{"id":"https://openalex.org/W2150315679","doi":"https://doi.org/10.1186/1752-0509-4-140","title":"A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1","display_name":"A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1","publication_year":2010,"publication_date":"2010-10-19","ids":{"openalex":"https://openalex.org/W2150315679","doi":"https://doi.org/10.1186/1752-0509-4-140","mag":"2150315679","pmid":"https://pubmed.ncbi.nlm.nih.gov/20959003"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-140","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-140","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-140","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-140","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022360631","display_name":"Martin I. Sigur\u00f0sson","orcid":"https://orcid.org/0000-0001-7054-0844"},"institutions":[{"id":"https://openalex.org/I165368041","display_name":"University of Iceland","ror":"https://ror.org/01db6h964","country_code":"IS","type":"education","lineage":["https://openalex.org/I165368041"]}],"countries":["IS"],"is_corresponding":false,"raw_author_name":"Martin I Sigurdsson","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland","institution_ids":["https://openalex.org/I165368041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031218218","display_name":"Neema Jamshidi","orcid":"https://orcid.org/0000-0003-3857-9735"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neema Jamshidi","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, California, 92093-0412, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, California, 92093-0412, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073807427","display_name":"Eir\u0131\u0301kur Steingr\u0131\u0301msson","orcid":"https://orcid.org/0000-0001-5826-7486"},"institutions":[{"id":"https://openalex.org/I165368041","display_name":"University of Iceland","ror":"https://ror.org/01db6h964","country_code":"IS","type":"education","lineage":["https://openalex.org/I165368041"]}],"countries":["IS"],"is_corresponding":false,"raw_author_name":"Eirikur Steingrimsson","raw_affiliation_strings":["Center for Systems Biology, University of Iceland, Reykjavik, Iceland","Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Biology, University of Iceland, Reykjavik, Iceland","institution_ids":["https://openalex.org/I165368041"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland","institution_ids":["https://openalex.org/I165368041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074725115","display_name":"Ines Thiele","orcid":"https://orcid.org/0000-0002-8071-7110"},"institutions":[{"id":"https://openalex.org/I165368041","display_name":"University of Iceland","ror":"https://ror.org/01db6h964","country_code":"IS","type":"education","lineage":["https://openalex.org/I165368041"]}],"countries":["IS"],"is_corresponding":true,"raw_author_name":"Ines Thiele","raw_affiliation_strings":["Center for Systems Biology, University of Iceland, Reykjavik, Iceland","Faculty of Industrial Engineering, Mechanical Engineering & Computer Science, University of Iceland, Reykjavik, Iceland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Biology, University of Iceland, Reykjavik, Iceland","institution_ids":["https://openalex.org/I165368041"]},{"raw_affiliation_string":"Faculty of Industrial Engineering, Mechanical Engineering & Computer Science, University of Iceland, Reykjavik, Iceland","institution_ids":["https://openalex.org/I165368041"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051097609","display_name":"Bernhard \u00d8. Palsson","orcid":"https://orcid.org/0000-0003-2357-6785"},"institutions":[{"id":"https://openalex.org/I165368041","display_name":"University of Iceland","ror":"https://ror.org/01db6h964","country_code":"IS","type":"education","lineage":["https://openalex.org/I165368041"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["IS","US"],"is_corresponding":true,"raw_author_name":"Bernhard \u00d8 Palsson","raw_affiliation_strings":["Center for Systems Biology, University of Iceland, Reykjavik, Iceland","Department of Bioengineering, University of California, San Diego, La Jolla, California, 92093-0412, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Biology, University of Iceland, Reykjavik, Iceland","institution_ids":["https://openalex.org/I165368041"]},{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, California, 