{"id":"https://openalex.org/W2165982972","doi":"https://doi.org/10.1186/1752-0509-4-50","title":"A formal model for analyzing drug combination effects and its application in TNF-\u03b1-induced NF\u03baB pathway","display_name":"A formal model for analyzing drug combination effects and its application in TNF-\u03b1-induced NF\u03baB pathway","publication_year":2010,"publication_date":"2010-04-25","ids":{"openalex":"https://openalex.org/W2165982972","doi":"https://doi.org/10.1186/1752-0509-4-50","mag":"2165982972","pmid":"https://pubmed.ncbi.nlm.nih.gov/20416113"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-50","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-50","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-50","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-50","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Han Yan","orcid":null},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Yan","raw_affiliation_strings":["Department of Automation and TNList, Tsinghua University, Beijing, 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Automation and TNList, Tsinghua University, Beijing, 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100335187","display_name":"Bo Zhang","orcid":"https://orcid.org/0000-0002-9958-6181"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Zhang","raw_affiliation_strings":["Department of Automation and TNList, Tsinghua University, Beijing, 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Automation and TNList, Tsinghua University, Beijing, 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076576399","display_name":"Shao Li","orcid":"https://orcid.org/0000-0002-8709-9167"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shao Li","raw_affiliation_strings":["Department of Automation and TNList, Tsinghua University, Beijing, 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Automation and TNList, Tsinghua University, Beijing, 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014109600","display_name":"Qianchuan Zhao","orcid":"https://orcid.org/0000-0002-7952-5621"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qianchuan Zhao","raw_affiliation_strings":["Department of Automation and TNList, Tsinghua University, Beijing, 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Automation and TNList, Tsinghua University, Beijing, 100084, China","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014109600","https://openalex.org/A5076576399"],"corresponding_institution_ids":["https://openalex.org/I99065089"],"apc_list":null,"apc_paid":null,"fwci":2.4665,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.89412626,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"4","issue":"1","first_page":"50","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.8434000015258789,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.8434000015258789,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.02539999969303608,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bliss","display_name":"BLISS","score":0.7354972958564758},{"id":"https://openalex.org/keywords/independence","display_name":"Independence (probability theory)","score":0.5996309518814087},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5873870849609375},{"id":"https://openalex.org/keywords/scalability","display_name":"Scalability","score":0.5277717113494873},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5225389003753662},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.48859602212905884},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.25007253885269165},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.20857617259025574},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16354584693908691},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.13599926233291626},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09365090727806091}],"concepts":[{"id":"https://openalex.org/C2780658912","wikidata":"https://www.wikidata.org/wiki/Q2877155","display_name":"BLISS","level":2,"score":0.7354972958564758},{"id":"https://openalex.org/C35651441","wikidata":"https://www.wikidata.org/wiki/Q625303","display_name":"Independence (probability theory)","level":2,"score":0.5996309518814087},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5873870849609375},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.5277717113494873},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5225389003753662},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.48859602212905884},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.25007253885269165},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20857617259025574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16354584693908691},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.13599926233291626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09365090727806091},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-4-50","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-50","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-50","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20416113","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20416113","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2873319","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2873319","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-50","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-50","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-50","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"awards":[{"id":"https://openalex.org/G2654480030","display_name":"\u75be\u75c5\u751f\u7269\u5206\u5b50\u7f51\u7edc\u7684\u7cfb\u7edf\u5efa\u6a21\u4e0e\u8c03\u63a7\u673a\u7406\u7814\u7a76","funder_award_id":"60934004","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6217304460","display_name":null,"funder_award_id":"60721003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6290068495","display_name":null,"funder_award_id":"60736027","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335785","display_name":"Project 211","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2165982972.pdf","grobid_xml":"https://content.openalex.org/works/W2165982972.