{"id":"https://openalex.org/W2031950455","doi":"https://doi.org/10.1186/1752-0509-4-80","title":"The biological context of HIV-1 host interactions reveals subtle insights into a system hijack","display_name":"The biological context of HIV-1 host interactions reveals subtle insights into a system hijack","publication_year":2010,"publication_date":"2010-06-07","ids":{"openalex":"https://openalex.org/W2031950455","doi":"https://doi.org/10.1186/1752-0509-4-80","mag":"2031950455","pmid":"https://pubmed.ncbi.nlm.nih.gov/20529270"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-80","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-80","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-80","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-80","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069596594","display_name":"Jonathan E. Dickerson","orcid":null},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jonathan E Dickerson","raw_affiliation_strings":["Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK","[Faculty of Life Sciences, University of Manchester, Manchester, UK]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"[Faculty of Life Sciences, University of Manchester, Manchester, UK]","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012024356","display_name":"John W. Pinney","orcid":"https://orcid.org/0000-0003-1813-2901"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John W Pinney","raw_affiliation_strings":["Division of Molecular Biosciences, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK","Division of Molecular Biosciences, Imperial College London, South Kensington Campus, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biosciences, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Division of Molecular Biosciences, Imperial College London, South Kensington Campus, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082064376","display_name":"David L. Robertson","orcid":"https://orcid.org/0000-0001-6338-0221"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David L Robertson","raw_affiliation_strings":["Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK","[Faculty of Life Sciences, University of Manchester, Manchester, UK]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"[Faculty of Life Sciences, University of Manchester, Manchester, UK]","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069596594"],"corresponding_institution_ids":["https://openalex.org/I28407311"],"apc_list":null,"apc_paid":null,"fwci":1.4923,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.8103315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"4","issue":"1","first_page":"80","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6862000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6862000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.19030000269412994,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10064","display_name":"Complex Network Analysis Techniques","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7042640447616577},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.62782883644104},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6267465949058533},{"id":"https://openalex.org/keywords/host","display_name":"Host (biology)","score":0.5627252459526062},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5459921956062317},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.5211687088012695},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4562034606933594},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.42388394474983215},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.40906471014022827},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.14628782868385315}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7042640447616577},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.62782883644104},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6267465949058533},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.5627252459526062},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5459921956062317},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5211687088012695},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4562034606933594},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42388394474983215},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.40906471014022827},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.14628782868385315},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016662","descriptor_name":"Virus Integration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016662","descriptor_name":"Virus Integration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016662","descriptor_name":"Virus Integration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016662","descriptor_name":"Virus Integration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1752-0509-4-80","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-80","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-80","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20529270","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20529270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:eprints.gla.ac.uk:122451","is_oa":false,"landing_page_url":"http://eprints.gla.ac.uk/view/author/37465.html>,","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/be263ffa-4400-49a3-9511-5eae911b504b","is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/be263ffa-4400-49a3-9511-5eae911b504b","pdf_url":"https://link.springer.com/content/pdf/10.1186/1752-0509-4-80.pdf","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dickerson, J