{"id":"https://openalex.org/W2113531097","doi":"https://doi.org/10.1186/1752-0509-4-35","title":"Prediction of novel synthetic pathways for the production of desired chemicals","display_name":"Prediction of novel synthetic pathways for the production of desired chemicals","publication_year":2010,"publication_date":"2010-03-28","ids":{"openalex":"https://openalex.org/W2113531097","doi":"https://doi.org/10.1186/1752-0509-4-35","mag":"2113531097","pmid":"https://pubmed.ncbi.nlm.nih.gov/20346180"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-35","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-35","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-35","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-35","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079252365","display_name":"Ayoun Cho","orcid":null},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Ayoun Cho","raw_affiliation_strings":["Department of Chemical & Biomolecular Engineering (BK21 program), KAIST, Daejeon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical & Biomolecular Engineering (BK21 program), KAIST, Daejeon, South Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024532352","display_name":"Hongseok Yun","orcid":"https://orcid.org/0000-0003-0497-6185"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hongseok Yun","raw_affiliation_strings":["Department of Chemical & Biomolecular Engineering (BK21 program), KAIST, Daejeon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical & Biomolecular Engineering (BK21 program), KAIST, Daejeon, South Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088406723","display_name":"Jin Hwan Park","orcid":"https://orcid.org/0000-0001-8384-7909"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Hwan Park","raw_affiliation_strings":["Department of Chemical & Biomolecular Engineering (BK21 program), KAIST, Daejeon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical & Biomolecular Engineering (BK21 program), KAIST, Daejeon, South Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100616675","display_name":"Sang Yup Lee","orcid":"https://orcid.org/0000-0003-0599-3091"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang Yup Lee","raw_affiliation_strings":["Department of Chemical & Biomolecular Engineering (BK21 program), KAIST, Daejeon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical & Biomolecular Engineering (BK21 program), KAIST, Daejeon, South Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073669041","display_name":"Sunwon Park","orcid":null},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sunwon Park","raw_affiliation_strings":["Department of Chemical & Biomolecular Engineering (BK21 program), KAIST, Daejeon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical & Biomolecular Engineering (BK21 program), KAIST, Daejeon, South Korea","institution_ids":["https://openalex.org/I157485424"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5079252365"],"corresponding_institution_ids":["https://openalex.org/I157485424"],"apc_list":null,"apc_paid":null,"fwci":5.1715,"has_fulltext":true,"cited_by_count":139,"citation_normalized_percentile":{"value":0.96293735,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"4","issue":"1","first_page":"35","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11053","display_name":"Process Optimization and Integration","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6388924717903137},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.6375093460083008},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6152287125587463},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.5866280794143677},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5651759505271912},{"id":"https://openalex.org/keywords/prioritization","display_name":"Prioritization","score":0.5070958137512207},{"id":"https://openalex.org/keywords/biological-pathway","display_name":"Biological pathway","score":0.4812643229961395},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.46880748867988586},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4559827446937561},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3340376317501068},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.33064278960227966},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.23057544231414795},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2003174126148224},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1373121738433838},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.123026043176651},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.09423711895942688}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6388924717903137},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.6375093460083008},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6152287125587463},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.5866280794143677},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5651759505271912},{"id":"https://openalex.org/C2777615720","wikidata":"https://www.wikidata.org/wiki/Q11888847","display_name":"Prioritization","level":2,"score":0.5070958137512207},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.4812643229961395},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.46880748867988586},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4559827446937561},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3340376317501068},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.33064278960227966},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23057544231414795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2003174126148224},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1373121738433838},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.123026043176651},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09423711895942688},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000440","descriptor_name":"Butanols","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000440","descriptor_name":"Butanols","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000440","descriptor_name":"Butanols","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002625","descriptor_name":"Chemistry, Organic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002625","descriptor_name":"Chemistry, Organic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002625","descriptor_name":"Chemistry, Organic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056804","descriptor_name":"Biofuels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056804","descriptor_name":"Biofuels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056804","descriptor_name":"Biofuels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-4-35","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-35","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-35","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20346180","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20346180","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:112af560271f402ba53a9de54a07487b","is_oa":false,"landing_page_url":"https://doaj.org/article/112af560271f402ba53a9de54a07487b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 