{"id":"https://openalex.org/W2054292967","doi":"https://doi.org/10.1186/1752-0509-5-125","title":"A Systems Biology Strategy for Predicting Similarities and Differences of Drug Effects: Evidence for Drug-specific Modulation of Inflammation in Atherosclerosis","display_name":"A Systems Biology Strategy for Predicting Similarities and Differences of Drug Effects: Evidence for Drug-specific Modulation of Inflammation in Atherosclerosis","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2054292967","doi":"https://doi.org/10.1186/1752-0509-5-125","mag":"2054292967","pmid":"https://pubmed.ncbi.nlm.nih.gov/21838869"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-125","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-125","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-125","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-125","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063674598","display_name":"Robert Kleemann","orcid":"https://orcid.org/0000-0002-1350-0149"},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"funder","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Robert Kleemann","raw_affiliation_strings":["Metabolic Health Research, TNO, Zernikedreef 9, Leiden, The Netherlands. robert.kleemann@tno.nl","Metabolic Health Research, TNO, Leiden, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Metabolic Health Research, TNO, Zernikedreef 9, Leiden, The Netherlands. robert.kleemann@tno.nl","institution_ids":["https://openalex.org/I148297040"]},{"raw_affiliation_string":"Metabolic Health Research, TNO, Leiden, The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051426978","display_name":"Svetlana Bureeva","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Svetlana Bureeva","raw_affiliation_strings":["GeneGo, Inc., 5901 Priestly Drive, Carlsbad, CA, 92008, USA","GeneGo, Inc., Carlsbad, USA"],"affiliations":[{"raw_affiliation_string":"GeneGo, Inc., 5901 Priestly Drive, Carlsbad, CA, 92008, USA","institution_ids":[]},{"raw_affiliation_string":"GeneGo, Inc., Carlsbad, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040924718","display_name":"Ally Perlina","orcid":"https://orcid.org/0000-0002-3554-7124"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ally Perlina","raw_affiliation_strings":["GeneGo, Inc., 5901 Priestly Drive, Carlsbad, CA, 92008, USA","GeneGo, Inc., Carlsbad, USA"],"affiliations":[{"raw_affiliation_string":"GeneGo, Inc., 5901 Priestly Drive, Carlsbad, CA, 92008, USA","institution_ids":[]},{"raw_affiliation_string":"GeneGo, Inc., Carlsbad, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077112909","display_name":"Jim Kaput","orcid":"https://orcid.org/0000-0001-6147-3491"},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]},{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I2252230247","display_name":"Institute for Work and Health","ror":"https://ror.org/02rycsd19","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2252230247"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Jim Kaput","raw_affiliation_strings":["Division of Personalized Nutrition and Medicine FDA, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA","Nestle Institute of Health Sciences, EPFL Campus B\u00e2timent G at Quartier de l'Innovation, Lausanne, 1015, Switzerland","Nestle Institute of Health Sciences, EPFL Campus B\u00e2timent G at Quartier de l\u2019Innovation, Lausanne, Switzerland","Division of Personalized Nutrition and Medicine FDA, National Center for Toxicological Research, Jefferson, USA"],"affiliations":[{"raw_affiliation_string":"Division of Personalized Nutrition and Medicine FDA, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I1304557061"]},{"raw_affiliation_string":"Nestle Institute of Health Sciences, EPFL Campus B\u00e2timent G at Quartier de l'Innovation, Lausanne, 1015, Switzerland","institution_ids":["https://openalex.org/I5124864","https://openalex.org/I2252230247"]},{"raw_affiliation_string":"Nestle Institute of Health Sciences, EPFL Campus B\u00e2timent G at Quartier de l\u2019Innovation, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864","https://openalex.org/I4210112383","https://openalex.org/I2252230247"]},{"raw_affiliation_string":"Division of Personalized Nutrition and Medicine FDA, National Center for Toxicological Research, Jefferson, USA","institution_ids":["https://openalex.org/I1304557061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045947300","display_name":"Lars Verschuren","orcid":"https://orcid.org/0000-0002-7847-9037"},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"funder","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lars Verschuren","raw_affiliation_strings":["Metabolic Health Research, TNO, Zernikedreef 9, Leiden, 2333, CK, The Netherlands","Microbiology and Systems Biology, TNO, Utrechtseweg 48, Zeist, 3704, HE, The Netherlands","Metabolic Health Research, TNO, Leiden, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Metabolic Health Research, TNO, Zernikedreef 9, Leiden, 2333, CK, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Microbiology and Systems Biology, TNO, Utrechtseweg 48, Zeist, 3704, HE, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Metabolic Health Research, TNO, Leiden, The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088201376","display_name":"Peter