{"id":"https://openalex.org/W2113088508","doi":"https://doi.org/10.1186/1752-0509-4-163","title":"Integrated analysis of mutations, miRNA and mRNA expression in glioblastoma","display_name":"Integrated analysis of mutations, miRNA and mRNA expression in glioblastoma","publication_year":2010,"publication_date":"2010-11-29","ids":{"openalex":"https://openalex.org/W2113088508","doi":"https://doi.org/10.1186/1752-0509-4-163","mag":"2113088508","pmid":"https://pubmed.ncbi.nlm.nih.gov/21114830"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-163","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-163","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-163","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-163","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109219344","display_name":"Hua Dong","orcid":"https://orcid.org/0009-0001-3064-4777"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":null,"type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Hua Dong","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China","State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China","Human Genetics Center, The University of Texas School of Public Health, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]},{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]},{"raw_affiliation_string":"Human Genetics Center, The University of Texas School of Public Health, Houston, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009034219","display_name":"Li Luo","orcid":"https://orcid.org/0000-0003-0728-8628"},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Luo","raw_affiliation_strings":["Human Genetics Center, The University of Texas School of Public Health, Houston, TX, 77030, USA","Human Genetics Center, The University of Texas School of Public Health, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genetics Center, The University of Texas School of Public Health, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Human Genetics Center, The University of Texas School of Public Health, Houston, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090786133","display_name":"Shengjun Hong","orcid":"https://orcid.org/0000-0002-1753-8777"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":null,"type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengjun Hong","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China","State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]},{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073598161","display_name":"Hoicheong Siu","orcid":null},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":null,"type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hoicheong Siu","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China","State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]},{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090455375","display_name":"Yanghua Xiao","orcid":"https://orcid.org/0000-0001-8403-9591"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanghua Xiao","raw_affiliation_strings":["Department of Computing and Information Technology, Shanghai (International) Database Research Center, Fudan University, Shanghai, 200433, China","Department of Computing and Information Technology, Shanghai (International) Database Research Center, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computing and Information Technology, Shanghai (International) Database Research Center, Fudan University, Shanghai, 200433, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Computing and Information Technology, Shanghai (International) Database Research Center, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100364769","display_name":"Jin Li","orcid":"https://orcid.org/0000-0001-9201-2321"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":null,"type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Jin","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China","State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]},{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403643","display_name":"Rui Chen","orcid":"https://orcid.org/0000-0002-4387-9735"},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rui Chen","raw_affiliation_strings":["Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA","Department of Molecular and Human Genetics Baylor College of Medicine, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Molecular and Human Genetics Baylor College of Medicine, Houston, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017745566","display_name":"Momiao Xiong","orcid":"https://orcid.org/0000-0003-0635-5796"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":null,"type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Momiao Xiong","raw_affiliation_strings":["Human Genetics Center, The University of Texas School of Public Health, Houston, TX, 77030, USA","State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China","State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China","Human Genetics Center, The University of Texas School of Public Health, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genetics Center, The University of Texas School of Public Health, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]},{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]},{"raw_affiliation_string":"Human Genetics Center, The University of Texas School of Public Health, Houston, USA","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5017745566"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242","https://openalex.org/I919571938"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":3.7336,"has_fulltext":true,"cited_by_count":103,"citation_normalized_percentile":{"value":0.94096685,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"4","issue":"1","first_page":"163","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.46869999170303345,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.46869999170303345,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.10000000149011612,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0430000014603138,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"Expression quantitative trait loci","score":0.8542371988296509},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.8035339117050171},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7058184742927551},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6263295412063599},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5978101491928101},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"Loss of heterozygosity","score":0.55757075548172},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5200424194335938},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.44616618752479553},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4259568452835083},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4237607419490814},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4131002128124237},{"id":"https://openalex.org/keywords/allele","display_name":"Allele","score":0.1708730161190033},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.1689830720424652},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.08246716856956482}],"concepts":[{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.8542371988296509},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8035339117050171},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7058184742927551},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6263295412063599},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5978101491928101},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.55757075548172},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5200424194335938},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.44616618752479553},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4259568452835083},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4237607419490814},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4131002128124237},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.1708730161190033},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.1689830720424652},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08246716856956482}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-4-163","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-163","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-163","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:21114830","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21114830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:edeabf84fb0f4e45b2840ec660c3d4c4","is_oa":false,"landing_page_url":"https://doaj.org/article/edeabf84fb0f4e45b2840ec660c3d4c4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 