{"id":"https://openalex.org/W2166445591","doi":"https://doi.org/10.1186/1752-0509-4-161","title":"Confidence from uncertainty - A multi-target drug screening method from robust control theory","display_name":"Confidence from uncertainty - A multi-target drug screening method from robust control theory","publication_year":2010,"publication_date":"2010-11-24","ids":{"openalex":"https://openalex.org/W2166445591","doi":"https://doi.org/10.1186/1752-0509-4-161","mag":"2166445591","pmid":"https://pubmed.ncbi.nlm.nih.gov/21106087"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-161","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-161","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-161","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-161","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040741722","display_name":"Camilla Luni","orcid":"https://orcid.org/0000-0002-1211-9629"},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Camilla Luni","raw_affiliation_strings":["Department of Chemical Engineering, University of California, Santa Barbara, CA 93106-5080, USA","Department of Chemical Engineering, University of California, Santa Barbara, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of California, Santa Barbara, CA 93106-5080, USA","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of California, Santa Barbara, USA","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011546242","display_name":"Jason E. Shoemaker","orcid":"https://orcid.org/0000-0003-3315-7103"},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason E Shoemaker","raw_affiliation_strings":["Department of Chemical Engineering, University of California, Santa Barbara, CA, 93106-5080, USA","Department of Chemical Engineering, University of California, Santa Barbara, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of California, Santa Barbara, CA, 93106-5080, USA","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of California, Santa Barbara, USA","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017252408","display_name":"Kevin R. Sanft","orcid":"https://orcid.org/0000-0001-8536-2016"},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin R Sanft","raw_affiliation_strings":["Department of Computer Science, University of California, Santa Barbara, CA, 93106-5070, USA","Department of Computer Science, University of California, Santa Barbara, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of California, Santa Barbara, CA, 93106-5070, USA","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Department of Computer Science, University of California, Santa Barbara, USA","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021640058","display_name":"Linda Petzold","orcid":"https://orcid.org/0000-0001-6251-6078"},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda R Petzold","raw_affiliation_strings":["Department of Computer Science, University of California, Santa Barbara, CA, 93106-5070, USA","Department of Computer Science, University of California, Santa Barbara, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of California, Santa Barbara, CA, 93106-5070, USA","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Department of Computer Science, University of California, Santa Barbara, USA","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103218398","display_name":"Francis J. Doyle","orcid":"https://orcid.org/0000-0001-5342-4083"},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Francis J Doyle","raw_affiliation_strings":["Department of Chemical Engineering, University of California, Santa Barbara, CA, 93106-5080, USA","Department of Chemical Engineering, University of California, Santa Barbara, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of California, Santa Barbara, CA, 93106-5080, USA","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of California, Santa Barbara, USA","institution_ids":["https://openalex.org/I154570441"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5103218398"],"corresponding_institution_ids":["https://openalex.org/I154570441"],"apc_list":null,"apc_paid":null,"fwci":1.221,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.78680773,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"4","issue":"1","first_page":"161","last_page":"161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9269000291824341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9269000291824341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.8072104454040527},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6543431282043457},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6472100615501404},{"id":"https://openalex.org/keywords/parametric-statistics","display_name":"Parametric statistics","score":0.5980151295661926},{"id":"https://openalex.org/keywords/exploit","display_name":"Exploit","score":0.5503742098808289},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.5021440982818604},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.44347497820854187},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.39113110303878784},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3517456650733948},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3506927788257599},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23610681295394897},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1506543755531311},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.14299750328063965}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.8072104454040527},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6543431282043457},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6472100615501404},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.5980151295661926},{"id":"https://openalex.org/C165696696","wikidata":"https://www.wikidata.org/wiki/Q11287","display_name":"Exploit","level":2,"score":0.5503742098808289},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.5021440982818604},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.44347497820854187},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.39113110303878784},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3517456650733948},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3506927788257599},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23610681295394897},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1506543755531311},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14299750328063965},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1752-0509-4-161","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-161","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-161","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:21106087","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21106087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:cris.unibo.it:11585/776250","is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/776250","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt2h46z86m","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/2h46z86m","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, vol 4, iss 