{"id":"https://openalex.org/W2138767597","doi":"https://doi.org/10.1186/1752-0509-4-31","title":"Genome-scale metabolic analysis of Clostridium thermocellum for bioethanol production","display_name":"Genome-scale metabolic analysis of Clostridium thermocellum for bioethanol production","publication_year":2010,"publication_date":"2010-03-22","ids":{"openalex":"https://openalex.org/W2138767597","doi":"https://doi.org/10.1186/1752-0509-4-31","mag":"2138767597","pmid":"https://pubmed.ncbi.nlm.nih.gov/20307315"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-31","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-31","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-31","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-31","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032126274","display_name":"Seth B. Roberts","orcid":null},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Seth B Roberts","raw_affiliation_strings":["Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA","Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, 23284, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, 23284, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027492383","display_name":"Christopher M. Gowen","orcid":null},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M Gowen","raw_affiliation_strings":["Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, 23284, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, 23284, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020628068","display_name":"J. Paul Brooks","orcid":"https://orcid.org/0000-0003-0423-8422"},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Paul Brooks","raw_affiliation_strings":["Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, 23284, USA","Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, Richmond, VA, 23284, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, 23284, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, Richmond, VA, 23284, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047715802","display_name":"Stephen S. Fong","orcid":"https://orcid.org/0000-0003-2171-7783"},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen S Fong","raw_affiliation_strings":["Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, 23284, USA","Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, 23284, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, 23284, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, 23284, USA","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5032126274"],"corresponding_institution_ids":["https://openalex.org/I184840846"],"apc_list":null,"apc_paid":null,"fwci":9.3467,"has_fulltext":true,"cited_by_count":116,"citation_normalized_percentile":{"value":0.98489219,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"4","issue":"1","first_page":"31","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.4821000099182129,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.4821000099182129,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.4374000132083893,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clostridium-thermocellum","display_name":"Clostridium thermocellum","score":0.9801229238510132},{"id":"https://openalex.org/keywords/cellobiose","display_name":"Cellobiose","score":0.7737453579902649},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.6343948841094971},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"Metabolic engineering","score":0.5952736139297485},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5579255223274231},{"id":"https://openalex.org/keywords/ethanol-fuel","display_name":"Ethanol fuel","score":0.5042546987533569},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.4943084716796875},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4442852735519409},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.4297764301300049},{"id":"https://openalex.org/keywords/biofuel","display_name":"Biofuel","score":0.38024619221687317},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.3254047632217407},{"id":"https://openalex.org/keywords/biotechnology","display_name":"Biotechnology","score":0.31007975339889526},{"id":"https://openalex.org/keywords/cellulose","display_name":"Cellulose","score":0.272611141204834},{"id":"https://openalex.org/keywords/cellulase","display_name":"Cellulase","score":0.23891401290893555},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.23821932077407837},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.17957830429077148}],"concepts":[{"id":"https://openalex.org/C2776061948","wikidata":"https://www.wikidata.org/wiki/Q3681172","display_name":"Clostridium thermocellum","level":4,"score":0.9801229238510132},{"id":"https://openalex.org/C2780412358","wikidata":"https://www.wikidata.org/wiki/Q409017","display_name":"Cellobiose","level":4,"score":0.7737453579902649},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.6343948841094971},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.5952736139297485},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5579255223274231},{"id":"https://openalex.org/C65183824","wikidata":"https://www.wikidata.org/wiki/Q194361","display_name":"Ethanol