{"id":"https://openalex.org/W2071921819","doi":"https://doi.org/10.1186/1752-0509-5-100","title":"Systems analysis of multiple regulator perturbations allows discovery of virulence factors in Salmonella","display_name":"Systems analysis of multiple regulator perturbations allows discovery of virulence factors in Salmonella","publication_year":2011,"publication_date":"2011-06-28","ids":{"openalex":"https://openalex.org/W2071921819","doi":"https://doi.org/10.1186/1752-0509-5-100","mag":"2071921819","pmid":"https://pubmed.ncbi.nlm.nih.gov/21711513"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-5-100","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-100","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-100","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-100","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049559685","display_name":"Hyunjin Yoon","orcid":"https://orcid.org/0000-0002-2252-9402"},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyunjin Yoon","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon 97239, USA","Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon 97239, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068615364","display_name":"Charles Ansong","orcid":"https://orcid.org/0000-0001-5793-8559"},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Ansong","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA","Pacific Northwest National Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA","institution_ids":["https://openalex.org/I142606810"]},{"raw_affiliation_string":"Pacific Northwest National Laboratory","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020608405","display_name":"Jason McDermott","orcid":"https://orcid.org/0000-0003-2961-2572"},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason E McDermott","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA","Pacific Northwest National Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA","institution_ids":["https://openalex.org/I142606810"]},{"raw_affiliation_string":"Pacific Northwest National Laboratory","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marina Gritsenko","orcid":null},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Gritsenko","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA","Pacific Northwest National Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA","institution_ids":["https://openalex.org/I142606810"]},{"raw_affiliation_string":"Pacific Northwest National Laboratory","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023982706","display_name":"Richard Smith","orcid":"https://orcid.org/0000-0002-2381-2349"},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D Smith","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA","Pacific Northwest National Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA","institution_ids":["https://openalex.org/I142606810"]},{"raw_affiliation_string":"Pacific Northwest National Laboratory","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091655566","display_name":"Fred Heffron","orcid":null},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred Heffron","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, 97239, USA","Department of Molecular Microbiology & Immunology, Oregon Health & Science University,Portland,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, 97239, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Molecular Microbiology & Immunology, Oregon Health & Science University,Portland,USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089245822","display_name":"Joshua Adkins","orcid":"https://orcid.org/0000-0003-0399-0700"},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua N Adkins","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA","Pacific Northwest National Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA","institution_ids":["https://openalex.org/I142606810"]},{"raw_affiliation_string":"Pacific Northwest National Laboratory","institution_ids":["https://openalex.org/I142606810"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089245822"],"corresponding_institution_ids":["https://openalex.org/I142606810"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":1.8252,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.84984373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"100","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6392999887466431,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6392999887466431,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.055399999022483826,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.048900000751018524,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virulence","display_name":"Virulence","score":0.982089638710022},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7680881023406982},{"id":"https://openalex.org/keywords/salmonella","display_name":"Salmonella","score":0.658811628818512},{"id":"https://openalex.org/keywords/effector","display_name":"Effector","score":0.635077714920044},{"id":"https://openalex.org/keywords/regulator","display_name":"Regulator","score":0.5910049080848694},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.5211591720581055},{"id":"https://openalex.org/keywords/type-three-secretion-system","display_name":"Type three secretion system","score":0.509807288646698},{"id":"https://openalex.org/keywords/virulence-factor","display_name":"Virulence