{"id":"https://openalex.org/W1967085308","doi":"https://doi.org/10.1186/1752-0509-4-5","title":"Blood flow controls coagulation onset via the positive feedback of factor VII activation by factor Xa","display_name":"Blood flow controls coagulation onset via the positive feedback of factor VII activation by factor Xa","publication_year":2010,"publication_date":"2010-01-26","ids":{"openalex":"https://openalex.org/W1967085308","doi":"https://doi.org/10.1186/1752-0509-4-5","mag":"1967085308","pmid":"https://pubmed.ncbi.nlm.nih.gov/20102623"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029278386","display_name":"A. M. Shibeko","orcid":"https://orcid.org/0000-0003-1494-3125"},"institutions":[{"id":"https://openalex.org/I4210100648","display_name":"Federal State Institution Hematology Research Center","ror":"https://ror.org/015fskz95","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210100648","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Alexey M Shibeko","raw_affiliation_strings":["National Research Center for Hematology, 4a Novyi Zykovskii pr, Moscow 125167, Russia","National Research Center for Hematology, 4a Novyi Zykovskii pr., Moscow, 125167, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Center for Hematology, 4a Novyi Zykovskii pr, Moscow 125167, Russia","institution_ids":[]},{"raw_affiliation_string":"National Research Center for Hematology, 4a Novyi Zykovskii pr., Moscow, 125167, Russia","institution_ids":["https://openalex.org/I4210100648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017312602","display_name":"\u0415\u043a\u0430\u0442\u0435\u0440\u0438\u043d\u0430 \u0421. \u041b\u043e\u0431\u0430\u043d\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-8309-7199"},"institutions":[{"id":"https://openalex.org/I4210100648","display_name":"Federal State Institution Hematology Research Center","ror":"https://ror.org/015fskz95","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210100648","https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"Ekaterina S Lobanova","raw_affiliation_strings":["Albert Eye Research Institute, Duke University Medical Center, Durham, North Carolina, 27710, USA","National Research Center for Hematology, 4a Novyi Zykovskii pr., Moscow, 125167, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Eye Research Institute, Duke University Medical Center, Durham, North Carolina, 27710, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I170897317"]},{"raw_affiliation_string":"National Research Center for Hematology, 4a Novyi Zykovskii pr., Moscow, 125167, Russia","institution_ids":["https://openalex.org/I4210100648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058001042","display_name":"Mikhail A. Panteleev","orcid":"https://orcid.org/0000-0002-8128-7757"},"institutions":[{"id":"https://openalex.org/I4210100648","display_name":"Federal State Institution Hematology Research Center","ror":"https://ror.org/015fskz95","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210100648","https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210122842","display_name":"Center for Theoretical Problems of Physicochemical Pharmacology","ror":"https://ror.org/02ncvqp37","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210115279","https://openalex.org/I4210122842"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Mikhail A Panteleev","raw_affiliation_strings":["Center for Theoretical Problems of Physicochemical Pharmacology, 4 Kosygina str., Moscow, 119991, Russia","National Research Center for Hematology, 4a Novyi Zykovskii pr., Moscow, 125167, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Theoretical Problems of Physicochemical Pharmacology, 4 Kosygina str., Moscow, 119991, Russia","institution_ids":["https://openalex.org/I4210122842"]},{"raw_affiliation_string":"National Research Center for Hematology, 4a Novyi Zykovskii pr., Moscow, 125167, Russia","institution_ids":["https://openalex.org/I4210100648"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080077871","display_name":"\u0424\u0430\u0437\u043e\u0438\u043b \u0418. \u0410\u0442\u0430\u0443\u043b\u043b\u0430\u0445\u0430\u043d\u043e\u0432","orcid":"https://orcid.org/0000-0002-6668-0948"},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]},{"id":"https://openalex.org/I4210122842","display_name":"Center for Theoretical Problems of Physicochemical Pharmacology","ror":"https://ror.org/02ncvqp37","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210115279","https://openalex.org/I4210122842"]},{"id":"https://openalex.org/I4210100648","display_name":"Federal State Institution Hematology Research Center","ror":"https://ror.org/015fskz95","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210100648","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Fazoil