{"id":"https://openalex.org/W2026759723","doi":"https://doi.org/10.1186/1752-0509-5-105","title":"Construction of a computable cell proliferation network focused on non-diseased lung cells","display_name":"Construction of a computable cell proliferation network focused on non-diseased lung cells","publication_year":2011,"publication_date":"2011-07-02","ids":{"openalex":"https://openalex.org/W2026759723","doi":"https://doi.org/10.1186/1752-0509-5-105","mag":"2026759723","pmid":"https://pubmed.ncbi.nlm.nih.gov/21722388"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-105","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-105","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-105","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-105","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063095459","display_name":"Jurjen W. Westra","orcid":null},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]},{"id":"https://openalex.org/I4210160988","display_name":"Selventa (United States)","ror":"https://ror.org/051d2r706","country_code":"US","type":"company","lineage":["https://openalex.org/I4210160988"]}],"countries":["CH","US"],"is_corresponding":true,"raw_author_name":"Jurjen W Westra","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuch\u00e2tel, Switzerland","Selventa, One Alewife Center, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]},{"raw_affiliation_string":"Selventa, One Alewife Center, Cambridge, USA","institution_ids":["https://openalex.org/I4210160988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112609781","display_name":"Walter K. Schlage","orcid":null},"institutions":[{"id":"https://openalex.org/I4210114941","display_name":"Philip Morris International (Germany)","ror":"https://ror.org/022jdjx35","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210088192","https://openalex.org/I4210114941"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Walter K Schlage","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr.3, 51149, Koeln, Germany","Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Koeln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr.3, 51149, Koeln, Germany","institution_ids":["https://openalex.org/I4210114941"]},{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Koeln, Germany","institution_ids":["https://openalex.org/I4210114941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028814059","display_name":"Brian P. Frushour","orcid":null},"institutions":[{"id":"https://openalex.org/I4210160988","display_name":"Selventa (United States)","ror":"https://ror.org/051d2r706","country_code":"US","type":"company","lineage":["https://openalex.org/I4210160988"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian P Frushour","raw_affiliation_strings":["Selventa, One Alewife Center, Cambridge, MA, 02140, USA","Selventa, One Alewife Center, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selventa, One Alewife Center, Cambridge, MA, 02140, USA","institution_ids":["https://openalex.org/I4210160988"]},{"raw_affiliation_string":"Selventa, One Alewife Center, Cambridge, USA","institution_ids":["https://openalex.org/I4210160988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036639166","display_name":"Stephan Gebel","orcid":"https://orcid.org/0000-0001-5086-8324"},"institutions":[{"id":"https://openalex.org/I4210114941","display_name":"Philip Morris International (Germany)","ror":"https://ror.org/022jdjx35","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210088192","https://openalex.org/I4210114941"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephan Gebel","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr.3, 51149, Koeln, Germany","Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Koeln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr.3, 51149, Koeln, Germany","institution_ids":["https://openalex.org/I4210114941"]},{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Koeln, Germany","institution_ids":["https://openalex.org/I4210114941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086348189","display_name":"Natalie L. Catlett","orcid":null},"institutions":[{"id":"https://openalex.org/I4210160988","display_name":"Selventa (United States)","ror":"https://ror.org/051d2r706","country_code":"US","type":"company","lineage":["https://openalex.org/I4210160988"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie L Catlett","raw_affiliation_strings":["Selventa, One Alewife Center, Cambridge, MA, 02140, USA","Selventa, One Alewife Center, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selventa, One Alewife Center, Cambridge, MA, 02140, USA","institution_ids":["https://openalex.org/I4210160988"]},{"raw_affiliation_string":"Selventa, One Alewife Center, Cambridge, USA","institution_ids":["https://openalex.org/I4210160988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027626310","display_name":"Wanjiang Han","orcid":null},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Wanjiang Han","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000, Neuch\u00e2tel, Switzerland","Philip Morris International R&D, Philip Morris Products