{"id":"https://openalex.org/W1983134755","doi":"https://doi.org/10.1186/1752-0509-4-127","title":"Genomic distance entrained clustering and regression modelling highlights interacting genomic regions contributing to proliferation in breast cancer","display_name":"Genomic distance entrained clustering and regression modelling highlights interacting genomic regions contributing to proliferation in breast cancer","publication_year":2010,"publication_date":"2010-09-08","ids":{"openalex":"https://openalex.org/W1983134755","doi":"https://doi.org/10.1186/1752-0509-4-127","mag":"1983134755","pmid":"https://pubmed.ncbi.nlm.nih.gov/20825665"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-127","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-127","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-127","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-127","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113505294","display_name":"Tim J. Dexter","orcid":null},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2799938689","display_name":"Breast Cancer Now","ror":"https://ror.org/02qa92s63","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2799938689"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Tim J Dexter","raw_affiliation_strings":["Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK. tim.dexter@icr.ac.uk","Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK. tim.dexter@icr.ac.uk","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2799938689"]},{"raw_affiliation_string":"Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061470053","display_name":"David Sims","orcid":"https://orcid.org/0000-0001-8960-8335"},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Sims","raw_affiliation_strings":["Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK","Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063297467","display_name":"Costas Mitsopoulos","orcid":"https://orcid.org/0000-0002-9116-5921"},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Costas Mitsopoulos","raw_affiliation_strings":["Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK","Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073016473","display_name":"Alan Mackay","orcid":"https://orcid.org/0000-0003-3323-4017"},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan Mackay","raw_affiliation_strings":["Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK","Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054103832","display_name":"Anita Grigoriadis","orcid":"https://orcid.org/0000-0003-3434-201X"},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anita Grigoriadis","raw_affiliation_strings":["Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK","Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053951070","display_name":"Amar Ahmad","orcid":"https://orcid.org/0000-0002-1245-868X"},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amar S Ahmad","raw_affiliation_strings":["Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK","Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022425237","display_name":"Marketa Zvelebil","orcid":"https://orcid.org/0000-0001-8018-5591"},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marketa Zvelebil","raw_affiliation_strings":["Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK","Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK","institution_ids":["https://openalex.org/I142947616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5113505294"],"corresponding_institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2799938689"],"apc_list":null,"apc_paid":null,"fwci":0.9456,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.77464933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"4","issue":"1","first_page":"127","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.4293000102043152,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.4293000102043152,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.11159999668598175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.094200000166893,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.6957013607025146},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6911126971244812},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.6684576272964478},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6048687696456909},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"Copy-number variation","score":0.5035197138786316},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4773293137550354},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.4702538251876831},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.4695383310317993},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4404025077819824},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.4314323663711548},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4292716383934021},{"id":"https://openalex.org/keywords/hierarchical-clustering","display_name":"Hierarchical clustering","score":0.4273318350315094},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.41586992144584656},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.41517090797424316},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33468693494796753},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.33318638801574707},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.12092509865760803}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6957013607025146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6911126971244812},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6684576272964478},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6048687696456909},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.5035197138786316},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4773293137550354},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4702538251876831},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.4695383310317993},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4404025077819824},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4314323663711548},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4292716383934021},{"id":"https://openalex.org/C92835128","wikidata":"https://www.wikidata.org/wiki/Q1277447","display_name":"Hierarchical clustering","level":3,"score":0.4273318350315094},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.41586992144584656},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41517090797424316},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33468693494796753},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.33318638801574707},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12092509865760803},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-4-127","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-127","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-127","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20825665","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20825665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/85af1d0b-1800-48d7-983f-8efff0afdde8","is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/85af1d0b-1800-48d7-983f-8efff0afdde8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dexter, T