{"id":"https://openalex.org/W2152768535","doi":"https://doi.org/10.1186/1752-0509-5-139","title":"Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells","display_name":"Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2152768535","doi":"https://doi.org/10.1186/1752-0509-5-139","mag":"2152768535","pmid":"https://pubmed.ncbi.nlm.nih.gov/21880148"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-139","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-139","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-139","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-139","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073937073","display_name":"Danyel Jennen","orcid":"https://orcid.org/0000-0002-8618-2487"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Danyel Jennen","raw_affiliation_strings":["Department of Toxicogenomics, Maastricht University, the Netherlands. danyel.jennen@maastrichtuniversity.nl","Department of Toxicogenomics, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicogenomics, Maastricht University, the Netherlands. danyel.jennen@maastrichtuniversity.nl","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Department of Toxicogenomics, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053104463","display_name":"Ainhoa Ruiz\u2010Aracama","orcid":"https://orcid.org/0000-0002-2004-425X"},"institutions":[{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ainhoa Ruiz-Aracama","raw_affiliation_strings":["Netherlands Toxicogenomics Centre, PO Box 616, 6200, MD, Maastricht, the Netherlands","RIKILT-Institute of Food Safety, Wageningen University and Research Centre, PO Box 230, 6700, AE, Wageningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Netherlands Toxicogenomics Centre, PO Box 616, 6200, MD, Maastricht, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"RIKILT-Institute of Food Safety, Wageningen University and Research Centre, PO Box 230, 6700, AE, Wageningen, the Netherlands","institution_ids":["https://openalex.org/I913481162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006101778","display_name":"Christina Magkoufopoulou","orcid":"https://orcid.org/0000-0002-9460-3149"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Christina Magkoufopoulou","raw_affiliation_strings":["Department of Toxicogenomics, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicogenomics, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016939757","display_name":"Ad Peijnenburg","orcid":"https://orcid.org/0000-0002-5738-0097"},"institutions":[{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ad Peijnenburg","raw_affiliation_strings":["Netherlands Toxicogenomics Centre, PO Box 616, 6200, MD, Maastricht, the Netherlands","RIKILT-Institute of Food Safety, Wageningen University and Research Centre, PO Box 230, 6700, AE, Wageningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Netherlands Toxicogenomics Centre, PO Box 616, 6200, MD, Maastricht, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"RIKILT-Institute of Food Safety, Wageningen University and Research Centre, PO Box 230, 6700, AE, Wageningen, the Netherlands","institution_ids":["https://openalex.org/I913481162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017963678","display_name":"Arjen Lommen","orcid":null},"institutions":[{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Arjen Lommen","raw_affiliation_strings":["Netherlands Toxicogenomics Centre, PO Box 616, 6200, MD, Maastricht, the Netherlands","RIKILT-Institute of Food Safety, Wageningen University and Research Centre, PO Box 230, 6700, AE, Wageningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Netherlands Toxicogenomics Centre, PO Box 616, 6200, MD, Maastricht, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"RIKILT-Institute of Food Safety, Wageningen University and Research Centre, PO Box 230, 6700, AE, Wageningen, the Netherlands","institution_ids":["https://openalex.org/I913481162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053509816","display_name":"Joost van Delft","orcid":null},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joost van Delft","raw_affiliation_strings":["Department of Toxicogenomics, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands","Netherlands Toxicogenomics Centre, PO Box 616, 6200, MD, Maastricht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicogenomics, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Netherlands Toxicogenomics Centre, PO Box 616, 6200, MD, Maastricht, the Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111676146","display_name":"Jos Kleinjans","orcid":null},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jos Kleinjans","raw_affiliation_strings":["Department of Toxicogenomics, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands","Netherlands Toxicogenomics Centre, PO Box 616, 6200, MD, Maastricht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicogenomics, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Netherlands Toxicogenomics Centre, PO Box 616, 6200, MD, Maastricht, the Netherlands","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5073937073"],"corresponding_institution_ids":["https://openalex.org/I34352273"],"apc_list":null,"apc_paid":null,"fwci":3.777,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.92247226,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"139","last_page":"139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.37369999289512634,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.37369999289512634,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.14429999887943268,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.10670000314712524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.7606421709060669},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6792007088661194},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"Carcinogenesis","score":0.6474342942237854},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.5536200404167175},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5386568903923035},{"id":"https://openalex.org/keywords/mode-of-action","display_name":"Mode