4, Iss 1, p 163 (2010)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2026454","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3002314","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-163","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-163","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-163","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6000000238418579,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G7833857214","display_name":null,"funder_award_id":"P50 AR054144-01","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7907984223","display_name":null,"funder_award_id":"P01 AR052915-01A1","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8066770347","display_name":null,"funder_award_id":"R01AR057120-01","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2113088508.pdf","grobid_xml":"https://content.openalex.org/works/W2113088508.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W152206099","https://openalex.org/W1529267387","https://openalex.org/W1534214108","https://openalex.org/W1572687140","https://openalex.org/W1580788756","https://openalex.org/W1602254130","https://openalex.org/W1950498857","https://openalex.org/W1970633843","https://openalex.org/W1978834849","https://openalex.org/W1979181492","https://openalex.org/W1980541971","https://openalex.org/W1984154404","https://openalex.org/W1985923121","https://openalex.org/W1989851006","https://openalex.org/W1993330342","https://openalex.org/W1999555459","https://openalex.org/W2001334414","https://openalex.org/W2004805860","https://openalex.org/W2012642411","https://openalex.org/W2015631955","https://openalex.org/W2017199818","https://openalex.org/W2017435031","https://openalex.org/W2019963171","https://openalex.org/W2021572567","https://openalex.org/W2023568503","https://openalex.org/W2025183726","https://openalex.org/W2028395883","https://openalex.org/W2029387902","https://openalex.org/W2030613016","https://openalex.org/W2032766715","https://openalex.org/W2034595398","https://openalex.org/W2034672926","https://openalex.org/W2035459770","https://openalex.org/W2035947233","https://openalex.org/W2037631027","https://openalex.org/W2040827479","https://openalex.org/W2041725399","https://openalex.org/W2058148991","https://openalex.org/W2065566217","https://openalex.org/W2065899119","https://openalex.org/W2066715779","https://openalex.org/W2067961704","https://openalex.org/W2075728036","https://openalex.org/W2078653684","https://openalex.org/W2092501057","https://openalex.org/W2104517740","https://openalex.org/W2106278308","https://openalex.org/W2106599302","https://openalex.org/W2107580398","https://openalex.org/W2113390076","https://openalex.org/W2115421008","https://openalex.org/W2118054479","https://openalex.org/W2120294133","https://openalex.org/W2121936213","https://openalex.org/W2126394078","https://openalex.org/W2127787180","https://openalex.org/W2128139892","https://openalex.org/W2128768066","https://openalex.org/W2139128338","https://openalex.org/W2142798790","https://openalex.org/W2146684369","https://openalex.org/W2149661262","https://openalex.org/W2150169944","https://openalex.org/W2151794458","https://openalex.org/W2155818262","https://openalex.org/W2156247618","https://openalex.org/W2158217645","https://openalex.org/W2165867280","https://openalex.org/W4238448376","https://openalex.org/W4320800138"],"related_works":["https://openalex.org/W2020355323","https://openalex.org/W3012307849","https://openalex.org/W2010571965","https://openalex.org/W2602141149","https://openalex.org/W2002709996","https://openalex.org/W3128451840","https://openalex.org/W4387092964","https://openalex.org/W2103471012","https://openalex.org/W2966064480","https://openalex.org/W2380236774"],"abstract_inverted_index":{"BACKGROUND:":[0],"Glioblastoma":[1],"arises":[2],"from":[3],"complex":[4,49],"interactions":[5],"between":[6],"a":[7],"variety":[8],"of":[9,48,57,65,74,76,86,106,110,127,143,168,242,253,263],"genetic":[10,23],"alterations":[11],"and":[12,28,42,51,72,122,184,201,214,219,230,235,266],"environmental":[13],"perturbations.":[14],"Little":[15],"attention":[16],"has":[17,256],"been":[18],"paid":[19],"to":[20,39,45,103,133,193,259],"understanding":[21],"how":[22],"variations,":[24],"altered":[25],"gene":[26,94],"expression":[27,31,199],"microRNA":[29],"(miRNA)":[30],"are":[32,69,90,112],"integrated":[33,251],"into":[34],"networks":[35,121],"which":[36,66,87,111,128,144],"act":[37],"together":[38],"alter":[40],"regulation":[41],"finally":[43],"lead":[44],"the":[46,104,107,162,165,169,195,257,261],"emergence":[47],"phenotypes":[50],"glioblastoma.":[52,202],"RESULTS:":[53],"We":[54,116,137,203],"identified":[55,80,99,138,204],"association":[56,73],"somatic":[58,225],"mutations":[59],"in":[60,81,151,164,177],"14":[61,145],"genes":[62,68,83,89,101,163],"with":[63,84],"glioblastoma,":[64,85],"8":[67],"newly":[70,91],"identified,":[71],"loss":[75],"heterozygosity":[77,243],"(LOH)":[78,244],"is":[79],"11":[82],"9":[88],"discovered.":[92],"By":[93],"coexpression":[95,120],"network":[96,167],"analysis,":[97],"we":[98,158,189],"15":[100],"essential":[102],"function":[105],"network,":[108],"most":[109],"cancer":[113,178],"related":[114,132,179],"genes.":[115],"also":[117,159],"constructed":[118],"miRNA":[119,222,238],"found":[123,160],"19":[124,171],"important":[125,172],"miRNAs":[126,173],"3":[129],"were":[130,146,174],"significantly":[131],"glioblastoma":[134],"patients'":[135],"survival.":[136],"3,953":[139],"predicted":[140],"miRNA-mRNA":[141],"pairs,":[142],"previously":[147],"verified":[148],"by":[149],"experiments":[150],"other":[152],"groups.":[153],"Using":[154],"pathway":[155,196],"enrichment":[156],"analysis":[157,252],"that":[161,250],"target":[166],"top":[170],"mainly":[175],"involved":[176],"signaling":[180],"pathways,":[181],"synaptic":[182],"transmission":[183],"nervous":[185],"systems":[186],"processes.":[187],"Finally,":[188],"developed":[190],"new":[191],"methods":[192],"decipher":[194],"connecting":[197],"mutations,":[198],"information":[200],"4":[205],"cis-expression":[206],"quantitative":[207],"trait":[208],"locus":[209],"(eQTL):":[210],"TP53,":[211],"EGFR,":[212],"NF1":[213],"PIK3C2G;":[215],"262":[216],"trans":[217,221],"eQTL":[218,223,234,239],"26":[220],"for":[224,240],"mutation;":[226],"2":[227],"cis-eQTL:":[228],"NRAP":[229],"EGFR;":[231],"409":[232],"trans-":[233,237],"27":[236],"lost":[241],"mutation.":[245],"CONCLUSIONS:":[246],"Our":[247],"results":[248],"demonstrate":[249],"multi-dimensional":[254],"data":[255],"potential":[258],"unravel":[260],"mechanism":[262],"tumor":[264],"initiation":[265],"progression.":[267]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":14}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}