eb98289f9f4455bc1bf489c9645992","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 5, Iss 1, p 173 (2011)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3214889","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3214889","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-173","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-173","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-173","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2393799066","display_name":null,"funder_award_id":"ANR-07-BLAN-0360-02","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4838538532","display_name":null,"funder_award_id":"ANR-07-BLAN-0360","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2047158621.pdf","grobid_xml":"https://content.openalex.org/works/W2047158621.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1446286296","https://openalex.org/W1571703443","https://openalex.org/W1783384641","https://openalex.org/W1971045545","https://openalex.org/W1974260422","https://openalex.org/W1975399897","https://openalex.org/W1976099055","https://openalex.org/W1977320434","https://openalex.org/W1982753455","https://openalex.org/W2000778220","https://openalex.org/W2006062026","https://openalex.org/W2006101516","https://openalex.org/W2008003969","https://openalex.org/W2013415260","https://openalex.org/W2021109236","https://openalex.org/W2026254663","https://openalex.org/W2031972450","https://openalex.org/W2034073307","https://openalex.org/W2039254203","https://openalex.org/W2050721857","https://openalex.org/W2061371090","https://openalex.org/W2062753466","https://openalex.org/W2065304353","https://openalex.org/W2070637646","https://openalex.org/W2074986735","https://openalex.org/W2077436442","https://openalex.org/W2082565035","https://openalex.org/W2084737875","https://openalex.org/W2098370509","https://openalex.org/W2100057937","https://openalex.org/W2100308967","https://openalex.org/W2106647330","https://openalex.org/W2109248504","https://openalex.org/W2109415448","https://openalex.org/W2113894722","https://openalex.org/W2116447934","https://openalex.org/W2118128448","https://openalex.org/W2122964432","https://openalex.org/W2123774841","https://openalex.org/W2124287644","https://openalex.org/W2133102806","https://openalex.org/W2136850043","https://openalex.org/W2137531873","https://openalex.org/W2139287303","https://openalex.org/W2145412238","https://openalex.org/W2150164439","https://openalex.org/W2152231771","https://openalex.org/W2158742931","https://openalex.org/W2162379361","https://openalex.org/W2162891889","https://openalex.org/W2163485494","https://openalex.org/W2166043581","https://openalex.org/W2167869241","https://openalex.org/W2169805130","https://openalex.org/W2170621128"],"related_works":["https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W2101501829","https://openalex.org/W2985427592","https://openalex.org/W2003194288","https://openalex.org/W2060263731","https://openalex.org/W391093122","https://openalex.org/W1521239975","https://openalex.org/W4361305867","https://openalex.org/W2485322604"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,180],"mitochondrial":[2,337],"inner":[3],"membrane":[4],"contains":[5],"five":[6],"large":[7],"complexes":[8,25,278],"that":[9,52,65,200,227,245],"are":[10,55],"essential":[11,231],"for":[12,57,253,316],"oxidative":[13],"phosphorylation.":[14],"Although":[15],"the":[16,19,23,58,66,98,104,107,111,143,146,164,187,203,220,238,242,246,256,259,269,291,300,334],"structure":[17],"and":[18,110,117,121,134,145,160,208,214,240,244,274,280],"catalytic":[20],"mechanisms":[21],"of":[22,60,114,149,157,166,182,196,222,248,258,277,293,302,336],"respiratory":[24,260,303,317],"have":[26,44,72,80,308],"been":[27,45,74,309],"progressively":[28],"established,":[29],"their":[30,283],"biogenesis":[31,257,301,335],"is":[32,50,229],"far":[33],"from":[34,186],"being":[35],"fully":[36],"understood.":[37],"Very":[38],"few":[39],"complex":[40,91,115,150,158,167,204],"III":[41,92,116,205,279],"assembly":[42,59,112,165,275],"factors":[43,54,89,113,276],"identified":[46],"so":[47],"far.":[48],"It":[49,128],"probable":[51],"more":[53],"needed":[56],"a":[61,82,126,194,234,294,328],"functional":[62],"complex,":[63],"but":[64],"genetic":[67,213,313],"approaches":[68,217],"used":[69,118,212],"to":[70,76,86,124,192,218,326,332],"date":[71],"not":[73,307],"able":[75],"identify":[77,87,193],"them.":[78],"We":[79,95,210],"developed":[81],"systems":[83,264,322],"biology":[84,216,265,323],"approach":[85,266,288,324],"new":[88,295,330],"controlling":[90],"biogenesis.":[93,284],"RESULTS:":[94],"collected":[96],"all":[97],"physical":[99],"protein-protein":[100],"interactions":[101],"(PPI)":[102],"involving":[103],"core":[105,144],"subunits,":[106],"supernumerary":[108,147],"subunits":[109,148,156,206,273],"Cytoscape":[119],"2.6.3":[120],"its":[122],"plugins":[123],"construct":[125],"network.":[127],"was":[129,171],"then":[130,172,211],"divided":[131],"into":[132,177],"overlapping":[133],"highly":[135],"interconnected":[136],"sub-graphs":[137,185],"with":[138,174,202,233],"clusterONE.":[139],"One":[140],"sub-graph":[141,170,189],"contained":[142,154],"III,":[151],"it":[152],"also":[153],"some":[155],"IV":[159,281],"proteins":[161],"participating":[162],"in":[163,237,241,255,299],"IV.":[168],"This":[169],"split":[173],"another":[175],"algorithm":[176],"two":[178,184],"sub-graphs.":[179],"subtraction":[181],"these":[183],"previous":[188],"allowed":[190,290],"us":[191],"protein":[195,232,250],"unknown":[197],"function":[198,221],"Usb1p/Ylr132p":[199],"interacts":[201],"Qcr2p":[207],"Cor1p.":[209],"cell":[215],"investigate":[219],"Usb1p.":[223],"Preliminary":[224],"results":[225],"indicated":[226],"Usb1p":[228],"an":[230],"dual":[235],"localization":[236],"nucleus":[239],"mitochondria,":[243],"over-expression":[247],"this":[249,287,321],"can":[251],"compensate":[252],"defects":[254],"complexes.":[261,339],"CONCLUSIONS:":[262],"Our":[263],"has":[267,289],"highlighted":[268],"multiple":[270],"associations":[271],"between":[272],"during":[282],"In":[285],"addition,":[286],"identification":[292],"factor,":[296],"Usb1p,":[297],"involved":[298],"complexes,":[304],"which":[305],"could":[306],"found":[310],"using":[311],"classical":[312],"screens":[314],"looking":[315],"deficient":[318],"mutants.":[319],"Thus,":[320],"appears":[325],"be":[327],"fruitful":[329],"way":[331],"study":[333],"multi-subunit":[338]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-27T08:26:11.824852","created_date":"2025-10-10T00:00:00"}