{"id":"https://openalex.org/W2148836370","doi":"https://doi.org/10.1186/1752-0509-4-81","title":"A circuit model of the temporal pattern generator of Caenorhabditis egg-laying behavior","display_name":"A circuit model of the temporal pattern generator of Caenorhabditis egg-laying behavior","publication_year":2010,"publication_date":"2010-06-07","ids":{"openalex":"https://openalex.org/W2148836370","doi":"https://doi.org/10.1186/1752-0509-4-81","mag":"2148836370","pmid":"https://pubmed.ncbi.nlm.nih.gov/20529297"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-81","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-81","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-81","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-81","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067099035","display_name":"Mi Zhang","orcid":"https://orcid.org/0000-0001-6410-6128"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mi Zhang","raw_affiliation_strings":["Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA","Division of Biology, University of California, San Diego, La Jolla, CA, 92093, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Division of Biology, University of California, San Diego, La Jolla, CA, 92093, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050316172","display_name":"William R Schafer","orcid":"https://orcid.org/0000-0002-6676-8034"},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"William R Schafer","raw_affiliation_strings":["Division of Biology, University of California, San Diego, La Jolla, CA, 92093, USA","Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, University of California, San Diego, La Jolla, CA, 92093, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070145336","display_name":"Rainer Breitling","orcid":"https://orcid.org/0000-0001-7173-0922"},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB","NL"],"is_corresponding":true,"raw_author_name":"Rainer Breitling","raw_affiliation_strings":["Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK","Groningen Bioinformatics Centre, University of Groningen, 9751 NN, Haren, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK","institution_ids":["https://openalex.org/I7882870"]},{"raw_affiliation_string":"Groningen Bioinformatics Centre, University of Groningen, 9751 NN, Haren, The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5050316172","https://openalex.org/A5070145336"],"corresponding_institution_ids":["https://openalex.org/I169381384","https://openalex.org/I170203145","https://openalex.org/I36258959","https://openalex.org/I7882870"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.1765,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.44896502,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"4","issue":"1","first_page":"81","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8231013417243958},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5285897254943848},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.49631696939468384},{"id":"https://openalex.org/keywords/generator","display_name":"Generator (circuit theory)","score":0.47122490406036377},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45663052797317505},{"id":"https://openalex.org/keywords/animal-behavior","display_name":"Animal behavior","score":0.4380122423171997},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.2534618079662323},{"id":"https://openalex.org/keywords/zoology","display_name":"Zoology","score":0.20741015672683716},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.17684811353683472},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.08715134859085083}],"concepts":[{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.8231013417243958},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5285897254943848},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49631696939468384},{"id":"https://openalex.org/C2780992000","wikidata":"https://www.wikidata.org/wiki/Q17016113","display_name":"Generator (circuit theory)","level":3,"score":0.47122490406036377},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45663052797317505},{"id":"https://openalex.org/C2988419192","wikidata":"https://www.wikidata.org/wiki/Q7155","display_name":"Animal behavior","level":2,"score":0.4380122423171997},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2534618079662323},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.20741015672683716},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.17684811353683472},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08715134859085083},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002107","descriptor_name":"Caenorhabditis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002107","descriptor_name":"Caenorhabditis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002107","descriptor_name":"Caenorhabditis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002107","descriptor_name":"Caenorhabditis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010058","descriptor_name":"Oviposition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010058","descriptor_name":"Oviposition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010058","descriptor_name":"Oviposition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010058","descriptor_name":"Oviposition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1186/1752-0509-4-81","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-81","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-81","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20529297","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20529297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/1f818f5b-ec92-43a0-bfd9-ca7a38acd844","is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/1f818f5b-ec92-43a0-bfd9-ca7a38acd844","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhang, M, Schafer, W