{"id":"https://openalex.org/W2127113094","doi":"https://doi.org/10.1186/1752-0509-4-169","title":"Defining the antigen receptor-dependent regulatory network that induces arrest of cycling immature B-lymphocytes","display_name":"Defining the antigen receptor-dependent regulatory network that induces arrest of cycling immature B-lymphocytes","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2127113094","doi":"https://doi.org/10.1186/1752-0509-4-169","mag":"2127113094","pmid":"https://pubmed.ncbi.nlm.nih.gov/21143896"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-169","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-169","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-169","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-169","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030909615","display_name":"Mohammad Sarwar Jamal","orcid":"https://orcid.org/0000-0001-7044-887X"},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IN","IT"],"is_corresponding":false,"raw_author_name":"Mohammad Sarwar Jamal","raw_affiliation_strings":["International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India","Immunology Group International Centre for Genetic Engineering and Biotechnology Aruna Asaf Ali Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210142124"]},{"raw_affiliation_string":"Immunology Group International Centre for Genetic Engineering and Biotechnology Aruna Asaf Ali Marg, New Delhi, India","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090979500","display_name":"Srikanth Ravichandran","orcid":null},"institutions":[{"id":"https://openalex.org/I110166357","display_name":"University of Delhi","ror":"https://ror.org/04gzb2213","country_code":"IN","type":"education","lineage":["https://openalex.org/I110166357"]},{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IN","IT"],"is_corresponding":false,"raw_author_name":"Srikanth Ravichandran","raw_affiliation_strings":["Department of Physics and Astrophysics, University of Delhi, New Delhi, 110007, India","Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India","Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg","University of Delhi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Astrophysics, University of Delhi, New Delhi, 110007, India","institution_ids":["https://openalex.org/I110166357"]},{"raw_affiliation_string":"Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India","institution_ids":["https://openalex.org/I4210142124"]},{"raw_affiliation_string":"Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg","institution_ids":["https://openalex.org/I91080651"]},{"raw_affiliation_string":"University of Delhi","institution_ids":["https://openalex.org/I110166357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087303673","display_name":"Noor Jailkhani","orcid":"https://orcid.org/0000-0002-4933-1068"},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IN","IT"],"is_corresponding":false,"raw_author_name":"Noor Jailkhani","raw_affiliation_strings":["Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India","Immunology Group International Centre for Genetic Engineering and Biotechnology Aruna Asaf Ali Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India","institution_ids":["https://openalex.org/I4210142124"]},{"raw_affiliation_string":"Immunology Group International Centre for Genetic Engineering and Biotechnology Aruna Asaf Ali Marg, New Delhi, India","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082491317","display_name":"Samrat Chatterjee","orcid":"https://orcid.org/0000-0002-5010-2799"},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IN","IT"],"is_corresponding":false,"raw_author_name":"Samrat Chatterjee","raw_affiliation_strings":["Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India","Immunology Group International Centre for Genetic Engineering and Biotechnology Aruna Asaf Ali Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India","institution_ids":["https://openalex.org/I4210142124"]},{"raw_affiliation_string":"Immunology Group International Centre for Genetic Engineering and Biotechnology Aruna Asaf Ali Marg, New Delhi, India","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053617180","display_name":"Raina Dua","orcid":null},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IN","IT"],"is_corresponding":false,"raw_author_name":"Raina Dua","raw_affiliation_strings":["Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India","Immunology Group International Centre for Genetic Engineering and Biotechnology Aruna Asaf Ali Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India","institution_ids":["https://openalex.org/I4210142124"]},{"raw_affiliation_string":"Immunology Group International Centre for Genetic Engineering and Biotechnology Aruna Asaf Ali Marg, New Delhi, India","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027945117","display_name":"Kanury V. S. Rao","orcid":"https://orcid.org/0000-0002-7612-4822"},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IN","IT"],"is_corresponding":true,"raw_author_name":"Kanury VS Rao","raw_affiliation_strings":["Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India","Immunology Group International Centre for Genetic Engineering and Biotechnology Aruna Asaf Ali Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India","institution_ids":["https://openalex.org/I4210142124"]},{"raw_affiliation_string":"Immunology