92093-0412, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051097609","https://openalex.org/A5074725115"],"corresponding_institution_ids":["https://openalex.org/I165368041","https://openalex.org/I36258959"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":3.985,"has_fulltext":true,"cited_by_count":164,"citation_normalized_percentile":{"value":0.94675295,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"4","issue":"1","first_page":"140","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9430000185966492,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9430000185966492,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6916688084602356},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.683833658695221},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.637694239616394},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5691984295845032},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5567210912704468},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4393087327480316},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.41259026527404785},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3961648941040039}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6916688084602356},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.683833658695221},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.637694239616394},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5691984295845032},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5567210912704468},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4393087327480316},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.41259026527404785},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3961648941040039}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008071","descriptor_name":"Lipoprotein Lipase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D008071","descriptor_name":"Lipoprotein Lipase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D008071","descriptor_name":"Lipoprotein Lipase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1186/1752-0509-4-140","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-140","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-140","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2978158","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2978158","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmid:20959003","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20959003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:64b8d41f36d4449490c2e58a6d1ef45f","is_oa":false,"landing_page_url":"https://doaj.org/article/64b8d41f36d4449490c2e58a6d1ef45f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology, Vol 4, Iss 1, p 140 (2010)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt0ck1p05f","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/0ck1p05f","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, vol 4, iss 1","raw_type":"article"},{"id":"pmh:oai:orbilu.uni.lu:10993/16520","is_oa":true,"landing_page_url":"http://orbilu.uni.lu/handle/10993/16520","pdf_url":null,"source":{"id":"https://openalex.org/S4306401815","display_name":"Open Repository and Bibliography (University of Luxembourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I186903577","host_organization_name":"University of Luxembourg","host_organization_lineage":["https://openalex.org/I186903577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, 4, 140 (2010)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:www.hirsla.lsh.is:2336/124268","is_oa":false,"landing_page_url":"http://hdl.handle.net/2336/124268","pdf_url":null,"source":{"id":"https://openalex.org/S4306401083","display_name":"Hirsla (Landsp\u00edtali University Hospital)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210106610","host_organization_name":"National University Hospital of Iceland","host_organization_lineage":["https://openalex.org/I4210106610"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:qt0ck1p05f","is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/0ck1p05f","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sigurdsson, Martin I; Jamshidi, Neema; Steingrimsson, Eirikur; Thiele, Ines; &amp; Palsson, Bernhard \u00c3\u0098. (2010). A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1. BMC Systems Biology, 4(1), 140. doi: http://dx.doi.org/10.1186/1752-0509-4-140. Retrieved from: http://www.escholarship.org/uc/item/0ck1p05f","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-140","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-140","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-140","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5109416726","display_name":null,"funder_award_id":"T32 HL 007089","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2150315679.pdf"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1490544414","https://openalex.org/W1513705282","https://openalex.org/W1534027430","https://openalex.org/W1966286251","https://openalex.org/W1966807310","https://openalex.org/W1968798810","https://openalex.org/W1970250905","https://openalex.org/W1974255105","https://openalex.org/W1974260251","https://openalex.org/W1976937901","https://openalex.org/W1986656046","https://openalex.org/W1989061197","https://openalex.org/W1996529795","https://openalex.org/W1996791690","https://openalex.org/W1997521696","https://openalex.org/W1997876559","https://openalex.org/W1998577003","https://openalex.org/W2002277947","https://openalex.org/W2010707723","https://openalex.org/W2012015138","https://openalex.org/W2012354624","https://openalex.org/W2015751324","https://openalex.org/W2019516978","https://openalex.org/W2026656222","https://openalex.org/W2029007900","https://openalex.org/W2031993452","https://openalex.org/W2035787551","https://openalex.org/W2047632644","https://openalex.org/W2052960044","https://openalex.org/W2054506883","https://openalex.org/W2054847530","