S.A., Neuch\u00e2tel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000, Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]},{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Products S.A., Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091542186","display_name":"Sean Eddy","orcid":"https://orcid.org/0000-0001-8578-3443"},"institutions":[{"id":"https://openalex.org/I4210160988","display_name":"Selventa (United States)","ror":"https://ror.org/051d2r706","country_code":"US","type":"company","lineage":["https://openalex.org/I4210160988"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean F Eddy","raw_affiliation_strings":["Selventa, One Alewife Center, Cambridge, MA, 02140, USA","Selventa, One Alewife Center, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selventa, One Alewife Center, Cambridge, MA, 02140, USA","institution_ids":["https://openalex.org/I4210160988"]},{"raw_affiliation_string":"Selventa, One Alewife Center, Cambridge, USA","institution_ids":["https://openalex.org/I4210160988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079049222","display_name":"Arnd Hengstermann","orcid":null},"institutions":[{"id":"https://openalex.org/I4210114941","display_name":"Philip Morris International (Germany)","ror":"https://ror.org/022jdjx35","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210088192","https://openalex.org/I4210114941"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Arnd Hengstermann","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr.3, 51149, Koeln, Germany","Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Koeln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr.3, 51149, Koeln, Germany","institution_ids":["https://openalex.org/I4210114941"]},{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Koeln, Germany","institution_ids":["https://openalex.org/I4210114941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048902568","display_name":"Andrea Matthews","orcid":null},"institutions":[{"id":"https://openalex.org/I4210160988","display_name":"Selventa (United States)","ror":"https://ror.org/051d2r706","country_code":"US","type":"company","lineage":["https://openalex.org/I4210160988"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea L Matthews","raw_affiliation_strings":["Selventa, One Alewife Center, Cambridge, MA, 02140, USA","Selventa, One Alewife Center, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selventa, One Alewife Center, Cambridge, MA, 02140, USA","institution_ids":["https://openalex.org/I4210160988"]},{"raw_affiliation_string":"Selventa, One Alewife Center, Cambridge, USA","institution_ids":["https://openalex.org/I4210160988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071237640","display_name":"Carole Mathis","orcid":"https://orcid.org/0000-0003-3920-3756"},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Carole Mathis","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000, Neuch\u00e2tel, Switzerland","Philip Morris International R&D, Philip Morris Products S.A., Neuch\u00e2tel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000, Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]},{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Products S.A., Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109314824","display_name":"Rosemarie B. Lichtner","orcid":null},"institutions":[{"id":"https://openalex.org/I4210114941","display_name":"Philip Morris International (Germany)","ror":"https://ror.org/022jdjx35","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210088192","https://openalex.org/I4210114941"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rosemarie B Lichtner","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr.3, 51149, Koeln, Germany","Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Koeln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr.3, 51149, Koeln, Germany","institution_ids":["https://openalex.org/I4210114941"]},{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Koeln, Germany","institution_ids":["https://openalex.org/I4210114941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009882702","display_name":"Carine Poussin","orcid":"https://orcid.org/0000-0001-9729-6853"},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Carine Poussin","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000, Neuch\u00e2tel, Switzerland","Philip Morris International R&D, Philip Morris Products S.A., Neuch\u00e2tel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000, Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]},{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Products S.A., Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011233293","display_name":"Marja Talikka","orcid":"https://orcid.org/0000-0001-8105-5756"},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marja Talikka","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000, Neuch\u00e2tel, Switzerland","Philip Morris International R&D, Philip Morris Products S.A., Neuch\u00e2tel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000, Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]},{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Products