{"id":"https://openalex.org/W2096169903","doi":"https://doi.org/10.1186/1752-0509-4-60","title":"Coordinated modular functionality and prognostic potential of a heart failure biomarker-driven interaction network","display_name":"Coordinated modular functionality and prognostic potential of a heart failure biomarker-driven interaction network","publication_year":2010,"publication_date":"2010-05-12","ids":{"openalex":"https://openalex.org/W2096169903","doi":"https://doi.org/10.1186/1752-0509-4-60","mag":"2096169903","pmid":"https://pubmed.ncbi.nlm.nih.gov/20462429"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-60","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-60","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-60","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-60","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050612781","display_name":"Francisco Azuaje","orcid":"https://orcid.org/0000-0002-9207-9072"},"institutions":[{"id":"https://openalex.org/I4210144605","display_name":"Laboratoire National de Sant\u00e9","ror":"https://ror.org/04y798z66","country_code":"LU","type":"facility","lineage":["https://openalex.org/I4210144605"]}],"countries":["LU"],"is_corresponding":true,"raw_author_name":"Francisco Azuaje","raw_affiliation_strings":["Laboratory of Cardiovascular Research, Centre de Recherche Public-Sant\u00e9, L-1150 Luxembourg. francisco.azuaje@crp-sante.lu","Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Research, Centre de Recherche Public-Sant\u00e9, L-1150 Luxembourg. francisco.azuaje@crp-sante.lu","institution_ids":["https://openalex.org/I4210144605"]},{"raw_affiliation_string":"Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg","institution_ids":["https://openalex.org/I4210144605"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052329481","display_name":"Yvan Devaux","orcid":"https://orcid.org/0000-0002-5321-8543"},"institutions":[{"id":"https://openalex.org/I4210144605","display_name":"Laboratoire National de Sant\u00e9","ror":"https://ror.org/04y798z66","country_code":"LU","type":"facility","lineage":["https://openalex.org/I4210144605"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Yvan Devaux","raw_affiliation_strings":["Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg","institution_ids":["https://openalex.org/I4210144605"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103518794","display_name":"Daniel R. Wagner","orcid":null},"institutions":[{"id":"https://openalex.org/I162487826","display_name":"Centre Hospitalier de Luxembourg","ror":"https://ror.org/03xq7w797","country_code":"LU","type":"healthcare","lineage":["https://openalex.org/I162487826"]},{"id":"https://openalex.org/I4210144605","display_name":"Laboratoire National de Sant\u00e9","ror":"https://ror.org/04y798z66","country_code":"LU","type":"facility","lineage":["https://openalex.org/I4210144605"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Daniel R Wagner","raw_affiliation_strings":["Division of Cardiology, Centre Hospitalier, L-1210, Luxembourg","Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Centre Hospitalier, L-1210, Luxembourg","institution_ids":["https://openalex.org/I162487826"]},{"raw_affiliation_string":"Laboratory of Cardiovascular Research, Centre de Recherche Public - Sant\u00e9, L-1150, Luxembourg","institution_ids":["https://openalex.org/I4210144605"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050612781"],"corresponding_institution_ids":["https://openalex.org/I4210144605"],"apc_list":null,"apc_paid":null,"fwci":2.4509,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.88972993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"4","issue":"1","first_page":"60","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.957099974155426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.69392991065979},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6804096698760986},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.6257047653198242},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5635543465614319},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5365443825721741},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.5164930820465088},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5045315027236938},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4916432499885559},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4292391836643219},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.34685951471328735},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.28047722578048706},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.16192924976348877},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13218718767166138}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.69392991065979},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6804096698760986},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.6257047653198242},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5635543465614319},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5365443825721741},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5164930820465088},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5045315027236938},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4916432499885559},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4292391836643219},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34685951471328735},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28047722578048706},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16192924976348877},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13218718767166138},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-4-60","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-60","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-60","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20462429","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20462429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:463922ad9afa4a78ba68fd918bac2d5f","is_oa":false,"landing_page_url":"https://doaj.org/article/463922ad9afa4a78ba68fd918bac2d5f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 4, Iss 1, p 60 (2010)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2890499","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2890499","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-60","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-60","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-60","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4099999964237213,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2096169903.pdf","grobid_xml":"https://content.openalex.org/works/W2096169903.