{"id":"https://openalex.org/W2011863452","doi":"https://doi.org/10.1186/1752-0509-4-130","title":"Statistical inference of the time-varying structure of gene-regulation networks","display_name":"Statistical inference of the time-varying structure of gene-regulation networks","publication_year":2010,"publication_date":"2010-09-22","ids":{"openalex":"https://openalex.org/W2011863452","doi":"https://doi.org/10.1186/1752-0509-4-130","mag":"2011863452","pmid":"https://pubmed.ncbi.nlm.nih.gov/20860793"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-130","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-130","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-130","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-130","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044919124","display_name":"Sophie L\u00e8bre","orcid":"https://orcid.org/0000-0003-3444-2416"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sophie L\u00e8bre","raw_affiliation_strings":["Center for Bioinformatics, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081920760","display_name":"Jennifer Becq","orcid":null},"institutions":[{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jennifer Becq","raw_affiliation_strings":["Dynamique des Structures et Interactions des Macromolcules Biologiques (DSIMB), INSERM U 665, Paris, F-75015, France","Dynamique des Structures et Interactions des Macromol\u00e9cules Biologiques (DSIMB), INSERM U 665, Paris, F-75015, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dynamique des Structures et Interactions des Macromolcules Biologiques (DSIMB), INSERM U 665, Paris, F-75015, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210146787"]},{"raw_affiliation_string":"Dynamique des Structures et Interactions des Macromol\u00e9cules Biologiques (DSIMB), INSERM U 665, Paris, F-75015, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210146787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062684374","display_name":"Fr\u00e9d\u00e9ric Devaux","orcid":"https://orcid.org/0000-0002-0039-9096"},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Devaux","raw_affiliation_strings":["Laboratoire de G\u00e9nomique des Microorganismes, CNRS FRE 3214, Universit\u00e9 Pierre et Marie Curie, Institut des Cordeliers, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de G\u00e9nomique des Microorganismes, CNRS FRE 3214, Universit\u00e9 Pierre et Marie Curie, Institut des Cordeliers, Paris, France","institution_ids":["https://openalex.org/I4210092322","https://openalex.org/I39804081","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042789303","display_name":"Michael P. H. Stumpf","orcid":"https://orcid.org/0000-0002-3577-1222"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael PH Stumpf","raw_affiliation_strings":["Center for Bioinformatics, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073920762","display_name":"Ga\u00eblle Lelandais","orcid":"https://orcid.org/0000-0002-2842-6172"},"institutions":[{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ga\u00eblle Lelandais","raw_affiliation_strings":["Dynamique des Structures et Interactions des Macromolcules Biologiques (DSIMB), INSERM U 665, Paris, F-75015, France","Dynamique des Structures et Interactions des Macromol\u00e9cules Biologiques (DSIMB), INSERM U 665, Paris, F-75015, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dynamique des Structures et Interactions des Macromolcules Biologiques (DSIMB), INSERM U 665, Paris, F-75015, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210146787"]},{"raw_affiliation_string":"Dynamique des Structures et Interactions des Macromol\u00e9cules Biologiques (DSIMB), INSERM U 665, Paris, F-75015, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210146787"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5044919124"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":6.1202,"has_fulltext":true,"cited_by_count":197,"citation_normalized_percentile":{"value":0.9718233,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"4","issue":"1","first_page":"130","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.5084999799728394,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.5084999799728394,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.3174000084400177,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11303","display_name":"Bayesian Modeling and Causal Inference","score":0.02500000037252903,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.7634090185165405},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.7018216848373413},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6730237603187561},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6685702800750732},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.6108413934707642},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.5542720556259155},{"id":"https://openalex.org/keywords/exploit","display_name":"Exploit","score":0.5345864295959473},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41749364137649536},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3380342125892639},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.27830445766448975},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2269604504108429},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.20226430892944336},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.17633932828903198},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13998055458068848}],"concepts":[{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.7634090185165405},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.7018216848373413},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6730237603187561},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6685702800750732},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6108413934707642},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.5542720556259155},{"id":"https://openalex.org/C165696696","wikidata":"https://www.wikidata.org/wiki/Q11287","display_name":"Exploit","level":2,"score":0.5345864295959473},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41749364137649536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3380342125892639},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27830445766448975},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2269604504108429},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.20226430892944336},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17633932828903198},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13998055458068848},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001542","descriptor_name":"Benomyl","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":false},{"descriptor_ui":"D001542","descriptor_name":"Benomyl","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":false},{"descriptor_ui":"D001542","descriptor_name":"Benomyl","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":false},{"descriptor_ui":"D001542","descriptor_name":"Benomyl","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-4-130","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-130","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-130","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20860793","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20860793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/246065","is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/246065","pdf_url":"http://hdl.handle.net/11343/246065","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:inserm-00663719v1","is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-00663719","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, 