fuel","level":3,"score":0.5042546987533569},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.4943084716796875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4442852735519409},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4297764301300049},{"id":"https://openalex.org/C53991642","wikidata":"https://www.wikidata.org/wiki/Q128991","display_name":"Biofuel","level":2,"score":0.38024619221687317},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3254047632217407},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.31007975339889526},{"id":"https://openalex.org/C2779251873","wikidata":"https://www.wikidata.org/wiki/Q80294","display_name":"Cellulose","level":2,"score":0.272611141204834},{"id":"https://openalex.org/C141603559","wikidata":"https://www.wikidata.org/wiki/Q410324","display_name":"Cellulase","level":3,"score":0.23891401290893555},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23821932077407837},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.17957830429077148},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002475","descriptor_name":"Cellobiose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002475","descriptor_name":"Cellobiose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002475","descriptor_name":"Cellobiose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002475","descriptor_name":"Cellobiose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D048013","descriptor_name":"Acetivibrio thermocellus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048013","descriptor_name":"Clostridium thermocellum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048013","descriptor_name":"Clostridium thermocellum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048013","descriptor_name":"Clostridium thermocellum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056804","descriptor_name":"Biofuels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056804","descriptor_name":"Biofuels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056804","descriptor_name":"Biofuels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056804","descriptor_name":"Biofuels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-4-31","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-31","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-31","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20307315","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20307315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:scholarscompass.vcu.edu:clse_pubs-1000","is_oa":true,"landing_page_url":"https://scholarscompass.vcu.edu/clse_pubs/1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196340","display_name":"VCU Scholars Compass (Virginia Commonwealth University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I184840846","host_organization_name":"Virginia Commonwealth University","host_organization_lineage":["https://openalex.org/I184840846"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chemical and Life Science Engineering Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:025f9d9239de413a8ad7c81bdc333126","is_oa":false,"landing_page_url":"https://doaj.org/article/025f9d9239de413a8ad7c81bdc333126","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 4, Iss 1, p 31 (2010)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2852388","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2852388","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-31","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-31","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-31","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4399999976158142,"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2138767597.pdf","grobid_xml":"https://content.openalex.org/works/W2138767597.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1484645182","https://openalex.org/W1522565043","https://openalex.org/W1530832038","https://openalex.org/W1597762351","https://openalex.org/W1607116854","https://openalex.org/W1758395617","https://openalex.org/W1801056996","https://openalex.org/W1807501879","https://openalex.org/W1919620633","https://openalex.org/W1956876165","https://openalex.org/W1965516093","https://openalex.org/W1966590368","https://openalex.org/W1967467383","https://openalex.org/W1969253588","https://openalex.org/W1976266924","https://openalex.org/W1980207389","https://openalex.org/W1983560298","https://openalex.org/W1990717355","https://openalex.org/W1992306474","https://openalex.org/W1996912752","https://openalex.org/W1997600775","https://openalex.org/W2003489966","https://openalex.org/W2004964623","https://openalex.org/W2008715595","https://openalex.org/W2008875008","https://openalex.org/W2009990638","https://openalex.org/W2016995298","https://