{"id":"https://openalex.org/W2053307381","doi":"https://doi.org/10.1186/1752-0509-4-152","title":"Noisy-threshold control of cell death","display_name":"Noisy-threshold control of cell death","publication_year":2010,"publication_date":"2010-11-10","ids":{"openalex":"https://openalex.org/W2053307381","doi":"https://doi.org/10.1186/1752-0509-4-152","mag":"2053307381","pmid":"https://pubmed.ncbi.nlm.nih.gov/21067567"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-152","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-152","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-152","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-152","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055607247","display_name":"Jos\u00e9 M. G. Vilar","orcid":"https://orcid.org/0000-0003-4037-0746"},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I110594554","display_name":"Ikerbasque","ror":"https://ror.org/01cc3fy72","country_code":"ES","type":"other","lineage":["https://openalex.org/I110594554"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jose MG Vilar","raw_affiliation_strings":["Biophysics Unit, CSIC-UPV/EHU and Department of Biochemistry and Molecular Biology, University of the Basque Country, PO Box 644, 48080 Bilbao, Spain. j.vilar@ikerbasque.org","Biophysics Unit (CSIC-UPV/EHU) and Department of Biochemistry and Molecular Biology, University of the Basque Country","IKERBASQUE, Basque Foundation for Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics Unit, CSIC-UPV/EHU and Department of Biochemistry and Molecular Biology, University of the Basque Country, PO Box 644, 48080 Bilbao, Spain. j.vilar@ikerbasque.org","institution_ids":["https://openalex.org/I169108374"]},{"raw_affiliation_string":"Biophysics Unit (CSIC-UPV/EHU) and Department of Biochemistry and Molecular Biology, University of the Basque Country","institution_ids":["https://openalex.org/I169108374"]},{"raw_affiliation_string":"IKERBASQUE, Basque Foundation for Science","institution_ids":["https://openalex.org/I110594554"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055607247"],"corresponding_institution_ids":["https://openalex.org/I110594554","https://openalex.org/I169108374"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.10768232,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"4","issue":"1","first_page":"152","last_page":"152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9085000157356262,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9085000157356262,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.031700000166893005,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"Programmed cell death","score":0.7752558588981628},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.6379462480545044},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.5746514201164246},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.5412397384643555},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.5159314274787903},{"id":"https://openalex.org/keywords/cellular-adaptation","display_name":"Cellular adaptation","score":0.514167308807373},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5097252726554871},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5049253106117249},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.48705723881721497},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.46187520027160645},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.2645171880722046},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14337369799613953},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.08280381560325623}],"concepts":[{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.7752558588981628},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.6379462480545044},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5746514201164246},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5412397384643555},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5159314274787903},{"id":"https://openalex.org/C156902634","wikidata":"https://www.wikidata.org/wiki/Q5058346","display_name":"Cellular adaptation","level":3,"score":0.514167308807373},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5097252726554871},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5049253106117249},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48705723881721497},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.46187520027160645},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2645171880722046},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14337369799613953},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08280381560325623},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-4-152","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-152","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-152","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:21067567","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21067567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:addi.ehu.es:10810/4215","is_oa":true,"landing_page_url":"http://hdl.handle.net/10810/4215","pdf_url":null,"source":{"id":"https://openalex.org/S4306400469","display_name":"Communities