Group International Centre for Genetic Engineering and Biotechnology Aruna Asaf Ali Marg, New Delhi, India","institution_ids":["https://openalex.org/I91080651"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027945117"],"corresponding_institution_ids":["https://openalex.org/I4210142124","https://openalex.org/I91080651"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.1079,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.50679014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"4","issue":"1","first_page":"169","last_page":"169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9348999857902527,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9348999857902527,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.7181229591369629},{"id":"https://openalex.org/keywords/lyn","display_name":"LYN","score":0.6540372371673584},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6344054937362671},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.5187544822692871},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.4535239636898041},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.43393951654434204},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.41701340675354004},{"id":"https://openalex.org/keywords/b-cell-receptor","display_name":"B-cell receptor","score":0.41685670614242554},{"id":"https://openalex.org/keywords/central-tolerance","display_name":"Central tolerance","score":0.41273194551467896},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"Tyrosine kinase","score":0.3226293623447418},{"id":"https://openalex.org/keywords/t-cell","display_name":"T cell","score":0.31739962100982666},{"id":"https://openalex.org/keywords/b-cell","display_name":"B cell","score":0.25980859994888306},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.20783144235610962},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.11878341436386108},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10984617471694946},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1003696620464325}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7181229591369629},{"id":"https://openalex.org/C175818844","wikidata":"https://www.wikidata.org/wiki/Q2463389","display_name":"LYN","level":4,"score":0.6540372371673584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6344054937362671},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5187544822692871},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4535239636898041},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43393951654434204},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.41701340675354004},{"id":"https://openalex.org/C157695867","wikidata":"https://www.wikidata.org/wiki/Q1100474","display_name":"B-cell receptor","level":4,"score":0.41685670614242554},{"id":"https://openalex.org/C2778830056","wikidata":"https://www.wikidata.org/wiki/Q606766","display_name":"Central tolerance","level":4,"score":0.41273194551467896},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.3226293623447418},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.31739962100982666},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.25980859994888306},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20783144235610962},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.11878341436386108},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10984617471694946},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1003696620464325},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019307","descriptor_name":"1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019307","descriptor_name":"1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019307","descriptor_name":"1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019307","descriptor_name":"1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019307","descriptor_name":"1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019307","descriptor_name":"1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-4-169","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-169","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-169","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:21143896","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21143896","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:a3bdc39f4ea64a7f82a9006b5a110877","is_oa":false,"landing_page_url":"https://doaj.org/article/a3bdc39f4ea64a7f82a9006b5a110877","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 4, Iss 1, p 169 (2010)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3004859","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3004859","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-169","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-169","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-169","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7200000286102295,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2127113094.pdf","grobid_xml":"https://content.openalex.org/works/W2127113094.