of action","score":0.4695252478122711},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.4458692967891693},{"id":"https://openalex.org/keywords/carcinogen","display_name":"Carcinogen","score":0.4305959939956665},{"id":"https://openalex.org/keywords/toxicity","display_name":"Toxicity","score":0.41834181547164917},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3458714783191681},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2877933979034424},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2798807621002197},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2580326795578003},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.25320205092430115},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2290419638156891}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7606421709060669},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6792007088661194},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6474342942237854},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5536200404167175},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5386568903923035},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.4695252478122711},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4458692967891693},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.4305959939956665},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.41834181547164917},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3458714783191681},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2877933979034424},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2798807621002197},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2580326795578003},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25320205092430115},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2290419638156891},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072317","descriptor_name":"Polychlorinated Dibenzodioxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000072317","descriptor_name":"Polychlorinated Dibenzodioxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000072317","descriptor_name":"Polychlorinated Dibenzodioxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000072317","descriptor_name":"Polychlorinated Dibenzodioxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000072317","descriptor_name":"Polychlorinated Dibenzodioxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002274","descriptor_name":"Carcinogens, Environmental","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002274","descriptor_name":"Carcinogens, Environmental","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002274","descriptor_name":"Carcinogens, Environmental","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002274","descriptor_name":"Carcinogens, Environmental","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002274","descriptor_name":"Carcinogens, Environmental","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-5-139","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-139","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-139","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:21880148","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21880148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/ad3649ab-e05c-4ab0-8b02-85c33f4b7cd7","is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/ad3649ab-e05c-4ab0-8b02-85c33f4b7cd7","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jennen, D, Ruiz-Aracama, A, Magkoufopoulou, C, Peijnenburg, A A C M, Lommen, A, van Delft, J & Kleinjans, J 2011, 'Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells', BMC Systems Biology, vol. 5, pp. 13. https://doi.org/10.1186/1752-0509-5-139","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:library.wur.nl:wurpubs/410166","is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/integrating-transcriptomics-and-metabonomics-to-unravel-modes-of-","pdf_url":null,"source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ISSN: 1752-0509","raw_type":"Article/Letter to editor"},{"id":"pmh:oai:europepmc.org:2239583","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3231768","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-139","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-139","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-139","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3926241321","display_name":null,"funder_award_id":"MFA6809","funder_id":"https://openalex.org/F4320334893","funder_display_name":"Stichting voor de Technische Wetenschappen"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320334893","display_name":"Stichting voor de Technische Wetenschappen","ror":"https://ror.org/057tq3593"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2152768535.pdf","grobid_xml":"https://content.openalex.org/works/W2152768535.