openalex.org/W2019631913","https://openalex.org/W2029014086","https://openalex.org/W2037718952","https://openalex.org/W2045167474","https://openalex.org/W2048214825","https://openalex.org/W2051825569","https://openalex.org/W2058867396","https://openalex.org/W2062245653","https://openalex.org/W2068872007","https://openalex.org/W2072280409","https://openalex.org/W2073356036","https://openalex.org/W2075833540","https://openalex.org/W2079531107","https://openalex.org/W2083011190","https://openalex.org/W2090385974","https://openalex.org/W2096245011","https://openalex.org/W2096306398","https://openalex.org/W2098839738","https://openalex.org/W2104108767","https://openalex.org/W2106806321","https://openalex.org/W2121108655","https://openalex.org/W2123060905","https://openalex.org/W2130364940","https://openalex.org/W2139209048","https://openalex.org/W2140861527","https://openalex.org/W2144944670","https://openalex.org/W2146033561","https://openalex.org/W2152186211","https://openalex.org/W2157635835","https://openalex.org/W2159482845","https://openalex.org/W2161062388","https://openalex.org/W2165674132","https://openalex.org/W2170270393","https://openalex.org/W4211054902","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W125249894","https://openalex.org/W4250322851","https://openalex.org/W2072437253","https://openalex.org/W1831867993","https://openalex.org/W2974920611","https://openalex.org/W2064316050","https://openalex.org/W1873018053","https://openalex.org/W2010202833","https://openalex.org/W1489178042","https://openalex.org/W1964419855"],"abstract_inverted_index":{"BACKGROUND:":[0],"Microorganisms":[1],"possess":[2],"diverse":[3],"metabolic":[4,99,138,266],"capabilities":[5],"that":[6,24,31,205,232],"can":[7,33],"potentially":[8],"be":[9],"leveraged":[10],"for":[11,52,88,111,145,172,197,249,268],"efficient":[12],"production":[13,54,64],"of":[14,68,83,91,101,117,130,135,150,152,159,189,199,221,241,271],"biofuels.":[15],"Clostridium":[16],"thermocellum":[17,85,103,110,243,273],"(ATCC":[18],"27405)":[19],"is":[20,25,55,73,233],"a":[21,80,93,127,131,230,246],"thermophilic":[22],"anaerobe":[23],"both":[26],"cellulolytic":[27],"and":[28,40,104,126,148,168,176,192,195,202,218,224,244,274],"ethanologenic,":[29],"meaning":[30],"it":[32,43],"directly":[34],"use":[35],"the":[36,56,60,89,98,160,183,186,190,238,264,279],"plant":[37],"sugar,":[38],"cellulose,":[39],"biochemically":[41],"convert":[42],"to":[44,58,62,96,107,141,258],"ethanol.":[45],"A":[46],"major":[47],"challenge":[48],"in":[49,278],"using":[50,165,179],"microorganisms":[51],"chemical":[53],"need":[57],"modify":[59],"organism":[61,72],"increase":[63,207],"efficiency.":[65],"The":[66,114,133,157],"process":[67,134],"properly":[69],"engineering":[70],"an":[71],"typically":[74],"arduous.":[75],"RESULTS:":[76],"Here":[77],"we":[78,227,255],"present":[79],"genome-scale":[81],"model":[82,115,139,162,181,231],"C.":[84,102,109,242,272],"metabolism,":[86],"iSR432,":[87],"purpose":[90],"establishing":[92],"computational":[94],"tool":[95],"study":[97],"network":[100,216],"facilitate":[105],"efforts":[106],"engineer":[108],"biofuel":[112],"production.":[113,209],"consists":[116],"577":[118],"reactions":[119],"involving":[120],"525":[121],"intracellular":[122],"metabolites,":[123],"432":[124],"genes,":[125],"proteomic-based":[128],"representation":[129],"cellulosome.":[132],"constructing":[136],"this":[137,180],"led":[140],"suggested":[142],"annotation":[143],"refinements":[144],"27":[146],"genes":[147],"identification":[149],"areas":[151],"metabolism":[153],"requiring":[154],"further":[155],"study.":[156],"accuracy":[158],"iSR432":[161],"was":[163],"tested":[164],"experimental":[166,219],"growth":[167,173],"by-product":[169],"secretion":[170,194],"data":[171],"on":[174],"cellobiose":[175],"fructose.":[177],"Analysis":[178],"captures":[182],"relationship":[184],"between":[185],"reduction-oxidation":[187],"state":[188],"cell":[191],"ethanol":[193,208],"allowed":[196],"prediction":[198],"gene":[200],"deletions":[201],"environmental":[203],"conditions":[204],"would":[206],"CONCLUSIONS:":[210],"By":[211],"incorporating":[212],"genomic":[213],"sequence":[214],"data,":[215],"topology,":[217],"measurements":[220],"enzyme":[222],"activities":[223],"metabolite":[225],"fluxes,":[226],"have":[228],"generated":[229],"reasonably":[234],"accurate":[235],"at":[236],"predicting":[237],"cellular":[239],"phenotype":[240],"establish":[245],"strong":[247],"foundation":[248],"rational":[250],"strain":[251],"design.":[252],"In":[253],"addition,":[254],"are":[256],"able":[257],"draw":[259],"some":[260],"important":[261],"conclusions":[262],"regarding":[263],"underlying":[265],"mechanisms":[267],"observed":[269],"behaviors":[270],"highlight":[275],"remaining":[276],"gaps":[277],"existing":[280],"genome":[281],"annotations.":[282]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":12}],"updated_date":"2026-05-17T08:19:37.847499","created_date":"2025-10-10T00:00:00"}
