{"id":"https://openalex.org/W2099908487","doi":"https://doi.org/10.1186/1752-0509-4-51","title":"Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma","display_name":"Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma","publication_year":2010,"publication_date":"2010-04-27","ids":{"openalex":"https://openalex.org/W2099908487","doi":"https://doi.org/10.1186/1752-0509-4-51","mag":"2099908487","pmid":"https://pubmed.ncbi.nlm.nih.gov/20420713"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-51","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-51","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-51","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-51","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100709947","display_name":"Huiqing Liu","orcid":"https://orcid.org/0000-0002-5227-5204"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huiqing Liu","raw_affiliation_strings":["BioMaPS Institute, Rutgers University, Piscataway, NJ 08854, USA","BioMaPS Institute, Rutgers University, Piscataway, NJ, 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMaPS Institute, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"BioMaPS Institute, Rutgers University, Piscataway, NJ, 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090667008","display_name":"A. Rose Brannon","orcid":"https://orcid.org/0000-0003-4610-0149"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela R Brannon","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035638668","display_name":"Anupama Reddy","orcid":"https://orcid.org/0000-0003-1436-3702"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anupama R Reddy","raw_affiliation_strings":["BioMaPS Institute, Rutgers University, Piscataway, NJ, 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMaPS Institute, Rutgers University, Piscataway, NJ, 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037413866","display_name":"Gabriela Alexe","orcid":"https://orcid.org/0000-0002-5668-6297"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriela Alexe","raw_affiliation_strings":["Broad Institute of MIT and Harvard, 7 Cambridge Center, MA, 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of MIT and Harvard, 7 Cambridge Center, MA, 02142, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112035576","display_name":"Michael Seiler","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W Seiler","raw_affiliation_strings":["BioMaPS Institute, Rutgers University, Piscataway, NJ, 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMaPS Institute, Rutgers University, Piscataway, NJ, 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110293108","display_name":"Alexandra Arreola","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Arreola","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039290943","display_name":"Jay Oza","orcid":"https://orcid.org/0000-0001-6050-1913"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay H Oza","raw_affiliation_strings":["Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, 08903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, 08903, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065984250","display_name":"Ming Yao","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Yao","raw_affiliation_strings":["Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, 08903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, 08903, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065184997","display_name":"David Juan","orcid":"https://orcid.org/0000-0003-1912-9667"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Juan","raw_affiliation_strings":["Department of Pathology, Boston University Medical School, Boston, MA, 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Boston University Medical School, Boston, MA, 02118, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010983394","display_name":"Louis S. Liou","orcid":null},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I124574311","display_name":"Cambridge Health Alliance","ror":"https://ror.org/059c3mv67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I124574311"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis S Liou","raw_affiliation_strings":["Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, 02139, USA","Department of Pathology, Boston University Medical School, Boston, MA, 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, 02139, USA","institution_ids":["https://openalex.org/I124574311","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pathology, Boston University Medical School, Boston, MA, 02118, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061989008","display_name":"Shridar Ganesan","orcid":"https://orcid.org/0000-0002-5404-3044"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shridar Ganesan","raw_affiliation_strings":["Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, 08903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, 08903, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089778846","display_name":"Arnold J. Levine","orcid":"https://orcid.org/0000-0002-1871-6387"},"institutions":[{"id":"https://openalex.org/I40036882","display_name":"Institute for Advanced