R & Breitling, R 2010, 'A circuit model of the temporal pattern generator of Caenorhabditis egg-laying behavior', BMC Systems Biology, vol. 4, no. 1, 81. https://doi.org/10.1186/1752-0509-4-81","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/ec685680-7dce-48bb-a457-5ade3b270c4d","is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/ec685680-7dce-48bb-a457-5ade3b270c4d","pdf_url":"https://link.springer.com/content/pdf/10.1186/1752-0509-4-81.pdf","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Zhang, M, Schafer, W R & Breitling, R 2010, 'A circuit model of the temporal pattern generator of Caenorhabditis egg-laying behavior', BMC Systems Biology, vol. 4, 81. https://doi.org/10.1186/1752-0509-4-81","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2887794","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2887794","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1ce1af40fc464d5a99afcea495b00acb","is_oa":false,"landing_page_url":"https://doaj.org/article/1ce1af40fc464d5a99afcea495b00acb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 4, Iss 1, p 81 (2010)","raw_type":"article"},{"id":"pmh:oai:eprints.gla.ac.uk:40350","is_oa":false,"landing_page_url":"http://eprints.gla.ac.uk/40350/","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Articles"},{"id":"pmh:oai:pure.rug.nl:openaire/1f818f5b-ec92-43a0-bfd9-ca7a38acd844","is_oa":true,"landing_page_url":"https://hdl.handle.net/11370/1f818f5b-ec92-43a0-bfd9-ca7a38acd844","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zhang, M, Schafer, W R & Breitling, R 2010, 'A circuit model of the temporal pattern generator of Caenorhabditis egg-laying behavior', BMC Systems Biology, vol. 4, no. 1, 81. https://doi.org/10.1186/1752-0509-4-81","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/237821","is_oa":true,"landing_page_url":"http://www.dspace.cam.ac.uk/handle/1810/237821","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-81","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-81","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-81","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3060309567","display_name":null,"funder_award_id":"DA016445","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2148836370.pdf","grobid_xml":"https://content.openalex.org/works/W2148836370.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1538472072","https://openalex.org/W2046691888","https://openalex.org/W2061499365","https://openalex.org/W2062803569","https://openalex.org/W2094656362","https://openalex.org/W2100279782","https://openalex.org/W2107518572","https://openalex.org/W2125377667","https://openalex.org/W2156033174","https://openalex.org/W2169210837"],"related_works":["https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933","https://openalex.org/W1641042124"],"abstract_inverted_index":{"BACKGROUND:":[0],"Egg-laying":[1],"behavior":[2],"in":[3,18,127],"the":[4,35,78,99,103,112,137,155,159,170],"nematode":[5],"C.":[6],"elegans":[7],"displays":[8],"a":[9,42,46,62,73],"distinct":[10],"clustered":[11,171],"temporal":[12,79],"pattern:":[13],"egg-laying":[14,54,82,107,131,172],"events":[15,55],"occur":[16,60],"primarily":[17],"bursts":[19],"or":[20],"active":[21,36,58],"phases,":[22],"separated":[23],"by":[24,186],"inactive":[25,160],"phases":[26],"during":[27],"which":[28,144],"eggs":[29],"are":[30,141,152],"retained.":[31],"The":[32,175],"onset":[33],"of":[34,49,66,81,158],"phase":[37,59],"can":[38,182],"be":[39,84,184],"modeled":[40],"as":[41,116],"Poisson":[43],"process":[44],"with":[45,61],"time":[47,64,156],"constant":[48,65,157],"approximately":[50,67],"20":[51,68],"minutes,":[52],"while":[53],"within":[56],"an":[57,165],"faster":[63],"seconds.":[69],"Here":[70],"we":[71],"propose":[72,110,135],"cellular":[74],"model":[75,181],"for":[76,124,148,154],"how":[77],"pattern":[80],"might":[83],"generated,":[85],"based":[86],"on":[87],"genetic":[88],"and":[89,92,151],"cell-biological":[90],"experiments":[91],"statistical":[93],"analyses.":[94],"RESULTS:":[95],"We":[96,109,133],"suggest":[97],"that":[98,111,120,136,168],"HSN":[100,122,146],"neuron":[101,105],"is":[102],"executive":[104],"driving":[106],"events.":[108,132],"VC":[113],"neurons":[114],"act":[115],"\"single":[117],"egg":[118],"counters\"":[119],"inhibit":[121,145],"activity":[123,147],"short":[125],"periods":[126,150],"response":[128],"to":[129],"individual":[130],"further":[134],"uv1":[138],"neuroendocrine":[139],"cells":[140],"\"cluster":[142],"counters\",":[143],"longer":[149],"responsible":[153],"phase.":[161],"Together":[162],"they":[163],"form":[164],"integrated":[166],"circuit":[167],"drives":[169],"pattern.":[173],"CONCLUSIONS:":[174],"detailed":[176],"predictions":[177],"derived":[178],"from":[179],"this":[180],"now":[183],"tested":[185],"straightforward":[187],"validation":[188],"experiments.":[189]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-10T00:00:00"}