{"id":"https://openalex.org/W2109880272","doi":"https://doi.org/10.1186/1752-0509-4-53","title":"OptORF: Optimal metabolic and regulatory perturbations for metabolic engineering of microbial strains","display_name":"OptORF: Optimal metabolic and regulatory perturbations for metabolic engineering of microbial strains","publication_year":2010,"publication_date":"2010-04-28","ids":{"openalex":"https://openalex.org/W2109880272","doi":"https://doi.org/10.1186/1752-0509-4-53","mag":"2109880272","pmid":"https://pubmed.ncbi.nlm.nih.gov/20426856"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-53","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-53","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-53","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-53","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025386827","display_name":"Joonhoon Kim","orcid":"https://orcid.org/0000-0002-7425-1828"},"institutions":[{"id":"https://openalex.org/I2801044051","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801044051"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joonhoon Kim","raw_affiliation_strings":["Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA","DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, USA","Department of Chemical and Biological Engineering, University of Wisconsin\u2013Madison, Madison, USA"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, USA","institution_ids":["https://openalex.org/I2801044051","https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, University of Wisconsin\u2013Madison, Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059438505","display_name":"Jennifer L. Reed","orcid":"https://orcid.org/0000-0001-7854-6220"},"institutions":[{"id":"https://openalex.org/I2801044051","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801044051"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L Reed","raw_affiliation_strings":["DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, 53706, USA","Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA","DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, USA","Department of Chemical and Biological Engineering, University of Wisconsin\u2013Madison, Madison, USA"],"affiliations":[{"raw_affiliation_string":"DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, 53706, USA","institution_ids":["https://openalex.org/I2801044051"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, USA","institution_ids":["https://openalex.org/I2801044051","https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, University of Wisconsin\u2013Madison, Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025386827"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2801044051"],"apc_list":null,"apc_paid":null,"fwci":9.3524,"has_fulltext":true,"cited_by_count":216,"citation_normalized_percentile":{"value":0.9869928,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"4","issue":"1","first_page":"53","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.989799976348877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"Metabolic engineering","score":0.895064651966095},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6433953642845154},{"id":"https://openalex.org/keywords/flux-balance-analysis","display_name":"Flux balance analysis","score":0.6275866031646729},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6056646704673767},{"id":"https://openalex.org/keywords/isobutanol","display_name":"Isobutanol","score":0.6004093885421753},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5865387916564941},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.580995500087738},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.554705798625946},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5486210584640503},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.47620853781700134},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.47303956747055054},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.4314882755279541},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"Transcriptional regulation","score":0.41285771131515503},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3172527551651001},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2279067039489746},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.18101590871810913},{"id":"https://openalex.org/keywords/ethanol","display_name":"Ethanol","score":0.08731701970100403}],"concepts":[{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.895064651966095},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6433953642845154},{"id":"https://openalex.org/C167091322","wikidata":"https://www.wikidata.org/wiki/Q5463029","display_name":"Flux balance analysis","level":2,"score":0.6275866031646729},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6056646704673767},{"id":"https://openalex.org/C2777271787","wikidata":"https://www.wikidata.org/wiki/Q151797","display_name":"Isobutanol","level":3,"score":0.6004093885421753},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5865387916564941},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.580995500087738},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.554705798625946},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5486210584640503},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.47620853781700134},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.47303956747055054},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.4314882755279541},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.41285771131515503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3172527551651001},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2279067039489746},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18101590871810913},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.08731701970100403}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057005","descriptor_name":"Bioengineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057005","descriptor_name":"Bioengineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057005","descriptor_name":"Bioengineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-4-53","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-53","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-53","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20426856","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20426856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:624f9cc273564b64a92b66e5f26941ea","is_oa":true,"landing_page_url":"https://doaj.org/article/624f9cc273564b64a92b66e5f26941ea","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 