E, Pinney, J W & Robertson, D L 2010, 'The biological context of HIV-1 host interactions reveals subtle insights into a system hijack', BMC Systems Biology, vol. 4, 80. https://doi.org/10.1186/1752-0509-4-80","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pubmedcentral.nih.gov:2897785","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2897785","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:Publications/be263ffa-4400-49a3-9511-5eae911b504b","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:pure.atira.dk:publications/be263ffa-4400-49a3-9511-5eae911b504b","is_oa":true,"landing_page_url":"http://www.biomedcentral.com/1752-0509/4/80","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-80","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-80","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-80","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7400000095367432}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2031950455.pdf","grobid_xml":"https://content.openalex.org/works/W2031950455.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1527927437","https://openalex.org/W1966546784","https://openalex.org/W1986296710","https://openalex.org/W1996062837","https://openalex.org/W2006683252","https://openalex.org/W2014208555","https://openalex.org/W2017994420","https://openalex.org/W2027738518","https://openalex.org/W2033687160","https://openalex.org/W2056944867","https://openalex.org/W2074443723","https://openalex.org/W2077159940","https://openalex.org/W2083045667","https://openalex.org/W2096110335","https://openalex.org/W2100182517","https://openalex.org/W2107751776","https://openalex.org/W2116609981","https://openalex.org/W2119114096","https://openalex.org/W2119412782","https://openalex.org/W2130410032","https://openalex.org/W2130790725","https://openalex.org/W2131858707","https://openalex.org/W2150318080","https://openalex.org/W2159675211","https://openalex.org/W2159719688","https://openalex.org/W2171707538","https://openalex.org/W4244962194"],"related_works":["https://openalex.org/W2117112636","https://openalex.org/W2001981265","https://openalex.org/W2014134454","https://openalex.org/W3165388193","https://openalex.org/W2371177456","https://openalex.org/W274046748","https://openalex.org/W1804953925","https://openalex.org/W4246303233","https://openalex.org/W2371478427","https://openalex.org/W2410094472"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,76],"order":[2],"to":[3,10,117,144,174,214,256],"replicate,":[4],"HIV,":[5],"like":[6],"all":[7],"viruses,":[8],"needs":[9],"invade":[11],"a":[12,22,138,169,223,234,244,253],"host":[13,96,115,151,205],"cell":[14],"and":[15,31,60,88,101,104,111,149,163,200,219,270],"hijack":[16],"it":[17],"for":[18,130,142,171,197,246],"its":[19],"own":[20],"use,":[21],"process":[23],"that":[24,187,211],"involves":[25],"multiple":[26],"protein":[27],"interactions":[28,65,193,226,247,267],"between":[29,160],"virus":[30],"host.":[32],"The":[33,241],"HIV-1,":[34],"Human":[35],"Protein":[36],"Interaction":[37],"Database":[38],"available":[39],"at":[40],"NCBI's":[41],"website":[42],"captures":[43],"this":[44],"information":[45],"from":[46,99],"the":[47,57,69,73,114,134,204,263],"primary":[48],"literature,":[49,135],"containing":[50],"over":[51],"2,500":[52],"unique":[53],"interactions.":[54,126],"We":[55],"investigate":[56,79],"general":[58],"properties":[59,94],"biological":[61,106],"context":[62,107],"of":[63,72,95,113,225,237,243,265],"these":[64],"and,":[66],"thus,":[67],"explore":[68],"molecular":[70],"specificity":[71,264],"HIV-host":[74,192,266],"perturbation.":[75],"particular,":[77],"we":[78,136,154,167,185],"(i)":[80],"whether":[81],"HIV":[82,125,143,161,172],"preferentially":[83],"interacts":[84],"with":[85,123,146,176,182,216,227,248],"highly":[86,147,198,217],"connected":[87,148,199,218],"'central'":[89],"proteins,":[90],"(ii)":[91],"known":[92],"phenotypic":[93],"proteins":[97,116,177,202,221,251],"inferred":[98,164],"essentiality":[100],"disease-association":[102],"data,":[103],"(iii)":[105],"(molecular":[108],"function,":[109],"processes":[110],"location)":[112],"identify":[118],"attributes":[119],"most":[120],"strongly":[121],"associated":[122,181],"specific":[124],"RESULTS:":[127],"After":[128],"correcting":[129],"ascertainment":[131],"bias":[132],"in":[133,191,203,259],"demonstrate":[137],"significantly":[139],"greater":[140],"propensity":[141,213,245],"interact":[145,175,215],"central":[150,201,220],"proteins.":[152],"Unexpectedly,":[153],"find":[155,168,186],"there":[156],"are":[157,194],"no":[158],"associations":[159],"interaction":[162],"essentiality.":[165],"Similarly,":[166],"tendency":[170],"not":[173],"encoded":[178],"by":[179,274],"genes":[180],"disease.":[183],"Crucially,":[184],"functional":[188],"categories":[189],"over-represented":[190],"innately":[195],"enriched":[196],"system.":[206],"CONCLUSIONS:":[207],"Our":[208],"results":[209],"imply":[210],"HIV's":[212],"is":[222,268],"consequence":[224],"particular":[228],"cellular":[229],"functions,":[230],"rather":[231],"than":[232],"being":[233],"direct":[235],"effect":[236],"network":[238,275],"topological":[239],"properties.":[240,276],"lack":[242],"phenotypically":[249],"essential":[250],"suggests":[252],"selective":[254],"pressure":[255],"minimise":[257],"virulence":[258],"retroviral":[260],"evolution.":[261],"Thus,":[262],"complex,":[269],"only":[271],"superficially":[272],"explained":[273]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}