S.A., Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071981470","display_name":"Emilija Veljkovic","orcid":null},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Emilija Veljkovic","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000, Neuch\u00e2tel, Switzerland","Philip Morris International R&D, Philip Morris Products S.A., Neuch\u00e2tel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000, Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]},{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Products S.A., Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034689335","display_name":"Aaron A. Van Hooser","orcid":null},"institutions":[{"id":"https://openalex.org/I4210160988","display_name":"Selventa (United States)","ror":"https://ror.org/051d2r706","country_code":"US","type":"company","lineage":["https://openalex.org/I4210160988"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron A Van Hooser","raw_affiliation_strings":["Selventa, One Alewife Center, Cambridge, MA, 02140, USA","Selventa, One Alewife Center, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selventa, One Alewife Center, Cambridge, MA, 02140, USA","institution_ids":["https://openalex.org/I4210160988"]},{"raw_affiliation_string":"Selventa, One Alewife Center, Cambridge, USA","institution_ids":["https://openalex.org/I4210160988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070450933","display_name":"Benjamin Wong","orcid":"https://orcid.org/0009-0008-8104-6575"},"institutions":[{"id":"https://openalex.org/I4210160988","display_name":"Selventa (United States)","ror":"https://ror.org/051d2r706","country_code":"US","type":"company","lineage":["https://openalex.org/I4210160988"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Wong","raw_affiliation_strings":["Selventa, One Alewife Center, Cambridge, MA, 02140, USA","Selventa, One Alewife Center, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selventa, One Alewife Center, Cambridge, MA, 02140, USA","institution_ids":["https://openalex.org/I4210160988"]},{"raw_affiliation_string":"Selventa, One Alewife Center, Cambridge, USA","institution_ids":["https://openalex.org/I4210160988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111689503","display_name":"Michael J. Maria","orcid":null},"institutions":[{"id":"https://openalex.org/I4210160988","display_name":"Selventa (United States)","ror":"https://ror.org/051d2r706","country_code":"US","type":"company","lineage":["https://openalex.org/I4210160988"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J Maria","raw_affiliation_strings":["Selventa, One Alewife Center, Cambridge, MA, 02140, USA","Selventa, One Alewife Center, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selventa, One Alewife Center, Cambridge, MA, 02140, USA","institution_ids":["https://openalex.org/I4210160988"]},{"raw_affiliation_string":"Selventa, One Alewife Center, Cambridge, USA","institution_ids":["https://openalex.org/I4210160988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012278670","display_name":"Manuel C. Peitsch","orcid":"https://orcid.org/0000-0001-5324-359X"},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Manuel C Peitsch","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000, Neuch\u00e2tel, Switzerland","Philip Morris International R&D, Philip Morris Products S.A., Neuch\u00e2tel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000, Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]},{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Products S.A., Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009226296","display_name":"Ren\u00e9e Deehan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210160988","display_name":"Selventa (United States)","ror":"https://ror.org/051d2r706","country_code":"US","type":"company","lineage":["https://openalex.org/I4210160988"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renee Deehan","raw_affiliation_strings":["Selventa, One Alewife Center, Cambridge, MA, 02140, USA","Selventa, One Alewife Center, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selventa, One Alewife Center, Cambridge, MA, 02140, USA","institution_ids":["https://openalex.org/I4210160988"]},{"raw_affiliation_string":"Selventa, One Alewife Center, Cambridge, USA","institution_ids":["https://openalex.org/I4210160988"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087038430","display_name":"Julia Hoeng","orcid":"https://orcid.org/0000-0001-5371-6801"},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Julia Hoeng","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000, Neuch\u00e2tel, Switzerland","Philip Morris International R&D, Philip Morris Products S.A., Neuch\u00e2tel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000, Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]},{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Products