J, Sims, D, Mitsopoulos, C, Mackay, A, Grigoriadis, A, Ahmad, A S & Zvelebil, M 2010, 'Genomic distance entrained clustering and regression modelling highlights interacting genomic regions contributing to proliferation in breast cancer', Bmc Systems Biology. https://doi.org/10.1186/1752-0509-4-127","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:cfbb78c9921947c4b1cab93e5c08bbb9","is_oa":true,"landing_page_url":"https://doaj.org/article/cfbb78c9921947c4b1cab93e5c08bbb9","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 4, Iss 1, p 127 (2010)","raw_type":"article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/85af1d0b-1800-48d7-983f-8efff0afdde8","is_oa":true,"landing_page_url":"http://www.scopus.com/inward/record.url?scp=77956455124&partnerID=8YFLogxK","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dexter, T J, Sims, D, Mitsopoulos, C, Mackay, A, Grigoriadis, A, Ahmad, A S & Zvelebil, M 2010, 'Genomic distance entrained clustering and regression modelling highlights interacting genomic regions contributing to proliferation in breast cancer', Bmc Systems Biology. https://doi.org/10.1186/1752-0509-4-127","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pubmedcentral.nih.gov:2946304","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2946304","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-127","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-127","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-127","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7799999713897705}],"awards":[],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1983134755.pdf","grobid_xml":"https://content.openalex.org/works/W1983134755.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1494864623","https://openalex.org/W1607267312","https://openalex.org/W1980051146","https://openalex.org/W2007995029","https://openalex.org/W2016440433","https://openalex.org/W2018173663","https://openalex.org/W2020541351","https://openalex.org/W2041172149","https://openalex.org/W2050575125","https://openalex.org/W2059313996","https://openalex.org/W2060286439","https://openalex.org/W2066154261","https://openalex.org/W2071906932","https://openalex.org/W2076356585","https://openalex.org/W2087632344","https://openalex.org/W2093782158","https://openalex.org/W2096079397","https://openalex.org/W2105712639","https://openalex.org/W2118413367","https://openalex.org/W2120865735","https://openalex.org/W2133174470","https://openalex.org/W2135681892","https://openalex.org/W2136787567","https://openalex.org/W2137081277","https://openalex.org/W2141646633","https://openalex.org/W2150533948","https://openalex.org/W2150671673","https://openalex.org/W2154361640","https://openalex.org/W2158150128","https://openalex.org/W2163563958","https://openalex.org/W2612166593","https://openalex.org/W4245024447","https://openalex.org/W4297440291"],"related_works":["https://openalex.org/W2053053668","https://openalex.org/W2111172999","https://openalex.org/W2003922337","https://openalex.org/W1531528770","https://openalex.org/W2415025170","https://openalex.org/W1983994322","https://openalex.org/W2998765584","https://openalex.org/W3032874291","https://openalex.org/W1971926891","https://openalex.org/W153625360"],"abstract_inverted_index":{"BACKGROUND:":[0],"Genomic":[1],"copy":[2,125,151],"number":[3,126,152,237],"changes":[4,80],"and":[5,38,42,49,84,128,205,270],"regional":[6,79,136,217],"alterations":[7,25,129,162],"in":[8,16,66,81,111,130,154,187,247],"epigenetic":[9,43,148],"states":[10],"have":[11,234],"been":[12],"linked":[13],"to":[14,26,56,63,74,179,244,265,273],"grade":[15],"breast":[17,31,155,170,249],"cancer.":[18,156,250],"However,":[19],"the":[20,27,76,120,181,198,267],"relative":[21,182],"contribution":[22],"of":[23,29,40,118,123,144,147,160,184,209,219,224,238,252,258],"specific":[24],"pathology":[28],"different":[30],"cancer":[32,67,171],"subtypes":[33],"remains":[34],"unclear.":[35],"The":[36,191],"heterogeneity":[37],"interplay":[39],"genomic":[41,101,161,185,239,259],"variations":[44],"means":[45,117],"that":[46,60,135,241],"large":[47],"datasets":[48,214],"statistical":[50],"data":[51,94,110],"mining":[52],"methods":[53],"are":[54,61,142,163],"required":[55],"uncover":[57],"recurrent":[58,145],"patterns":[59,159],"likely":[62],"be":[64],"important":[65],"progression.":[68],"RESULTS:":[69],"We":[70,133],"employed":[71],"ridge":[72],"regression":[73],"model":[75,193],"relationship":[77],"between":[78,197],"gene":[82,92,108,212,221],"expression":[83,93,109,213],"proliferation.":[85],"Regional":[86],"features":[87],"were":[88],"extracted":[89],"from":[90,139],"tumour":[91,231],"using":[95],"a":[96,115,236],"novel":[97],"clustering":[98,141],"method,":[99],"called":[100],"distance":[102],"entrained":[103],"agglomerative":[104],"(GDEC)":[105],"clustering.":[106],"Using":[107],"this":[112],"way":[113],"provides":[114],"simple":[116],"integrating":[119],"phenotypic":[121],"effects":[122],"both":[124],"aberrations":[127,153],"chromatin":[131],"state.":[132],"show":[134],"metagenes":[137],"derived":[138],"GDEC":[140],"representative":[143],"regions":[146,186,201,240,254,260],"regulation":[149],"or":[150],"Furthermore,":[157],"detected":[158],"conserved":[164],"across":[165],"independent":[166,223],"oestrogen":[167],"receptor":[168],"positive":[169],"datasets.":[172],"Sequential":[173],"competitive":[174],"metagene":[175],"selection":[176],"was":[177],"used":[178],"reveal":[180,216],"importance":[183],"predicting":[188],"proliferation":[189,232,246],"rate.":[190],"predictive":[192],"suggested":[194],"additive":[195],"interactions":[196,271],"most":[199],"informative":[200],"such":[202,253],"as":[203],"8p22-12":[204],"8q13-22.":[206],"CONCLUSIONS:":[207],"Data-mining":[208],"large-scale":[210],"microarray":[211],"can":[215],"clusters":[218,229],"co-ordinate":[220],"expression,":[222],"cause.":[225],"By":[226],"correlating":[227],"these":[228],"with":[230],"we":[233],"identified":[235],"act":[242],"together":[243],"promote":[245],"ER+":[248],"Identification":[251],"should":[255],"enable":[256],"prioritisation":[257],"for":[261],"combinatorial":[262],"functional":[263],"studies":[264],"pinpoint":[266],"key":[268],"genes":[269],"contributing":[272],"tumourigenicity.":[274]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}