Study","ror":"https://ror.org/00f809463","country_code":"US","type":"facility","lineage":["https://openalex.org/I40036882"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnold J Levine","raw_affiliation_strings":["Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ, 08540, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ, 08540, USA","institution_ids":["https://openalex.org/I40036882","https://openalex.org/I4210155419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082240684","display_name":"W. Kimryn Rathmell","orcid":"https://orcid.org/0000-0002-4984-0225"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"WK Rathmell","raw_affiliation_strings":["Departments of Medicine and Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA","Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018308750","display_name":"Gyan Bhanot","orcid":"https://orcid.org/0000-0001-7822-5259"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I40036882","display_name":"Institute for Advanced Study","ror":"https://ror.org/00f809463","country_code":"US","type":"facility","lineage":["https://openalex.org/I40036882"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gyan V Bhanot","raw_affiliation_strings":["BioMaPS Institute, Rutgers University, Piscataway, NJ, 08854, USA","Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, 08903, USA","Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, 08854, USA","Department of Physics, Rutgers University, Piscataway, NJ, 08854, USA","Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ, 08540, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMaPS Institute, Rutgers University, Piscataway, NJ, 08854, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, 08903, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4390039325"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, 08854, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Physics, Rutgers University, Piscataway, NJ, 08854, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ, 08540, USA","institution_ids":["https://openalex.org/I40036882","https://openalex.org/I4210155419"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5018308750","https://openalex.org/A5082240684"],"corresponding_institution_ids":["https://openalex.org/I102322142","https://openalex.org/I114027177","https://openalex.org/I40036882","https://openalex.org/I4210155419","https://openalex.org/I4390039325","https://openalex.org/I4390039329"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":8.3251,"has_fulltext":true,"cited_by_count":246,"citation_normalized_percentile":{"value":0.98068041,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"4","issue":"1","first_page":"51","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8193832635879517},{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.7226543426513672},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7153612375259399},{"id":"https://openalex.org/keywords/untranslated-region","display_name":"Untranslated region","score":0.5695496797561646},{"id":"https://openalex.org/keywords/translation","display_name":"Translation (biology)","score":0.4951867163181305},{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"Clear cell renal cell carcinoma","score":0.4485892653465271},{"id":"https://openalex.org/keywords/three-prime-untranslated-region","display_name":"Three prime untranslated region","score":0.4451867938041687},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.394656777381897},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3397640883922577},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3022734224796295},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"Renal cell carcinoma","score":0.30010902881622314},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.1782454252243042},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10053524374961853}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8193832635879517},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.7226543426513672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7153612375259399},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.5695496797561646},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.4951867163181305},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.4485892653465271},{"id":"https://openalex.org/C22667442","wikidata":"https://www.wikidata.org/wiki/Q3272830","display_name":"Three prime untranslated region","level":5,"score":0.4451867938041687},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.394656777381897},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3397640883922577},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3022734224796295},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.30010902881622314},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1782454252243042},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10053524374961853}],"mesh":[{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039961","descriptor_name":"Semaphorins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039961","descriptor_name":"Semaphorins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039961","descriptor_name":"Semaphorins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