2010, 4 (1), pp.130. &#x27E8;10.1186/1752-0509-4-130&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:pubmedcentral.nih.gov:2955603","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2955603","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-130","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-130","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-130","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.5099999904632568}],"awards":[{"id":"https://openalex.org/G3986016001","display_name":null,"funder_award_id":"BB/E01612X/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6644416810","display_name":null,"funder_award_id":"BB/F005210/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7268656538","display_name":null,"funder_award_id":"BB/F005210/2","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320323765","display_name":"Institut National de la Transfusion Sanguine","ror":"https://ror.org/00fh58138"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2011863452.pdf","grobid_xml":"https://content.openalex.org/works/W2011863452.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1970208077","https://openalex.org/W1970679073","https://openalex.org/W1982891217","https://openalex.org/W1990072661","https://openalex.org/W1990552935","https://openalex.org/W2012804055","https://openalex.org/W2025803032","https://openalex.org/W2029135009","https://openalex.org/W2044646840","https://openalex.org/W2048335804","https://openalex.org/W2056218698","https://openalex.org/W2061425021","https://openalex.org/W2070672503","https://openalex.org/W2073307618","https://openalex.org/W2099235429","https://openalex.org/W2102291607","https://openalex.org/W2103017472","https://openalex.org/W2105581244","https://openalex.org/W2106706098","https://openalex.org/W2108589994","https://openalex.org/W2110517028","https://openalex.org/W2113401388","https://openalex.org/W2113827117","https://openalex.org/W2117838564","https://openalex.org/W2125631472","https://openalex.org/W2129505753","https://openalex.org/W2141027519","https://openalex.org/W2142561902","https://openalex.org/W2152227081","https://openalex.org/W2152246075","https://openalex.org/W2153453282","https://openalex.org/W2154293840","https://openalex.org/W2155205047","https://openalex.org/W2157076884","https://openalex.org/W2160836350","https://openalex.org/W2161304688","https://openalex.org/W2163467054","https://openalex.org/W2163856173","https://openalex.org/W2166303358","https://openalex.org/W2595840341","https://openalex.org/W2606211438","https://openalex.org/W3143625801","https://openalex.org/W3147334312","https://openalex.org/W3148216104","https://openalex.org/W3214323364","https://openalex.org/W4211177544","https://openalex.org/W4236636569","https://openalex.org/W4245929783","https://openalex.org/W4388323202"],"related_works":["https://openalex.org/W2155492529","https://openalex.org/W4252504573","https://openalex.org/W2158714033","https://openalex.org/W4385510321","https://openalex.org/W2101315668","https://openalex.org/W15348386","https://openalex.org/W4386628104","https://openalex.org/W2314128295","https://openalex.org/W78967844","https://openalex.org/W2131550814"],"abstract_inverted_index":{"BACKGROUND:":[0],"Biological":[1],"networks":[2,79],"are":[3,155],"highly":[4],"dynamic":[5],"in":[6,16,114,147,179,197],"response":[7,165],"to":[8,18,36,74,103,169,191],"environmental":[9],"and":[10,40,66,94,136,142,163,185,193],"physiological":[11],"cues.":[12],"This":[13],"variability":[14],"is":[15],"contrast":[17],"conventional":[19],"analyses":[20],"of":[21,90,107,138,160,166],"biological":[22,38,81,117,140,153,180],"networks,":[23],"which":[24,31],"have":[25],"overwhelmingly":[26],"employed":[27],"static":[28],"graph":[29],"models":[30],"stay":[32],"constant":[33],"over":[34,98],"time":[35],"describe":[37],"systems":[39,141,148,181],"their":[41,195],"underlying":[42],"molecular":[43],"interactions.":[44],"METHODS:":[45],"To":[46],"overcome":[47],"these":[48],"limitations,":[49],"we":[50],"propose":[51],"here":[52],"a":[53,91,115,187],"new":[54],"statistical":[55],"modelling":[56],"framework,":[57],"the":[58,88,105,127,134,157,164],"ARTIVA":[59,85,128,173],"formalism":[60],"(Auto":[61],"Regressive":[62],"TIme":[63],"VArying":[64],"models),":[65],"an":[67],"associated":[68],"inferential":[69],"procedure":[70],"that":[71,126],"allows":[72,101],"us":[73,102],"learn":[75,192],"temporally":[76],"varying":[77],"gene-regulation":[78],"from":[80,182],"time-course":[82,145],"expression":[83],"data.":[84],"simultaneously":[86],"infers":[87],"topology":[89],"regulatory":[92,108],"network":[93],"how":[95],"it":[96],"changes":[97],"time.":[99],"It":[100],"recover":[104,175],"chronology":[106],"associations":[109],"for":[110],"individual":[111],"genes":[112],"involved":[113],"specific":[116],"process":[118],"(development,":[119],"stress":[120],"response,":[121],"etc.).":[122],"RESULTS:":[123],"We":[124],"demonstrate":[125],"approach":[129],"generates":[130],"detailed":[131],"insights":[132],"into":[133],"function":[135],"dynamics":[137,196],"complex":[139],"exploits":[143],"efficiently":[144],"data":[146],"biology.":[149],"In":[150],"particular,":[151],"two":[152],"scenarios":[154],"analyzed:":[156],"developmental":[158],"stages":[159],"Drosophila":[161],"melanogaster":[162],"Saccharomyces":[167],"cerevisiae":[168],"benomyl":[170],"poisoning.":[171],"CONCLUSIONS:":[172],"does":[174],"essential":[176],"temporal":[177],"dependencies":[178],"transcriptional":[183],"data,":[184],"provide":[186],"natural":[188],"starting":[189],"point":[190],"investigate":[194],"greater":[198],"detail.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":14}],"updated_date":"2026-05-05T08:41:31.759640","created_date":"2025-10-10T00:00:00"}
