{"id":"https://openalex.org/W2024573773","doi":"https://doi.org/10.1186/1752-0509-4-86","title":"Comparative analysis of cis-regulation following stroke and seizures in subspaces of conserved eigensystems","display_name":"Comparative analysis of cis-regulation following stroke and seizures in subspaces of conserved eigensystems","publication_year":2010,"publication_date":"2010-06-17","ids":{"openalex":"https://openalex.org/W2024573773","doi":"https://doi.org/10.1186/1752-0509-4-86","mag":"2024573773","pmid":"https://pubmed.ncbi.nlm.nih.gov/20565733"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-86","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-86","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-86","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-86","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064559051","display_name":"Micha\u0142 D\u0105browski","orcid":"https://orcid.org/0000-0002-5335-158X"},"institutions":[{"id":"https://openalex.org/I4210153146","display_name":"Instytut Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego","ror":null,"country_code":"PL","type":null,"lineage":["https://openalex.org/I4210153146"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Michal Dabrowski","raw_affiliation_strings":["Laboratory of Transcription Regulation, Department of Cell Biology, Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland. m.dabrowski@nencki.gov.pl","Laboratory of Transcription Regulation, Department of Cell Biology, Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Transcription Regulation, Department of Cell Biology, Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland. m.dabrowski@nencki.gov.pl","institution_ids":["https://openalex.org/I4210153146"]},{"raw_affiliation_string":"Laboratory of Transcription Regulation, Department of Cell Biology, Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010400627","display_name":"Norbert Dojer","orcid":"https://orcid.org/0000-0001-5653-1167"},"institutions":[{"id":"https://openalex.org/I4654613","display_name":"University of Warsaw","ror":"https://ror.org/039bjqg32","country_code":"PL","type":"education","lineage":["https://openalex.org/I4654613"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Norbert Dojer","raw_affiliation_strings":["Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw, Institute of Informatics, Banacha 2, 02-097, Warsaw, Poland","Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw, Institute of Informatics, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw, Institute of Informatics, Banacha 2, 02-097, Warsaw, Poland","institution_ids":["https://openalex.org/I4654613"]},{"raw_affiliation_string":"Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw, Institute of Informatics, Warsaw, Poland","institution_ids":["https://openalex.org/I4654613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064547338","display_name":"Ma\u0142gorzata Zawadzka","orcid":"https://orcid.org/0000-0002-3637-2709"},"institutions":[{"id":"https://openalex.org/I16778253","display_name":"Instytut Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego","ror":"https://ror.org/04waf7p94","country_code":"PL","type":"facility","lineage":["https://openalex.org/I16778253","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Malgorzata Zawadzka","raw_affiliation_strings":["Department of Cell Biology, Laboratory of Transcription Regulation, Nencki Institute, Pasteura 3, 02-093, Warsaw, Poland","Department of Cell Biology, Laboratory of Transcription Regulation, Nencki Institute, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Laboratory of Transcription Regulation, Nencki Institute, Pasteura 3, 02-093, Warsaw, Poland","institution_ids":["https://openalex.org/I16778253"]},{"raw_affiliation_string":"Department of Cell Biology, Laboratory of Transcription Regulation, Nencki Institute, Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033742662","display_name":"Jakub Mieczkowski","orcid":"https://orcid.org/0000-0002-2091-012X"},"institutions":[{"id":"https://openalex.org/I16778253","display_name":"Instytut Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego","ror":"https://ror.org/04waf7p94","country_code":"PL","type":"facility","lineage":["https://openalex.org/I16778253","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jakub Mieczkowski","raw_affiliation_strings":["Department of Cell Biology, Laboratory of Transcription Regulation, Nencki Institute, Pasteura 3, 02-093, Warsaw, Poland","Department of Cell Biology, Laboratory of Transcription Regulation, Nencki Institute, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Laboratory of Transcription Regulation, Nencki Institute, Pasteura 3, 02-093, Warsaw, Poland","institution_ids":["https://openalex.org/I16778253"]},{"raw_affiliation_string":"Department of Cell Biology, Laboratory of Transcription Regulation, Nencki Institute, Warsaw, Poland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055257104","display_name":"Bo\u017cena