I Ataullakhanov","raw_affiliation_strings":["Center for Theoretical Problems of Physicochemical Pharmacology, 4 Kosygina str., Moscow, 119991, Russia","Department of Physics, Moscow State University, 1 Vorobyevy gory, Moscow, 119991, Russia","National Research Center for Hematology, 4a Novyi Zykovskii pr., Moscow, 125167, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Theoretical Problems of Physicochemical Pharmacology, 4 Kosygina str., Moscow, 119991, Russia","institution_ids":["https://openalex.org/I4210122842"]},{"raw_affiliation_string":"Department of Physics, Moscow State University, 1 Vorobyevy gory, Moscow, 119991, Russia","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"National Research Center for Hematology, 4a Novyi Zykovskii pr., Moscow, 125167, Russia","institution_ids":["https://openalex.org/I4210100648"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5029278386"],"corresponding_institution_ids":["https://openalex.org/I4210100648"],"apc_list":null,"apc_paid":null,"fwci":2.074,"has_fulltext":true,"cited_by_count":71,"citation_normalized_percentile":{"value":0.86686629,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"4","issue":"1","first_page":"5","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9735000133514404,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9735000133514404,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coagulation","display_name":"Coagulation","score":0.7296984791755676},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"Tissue factor","score":0.7043768167495728},{"id":"https://openalex.org/keywords/thrombus","display_name":"Thrombus","score":0.6687663793563843},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4926369786262512},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"Negative feedback","score":0.48194098472595215},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.4771530032157898},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.46028652787208557},{"id":"https://openalex.org/keywords/tissue-factor-pathway-inhibitor","display_name":"Tissue factor pathway inhibitor","score":0.45330509543418884},{"id":"https://openalex.org/keywords/factor-v","display_name":"Factor V","score":0.42850661277770996},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.37710195779800415},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3536856174468994},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3509455919265747},{"id":"https://openalex.org/keywords/thrombosis","display_name":"Thrombosis","score":0.3457674980163574},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3328646421432495},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.26799386739730835},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.18828654289245605},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13459226489067078}],"concepts":[{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.7296984791755676},{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.7043768167495728},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.6687663793563843},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4926369786262512},{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.48194098472595215},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4771530032157898},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.46028652787208557},{"id":"https://openalex.org/C2777151630","wikidata":"https://www.wikidata.org/wiki/Q14878075","display_name":"Tissue factor pathway inhibitor","level":4,"score":0.45330509543418884},{"id":"https://openalex.org/C2776046644","wikidata":"https://www.wikidata.org/wiki/Q422831","display_name":"Factor V","level":3,"score":0.42850661277770996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37710195779800415},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3536856174468994},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3509455919265747},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.3457674980163574},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3328646421432495},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26799386739730835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18828654289245605},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13459226489067078},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005167","descriptor_name":"Factor VII","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005167","descriptor_name":"Factor VII","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005167","descriptor_name":"Factor VII","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015951","descriptor_name":"Factor Xa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015951","descriptor_name":"Factor