4, Iss 1, p 53 (2010)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2887412","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2887412","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-53","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-53","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-53","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1052503337","display_name":null,"funder_award_id":"FC02-07ER64494","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G222180108","display_name":null,"funder_award_id":"07ER64494","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G23300722","display_name":null,"funder_award_id":"DE-FC02-07ER64494","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G4063130707","display_name":null,"funder_award_id":"DE-FC02-07ER64494","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G4385836085","display_name":null,"funder_award_id":"FC02-07ER64494","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G4406015036","display_name":null,"funder_award_id":"DOE BER Office of Science DE-FC02-07ER64494","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G4553821525","display_name":null,"funder_award_id":"DOE BER Office of Science DE-FC02-07ER64494","funder_id":"https://openalex.org/F4320333880","funder_display_name":"Great Lakes Bioenergy Research Center"},{"id":"https://openalex.org/G6299481046","display_name":null,"funder_award_id":"DE-FC02-07ER64494","funder_id":"https://openalex.org/F4320333880","funder_display_name":"Great Lakes Bioenergy Research Center"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320333880","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2109880272.pdf","grobid_xml":"https://content.openalex.org/works/W2109880272.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1491585327","https://openalex.org/W1803645594","https://openalex.org/W1942489888","https://openalex.org/W1942979413","https://openalex.org/W1968350981","https://openalex.org/W1968629638","https://openalex.org/W1969983517","https://openalex.org/W1978119727","https://openalex.org/W1980207389","https://openalex.org/W1982309495","https://openalex.org/W1990928629","https://openalex.org/W1992695365","https://openalex.org/W1999309464","https://openalex.org/W2003489966","https://openalex.org/W2004964623","https://openalex.org/W2006672203","https://openalex.org/W2018994057","https://openalex.org/W2031681107","https://openalex.org/W2044525257","https://openalex.org/W2045780029","https://openalex.org/W2046254395","https://openalex.org/W2054506883","https://openalex.org/W2056669708","https://openalex.org/W2061274891","https://openalex.org/W2062819025","https://openalex.org/W2072388876","https://openalex.org/W2076372398","https://openalex.org/W2083011190","https://openalex.org/W2083693802","https://openalex.org/W2085075090","https://openalex.org/W2091124334","https://openalex.org/W2096245011","https://openalex.org/W2096626341","https://openalex.org/W2097346112","https://openalex.org/W2100818174","https://openalex.org/W2102164505","https://openalex.org/W2103041540","https://openalex.org/W2104669330","https://openalex.org/W2106176351","https://openalex.org/W2111421616","https://openalex.org/W2111967267","https://openalex.org/W2112933558","https://openalex.org/W2123460174","https://openalex.org/W2128746754","https://openalex.org/W2130364940","https://openalex.org/W2141360045","https://openalex.org/W2143861551","https://openalex.org/W2148899088","https://openalex.org/W2154061034","https://openalex.org/W2154797402","https://openalex.org/W2160042078","https://openalex.org/W2164293128","https://openalex.org/W2168244801","https://openalex.org/W2169028134","https://openalex.org/W2170427655","https://openalex.org/W4245220017"],"related_works":["https://openalex.org/W3196676995","https://openalex.org/W2126646394","https://openalex.org/W3047447888","https://openalex.org/W2053717739","https://openalex.org/W2563192597","https://openalex.org/W1984577552","https://openalex.org/W1992844569","https://openalex.org/W3130044579","https://openalex.org/W2613838074","https://openalex.org/W2242337664"],"abstract_inverted_index":{"By":[0],"taking":[1],"regulatory":[2],"effects":[3],"into":[4],"account,":[5],"OptORF":[6,48],"can":[7,53],"propose":[8],"changes":[9],"such":[10],"as":[11],"the":[12,25,46,58],"overexpression":[13],"of":[14,19,27,60],"metabolic":[15,28],"genes":[16],"or":[17],"deletion":[18,26],"transcriptional":[20],"factors,":[21],"in":[22,40,63],"addition":[23],"to":[24,33,56],"genes,":[29],"that":[30],"may":[31],"lead":[32],"faster":[34],"evolutionary":[35],"trajectories.":[36],"While":[37],"biofuel":[38],"production":[39,59],"E.":[41],"coli":[42],"is":[43,50],"evaluated":[44],"here,":[45],"developed":[47],"approach":[49],"general":[51],"and":[52],"be":[54],"applied":[55],"optimize":[57],"different":[61],"compounds":[62],"other":[64],"biological":[65],"systems.":[66]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":28},{"year":2012,"cited_by_count":20}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}