in ADDI (Universidad del Pais Vasco)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210131160","host_organization_name":"Material Physics Center","host_organization_lineage":["https://openalex.org/I4210131160"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digital.csic.es:10261/33549","is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/33549","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"},{"id":"pmh:oai:hispana.mcu.es:8212613","is_oa":false,"landing_page_url":"https://hispana.mcu.es/es/registros/registro.do?tipoRegistro=MTD&idBib=8212613","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2992511","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2992511","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-152","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-152","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-152","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2687779936","display_name":null,"funder_award_id":"FIS2009-10352","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":"https://ror.org/034900433"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2053307381.pdf","grobid_xml":"https://content.openalex.org/works/W2053307381.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W406401323","https://openalex.org/W639852821","https://openalex.org/W1483388049","https://openalex.org/W1607777232","https://openalex.org/W1970101770","https://openalex.org/W1989053944","https://openalex.org/W1991865867","https://openalex.org/W1993009001","https://openalex.org/W1999777663","https://openalex.org/W2008856079","https://openalex.org/W2016781930","https://openalex.org/W2021597697","https://openalex.org/W2034269086","https://openalex.org/W2037768790","https://openalex.org/W2040566047","https://openalex.org/W2047614519","https://openalex.org/W2050826226","https://openalex.org/W2059266203","https://openalex.org/W2065285374","https://openalex.org/W2077046573","https://openalex.org/W2078807740","https://openalex.org/W2082044596","https://openalex.org/W2090684431","https://openalex.org/W2091206106","https://openalex.org/W2094934486","https://openalex.org/W2097651998","https://openalex.org/W2103894337","https://openalex.org/W2108493072","https://openalex.org/W2147357406","https://openalex.org/W2154393411","https://openalex.org/W2171280873","https://openalex.org/W2171327609","https://openalex.org/W2264709743","https://openalex.org/W4230627429","https://openalex.org/W4255777804"],"related_works":["https://openalex.org/W2103599065","https://openalex.org/W2394514550","https://openalex.org/W2997567050","https://openalex.org/W2051583827","https://openalex.org/W2097812111","https://openalex.org/W2078925029","https://openalex.org/W2008548563","https://openalex.org/W2808663575","https://openalex.org/W2405904557","https://openalex.org/W2774136235"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cellular":[1],"responses":[2,75],"to":[3,45,95],"death-promoting":[4],"stimuli":[5],"typically":[6],"proceed":[7],"through":[8],"a":[9,14,85,106,112,162],"differentiated":[10],"multistage":[11],"process,":[12],"involving":[13],"lag":[15],"phase,":[16],"extensive":[17],"death,":[18,118],"and":[19,133,171],"potential":[20],"adaptation.":[21,175],"Deregulation":[22],"of":[23,26,32,52,63,81,102,115,129,168,174],"this":[24,103],"chain":[25],"events":[27],"is":[28,37],"at":[29],"the":[30,49,60,79,97,130,172],"root":[31],"many":[33,64],"diseases.":[34],"Improper":[35],"adaptation":[36,136],"particularly":[38],"important":[39],"because":[40],"it":[41],"allows":[42],"cell":[43,117],"sub-populations":[44],"survive":[46],"even":[47],"in":[48,59,93,105,139],"continuous":[50],"presence":[51],"death":[53,158],"conditions,":[54],"which":[55,144],"results,":[56],"among":[57],"others,":[58],"eventual":[61],"failure":[62],"targeted":[65],"anticancer":[66],"therapies.":[67],"RESULTS:":[68],"Here,":[69],"I":[70],"show":[71],"that":[72,89,151],"these":[73],"typical":[74],"arise":[76],"naturally":[77],"from":[78],"interplay":[80],"intracellular":[82],"variability":[83,170],"with":[84,120,137],"threshold-based":[86],"control":[87],"mechanism":[88,104],"detects":[90],"cellular":[91,98],"changes":[92],"addition":[94],"just":[96],"state":[99],"itself.":[100],"Implementation":[101],"quantitative":[107],"model":[108],"for":[109,125],"T-cell":[110],"apoptosis,":[111],"prototypical":[113],"example":[114],"programmed":[116],"captures":[119],"exceptional":[121],"accuracy":[122],"experimental":[123],"observations":[124],"different":[126],"expression":[127],"levels":[128],"oncogene":[131],"Bcl-xL":[132],"directly":[134],"links":[135],"noise":[138],"an":[140],"ATP":[141],"threshold":[142],"below":[143],"cells":[145],"die.":[146],"CONCLUSIONS:":[147],"These":[148],"results":[149],"indicate":[150],"oncogenes":[152],"like":[153],"Bcl-xL,":[154],"besides":[155],"regulating":[156],"absolute":[157],"values,":[159],"can":[160],"have":[161],"novel":[163],"role":[164],"as":[165],"active":[166],"controllers":[167],"cell-cell":[169],"extent":[173]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}