039961","descriptor_name":"Semaphorins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1752-0509-4-51","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-51","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-51","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20420713","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20420713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:cdr.lib.unc.edu:uuid:da29f3eb-0eab-41d4-a8e8-0cb74cc8e4c0","is_oa":true,"landing_page_url":"https://cdr.lib.unc.edu/record/uuid:da29f3eb-0eab-41d4-a8e8-0cb74cc8e4c0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:alma.01RUT_INST:11664982760004646","is_oa":false,"landing_page_url":"https://scholarship.libraries.rutgers.edu/esploro/outputs/journalArticle/Identifying-mRNA-targets-of-microRNA-dysregulated/991031665623104646","pdf_url":null,"source":{"id":"https://openalex.org/S4210197018","display_name":"View","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:doaj.org/article:f065e626c7fd49caa96aff9213bf367d","is_oa":false,"landing_page_url":"https://doaj.org/article/f065e626c7fd49caa96aff9213bf367d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 4, Iss 1, p 51 (2010)","raw_type":"article"},{"id":"pmh:oai:open.bu.edu:2144/3335","is_oa":true,"landing_page_url":"https://hdl.handle.net/2144/3335","pdf_url":null,"source":{"id":"https://openalex.org/S4306402384","display_name":"OpenBU (Boston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I111088046","host_organization_name":"Boston University","host_organization_lineage":["https://openalex.org/I111088046"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2876063","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2876063","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-51","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-51","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-51","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.699999988079071}],"awards":[{"id":"https://openalex.org/G1753523693","display_name":null,"funder_award_id":"R01 CA121781","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309886","display_name":"Rutgers Cancer Institute of New Jersey","ror":"https://ror.org/05vt9qd57"},{"id":"https://openalex.org/F4320320548","display_name":"Crawford Fund","ror":"https://ror.org/04cpjyv67"},{"id":"https://openalex.org/F4320332500","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2099908487.pdf","grobid_xml":"https://content.openalex.org/works/W2099908487.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W410897752","https://openalex.org/W1539580637","https://openalex.org/W1562829802","https://openalex.org/W1648301895","https://openalex.org/W1883934225","https://openalex.org/W1963691340","https://openalex.org/W1964895626","https://openalex.org/W1967226516","https://openalex.org/W1971454589","https://openalex.org/W1973144992","https://openalex.org/W1974650935","https://openalex.org/W1983514447","https://openalex.org/W1983991097","https://openalex.org/W1992272392","https://openalex.org/W1992304298","https://openalex.org/W1992499158","https://openalex.org/W1995767058","https://openalex.org/W1997202892","https://openalex.org/W1999787565","https://openalex.org/W2002995168","https://openalex.org/W2005942192","https://openalex.org/W2006797972","https://openalex.org/W2007103799","https://openalex.org/W2009326616","https://openalex.org/W2011938376","https://openalex.org/W2013411499","https://openalex.org/W2013411684","https://openalex.org/W2017199818","https://openalex.org/W2025449301","https://openalex.org/W2026354664","https://openalex.org/W2027097496","https://openalex.org/W2030093783","https://openalex.org/W2035459770","https://openalex.org/W2035987476","https://openalex.org/W2038167014","https://openalex.org/W2038622868","https://openalex.org/W2039164708","https://openalex.org/W2045881743","https://openalex.org/W2047316081","https://openalex.org/W2050869737","https://openalex.org/W2051352765","https://openalex.org/W2059073003","https://openalex.org/W2066442082","https://openalex.org/W2074629894","https://openalex.org/W2074713811","https://openalex.org/W2077515343","https://openalex.org/W2080951960","https://openalex.org/W2085833889","https://openalex.org/W2088738576","https://openalex.org/W2090219560","https://openalex.org/W2093557716","https://openalex.org/W2102091738","https://openalex.org/W2102601764","https://openalex.org/W2104146201","https://openalex.org/W2104610341","https://openalex.org/W2107369553","https://openalex.org/W2109363337","https://openalex.org/W2110320497","https://openalex.org/W2116089873","https://openalex.org/W2117391818","https://openalex.org/W2119435489","https://openalex.org/W2120456037","https://openalex.org/W2120785986","https://openalex.org/W2123214754","https://openalex.org/W2125120607","https://openalex.org/W2128674168","https://openalex.org/W2128865130","https://openalex.org/W2129873928","https://openalex.org/W2130281728","https://openalex.org/W2130979840","https://openalex.org/W2131596261","https://openalex.org/W2135810600","https://openalex.org/W2135836598","https://openalex.org/W2137517357","https://openalex.org/W2139030718","https://openalex.org/W2144154026","https