4, Iss 1, p 35 (2010)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:1920505","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2873314","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:koasas.kaist.ac.kr:10203/23363","is_oa":false,"landing_page_url":"http://hdl.handle.net/10203/23363","pdf_url":null,"source":{"id":"https://openalex.org/S4306402435","display_name":"KAIST Institutional Repository (KAIST)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I157485424","host_organization_name":"Korea Advanced Institute of Science and Technology","host_organization_lineage":["https://openalex.org/I157485424"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-35","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-35","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-35","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/12","score":0.4399999976158142,"display_name":"Responsible consumption and production"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320322349","display_name":"Ministry of Education, Science and Technology","ror":"https://ror.org/01p262204"},{"id":"https://openalex.org/F4320330906","display_name":"LG Chem","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2113531097.pdf","grobid_xml":"https://content.openalex.org/works/W2113531097.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1530303756","https://openalex.org/W1536226251","https://openalex.org/W1550965069","https://openalex.org/W1958274537","https://openalex.org/W1975147762","https://openalex.org/W1975755330","https://openalex.org/W1978119727","https://openalex.org/W1980352552","https://openalex.org/W2002187478","https://openalex.org/W2014348203","https://openalex.org/W2022741035","https://openalex.org/W2038702914","https://openalex.org/W2045622192","https://openalex.org/W2049929499","https://openalex.org/W2054661806","https://openalex.org/W2058141842","https://openalex.org/W2060097376","https://openalex.org/W2068687524","https://openalex.org/W2073150308","https://openalex.org/W2083527495","https://openalex.org/W2083787774","https://openalex.org/W2090631504","https://openalex.org/W2092471565","https://openalex.org/W2092899907","https://openalex.org/W2099264865","https://openalex.org/W2102164505","https://openalex.org/W2104619491","https://openalex.org/W2110030937","https://openalex.org/W2126943212","https://openalex.org/W2128746754","https://openalex.org/W2132250012","https://openalex.org/W2133298156","https://openalex.org/W2135206190","https://openalex.org/W2148842928","https://openalex.org/W2149939875","https://openalex.org/W2152488335","https://openalex.org/W2159482845","https://openalex.org/W2168504993","https://openalex.org/W2487453307","https://openalex.org/W2498752956","https://openalex.org/W2911346016","https://openalex.org/W4251903194","https://openalex.org/W4285719527","https://openalex.org/W4294216483","https://openalex.org/W4298226842"],"related_works":["https://openalex.org/W2057769265","https://openalex.org/W2338895903","https://openalex.org/W1911418903","https://openalex.org/W3044523069","https://openalex.org/W2024161258","https://openalex.org/W2136248167","https://openalex.org/W2126646394","https://openalex.org/W2211443823","https://openalex.org/W3144585500","https://openalex.org/W4211049090"],"abstract_inverted_index":{"BACKGROUND:":[0],"There":[1],"have":[2],"been":[3],"several":[4],"methods":[5,60],"developed":[6,243],"for":[7,103,202,250,262],"the":[8,16,39,72,77,99,104,125,173,194,198,203,227,231,240,251,263],"prediction":[9,213],"of":[10,18,45,58,106,141,156,161,178,196,205,230,255,266],"synthetic":[11,175,189,200,222],"metabolic":[12,257],"pathways":[13,25,102,144,201,223,258],"leading":[14],"to":[15,50,53,69,71,145,171,259],"production":[17,204,265],"desired":[19,108],"chemicals.":[20],"In":[21,76,152],"these":[22,59,179],"approaches,":[23],"novel":[24,100,199,256],"were":[26,167,210,224],"predicted":[27,46],"based":[28,116],"on":[29,62,113,117],"chemical":[30,109],"structure":[31],"changes,":[32],"enzymatic":[33],"information,":[34],"and/or":[35],"reaction":[36,121],"mechanisms,":[37],"but":[38],"approaches":[40],"generating":[41],"a":[42,82,86,90,107,186,215],"huge":[43],"number":[44],"results":[47],"are":[48,67],"difficult":[49],"be":[51,182,248,260],"applied":[52],"real":[54],"experiments.":[55],"Also,":[56],"some":[57],"focus":[61],"specific":[63],"pathways,":[64],"and":[65,120,135,164,208,269],"thus":[66],"limited":[68],"expansion":[70],"whole":[73],"metabolism.":[74],"RESULTS:":[75],"present":[78,123],"study,":[79],"we":[80],"propose":[81],"system":[83,126,241],"framework":[84,242],"employing":[85,132],"retrosynthesis":[87],"model":[88],"with":[89,111],"prioritization":[91,129],"scoring":[92,130],"algorithm.":[93],"This":[94],"new":[95,154],"strategy":[96],"allows":[97,139],"deducing":[98],"promising":[101],"synthesis":[105],"together":[110],"information":[112],"enzymes":[114],"involved":[115],"structural":[118],"changes":[119],"mechanisms":[122],"in":[124,218,244,252],"database.":[127],"The":[128,212],"algorithm":[131],"Tanimoto":[133],"coefficient":[134],"group":[136],"contribution":[137],"method":[138],"examination":[140],"structurally":[142],"qualified":[143],"recognize":[146],"which":[147,219],"pathway":[148,162,190,233],"is":[149,191,237],"more":[150],"appropriate.":[151],"addition,":[153],"concepts":[155],"binding":[157],"site":[158],"covalence,":[159],"estimation":[160],"distance":[163],"organism":[165],"specificity":[166],"taken":[168],"into":[169],"account":[170],"identify":[172],"best":[174],"pathway.":[176],"Parameters":[177],"factors":[180],"can":[181],"evolutionarily":[183],"optimized":[184],"when":[185],"newly":[187],"proven":[188],"registered.":[192],"As":[193],"proofs":[195],"concept,":[197],"isobutanol,":[206],"3-hydroxypropionate,":[207],"butyryl-CoA":[209],"predicted.":[211],"shows":[214],"high":[216],"reliability,":[217],"experimentally":[220],"verified":[221],"listed":[225],"within":[226],"top":[228],"0.089%":[229],"identified":[232],"candidates.":[234],"CONCLUSIONS:":[235],"It":[236],"expected":[238],"that":[239],"this":[245],"study":[246],"would":[247],"useful":[249],"silico":[253],"design":[254],"employed":[261],"efficient":[264],"chemicals,":[267],"fuels":[268],"materials.":[270]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":15}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}