S.A., Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":20,"corresponding_author_ids":["https://openalex.org/A5063095459"],"corresponding_institution_ids":["https://openalex.org/I2800621710","https://openalex.org/I4210160988"],"apc_list":null,"apc_paid":null,"fwci":3.5916,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.93600629,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"5","issue":"1","first_page":"105","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.38440001010894775,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.38440001010894775,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.11580000072717667,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.06750000268220901,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.7827839851379395},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.7013945579528809},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5886351466178894},{"id":"https://openalex.org/keywords/cell-growth","display_name":"Cell growth","score":0.579303503036499},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5408506989479065},{"id":"https://openalex.org/keywords/modelling-biological-systems","display_name":"Modelling biological systems","score":0.5008409023284912},{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.4629206657409668},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.44218456745147705},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4369971752166748},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.4340283274650574},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.432839572429657},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3976823091506958},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.13987329602241516},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12115061283111572},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08335700631141663}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.7827839851379395},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.7013945579528809},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5886351466178894},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.579303503036499},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5408506989479065},{"id":"https://openalex.org/C137866125","wikidata":"https://www.wikidata.org/wiki/Q4299308","display_name":"Modelling biological systems","level":3,"score":0.5008409023284912},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4629206657409668},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.44218456745147705},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4369971752166748},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4340283274650574},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.432839572429657},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3976823091506958},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13987329602241516},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12115061283111572},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08335700631141663}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-5-105","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-105","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-105","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:21722388","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21722388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:4a2accf0081745b1876457c8c41cb14b","is_oa":false,"landing_page_url":"https://doaj.org/article/4a2accf0081745b1876457c8c41cb14b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 5, Iss 1, p 105 (2011)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3160372","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3160372","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-105","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-105","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-105","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6299999952316284,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320315260","display_name":"Philip Morris International","ror":"https://ror.org/005rxfw29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2026759723.pdf","grobid_xml":"https://content.openalex.org/works/W2026759723.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W52410658","https://openalex.org/W1533335653","https://openalex.org/W1648092828","https://openalex.org/W1839126941","https://openalex.org/W1933454536","https://openalex.org/W1963246255","https://openalex.org/W1972658902","https://openalex.org/W1974023348","https://openalex.org/W1975701950","https://openalex.org/W1976760549","https://openalex.org/W1977972521","https://openalex.org/W1978735852","https://openalex.org/W1980878904","https://openalex.org/W1984252723","https://openalex.org/W1990007473","https://openalex.org/W1990213657","https://openalex.org/W2011642803","https://openalex.org/W2016434015","https://openalex.org/W2028508763","https://openalex.org/W2029916442","https://openalex.org/W2030232684","https://openalex.org/W2032541432","https://openalex.org/W2032770280","https://openalex.org/W2032879846","https://openalex.org/W2034269086","https://openalex.org/W2036287744","https://openalex.org/W2042176329","https://openalex.org/W2047877191","https://openalex.org/W2051056083","https://openalex.org/W2071438535","https://openalex.org/W2072212530","https://openalex.org/W2073872478","https://openalex.org/W2078434966","https://openalex.org/W2081098333","https://openalex.org/W2082427792","https://openalex.org/W2086602499","https://openalex.org/W2104166019","https://openalex.org/W2110042849","https://openalex.org/W2117839670","https://openalex.org/W2118755647","https://openalex.org/W2130017811","https://openalex.org/W2146727483","https://openalex.org/W2146820673","https://openalex.org/W2147850863","https://openalex.org/W2149454565","https://openalex.org/W2150908245","https://openalex.org/W2157409103","https://openalex.org/W2160697532","https://openalex.org/W2162262059","https://openalex.org/W2164101293","https://openalex.org/W2170989872","https://openalex.org/W2171437346","https://openalex.org/W2318845086","https://openalex.org/W2327590178","https://openalex.org/W2462387289","https://openalex.org/W2582112616","https://openalex.org/W3217585045","https://openalex.org/W4246853992"],"related_works":["https://openalex.org/W2158714033","https://openalex.org/W1975586684","https://openalex.org/W2063941210","https://openalex.org/W2127864418","https://openalex.org/W4206945140","https://openalex.org/W4386628104","https://openalex.org/W2606847111","https://openalex.org/W2598362101","https://openalex.org/W2947028852","https://openalex.org/W2212032968"],"abstract_inverted_index":{"BACKGROUND:":[0],"Critical":[1],"to":[2,20,22,40,64,85,119,155,311],"advancing":[3],"the":[4,12,23,42,47,66,93,129,156,218,240,258,269,277,284,300,306,312],"systems-level":[5,126],"evaluation":[6,298,316],"of":[7,14,25,46,69,128,132,158,179,220,243,260,276,299,305,317],"complex":[8],"biological":[9,67,83,130,151,189,249],"processes":[10],"is":[11,80,288,327],"development":[13],"comprehensive":[15,271],"networks":[16,35],"and":[17,54,73,109,170,173,175,184,211,230,314],"computational":[18],"methods":[19],"apply":[21],"analysis":[24],"systems":[26,61,253,321],"biology":[27,45,62,254,322],"data":[28,63,201,237,323],"(transcriptomics,":[29],"proteomics/phosphoproteomics,":[30],"metabolomics,":[31],"etc.).":[32],"Ideally,":[33],"these":[34],"will":[36],"be":[37,56],"specifically":[38],"designed":[39],"capture":[41,86],"normal,":[43],"non-diseased":[44,135],"tissue":[48],"or":[49],"cell":[50,78,145,161,206,213,225,281,318],"types":[51],"under":[52],"investigation,":[53],"can":[55],"used":[57],"with":[58,204],"experimentally":[59],"generated":[60],"assess":[65],"impact":[68,131,250],"perturbations":[70,133],"like":[71],"xenobiotics":[72],"other":[74],"cellular":[75],"stresses.":[76],"Lung":[77],"proliferation":[79,97,162,207,282,319],"a":[81,89,125,141,177,247],"key":[82],"process":[84],"in":[87,99,209,217,224,274,283],"such":[88,113],"network":[90,114,143,148,192,287,307,326],"model,":[91],"given":[92],"pivotal":[94],"role":[95],"that":[96,153],"plays":[98],"lung":[100,137,160,210],"diseases":[101],"including":[102],"cancer,":[103],"chronic":[104],"obstructive":[105],"pulmonary":[106],"disease":[107],"(COPD),":[108],"fibrosis.":[110],"Unfortunately,":[111],"no":[112],"has":[115],"been":[116],"available":[117,328],"prior":[118],"this":[120,244,263],"work.":[121],"RESULTS:":[122],"To":[123,257],"further":[124],"assessment":[127,251],"on":[134,290],"mammalian":[136],"cells,":[138],"we":[139],"constructed":[140],"lung-focused":[142,264],"for":[144,246,329],"proliferation.":[146],"The":[147,191,286,302,325],"encompasses":[149],"diverse":[150],"areas":[152],"lead":[154],"regulation":[157,227],"normal":[159],"(Cell":[163],"Cycle,":[164],"Growth":[165],"Factors,":[166],"Cell":[167,265],"Interaction,":[168],"Intra-":[169],"Extracellular":[171],"Signaling,":[172],"Epigenetics),":[174],"contains":[176],"total":[178],"848":[180],"nodes":[181],"(biological":[182],"entities)":[183],"1597":[185],"edges":[186],"(relationships":[187],"between":[188],"entities).":[190],"was":[193],"verified":[194],"using":[195,252,320],"four":[196],"published":[197],"gene":[198],"expression":[199],"profiling":[200],"sets":[202],"associated":[203],"measured":[205],"endpoints":[208],"lung-related":[212],"types.":[214],"Predicted":[215],"changes":[216],"activity":[219],"core":[221],"machinery":[222],"involved":[223],"cycle":[226],"(RB1,":[228],"CDKN1A,":[229],"MYC/MYCN)":[231],"are":[232],"statistically":[233],"supported":[234],"across":[235],"multiple":[236],"sets,":[238],"underscoring":[239],"general":[241],"applicability":[242],"approach":[245],"network-wide":[248],"data.":[255],"CONCLUSIONS:":[256],"best":[259],"our":[261],"knowledge,":[262],"Proliferation":[266],"Network":[267],"provides":[268],"most":[270],"connectivity":[272],"map":[273],"existence":[275],"molecular":[278],"mechanisms":[279],"regulating":[280],"lung.":[285],"based":[289],"fully":[291],"referenced":[292],"causal":[293],"relationships":[294],"obtained":[295],"from":[296],"extensive":[297],"literature.":[301],"computable":[303],"structure":[304],"enables":[308],"its":[309],"application":[310],"qualitative":[313],"quantitative":[315],"sets.":[324],"public":[330],"use.":[331]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":2}],"updated_date":"2026-05-21T09:19:25.381259","created_date":"2025-10-10T00:00:00"}