://openalex.org/W2145936343","https://openalex.org/W2146637150","https://openalex.org/W2150536104","https://openalex.org/W2150597604","https://openalex.org/W2151091624","https://openalex.org/W2152057203","https://openalex.org/W2154040159","https://openalex.org/W2155131748","https://openalex.org/W2156578353","https://openalex.org/W2162224376","https://openalex.org/W2162419009","https://openalex.org/W2171697766","https://openalex.org/W2372164875","https://openalex.org/W2415549799","https://openalex.org/W2597632520","https://openalex.org/W2608030370","https://openalex.org/W3023299375","https://openalex.org/W4214489112","https://openalex.org/W4237473415","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2386767893","https://openalex.org/W2130669936","https://openalex.org/W3145919624","https://openalex.org/W4230503687","https://openalex.org/W977309228","https://openalex.org/W2050159684","https://openalex.org/W2066198055","https://openalex.org/W2073461718","https://openalex.org/W2029260884","https://openalex.org/W2752065691"],"abstract_inverted_index":{"BACKGROUND:":[0],"MicroRNA":[1],"regulate":[2],"mRNA":[3,24,63,92,123,174,181,193,368,396],"levels":[4,127,141,201,274,369],"in":[5,35,68,74,85,103,147,202,226,239,250,355],"a":[6,42,57,86,185,235,337,343,389],"tissue":[7,50,393],"specific":[8],"way,":[9],"either":[10],"by":[11,18,197,233,332,336],"inducing":[12],"degradation":[13,178],"of":[14,26,52,65,179,184,255,262,264,275,283,285,307,324,330,353,375,381,391,398],"the":[15,101,107,122,138,156,180,221,304],"transcript":[16,182],"or":[17,21],"inhibiting":[19],"translation":[20],"transcription.":[22],"Putative":[23,207],"targets":[25,64,175,352,397],"microRNA":[27,66,102,125,191,354,366],"identified":[28,196,212,315],"from":[29,70,131,213],"seed":[30,97,108,187,216,222,376],"sequence":[31,98,109,188,217,223,377],"matches":[32,40,386],"are":[33,142,194,211,230],"available":[34],"many":[36,247],"databases.":[37],"However,":[38],"such":[39],"have":[41,94],"high":[43,134],"false":[44],"positive":[45],"rate":[46],"and":[47,118,124,136,144,154,165,192,258,269,272,292,303,312,345,367,378,387],"cannot":[48],"identify":[49,61,349,388],"specificity":[51],"regulation.":[53],"RESULTS:":[54],"We":[55,152,296,341],"describe":[56,342],"simple":[58,344],"method":[59,157,245,347],"to":[60,100,173,348],"direct":[62,350],"dysregulated":[67,208,399],"cancers":[69],"expression":[71,126,140,200,382],"level":[72],"measurements":[73],"patient":[75],"matched":[76,166,325],"tumor/normal":[77,371],"samples.":[78,151,206,243,327],"The":[79,244,328,358],"word":[80],"\"direct\"":[81],"is":[82,111],"used":[83],"here":[84],"strict":[87],"sense":[88],"to:":[89],"a)":[90],"represent":[91],"which":[93,176],"an":[95,321],"exact":[96],"match":[99,110],"their":[104,199],"3'UTR,":[105],"b)":[106],"strictly":[112],"conserved":[113,225],"across":[114],"mouse,":[115],"human,":[116],"rat":[117],"dog":[119],"genomes,":[120],"c)":[121],"can":[128],"distinguish":[129],"tumor":[130,148,203,240,286],"normal":[132,150,167,205,242],"with":[133],"significance":[135],"d)":[137],"microRNA/mRNA":[139,209,316],"strongly":[143],"significantly":[145],"anti-correlated":[146],"and/or":[149,241],"apply":[153],"validate":[155],"using":[158,215],"clear":[159],"cell":[160],"Renal":[161],"Cell":[162],"Carcinoma":[163],"(ccRCC)":[164],"kidney":[168],"samples,":[169,372],"limiting":[170],"our":[171],"analysis":[172],"undergo":[177],"because":[183],"perfect":[186],"match.":[189],"Dysregulated":[190],"first":[195],"comparing":[198],"vs":[204],"pairs":[210,317],"these":[214],"matches,":[218],"requiring":[219,234],"that":[220],"be":[224],"human/dog/rat/mouse":[227],"genomes.":[228],"These":[229],"further":[231],"pruned":[232],"strong":[236,299,379],"anti-correlation":[237,300,380],"signature":[238,364],"revealed":[246],"new":[248],"regulations":[249],"ccRCC.":[251],"For":[252],"instance,":[253],"loss":[254,282],"miR-149,":[256],"miR-200c":[257],"mir-141":[259],"causes":[260],"gain":[261],"function":[263,284],"oncogenes":[265],"(KCNMA1,":[266],"LOX),":[267],"VEGFA":[268,302],"SEMA6A":[270,331],"respectively":[271],"increased":[273],"miR-142-3p,":[276],"miR-185,":[277],"mir-34a,":[278],"miR-224,":[279],"miR-21":[280],"cause":[281],"suppressors":[287],"LRRC2,":[288],"PTPN13,":[289],"SFRP1,":[290],"ERBB4,":[291],"(SLC12A1,":[293],"TCF21)":[294],"respectively.":[295],"also":[297],"found":[298],"between":[301,370],"miR-200":[305],"family":[306],"microRNA:":[308],"miR-200a*,":[309],"200b,":[310],"200c":[311],"miR-141.":[313],"Several":[314],"were":[318],"validated":[319],"on":[320],"independent":[322],"set":[323],"ccRCC/normal":[326],"regulation":[329],"miR-141":[333],"was":[334],"verified":[335],"transfection":[338],"assay.":[339],"CONCLUSIONS:":[340],"reliable":[346],"gene":[351],"any":[356],"cancer.":[357],"constraints":[359],"we":[360],"impose":[361],"(strong":[362],"dysregulation":[363],"for":[365],"evolutionary":[373],"conservation":[374],"levels)":[383],"remove":[384],"spurious":[385],"subset":[390],"robust,":[392],"specific,":[394],"functional":[395],"microRNA.":[400]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":29}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}