factor","score":0.5006215572357178},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4697055518627167},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.46495020389556885},{"id":"https://openalex.org/keywords/secretion","display_name":"Secretion","score":0.4576415717601776},{"id":"https://openalex.org/keywords/cytoplasm","display_name":"Cytoplasm","score":0.42680680751800537},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.42399969696998596},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3862476348876953},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3333343267440796},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.24105381965637207},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.24067282676696777}],"concepts":[{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.982089638710022},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7680881023406982},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.658811628818512},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.635077714920044},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5910049080848694},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5211591720581055},{"id":"https://openalex.org/C130211564","wikidata":"https://www.wikidata.org/wiki/Q21199165","display_name":"Type three secretion system","level":4,"score":0.509807288646698},{"id":"https://openalex.org/C2781090273","wikidata":"https://www.wikidata.org/wiki/Q1623405","display_name":"Virulence factor","level":4,"score":0.5006215572357178},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4697055518627167},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.46495020389556885},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4576415717601776},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.42680680751800537},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42399969696998596},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3862476348876953},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3333343267440796},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24105381965637207},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.24067282676696777},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012475","descriptor_name":"Salmonella","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012475","descriptor_name":"Salmonella","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012475","descriptor_name":"Salmonella","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012475","descriptor_name":"Salmonella","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012475","descriptor_name":"Salmonella","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012475","descriptor_name":"Salmonella","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012475","descriptor_name":"Salmonella","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012475","descriptor_name":"Salmonella","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-5-100","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-100","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-100","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:21711513","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21711513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:3213010","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3213010","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-5-100","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-5-100","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-100","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1242655424","display_name":null,"funder_award_id":"DE-AC05-76RLO-1830","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G1310928793","display_name":null,"funder_award_id":"Y1-AI-8401","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1652101422","display_name":null,"funder_award_id":"R01 AI 022933","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1756126698","display_name":null,"funder_award_id":"DE-AC05-76RLO 1830","funder_id":"https://openalex.org/F4320338354","funder_display_name":"Pacific Northwest National Laboratory"},{"id":"https://openalex.org/G2251564489","display_name":null,"funder_award_id":"Y1-AI8401-01","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2936749764","display_name":null,"funder_award_id":"Y1 AI 489401","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2988778103","display_name":null,"funder_award_id":"DE-AC05?","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G490588625","display_name":null,"funder_award_id":"P41 RR018522","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G538270251","display_name":null,"funder_award_id":"DE\u2010AC05\u201076RLO1830","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G5654972545","display_name":null,"funder_award_id":"RR-018522","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5726405315","display_name":null,"funder_award_id":"DE-AC05","funder_id":"https://openalex.org/F4320306250","funder_display_name":"Battelle"},{"id":"https://openalex.org/G6048654274","display_name":null,"funder_award_id":"Y1-AI-8401-01","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G84288863","display_name":null,"funder_award_id":"DE\u2010AC05\u201076RLO 1830","funder_id":"https://openalex.org/F4320306250","funder_display_name":"Battelle"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320306250","display_name":"Battelle","ror":"https://ror.org/01h5tnr73"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337509","display_name":"Biological and Environmental Research","ror":"https://ror.org/0114b2m14"},{"id":"https://openalex.org/F4320338354","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071921819.pdf","grobid_xml":"https://content.openalex.org/works/W2071921819.