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W22787660","https://openalex.org/W1971937094","https://openalex.org/W1979003242","https://openalex.org/W1982428412","https://openalex.org/W1991509879","https://openalex.org/W1993804921","https://openalex.org/W1994803330","https://openalex.org/W2019234246","https://openalex.org/W2032755318","https://openalex.org/W2041004261","https://openalex.org/W2043256370","https://openalex.org/W2047940964","https://openalex.org/W2052763120","https://openalex.org/W2053062892","https://openalex.org/W2056099499","https://openalex.org/W2056254608","https://openalex.org/W2063166582","https://openalex.org/W2072120113","https://openalex.org/W2075411161","https://openalex.org/W2082163559","https://openalex.org/W2100025044","https://openalex.org/W2100585269","https://openalex.org/W2101181377","https://openalex.org/W2109555487","https://openalex.org/W2110175019","https://openalex.org/W2110502951","https://openalex.org/W2112192177","https://openalex.org/W2112456570","https://openalex.org/W2123406596","https://openalex.org/W2125613358","https://openalex.org/W2126717546","https://openalex.org/W2128252198","https://openalex.org/W2129010206","https://openalex.org/W2129550988","https://openalex.org/W2130162835","https://openalex.org/W2134672568","https://openalex.org/W2135893370","https://openalex.org/W2136760026","https://openalex.org/W2137531873","https://openalex.org/W2142890842","https://openalex.org/W2148075660","https://openalex.org/W2149376322","https://openalex.org/W2150318080","https://openalex.org/W2152495216","https://openalex.org/W2154947819","https://openalex.org/W2161353239","https://openalex.org/W2162142051","https://openalex.org/W2163485494","https://openalex.org/W2166468869","https://openalex.org/W2166525781","https://openalex.org/W2168264491","https://openalex.org/W2168301815","https://openalex.org/W2323769589","https://openalex.org/W4240661453"],"related_works":["https://openalex.org/W2114466827","https://openalex.org/W2135896045","https://openalex.org/W2155261113","https://openalex.org/W2156431842","https://openalex.org/W1584645941","https://openalex.org/W2278276487","https://openalex.org/W4311665222","https://openalex.org/W2092868481","https://openalex.org/W2005775729","https://openalex.org/W3108451992"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,127,195],"identification":[2,205],"of":[3,11,26,40,54,57,69,108,154,165,182,192,206],"potentially":[4,207],"relevant":[5,44],"biomarkers":[6,101,114,209],"and":[7,66,88,110,144,172,210,218],"a":[8,37,180,215],"deeper":[9],"understanding":[10,211],"molecular":[12],"mechanisms":[13,213],"related":[14],"to":[15,45,82,93,186],"heart":[16],"failure":[17],"(HF)":[18],"development":[19],"can":[20,79],"be":[21,80,103,118,177,187],"enhanced":[22],"by":[23,134,179],"the":[24,64,152,190,201,204],"implementation":[25],"biological":[27],"network-based":[28],"analyses.":[29],"To":[30],"support":[31,162],"these":[32],"efforts,":[33],"here":[34,199],"we":[35,148],"report":[36],"global":[38],"network":[39,72,77],"protein-protein":[41],"interactions":[42],"(PPIs)":[43],"HF,":[46],"which":[47],"was":[48],"characterized":[49],"through":[50],"integrative":[51],"bioinformatic":[52],"analyses":[53],"multiple":[55],"sources":[56],"\"omic\"":[58],"information.":[59],"RESULTS:":[60],"We":[61,167],"found":[62],"that":[63,99,136,151,170],"structural":[65],"functional":[67,90,174],"architecture":[68],"this":[70,125],"PPI":[71],"is":[73],"highly":[74,139],"modular.":[75],"These":[76],"modules":[78],"assigned":[81],"specialized":[83],"processes,":[84],"specific":[85],"cellular":[86],"regions":[87],"their":[89],"roles":[91],"tend":[92],"partially":[94],"overlap.":[95],"Our":[96],"results":[97],"suggest":[98],"HF":[100,143],"may":[102,161,176],"defined":[104],"as":[105,120],"key":[106],"coordinators":[107],"intra-":[109,171],"inter-module":[111,173],"communication.":[112],"Putative":[113],"can,":[115],"in":[116,214],"general,":[117],"distinguished":[119],"\"information":[121],"traffic\"":[122],"mediators":[123],"within":[124],"network.":[126],"top":[128],"high":[129,158],"traffic":[130,159],"proteins":[131],"are":[132,137],"encoded":[133],"genes":[135,160],"not":[138],"differentially":[140],"expressed":[141],"across":[142],"non-HF":[145],"patients.":[146],"Nevertheless,":[147],"present":[149],"evidence":[150],"integration":[153],"expression":[155],"patterns":[156],"from":[157],"accurate":[163],"prediction":[164],"HF.":[166],"quantitatively":[168],"demonstrate":[169],"activity":[175],"controlled":[178],"family":[181],"transcription":[183],"factors":[184],"known":[185],"associated":[188],"with":[189],"prevention":[191],"hypertrophy.":[193],"CONCLUSION:":[194],"systems-driven":[196],"analysis":[197],"reported":[198],"provides":[200],"basis":[202],"for":[203],"novel":[208],"HF-related":[212],"more":[216],"comprehensive":[217],"integrated":[219],"way.":[220]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-06-25T06:16:34.145877","created_date":"2016-06-24T00:00:00"}