Xa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015951","descriptor_name":"Factor Xa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-4-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20102623","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20102623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:dukespace.lib.duke.edu:10161/4386","is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/4386","pdf_url":null,"source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:pubmedcentral.nih.gov:2823678","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2823678","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.4000000059604645}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"},{"id":"https://openalex.org/F4320330091","display_name":"Moscow Institute of Physics and Technology","ror":"https://ror.org/00v0z9322"},{"id":"https://openalex.org/F4320334801","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1967085308.pdf","grobid_xml":"https://content.openalex.org/works/W1967085308.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W194949005","https://openalex.org/W1530591019","https://openalex.org/W1983973968","https://openalex.org/W1995899417","https://openalex.org/W1998233400","https://openalex.org/W1999694715","https://openalex.org/W2004336126","https://openalex.org/W2005654584","https://openalex.org/W2012802392","https://openalex.org/W2036284239","https://openalex.org/W2037887416","https://openalex.org/W2042957352","https://openalex.org/W2047786411","https://openalex.org/W2063284105","https://openalex.org/W2067045670","https://openalex.org/W2070976751","https://openalex.org/W2077012341","https://openalex.org/W2077864501","https://openalex.org/W2125573572","https://openalex.org/W2132984496","https://openalex.org/W2138328550","https://openalex.org/W2153530728","https://openalex.org/W4242443534","https://openalex.org/W4253382427"],"related_works":["https://openalex.org/W2040661685","https://openalex.org/W2381595026","https://openalex.org/W2038288110","https://openalex.org/W2263176790","https://openalex.org/W2977990172","https://openalex.org/W2273813768","https://openalex.org/W967179082","https://openalex.org/W2144242271","https://openalex.org/W1971013856","https://openalex.org/W2118966099"],"abstract_inverted_index":{"BACKGROUND:":[0],"Blood":[1],"coagulation":[2,68,156,208],"is":[3,11,16,113,160,194],"a":[4,37,63,72,83,99,117,195],"complex":[5],"network":[6],"of":[7,27,45,76,119,123,136,148,152,165,206],"biochemical":[8],"reactions,":[9],"which":[10],"peculiar":[12],"in":[13,24,40,66,82,95,98,102,182,210],"that":[14,34,88,111,192],"it":[15],"time-":[17],"and":[18,20,58,133,178,204],"space-dependent,":[19],"has":[21],"to":[22,49,54,59,116,158],"function":[23],"the":[25,67,96,120,142,146,163,174],"presence":[26],"rapid":[28],"flow.":[29],"Recent":[30],"experimental":[31,106],"reports":[32],"suggest":[33],"flow":[35,90,140],"plays":[36],"significant":[38],"role":[39],"its":[41],"regulation.":[42],"The":[43,150],"objective":[44],"this":[46,56,112,153,193],"study":[47],"was":[48],"use":[50],"systems":[51],"biology":[52],"techniques":[53],"investigate":[55],"regulation":[57],"identify":[60],"mechanisms":[61],"creating":[62],"flow-dependent":[64],"switch":[65,197],"onset.":[69],"RESULTS:":[70],"Using":[71],"detailed":[73],"mechanism-driven":[74],"model":[75,97],"tissue":[77,166],"factor":[78,125,130,137,167],"(TF)-initiated":[79],"thrombus":[80],"formation":[81,203],"two-dimensional":[84],"channel":[85],"we":[86],"demonstrate":[87],"blood":[89],"can":[91,189],"regulate":[92],"clotting":[93],"onset":[94],"threshold-like":[100],"manner,":[101],"agreement":[103],"with":[104,212],"existing":[105],"evidence.":[107],"Sensitivity":[108],"analysis":[109],"reveals":[110],"achieved":[114],"due":[115],"combination":[118],"positive":[121],"feedback":[122,147],"TF-bound":[124],"VII":[126],"activation":[127],"by":[128,139,162],"activated":[129],"X":[131],"(Xa)":[132],"effective":[134],"removal":[135],"Xa":[138],"from":[141,201],"activating":[143],"patch":[144],"depriving":[145],"\"ignition\".":[149],"level":[151],"trigger":[154],"(i.e.":[155],"sensitivity":[157],"flow)":[159],"controlled":[161],"activity":[164],"pathway":[168],"inhibitor.":[169],"CONCLUSIONS:":[170],"This":[171],"mechanism":[172],"explains":[173],"difference":[175],"between":[176],"red":[177],"white":[179],"thrombi":[180],"observed":[181],"vivo":[183],"at":[184],"different":[185],"shear":[186],"rates.":[187],"It":[188],"be":[190],"speculated":[191],"special":[196],"protecting":[198],"vascular":[199],"system":[200],"uncontrolled":[202],"spreading":[205],"active":[207],"factors":[209],"vessels":[211],"rapidly":[213],"flowing":[214],"blood.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}