1","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2284404","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3277951","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:www.research.unipd.it:11577/2668858","is_oa":true,"landing_page_url":"http://hdl.handle.net/11577/2668858","pdf_url":null,"source":{"id":"https://openalex.org/S4377196283","display_name":"Research Padua  Archive (University of Padua)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:qt2h46z86m","is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/2h46z86m","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Luni, Camilla; Shoemaker, Jason E; Sanft, Kevin R; Petzold, Linda R; & Doyle, Francis J. (2010). Confidence from uncertainty - A multi-target drug screening method from robust control theory. BMC Systems Biology, 4(1), 161. doi: http://dx.doi.org/10.1186/1752-0509-4-161. Retrieved from: http://www.escholarship.org/uc/item/2h46z86m","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-161","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-161","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-161","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16","score":0.5899999737739563}],"awards":[{"id":"https://openalex.org/G2289969244","display_name":null,"funder_award_id":"DFR3A-8-447850-23002","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G2478233338","display_name":null,"funder_award_id":"DE-FG02-04ER25621","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3284194659","display_name":null,"funder_award_id":"W911NF-09-D-0001","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G4365921341","display_name":null,"funder_award_id":"W911NF-09-D-0001","funder_id":"https://openalex.org/F4320338502","funder_display_name":"Institute for Collaborative Biotechnologies"},{"id":"https://openalex.org/G4942697830","display_name":"MUTLISCALE SIMULATION ALGORITHMS FOR BIOCHEMICAL SYSTEMS","funder_award_id":"FG02-04ER25621","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G7186324567","display_name":null,"funder_award_id":"DE-FG02-","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G7452299184","display_name":null,"funder_award_id":"W911NF","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G8684078510","display_name":null,"funder_award_id":"DE-FG02","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320338281","display_name":"Army Research Office","ror":"https://ror.org/05epdh915"},{"id":"https://openalex.org/F4320338502","display_name":"Institute for Collaborative Biotechnologies","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2166445591.pdf","grobid_xml":"https://content.openalex.org/works/W2166445591.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1538631790","https://openalex.org/W1644749979","https://openalex.org/W1895993106","https://openalex.org/W1970263201","https://openalex.org/W1973546808","https://openalex.org/W1975404751","https://openalex.org/W1980174030","https://openalex.org/W1987522464","https://openalex.org/W1990072743","https://openalex.org/W2040643166","https://openalex.org/W2042321087","https://openalex.org/W2049379257","https://openalex.org/W2055812500","https://openalex.org/W2060735144","https://openalex.org/W2070102480","https://openalex.org/W2075161553","https://openalex.org/W2095988107","https://openalex.org/W2099712428","https://openalex.org/W2099768941","https://openalex.org/W2099905447","https://openalex.org/W2106353254","https://openalex.org/W2109090100","https://openalex.org/W2111184079","https://openalex.org/W2131588967","https://openalex.org/W2132898753","https://openalex.org/W2133114049","https://openalex.org/W2134244720","https://openalex.org/W2140595402","https://openalex.org/W2142072523","https://openalex.org/W2150908245","https://openalex.org/W2154169469","https://openalex.org/W2155290699","https://openalex.org/W2156260160","https://openalex.org/W2163480486","https://openalex.org/W2167238904","https://openalex.org/W2168301815","https://openalex.org/W2169826465","https://openalex.org/W2177894108","https://openalex.org/W2191147391","https://openalex.org/W2296679604","https://openalex.org/W2318772898","https://openalex.org/W4211017114","https://openalex.org/W4243620103","https://openalex.org/W4299043053"],"related_works":["https://openalex.org/W2155261113","https://openalex.org/W2140279791","https://openalex.org/W2005775729","https://openalex.org/W2053764326","https://openalex.org/W2982120224","https://openalex.org/W2017641680","https://openalex.org/W2072067873","https://openalex.org/W3107156000","https://openalex.org/W3043026144","https://openalex.org/W2098501743"],"abstract_inverted_index":{"BACKGROUND:":[0],"Robustness":[1],"is":[2],"a":[3,12,70,128,155,168,172],"recognized":[4],"feature":[5],"of":[6,51,62,82,104,127,152,158,167,171,188,197,212,215],"biological":[7,76,227],"systems":[8],"that":[9,31,116],"evolved":[10],"as":[11,20,154],"defence":[13],"to":[14,39,58,73,99,119,140,178,185],"environmental":[15],"variability.":[16,228],"Complex":[17],"diseases":[18],"such":[19],"diabetes,":[21],"cancer,":[22],"bacterial":[23],"and":[24,112],"viral":[25],"infections,":[26],"exploit":[27],"the":[28,60,63,80,86,101,125,150,163,186,195,210,221],"same":[29],"mechanisms":[30],"allow":[32],"for":[33,191,209],"robust":[34,118,131],"behaviour":[35],"in":[36,65,108,149,194,220],"healthy":[37],"conditions":[38],"ensure":[40],"their":[41,52],"own":[42],"continuance.":[43],"Single":[44],"drug":[45,192],"therapies,":[46],"while":[47,84],"generally":[48],"potent":[49],"regulators":[50],"specific":[53],"protein/gene":[54],"targets,":[55],"often":[56],"fail":[57],"counter":[59],"robustness":[61,148],"disease":[64],"question.":[66],"Multi-drug":[67],"therapies":[68,145],"offer":[69],"powerful":[71],"means":[72,157,166],"restore":[74],"disrupted":[75],"networks,":[77],"by":[78,146,165,201],"targeting":[79],"subsystem":[81],"interest":[83],"preventing":[85],"diseased":[87],"network":[88,175,198],"from":[89,130],"reconciling":[90],"through":[91],"available,":[92],"redundant":[93],"mechanisms.":[94],"Modelling":[95],"techniques":[96],"are":[97,117],"needed":[98],"manage":[100],"high":[102],"number":[103],"combinatorial":[105],"possibilities":[106],"arising":[107],"multi-drug":[109,144],"therapeutic":[110],"design,":[111],"identify":[113,141],"synergistic":[114],"targets":[115],"system":[120],"uncertainty.":[121,180,203],"RESULTS:":[122],"We":[123,161],"present":[124],"application":[126],"method":[129,164],"control":[132],"theory,":[133],"Structured":[134],"Singular":[135],"Value":[136],"or":[137,225],"\u03bc-":[138],"analysis,":[139],"highly":[142],"effective":[143,189],"using":[147],"face":[151],"uncertainty":[153,216],"new":[156],"target":[159],"discrimination.":[160],"illustrate":[162],"case":[169],"study":[170],"negative":[173],"feedback":[174],"motif":[176],"subject":[177],"parametric":[179,202],"CONCLUSIONS:":[181],"The":[182,204],"paper":[183],"contributes":[184],"development":[187],"methods":[190],"screening":[193],"context":[196],"modelling":[199],"affected":[200],"results":[205],"have":[206],"wide":[207],"applicability":[208],"analysis":[211],"different":[213],"sources":[214],"like":[217],"noise":[218],"experienced":[219],"data,":[222],"neglected":[223],"dynamics,":[224],"intrinsic":[226]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}