Y. Wielinga","orcid":null},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"funder","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Peter Y Wielinga","raw_affiliation_strings":["Metabolic Health Research, TNO, Zernikedreef 9, Leiden, 2333, CK, The Netherlands","Metabolic Health Research, TNO, Leiden, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Metabolic Health Research, TNO, Zernikedreef 9, Leiden, 2333, CK, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Metabolic Health Research, TNO, Leiden, The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047447621","display_name":"Eva Hurt\u2010Camejo","orcid":"https://orcid.org/0000-0002-1704-6879"},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Eva Hurt-Camejo","raw_affiliation_strings":["Cardiovascular & Gastrointestinal Innovative Medicines Unit, AstraZeneca, Pepparedsleden 1, M\u00f6lndal, 43183, Sweden"],"affiliations":[{"raw_affiliation_string":"Cardiovascular & Gastrointestinal Innovative Medicines Unit, AstraZeneca, Pepparedsleden 1, M\u00f6lndal, 43183, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070287780","display_name":"Yuri Nikolsky","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuri Nikolsky","raw_affiliation_strings":["GeneGo, Inc., 5901 Priestly Drive, Carlsbad, CA, 92008, USA","GeneGo, Inc., Carlsbad, USA"],"affiliations":[{"raw_affiliation_string":"GeneGo, Inc., 5901 Priestly Drive, Carlsbad, CA, 92008, USA","institution_ids":[]},{"raw_affiliation_string":"GeneGo, Inc., Carlsbad, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049866928","display_name":"Ben van Ommen","orcid":"https://orcid.org/0000-0002-0124-9428"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ben van Ommen","raw_affiliation_strings":["Microbiology and Systems Biology, TNO, Utrechtseweg 48, Zeist, 3704, HE, The Netherlands","Microbiology and Systems Biology, TNO, Zeist, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Microbiology and Systems Biology, TNO, Utrechtseweg 48, Zeist, 3704, HE, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Microbiology and Systems Biology, TNO, Zeist, The Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110169024","display_name":"Teake Kooistra","orcid":null},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"funder","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Teake Kooistra","raw_affiliation_strings":["Metabolic Health Research, TNO, Zernikedreef 9, Leiden, 2333, CK, The Netherlands","Metabolic Health Research, TNO, Leiden, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Metabolic Health Research, TNO, Zernikedreef 9, Leiden, 2333, CK, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Metabolic Health Research, TNO, Leiden, The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5063674598"],"corresponding_institution_ids":["https://openalex.org/I148297040"],"apc_list":null,"apc_paid":null,"fwci":2.9299,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.90904067,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"5","issue":"1","first_page":"125","last_page":"125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6511889696121216},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5839806795120239},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.583355188369751},{"id":"https://openalex.org/keywords/fenofibrate","display_name":"Fenofibrate","score":0.5532914996147156},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5268443822860718},{"id":"https://openalex.org/keywords/inflammation","display_name":"Inflammation","score":0.4977893829345703},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.47474461793899536},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.4695482850074768},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.45398467779159546},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.4126632809638977},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3651765286922455},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.16910699009895325},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.1503148376941681}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6511889696121216},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5839806795120239},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.583355188369751},{"id":"https://openalex.org/C2778110834","wikidata":"https://www.wikidata.org/wiki/Q419724","display_name":"Fenofibrate","level":2,"score":0.5532914996147156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5268443822860718},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4977893829345703},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.47474461793899536},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4695482850074768},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.45398467779159546},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4126632809638977},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3651765286922455},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16910699009895325},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1503148376941681}],"mesh":[{"descriptor_ui":"D000068718","descriptor_name":"Rosuvastatin Calcium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068718","descriptor_name":"Rosuvastatin