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W588205466","https://openalex.org/W619602509","https://openalex.org/W1568151056","https://openalex.org/W1641228030","https://openalex.org/W1896693683","https://openalex.org/W1973932751","https://openalex.org/W1975455559","https://openalex.org/W1979569154","https://openalex.org/W1985572262","https://openalex.org/W1994663540","https://openalex.org/W2001259959","https://openalex.org/W2004297047","https://openalex.org/W2007393641","https://openalex.org/W2016802225","https://openalex.org/W2021044341","https://openalex.org/W2021674783","https://openalex.org/W2023970896","https://openalex.org/W2043892945","https://openalex.org/W2055498530","https://openalex.org/W2060737851","https://openalex.org/W2064740654","https://openalex.org/W2070102480","https://openalex.org/W2077945404","https://openalex.org/W2080777238","https://openalex.org/W2083090087","https://openalex.org/W2095399601","https://openalex.org/W2096439168","https://openalex.org/W2103562758","https://openalex.org/W2109169395","https://openalex.org/W2118986158","https://openalex.org/W2126907513","https://openalex.org/W2138843474","https://openalex.org/W2149932234","https://openalex.org/W2151672555","https://openalex.org/W2151753004","https://openalex.org/W2154169469","https://openalex.org/W2156435365","https://openalex.org/W2156761481","https://openalex.org/W2157603347","https://openalex.org/W2157692941","https://openalex.org/W2165240999","https://openalex.org/W2166565152","https://openalex.org/W2335854816","https://openalex.org/W2492011802","https://openalex.org/W3003553254","https://openalex.org/W4313341463"],"related_works":["https://openalex.org/W2884598295","https://openalex.org/W2313933600","https://openalex.org/W2334720037","https://openalex.org/W2033249454","https://openalex.org/W2100847845","https://openalex.org/W2477081420","https://openalex.org/W3212259716","https://openalex.org/W2387715358","https://openalex.org/W2316146925","https://openalex.org/W2617720359"],"abstract_inverted_index":{"BACKGROUND:":[0],"Drug":[1],"combination":[2,21,39,154,203],"therapy":[3,232],"is":[4],"commonly":[5],"used":[6],"in":[7,105,234,242],"clinical":[8],"practice.":[9],"Many":[10],"methods":[11],"including":[12],"Bliss":[13,30,192],"independence":[14,31,193],"method":[15,32,163,246],"have":[16],"been":[17],"proposed":[18],"for":[19,97,201],"drug":[20,38,101,168,202,231],"design":[22,40,74,204],"based":[23],"on":[24,139,170],"simulations":[25],"models":[26],"or":[27],"experiments.":[28],"Although":[29],"can":[33,86,120,219],"help":[34],"to":[35,68,164,222,250],"solve":[36],"the":[37,52,70,73,88,108,111,117,124,134,143,153,181,191,224,243],"problem":[41,226],"when":[42],"there":[43],"are":[44],"only":[45],"a":[46,82,148,197,235],"small":[47],"number":[48,53],"of":[49,54,63,72,94,100,110,116,126,136,142,227,229],"combinations,":[50],"as":[51],"combinations":[55,169],"increases,":[56],"it":[57],"may":[58],"not":[59],"be":[60,121,157,248],"scalable.":[61],"Exploration":[62],"system":[64,119,209],"structure":[65,90,93,138],"becomes":[66],"important":[67],"reduce":[69],"complexity":[71],"problem.":[75],"RESULTS:":[76],"In":[77,130],"this":[78,217],"paper,":[79],"we":[80,132,160],"deduced":[81],"mathematical":[83],"model":[84],"which":[85,152],"simplify":[87],"serial":[89,144],"and":[91,177,195,208],"parallel":[92],"biological":[95],"pathway":[96,176],"synergy":[98],"evaluation":[99],"combinations.":[102],"We":[103,146,185,214],"demonstrated":[104],"steady":[106],"state":[107],"sign":[109,125],"synergism":[112],"assessment":[113,228],"factor":[114,173],"derivative":[115],"original":[118],"predicted":[122],"by":[123,180,205],"its":[127],"simplified":[128],"system.":[129],"addition,":[131],"analyzed":[133],"influence":[135],"feedback":[137],"survival":[140],"ratio":[141],"structure.":[145],"provided":[147],"sufficient":[149],"condition":[150],"under":[151],"effect":[155,233],"could":[156,247],"maintained.":[158],"Furthermore,":[159],"applied":[161],"our":[162,245],"find":[165],"three":[166],"synergistic":[167],"tumor":[171],"necrosis":[172],"alpha-induced":[174],"NFkappaB":[175],"subsequently":[178],"verified":[179],"cell":[182],"experiment.":[183],"CONCLUSIONS:":[184],"identified":[186],"several":[187],"structural":[188],"properties":[189],"underlying":[190],"criterion,":[194],"developed":[196],"systematic":[198],"simplification":[199],"framework":[200],"combining":[206],"simulation":[207],"reaction":[210],"network":[211],"topology":[212],"analysis.":[213],"hope":[215],"that":[216],"work":[218],"provide":[220],"insights":[221],"tackle":[223],"challenging":[225],"combinational":[230],"large":[236],"scale":[237],"signaling":[238],"pathway.":[239],"And":[240],"hopefully":[241],"future":[244],"expanded":[249],"more":[251],"general":[252],"criteria.":[253]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":5}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}