{"id":"https://openalex.org/W2118119153","doi":"https://doi.org/10.1186/1752-0509-4-128","title":"Prediction of quantitative phenotypes based on genetic networks: a case study in yeast sporulation","display_name":"Prediction of quantitative phenotypes based on genetic networks: a case study in yeast sporulation","publication_year":2010,"publication_date":"2010-09-10","ids":{"openalex":"https://openalex.org/W2118119153","doi":"https://doi.org/10.1186/1752-0509-4-128","mag":"2118119153","pmid":"https://pubmed.ncbi.nlm.nih.gov/20828418"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-128","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-128","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-128","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-128","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008134007","display_name":"Li Shen","orcid":"https://orcid.org/0000-0002-5190-2851"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Li Shen","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093, USA","Department of Neuroscience, Mount Sinai School of Medicine, New York, USA","Department of Chemistry and Biochemistry, University of California, San Diego, San Diego, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Neuroscience, Mount Sinai School of Medicine, New York, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, San Diego, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047970786","display_name":"Iouri Chepelev","orcid":"https://orcid.org/0000-0002-2121-8805"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iouri Chepelev","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA","Laboratory of Molecular Immunology, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA","Department of Chemistry and Biochemistry, University of California, San Diego, San Diego, USA","Laboratory of Molecular Immunology, National Institutes of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Laboratory of Molecular Immunology, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, San Diego, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Laboratory of Molecular Immunology, National Institutes of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100454059","display_name":"Jie Liu","orcid":"https://orcid.org/0000-0002-1129-9584"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Liu","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA","Department of Chemistry and Biochemistry, University of California San Diego, San Diego, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California San Diego, San Diego, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100392138","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0002-9702-4441"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA","Department of Chemistry and Biochemistry, University of California San Diego, San Diego, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California San Diego, San Diego, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008134007"],"corresponding_institution_ids":["https://openalex.org/I36258959","https://openalex.org/I98704320"],"apc_list":null,"apc_paid":null,"fwci":0.814,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.7228777,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"4","issue":"1","first_page":"128","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6729999780654907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6729999780654907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.17409999668598175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.06319999694824219,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.7571864724159241},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.6682807207107544},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.599796712398529},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5626043677330017},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5443089604377747},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5334418416023254},{"id":"https://openalex.org/keywords/genetic-network","display_name":"Genetic network","score":0.5321725010871887},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4494301676750183},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44162315130233765},{"id":"https://openalex.org/keywords/boolean-network","display_name":"Boolean network","score":0.4143153429031372},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3913993537425995},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.09769436717033386},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.08862379193305969},{"id":"https://openalex.org/keywords/boolean-function","display_name":"Boolean function","score":0.07741302251815796}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.7571864724159241},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6682807207107544},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.599796712398529},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5626043677330017},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5443089604377747},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5334418416023254},{"id":"https://openalex.org/C2986044853","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Genetic network","level":3,"score":0.5321725010871887},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4494301676750183},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44162315130233765},{"id":"https://openalex.org/C134444547","wikidata":"https://www.wikidata.org/wiki/Q585230","display_name":"Boolean