Kami\u0144ska","orcid":"https://orcid.org/0000-0002-2642-4616"},"institutions":[{"id":"https://openalex.org/I16778253","display_name":"Instytut Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego","ror":"https://ror.org/04waf7p94","country_code":"PL","type":"facility","lineage":["https://openalex.org/I16778253","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Bozena Kaminska","raw_affiliation_strings":["Department of Cell Biology, Laboratory of Transcription Regulation, Nencki Institute, Pasteura 3, 02-093, Warsaw, Poland","Department of Cell Biology, Laboratory of Transcription Regulation, Nencki Institute, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Laboratory of Transcription Regulation, Nencki Institute, Pasteura 3, 02-093, Warsaw, Poland","institution_ids":["https://openalex.org/I16778253"]},{"raw_affiliation_string":"Department of Cell Biology, Laboratory of Transcription Regulation, Nencki Institute, Warsaw, Poland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5064559051"],"corresponding_institution_ids":["https://openalex.org/I4210153146"],"apc_list":null,"apc_paid":null,"fwci":0.4317,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.73231585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"4","issue":"1","first_page":"86","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.1500999927520752,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.1500999927520752,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.1387999951839447,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.08269999921321869,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6256563663482666},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.5987129807472229},{"id":"https://openalex.org/keywords/enhancer","display_name":"Enhancer","score":0.5649570226669312},{"id":"https://openalex.org/keywords/ap-1-transcription-factor","display_name":"AP-1 transcription factor","score":0.5605047345161438},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5586557388305664},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.5283989310264587},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5190497040748596},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4895058870315552},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4681805670261383},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3850889503955841},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.37968897819519043},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3309032917022705}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6256563663482666},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.5987129807472229},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.5649570226669312},{"id":"https://openalex.org/C102280478","wikidata":"https://www.wikidata.org/wiki/Q3270441","display_name":"AP-1 transcription factor","level":4,"score":0.5605047345161438},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5586557388305664},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5283989310264587},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5190497040748596},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4895058870315552},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4681805670261383},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3850889503955841},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.37968897819519043},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3309032917022705}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036961","descriptor_name":"Matrix Attachment Region Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036961","descriptor_name":"Matrix Attachment Region Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036961","descriptor_name":"Matrix Attachment Region Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-4-86","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-86","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-86","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20565733","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20565733","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2902439","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2902439","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-86","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-86","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-86","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.7300000190734863}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024573773.pdf","grobid_xml":"https://content.openalex.org/works/W2024573773.