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W912970237","https://openalex.org/W1579194856","https://openalex.org/W1853989628","https://openalex.org/W1891967301","https://openalex.org/W1955538589","https://openalex.org/W1966043817","https://openalex.org/W1970778758","https://openalex.org/W1973829843","https://openalex.org/W1976277533","https://openalex.org/W1976909856","https://openalex.org/W1977229794","https://openalex.org/W1977922773","https://openalex.org/W1979992202","https://openalex.org/W1982892640","https://openalex.org/W1989314811","https://openalex.org/W1991234756","https://openalex.org/W1994892306","https://openalex.org/W1995051707","https://openalex.org/W1998412925","https://openalex.org/W1998413580","https://openalex.org/W1998708612","https://openalex.org/W2003562853","https://openalex.org/W2008834310","https://openalex.org/W2010637767","https://openalex.org/W2021388555","https://openalex.org/W2023098599","https://openalex.org/W2025191426","https://openalex.org/W2033271766","https://openalex.org/W2037247915","https://openalex.org/W2038227488","https://openalex.org/W2040327621","https://openalex.org/W2043602832","https://openalex.org/W2046964618","https://openalex.org/W2048428058","https://openalex.org/W2049259339","https://openalex.org/W2050492959","https://openalex.org/W2051262075","https://openalex.org/W2053300710","https://openalex.org/W2053588008","https://openalex.org/W2053690403","https://openalex.org/W2054172123","https://openalex.org/W2055212957","https://openalex.org/W2058194275","https://openalex.org/W2058536680","https://openalex.org/W2059228550","https://openalex.org/W2061719652","https://openalex.org/W2061816270","https://openalex.org/W2072624946","https://openalex.org/W2079985246","https://openalex.org/W2080923255","https://openalex.org/W2083695927","https://openalex.org/W2087285715","https://openalex.org/W2096273662","https://openalex.org/W2096792579","https://openalex.org/W2097746233","https://openalex.org/W2102739915","https://openalex.org/W2105490346","https://openalex.org/W2106515170","https://openalex.org/W2110065044","https://openalex.org/W2110828752","https://openalex.org/W2112078762","https://openalex.org/W2118594662","https://openalex.org/W2125972803","https://openalex.org/W2127066475","https://openalex.org/W2134182089","https://openalex.org/W2135167572","https://openalex.org/W2135827569","https://openalex.org/W2137005762","https://openalex.org/W2141341794","https://openalex.org/W2149672625","https://openalex.org/W2155083835","https://openalex.org/W2159361114","https://openalex.org/W2163617578","https://openalex.org/W2166374547","https://openalex.org/W2166704190","https://openalex.org/W2167110681","https://openalex.org/W2169675397","https://openalex.org/W2170656342","https://openalex.org/W2170989872","https://openalex.org/W2415867315","https://openalex.org/W4238706709","https://openalex.org/W4290771711","https://openalex.org/W4292217335"],"related_works":["https://openalex.org/W2399513595","https://openalex.org/W161652093","https://openalex.org/W4388386498","https://openalex.org/W2028462563","https://openalex.org/W2942994004","https://openalex.org/W2042073451","https://openalex.org/W2982720988","https://openalex.org/W1998898023","https://openalex.org/W2041390973","https://openalex.org/W2030108052"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,202],"integration":[2],"of":[3,52,83,124,127,169,183,186,192],"different":[4],"'omics'":[5,135],"technologies":[6],"has":[7],"already":[8],"been":[9],"shown":[10],"in":[11,13,29,31,64,66,85,113,116,148,162,199,212,218],"several":[12,184],"vivo":[14,219],"studies":[15,214],"to":[16,24,37,97,174],"offer":[17],"a":[18,60,190],"complementary":[19],"insight":[20],"into":[21],"cellular":[22,33],"responses":[23,227],"toxic":[25,61],"challenges.":[26],"Being":[27],"interested":[28],"developing":[30],"vitro":[32,65,213],"models":[34],"as":[35,80,106,108,152],"alternative":[36],"animal-based":[38],"toxicity":[39],"assays,":[40],"we":[41],"hypothesize":[42],"that":[43],"combining":[44],"transcriptomics":[45],"and":[46,73],"metabonomics":[47,109],"data":[48],"improves":[49],"the":[50,56,75,86,89,98,128,153,164,187,225,235],"understanding":[51],"molecular":[53,226],"mechanisms":[54],"underlying":[55],"effects":[57],"caused":[58,228],"by":[59,229,234],"compound":[62],"also":[63,216],"human":[67,90],"cells.":[68],"To":[69],"test":[70],"this":[71,140],"hypothesis,":[72],"with":[74,210,217],"focus":[76],"on":[77,224],"non-genotoxic":[78],"carcinogenesis":[79],"an":[81,176,181],"endpoint":[82],"toxicity,":[84],"present":[87],"study,":[88],"hepatocarcinoma":[91],"cell":[92],"line":[93],"HepG2":[94,115],"was":[95],"exposed":[96],"well-known":[99],"environmental":[100],"carcinogen":[101],"2,3,7,8-tetrachlorodibenzo-p-dioxin":[102],"(TCDD).":[103],"RESULTS:":[104],"Transcriptomics":[105],"well":[107],"analyses":[110],"demonstrated":[111],"changes":[112,129],"TCDD-exposed":[114],"common":[117],"metabolic":[118],"processes,":[119],"e.g.":[120],"amino":[121],"acid":[122],"metabolism,":[123],"which":[125,163],"some":[126],"only":[130,208],"being":[131],"confirmed":[132],"if":[133],"both":[134],"were":[136,206,232],"integrated.":[137],"In":[138],"particular,":[139],"integrated":[141],"analysis":[142],"identified":[143],"unique":[144],"pathway":[145,160],"maps":[146],"involved":[147],"receptor-mediated":[149],"mechanisms,":[150],"such":[151],"G-protein":[154],"coupled":[155],"receptor":[156],"protein":[157],"(GPCR)":[158],"signaling":[159],"maps,":[161],"significantly":[165],"up-regulated":[166],"gene":[167],"son":[168],"sevenless":[170],"1":[171],"(SOS1)":[172],"seems":[173],"play":[175],"important":[177],"role.":[178],"SOS1":[179],"is":[180],"activator":[182],"members":[185],"RAS":[188],"superfamily,":[189],"group":[191],"small":[193],"GTPases":[194],"known":[195],"for":[196],"their":[197],"role":[198],"carcinogenesis.":[200],"CONCLUSIONS:":[201],"results":[203],"presented":[204],"here":[205],"not":[207],"comparable":[209],"other":[211],"but":[215],"studies.":[220],"Moreover,":[221],"new":[222],"insights":[223],"TCDD":[230],"exposure":[231],"gained":[233],"cross-omics":[236],"analysis.":[237]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}