network","level":3,"score":0.4143153429031372},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3913993537425995},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.09769436717033386},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08862379193305969},{"id":"https://openalex.org/C187455244","wikidata":"https://www.wikidata.org/wiki/Q942353","display_name":"Boolean function","level":2,"score":0.07741302251815796}],"mesh":[{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013172","descriptor_name":"Spores, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013172","descriptor_name":"Spores, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013172","descriptor_name":"Spores, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-4-128","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-128","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-128","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20828418","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20828418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:escholarship.org/ark:/13030/qt3xx2x4x7","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/3xx2x4x7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, vol 4, iss 1","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2944141","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2944141","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:qt3xx2x4x7","is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/3xx2x4x7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Shen, Li; Chepelev, Iouri; Liu, Jie; & Wang, Wei. (2010). Prediction of quantitative phenotypes based on genetic networks: a case study in yeast sporulation. BMC Systems Biology, 4(1), 128. doi: http://dx.doi.org/10.1186/1752-0509-4-128. Retrieved from: http://www.escholarship.org/uc/item/3xx2x4x7","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-128","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-128","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-128","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118119153.pdf","grobid_xml":"https://content.openalex.org/works/W2118119153.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1481919380","https://openalex.org/W1497136418","https://openalex.org/W1517816201","https://openalex.org/W1575910125","https://openalex.org/W1604959358","https://openalex.org/W1971224531","https://openalex.org/W1976386441","https://openalex.org/W1991920181","https://openalex.org/W2052551072","https://openalex.org/W2053961182","https://openalex.org/W2074395112","https://openalex.org/W2095956310","https://openalex.org/W2097498614","https://openalex.org/W2099656145","https://openalex.org/W2101606575","https://openalex.org/W2121905499","https://openalex.org/W2127392156","https://openalex.org/W2134092731","https://openalex.org/W2135951244","https://openalex.org/W2148851475","https://openalex.org/W2152227081","https://openalex.org/W2153453282","https://openalex.org/W2159198265","https://openalex.org/W2166570783"],"related_works":["https://openalex.org/W1422717320","https://openalex.org/W2794960257","https://openalex.org/W2330768201","https://openalex.org/W2108120899","https://openalex.org/W2128085946","https://openalex.org/W2349909726","https://openalex.org/W4319977964","https://openalex.org/W2802063128","https://openalex.org/W4385417763","https://openalex.org/W1965278175"],"abstract_inverted_index":{"BACKGROUND:":[0],"An":[1],"exciting":[2],"application":[3],"of":[4,88,97,112,140,152],"genetic":[5,16,46,122,158],"network":[6,27,47,53,71,92,123,159],"is":[7,29,132],"to":[8,54,134],"predict":[9,55],"phenotypic":[10],"consequences":[11],"for":[12,22],"environmental":[13],"cues":[14],"or":[15],"perturbations.":[17],"However,":[18],"de":[19],"novo":[20],"prediction":[21,138],"quantitative":[23,143,154],"phenotypes":[24,155],"based":[25,67,156],"on":[26,68,157],"topology":[28],"always":[30],"a":[31,39,45,120,136,162],"challenging":[32],"task.":[33],"RESULTS:":[34],"Using":[35],"yeast":[36,90],"sporulation":[37,56,91,98],"as":[38],"model":[40],"system,":[41],"we":[42],"have":[43,116],"assembled":[44],"from":[48,125],"literature":[49,131],"and":[50,86,93,130,160],"exploited":[51],"Boolean":[52],"efficiency":[57,99],"change":[58,100],"upon":[59],"deleting":[60],"individual":[61],"genes.":[62],"We":[63,115],"observe":[64],"that":[65,119],"predictions":[66],"the":[69,75,84,89,141,150],"curated":[70],"correlate":[72],"well":[73],"with":[74],"experimentally":[76],"measured":[77],"values.":[78],"In":[79],"addition,":[80],"computational":[81],"analysis":[82],"reveals":[83],"robustness":[85],"hysteresis":[87],"uncovers":[94],"several":[95],"patterns":[96],"caused":[101],"by":[102],"double":[103],"gene":[104],"deletion.":[105],"These":[106],"discoveries":[107],"may":[108],"guide":[109],"future":[110],"investigation":[111],"underlying":[113],"mechanisms.":[114],"also":[117],"shown":[118],"hybridized":[121],"reconstructed":[124],"both":[126],"temporal":[127],"microarray":[128],"data":[129],"able":[133],"achieve":[135],"satisfactory":[137],"accuracy":[139],"same":[142],"phenotypes.":[144],"CONCLUSIONS:":[145],"This":[146],"case":[147],"study":[148],"illustrates":[149],"value":[151],"predicting":[153],"provides":[161],"generic":[163],"approach.":[164]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}