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1534556330","https://openalex.org/W1576303512","https://openalex.org/W1589179621","https://openalex.org/W1841584100","https://openalex.org/W1964305071","https://openalex.org/W1965014584","https://openalex.org/W1966682532","https://openalex.org/W1969022350","https://openalex.org/W1971325714","https://openalex.org/W1980303046","https://openalex.org/W1988960910","https://openalex.org/W1989119979","https://openalex.org/W1991920181","https://openalex.org/W1994401189","https://openalex.org/W1996760543","https://openalex.org/W1997278591","https://openalex.org/W1998131823","https://openalex.org/W2008906462","https://openalex.org/W2037155998","https://openalex.org/W2039169438","https://openalex.org/W2049154263","https://openalex.org/W2051893623","https://openalex.org/W2056959062","https://openalex.org/W2063953032","https://openalex.org/W2064299963","https://openalex.org/W2068412840","https://openalex.org/W2069079132","https://openalex.org/W2071955212","https://openalex.org/W2073727170","https://openalex.org/W2074006029","https://openalex.org/W2078095350","https://openalex.org/W2081837126","https://openalex.org/W2097168572","https://openalex.org/W2102992354","https://openalex.org/W2104454968","https://openalex.org/W2106475754","https://openalex.org/W2108011868","https://openalex.org/W2108420379","https://openalex.org/W2109407861","https://openalex.org/W2110065044","https://openalex.org/W2110291136","https://openalex.org/W2113387206","https://openalex.org/W2115428292","https://openalex.org/W2119736042","https://openalex.org/W2120077398","https://openalex.org/W2136518208","https://openalex.org/W2144710927","https://openalex.org/W2146302811","https://openalex.org/W2148541040","https://openalex.org/W2149173660","https://openalex.org/W2151790869","https://openalex.org/W2153550523","https://openalex.org/W2155587014","https://openalex.org/W2158990108","https://openalex.org/W2162591320","https://openalex.org/W2163880258","https://openalex.org/W2169079203","https://openalex.org/W2170112109","https://openalex.org/W2172149172","https://openalex.org/W2611370172"],"related_works":["https://openalex.org/W1599818171","https://openalex.org/W2063259170","https://openalex.org/W2688223077","https://openalex.org/W3159317682","https://openalex.org/W2152611630","https://openalex.org/W2891762942","https://openalex.org/W2992086063","https://openalex.org/W2010571965","https://openalex.org/W3128451840","https://openalex.org/W2002709996"],"abstract_inverted_index":{"BACKGROUND:":[0],"It":[1],"is":[2],"often":[3],"desirable":[4],"to":[5,15,50,194,220],"separate":[6,231],"effects":[7,17,181,232],"of":[8,18,60,67,90,96,113,125,130,135,142,152,182,197,202,212,233],"different":[9,241],"regulators":[10],"on":[11,28,164,188,244],"gene":[12,52,91,176,189,203,245],"expression,":[13],"or":[14,34],"identify":[16],"the":[19,29,39,56,83,94,97,114,123,128,133,140,153,157,195,198,221],"same":[20],"regulator":[21],"across":[22],"several":[23],"systems.":[24],"Here,":[25],"we":[26,120],"focus":[27],"rat":[30,57,248],"brain":[31,192],"following":[32],"stroke":[33,61,84,228],"seizures,":[35],"and":[36,62,76,85,132,137,175,186,229,235],"demonstrate":[37,65],"how":[38],"two":[40,68],"tasks":[41],"can":[42],"be":[43],"approached":[44],"simultaneously.":[45],"RESULTS:":[46],"We":[47,64,87,146],"applied":[48],"SVD":[49],"time-series":[51],"expression":[53,92,190,246],"datasets":[54],"from":[55],"experimental":[58,108],"models":[59],"seizures.":[63,86],"conservation":[66],"eigensystems,":[69],"reflecting":[70],"inflammation":[71],"and/or":[72],"apoptosis":[73],"(eigensystem":[74,80],"2)":[75],"neuronal":[77,236],"synaptic":[78,143,222,237],"activity":[79],"3),":[81],"between":[82,171,227],"analyzed":[88],"cis-regulation":[89],"in":[93,127,139,191,247],"subspaces":[95],"conserved":[98,226],"eigensystems.":[99],"Bayesian":[100],"networks":[101],"analysis":[102],"was":[103],"performed":[104],"separately":[105],"for":[106,217],"either":[107],"model,":[109],"with":[110],"cross-system":[111],"validation":[112],"highest-ranking":[115],"features.":[116],"In":[117],"this":[118],"way,":[119],"correctly":[121],"re-discovered":[122],"role":[124],"AP1":[126],"regulation":[129,141],"apoptosis,":[131],"involvement":[134],"Creb":[136,187],"Egr":[138],"activity-related":[144],"genes.":[145],"identified":[147],"a":[148,169],"novel":[149],"antagonistic":[150],"effect":[151],"motif":[154],"recognized":[155],"by":[156,178,240],"nuclear":[158],"matrix":[159],"attachment":[160],"region-binding":[161],"protein":[162],"Satb1":[163,185],"AP1-driven":[165],"transcriptional":[166],"activation,":[167],"suggesting":[168],"link":[170],"chromatin":[172],"loop":[173],"structure":[174],"activation":[177],"AP1.":[179],"The":[180],"motifs":[183],"binding":[184],"conform":[193],"assumption":[196],"linear":[199],"response":[200],"model":[201],"regulation.":[204],"Our":[205],"data":[206],"also":[207],"suggest":[208],"that":[209],"numerous":[210],"enhancers":[211],"neuronal-specific":[213],"genes":[214],"are":[215],"important":[216],"their":[218],"responsiveness":[219],"activity.":[223],"CONCLUSION:":[224],"Eigensystems":[225],"seizures":[230],"inflammation/apoptosis":[234],"activity,":[238],"exerted":[239],"transcription":[242],"factors,":[243],"brain.":[249]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}