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W157090488","https://openalex.org/W202503473","https://openalex.org/W1498243670","https://openalex.org/W1500368251","https://openalex.org/W1589053023","https://openalex.org/W1601529283","https://openalex.org/W1736650634","https://openalex.org/W1858869267","https://openalex.org/W1888783223","https://openalex.org/W1968332969","https://openalex.org/W1981755459","https://openalex.org/W1982673353","https://openalex.org/W1990529844","https://openalex.org/W1996153912","https://openalex.org/W1996812791","https://openalex.org/W2003487528","https://openalex.org/W2011713160","https://openalex.org/W2011726658","https://openalex.org/W2016515395","https://openalex.org/W2016608590","https://openalex.org/W2017298826","https://openalex.org/W2025383376","https://openalex.org/W2030185879","https://openalex.org/W2037442572","https://openalex.org/W2037734776","https://openalex.org/W2045640927","https://openalex.org/W2046533194","https://openalex.org/W2052458695","https://openalex.org/W2052750950","https://openalex.org/W2054011315","https://openalex.org/W2061425021","https://openalex.org/W2063747149","https://openalex.org/W2065934473","https://openalex.org/W2066603202","https://openalex.org/W2068385982","https://openalex.org/W2071984843","https://openalex.org/W2076980233","https://openalex.org/W2081994887","https://openalex.org/W2087535194","https://openalex.org/W2097698606","https://openalex.org/W2099488350","https://openalex.org/W2100755177","https://openalex.org/W2102709557","https://openalex.org/W2105708181","https://openalex.org/W2106852219","https://openalex.org/W2108036428","https://openalex.org/W2109444989","https://openalex.org/W2110079308","https://openalex.org/W2117123429","https://openalex.org/W2123280311","https://openalex.org/W2127245021","https://openalex.org/W2130687290","https://openalex.org/W2131706188","https://openalex.org/W2139374966","https://openalex.org/W2146458813","https://openalex.org/W2154776006","https://openalex.org/W2155320925","https://openalex.org/W2162152190","https://openalex.org/W2162857699","https://openalex.org/W2163114708","https://openalex.org/W2163480486","https://openalex.org/W2165392091","https://openalex.org/W2201242299","https://openalex.org/W2419099630","https://openalex.org/W2916288174","https://openalex.org/W4247904703","https://openalex.org/W4255855797","https://openalex.org/W4256647194","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4234271408","https://openalex.org/W4237778989","https://openalex.org/W2003423830","https://openalex.org/W2000911314","https://openalex.org/W4245949927","https://openalex.org/W1993879491","https://openalex.org/W2415251987","https://openalex.org/W2538059914","https://openalex.org/W2036575265","https://openalex.org/W1533251160"],"abstract_inverted_index":{"BACKGROUND:":[0],"Engagement":[1],"of":[2,32,66,73,81,93,100,110,114,121,137,144,160,164,192,208,226,235,238],"the":[3,35,64,71,78,82,101,108,118,126,134,145,155,161,180,190,193,202,219,223,227,236,246,251],"antigen":[4,102,194],"receptor":[5,195,262],"on":[6],"immature":[7,74,258],"B-lymphocytes":[8],"leads":[9],"to":[10,62,107,151,196,218,250],"cell":[11,83,127],"cycle":[12],"arrest,":[13],"and":[14,199,254],"subsequent":[15,255],"apoptosis.":[16],"This":[17,104],"is":[18,40,42],"an":[19,232],"essential":[20],"process":[21],"for":[22],"eliminating":[23],"self":[24],"reactive":[25],"B":[26,75,259],"cells":[27,76,260],"during":[28],"its":[29],"different":[30],"stages":[31],"development.":[33],"However,":[34],"mechanism":[36],"by":[37],"which":[38,170],"it":[39],"achieved":[41],"not":[43],"completely":[44],"understood.":[45],"RESULTS:":[46],"Here":[47],"we":[48,86],"employed":[49],"a":[50,90,111,158,175,212],"systems":[51],"biology":[52],"approach":[53],"that":[54,69,88,133,222],"combined":[55],"extensive":[56],"experimentation":[57],"with":[58,117],"in":[59,77,125,167,257],"silico":[60],"methodologies":[61],"chart":[63],"network":[65,92],"receptor-activated":[67],"pathways":[68,140],"mediated":[70],"arrest":[72,253],"G1":[79,252],"phase":[80],"cycle.":[84],"Interestingly,":[85],"found":[87],"only":[89],"sparse":[91],"signaling":[94,139,204,229],"intermediates":[95],"was":[96,157,171],"recruited":[97],"upon":[98,261],"engagement":[99],"receptor.":[103],"then":[105,188],"led":[106],"activation":[109,163],"restricted":[112],"subset":[113],"transcription":[115],"factors,":[116],"consequent":[119],"induction":[120],"genes":[122],"primarily":[123],"involved":[124],"death":[128],"pathway.":[129],"Subsequent":[130],"experiments":[131],"revealed":[132],"weak":[135],"initiation":[136],"intracellular":[138,228],"derived":[141],"from":[142],"desensitization":[143,156],"receptor-proximal":[146],"protein":[147],"tyrosine":[148],"kinase":[149,166],"Lyn,":[150,198],"receptor-dependent":[152],"activation.":[153,263],"Intriguingly,":[154],"result":[159],"constitutive":[162],"this":[165],"unstimulated":[168],"cells,":[169],"likely":[172],"maintained":[173],"through":[174],"regulatory":[176],"feedback":[177],"loop":[178],"involving":[179],"p38":[181],"MAP":[182],"kinase.":[183],"The":[184],"high":[185],"basal":[186],"activity":[187],"attenuated":[189],"ability":[191],"recruit":[197],"thereby":[200],"also":[201],"downstream":[203],"intermediates.":[205],"Finally,":[206],"integration":[207],"these":[209],"results":[210,244],"into":[211],"mathematical":[213],"model":[214],"provided":[215],"further":[216],"substantiation":[217],"novel":[220],"finding":[221],"ground":[224],"state":[225],"machinery":[230],"constitutes":[231],"important":[233],"determinant":[234],"outcome":[237],"receptor-induced":[239],"cellular":[240],"responses.":[241],"CONCLUSIONS:":[242],"Our":[243],"identify":[245],"global":[247],"events":[248],"leading":[249],"apoptosis":[256]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}