Calcium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068718","descriptor_name":"Rosuvastatin Calcium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096926","descriptor_name":"Benzenesulfonamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005464","descriptor_name":"Fluorobenzenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005464","descriptor_name":"Fluorobenzenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005464","descriptor_name":"Fluorobenzenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005466","descriptor_name":"Fluorocarbons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006845","descriptor_name":"Hydrocarbons, Fluorinated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006845","descriptor_name":"Hydrocarbons, Fluorinated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006845","descriptor_name":"Hydrocarbons, Fluorinated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011345","descriptor_name":"Fenofibrate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011345","descriptor_name":"Fenofibrate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011345","descriptor_name":"Fenofibrate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D050436","descriptor_name":"Regulatory Elements, Transcriptional","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050436","descriptor_name":"Regulatory Elements, Transcriptional","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050436","descriptor_name":"Regulatory Elements, Transcriptional","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-5-125","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-125","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-125","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:21838869","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21838869","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_3011661","is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/114034","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, 5","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:e6d5045343ea4bdab210f6e61626bedb","is_oa":true,"landing_page_url":"https://doaj.org/article/e6d5045343ea4bdab210f6e61626bedb","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 5, Iss 1, p 125 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2167007","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3163556","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_3011661","is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/114034","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology","raw_type":"Article / Letter to editor"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-125","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-125","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-125","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320320915","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320328608","display_name":"Centre for Medical Systems Biology","ror":"https://ror.org/00e7dfm13"},{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2054292967.pdf","grobid_xml":"https://content.openalex.org/works/W2054292967.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W57306529","https://openalex.org/W1466907849","https://openalex.org/W1971909806","https://openalex.org/W1976616808","https://openalex.org/W1977646332","https://openalex.org/W1982257485","https://openalex.org/W1995195717","https://openalex.org/W2002266832","https://openalex.org/W2002409263","https://openalex.org/W2009476878","https://openalex.org/W2015663542","https://openalex.org/W2018466592","https://openalex.org/W2025782661","https://openalex.org/W2034722415","https://openalex.org/W2035713503","https://openalex.org/W2037252901","https://openalex.org/W2057086747","https://openalex.org/W2059526592","https://openalex.org/W2062941476","https://openalex.org/W2067332921","https://openalex.org/W2077885768","https://openalex.org/W2079932751","https://openalex.org/W2081028922","https://openalex.org/W2081044069","https://openalex.org/W2086342197","https://openalex.org/W2102914333","https://openalex.org/W2105155248","https://openalex.org/W2105924650","https://openalex.org/W2115765432","https://openalex.org/W2138972881","https://openalex.org/W2142746589","https://openalex.org/W2145780739","https://openalex.org/W2159087408","https://openalex.org/W2162011385","https://openalex.org/W2168192378","https://openalex.org/W2170148526","https://openalex.org/W2188752118","https://openalex.org/W2396440833"],"related_works":["https://openalex.org/W2385660497","https://openalex.org/W3035875868","https://openalex.org/W2181581914","https://openalex.org/W2385956122","https://openalex.org/W2025172711","https://openalex.org/W2116348090","https://openalex.org/W1966541296","https://openalex.org/W2385686208","https://openalex.org/W2127264463","https://openalex.org/W2764191054"],"abstract_inverted_index":{"Our":[0],"approach":[1],"provides":[2],"mechanistic":[3],"rationales":[4],"for":[5],"the":[6,19,25],"differential":[7],"and":[8,13,24],"common":[9],"effects":[10],"of":[11,21,27],"drugs":[12],"may":[14],"help":[15],"to":[16],"better":[17],"understand":[18],"origins":[20],"drug":[22],"actions":[23],"design":[26],"combination":[28],"therapies.":[29]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