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W1492437640","https://openalex.org/W1507485526","https://openalex.org/W1535438537","https://openalex.org/W1536743458","https://openalex.org/W1789015559","https://openalex.org/W1810119174","https://openalex.org/W1902457626","https://openalex.org/W1965197067","https://openalex.org/W1965201359","https://openalex.org/W1966350980","https://openalex.org/W1968846062","https://openalex.org/W1971357026","https://openalex.org/W1971681859","https://openalex.org/W1975913397","https://openalex.org/W1980189827","https://openalex.org/W1980767305","https://openalex.org/W1988136571","https://openalex.org/W1988272131","https://openalex.org/W1992322767","https://openalex.org/W1993587759","https://openalex.org/W1995062121","https://openalex.org/W1995887685","https://openalex.org/W1996770717","https://openalex.org/W1998847489","https://openalex.org/W2008916791","https://openalex.org/W2011098161","https://openalex.org/W2015313456","https://openalex.org/W2019512629","https://openalex.org/W2038065826","https://openalex.org/W2044525257","https://openalex.org/W2050783490","https://openalex.org/W2052212787","https://openalex.org/W2053679126","https://openalex.org/W2064099550","https://openalex.org/W2065146235","https://openalex.org/W2070548956","https://openalex.org/W2071928194","https://openalex.org/W2073207863","https://openalex.org/W2073470877","https://openalex.org/W2076696121","https://openalex.org/W2089208940","https://openalex.org/W2091480648","https://openalex.org/W2099147305","https://openalex.org/W2101938218","https://openalex.org/W2107094749","https://openalex.org/W2115625061","https://openalex.org/W2115765556","https://openalex.org/W2115778087","https://openalex.org/W2116137883","https://openalex.org/W2117144170","https://openalex.org/W2119177008","https://openalex.org/W2120926466","https://openalex.org/W2124114991","https://openalex.org/W2124289630","https://openalex.org/W2127041383","https://openalex.org/W2133591845","https://openalex.org/W2134412337","https://openalex.org/W2137861751","https://openalex.org/W2140193468","https://openalex.org/W2140371210","https://openalex.org/W2143705316","https://openalex.org/W2146098592","https://openalex.org/W2147830145","https://openalex.org/W2154021749","https://openalex.org/W2155310856","https://openalex.org/W2155627295","https://openalex.org/W2156782229","https://openalex.org/W2159643690","https://openalex.org/W2167367944","https://openalex.org/W2167730443","https://openalex.org/W2168024272","https://openalex.org/W2169127919","https://openalex.org/W2269092108","https://openalex.org/W2426085681"],"related_works":["https://openalex.org/W2470108822","https://openalex.org/W3216004349","https://openalex.org/W4224305457","https://openalex.org/W2116909324","https://openalex.org/W1549873021","https://openalex.org/W4244161128","https://openalex.org/W2115997854","https://openalex.org/W2120190359","https://openalex.org/W1577035833","https://openalex.org/W3012114985"],"abstract_inverted_index":{"BACKGROUND:":[0],"Systemic":[1],"bacterial":[2,184],"infections":[3],"are":[4,11,19,31,89],"highly":[5],"regulated":[6],"and":[7,74,102,110,171],"complex":[8],"processes":[9],"that":[10,18,87,176],"orchestrated":[12],"by":[13,22],"numerous":[14],"virulence":[15,66,72,90,109,142,148,173],"factors.":[16,67],"Genes":[17],"coordinately":[20],"controlled":[21],"the":[23,83,120,128,177],"set":[24],"of":[25,51,99,117,119,156,164,169],"regulators":[26,143],"required":[27,33,105],"for":[28,34,106,182],"systemic":[29],"infection":[30],"potentially":[32],"pathogenicity.":[35],"RESULTS:":[36],"In":[37],"this":[38,165],"study":[39],"we":[40],"present":[41],"a":[42,75,153],"systems":[43,124],"biology":[44],"approach":[45,178],"in":[46,125,160],"which":[47],"sample-matched":[48],"multi-omic":[49,136],"measurements":[50],"fourteen":[52],"virulence-essential":[53],"regulator":[54],"mutants":[55,140],"were":[56,104,111],"coupled":[57],"with":[58,94],"computational":[59],"network":[60],"analysis":[61],"to":[62,79,113],"efficiently":[63],"identify":[64],"Salmonella":[65,126,139],"Immunoblot":[68],"experiments":[69],"verified":[70],"network-predicted":[71],"factors":[73,91,149,174],"subset":[76],"was":[77],"determined":[78],"be":[80,114],"secreted":[81],"into":[82],"host":[84,95],"cytoplasm,":[85],"suggesting":[86],"they":[88],"directly":[92],"interacting":[93],"cellular":[96],"components.":[97],"Two":[98],"these,":[100],"SrfN":[101],"PagK2,":[103],"full":[107],"mouse":[108],"shown":[112],"translocated":[115,157],"independent":[116],"either":[118],"type":[121,129],"III":[122,130],"secretion":[123],"or":[127],"injectisome-related":[131],"flagellar":[132],"mechanism.":[133],"CONCLUSIONS:":[134],"Integrating":[135],"datasets":[137],"from":[138],"lacking":[141],"not":[144],"only":[145],"identified":[146],"novel":[147,172],"but":[150],"also":[151],"defined":[152],"new":[154],"class":[155],"effectors":[158],"involved":[159],"pathogenesis.":[161],"The":[162],"success":[163],"strategy":[166],"at":[167],"discovery":[168],"known":[170],"suggests":[175],"may":[179],"have":[180],"applicability":[181],"other":[183],"pathogens.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}