https://openalex.org/W2059008010","https://openalex.org/W2073714615","https://openalex.org/W2076262841","https://openalex.org/W2078355959","https://openalex.org/W2081010896","https://openalex.org/W2083011190","https://openalex.org/W2085993965","https://openalex.org/W2089476104","https://openalex.org/W2090888958","https://openalex.org/W2092934795","https://openalex.org/W2096525273","https://openalex.org/W2097895708","https://openalex.org/W2098824895","https://openalex.org/W2099946731","https://openalex.org/W2100833019","https://openalex.org/W2104108767","https://openalex.org/W2107390588","https://openalex.org/W2107459209","https://openalex.org/W2107580398","https://openalex.org/W2111329465","https://openalex.org/W2112062799","https://openalex.org/W2115358305","https://openalex.org/W2134394193","https://openalex.org/W2139553051","https://openalex.org/W2147472054","https://openalex.org/W2148133682","https://openalex.org/W2154061034","https://openalex.org/W2156382259","https://openalex.org/W2159482845","https://openalex.org/W2162183311","https://openalex.org/W2163841023","https://openalex.org/W2168082616","https://openalex.org/W2168909179","https://openalex.org/W2171305205","https://openalex.org/W2172196250","https://openalex.org/W4238101851","https://openalex.org/W4250297812","https://openalex.org/W4294216483","https://openalex.org/W4320800138"],"related_works":["https://openalex.org/W2086525401","https://openalex.org/W2006735166","https://openalex.org/W2079327011","https://openalex.org/W2053325634","https://openalex.org/W3178279768","https://openalex.org/W1969895229","https://openalex.org/W2108497208","https://openalex.org/W5284979","https://openalex.org/W4245853730","https://openalex.org/W4293079691"],"abstract_inverted_index":{"BACKGROUND:":[0],"Well-curated":[1],"and":[2,90,156],"validated":[3],"network":[4],"reconstructions":[5,15,35,76],"are":[6],"extremely":[7],"valuable":[8],"tools":[9],"in":[10,39,88,177,200,276],"systems":[11],"biology.":[12],"Detailed":[13],"metabolic":[14,75,117,194,231,274],"of":[16,33,49,77,111,114,133,170,192,205,254],"mammals":[17],"have":[18,225],"recently":[19],"emerged,":[20],"including":[21,80,278],"human":[22,50],"reconstructions.":[23],"They":[24],"raise":[25],"the":[26,29,45,81,115,140,161,193,206,241,258],"question":[27],"if":[28],"various":[30],"successful":[31],"applications":[32],"microbial":[34],"can":[36,219,244],"be":[37,198,221,245],"replicated":[38],"complex":[40],"organisms.":[41],"RESULTS:":[42],"We":[43,119,224,238],"mapped":[44],"published,":[46],"detailed":[47],"reconstruction":[48,85,138,145],"metabolism":[51],"(Recon":[52],"1)":[53],"to":[54,62,72,103,186,197,247,252],"other":[55],"mammals.":[56],"By":[57],"searching":[58],"for":[59,148,152,164,190,272],"genes":[60,65,150,173,195],"homologous":[61],"Recon":[63],"1":[64],"within":[66],"mammalian":[67],"genomes,":[68],"we":[69,100],"were":[70,101,174],"able":[71,102],"create":[73],"draft":[74,84],"five":[78],"mammals,":[79],"mouse.":[82],"Each":[83],"was":[86,184],"created":[87,226],"compartmentalized":[89],"non-compartmentalized":[91],"version":[92],"via":[93],"two":[94],"different":[95],"approaches.":[96],"Using":[97],"gap-filling":[98],"algorithms,":[99],"produce":[104],"all":[105],"cellular":[106],"components":[107],"with":[108,212],"three":[109],"out":[110],"four":[112],"versions":[113],"mouse":[116,144,162,229,242,259],"reconstruction.":[118],"finalized":[120],"a":[121,130,227],"functional":[122],"model":[123,163,183,243,266],"by":[124],"iterative":[125],"testing":[126],"until":[127],"it":[128],"passed":[129],"predefined":[131],"set":[132],"260":[134],"validation":[135],"tests.":[136],"The":[137,168],"is":[139,260],"largest,":[141],"most":[142],"comprehensive":[143],"to-date,":[146],"accounting":[147],"1,415":[149],"coding":[151],"2,212":[153],"gene-associated":[154],"reactions":[155],"1,514":[157],"non-gene-associated":[158],"reactions.We":[159],"tested":[160],"phenotype":[165,249],"prediction":[166],"capabilities.":[167],"majority":[169],"predicted":[171],"essential":[172,176,199,270],"also":[175,220],"vivo.":[178,201],"However,":[179],"our":[180],"non-tissue":[181],"specific":[182],"unable":[185],"predict":[187],"gene":[188,209],"essentiality":[189],"many":[191],"shown":[196],"Our":[202],"knockout":[203],"simulation":[204],"lipoprotein":[207],"lipase":[208],"correlated":[210],"well":[211],"experimental":[213,263],"results,":[214],"suggesting":[215],"that":[216,240],"softer":[217],"phenotypes":[218,275],"simulated.":[222],"CONCLUSIONS:":[223],"high-quality":[228],"genome-scale":[230],"reconstruction,":[232],"iMM1415":[233],"(Mus":[234],"Musculus,":[235],"1415":[236],"genes).":[237],"demonstrate":[239],"used":[246],"perform":[248],"simulations,":[250],"similar":[251],"models":[253],"microbe":[255],"metabolism.":[256],"Since":[257],"an":[261,269],"important":[262],"organism,":[264],"this":[265],"should":[267],"become":[268],"tool":[271],"studying":[273],"mice,":[277],"outcomes":[279],"from":[280],"drug":[281],"screening.":[282]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":10}],"updated_date":"2026-08-14T07:06:38.338062","created_date":"2025-10-10T00:00:00"}
