{"id":"https://openalex.org/W2151730690","doi":"https://doi.org/10.1186/1752-0509-4-124","title":"Molecular mechanistic associations of human diseases","display_name":"Molecular mechanistic associations of human diseases","publication_year":2010,"publication_date":"2010-09-06","ids":{"openalex":"https://openalex.org/W2151730690","doi":"https://doi.org/10.1186/1752-0509-4-124","mag":"2151730690","pmid":"https://pubmed.ncbi.nlm.nih.gov/20815942"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-124","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-124","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-124","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-124","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077363176","display_name":"Philip Stegmaier","orcid":"https://orcid.org/0000-0002-1881-8746"},"institutions":[{"id":"https://openalex.org/I4210120325","display_name":"Biobase (Germany)","ror":"https://ror.org/0325nt175","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210120325"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Philip Stegmaier","raw_affiliation_strings":["BIOBASE GmbH, Halchtersche Strasse 33, D-38304 Wolfenb\u00fcttel, Germany. philip.stegmaier@biobase-international.com","BIOBASE GmbH, Halchtersche Strasse 33, D-38304, Wolfenb\u00fcttel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOBASE GmbH, Halchtersche Strasse 33, D-38304 Wolfenb\u00fcttel, Germany. philip.stegmaier@biobase-international.com","institution_ids":["https://openalex.org/I4210120325"]},{"raw_affiliation_string":"BIOBASE GmbH, Halchtersche Strasse 33, D-38304, Wolfenb\u00fcttel, Germany","institution_ids":["https://openalex.org/I4210120325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088685439","display_name":"Mathias Krull","orcid":null},"institutions":[{"id":"https://openalex.org/I4210120325","display_name":"Biobase (Germany)","ror":"https://ror.org/0325nt175","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210120325"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mathias Krull","raw_affiliation_strings":["BIOBASE GmbH, Halchtersche Strasse 33, D-38304 Wolfenbttel, Germany","BIOBASE GmbH, Halchtersche Strasse 33, D-38304, Wolfenb\u00fcttel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOBASE GmbH, Halchtersche Strasse 33, D-38304 Wolfenbttel, Germany","institution_ids":["https://openalex.org/I4210120325"]},{"raw_affiliation_string":"BIOBASE GmbH, Halchtersche Strasse 33, D-38304, Wolfenb\u00fcttel, Germany","institution_ids":["https://openalex.org/I4210120325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063806596","display_name":"Nico Voss","orcid":null},"institutions":[{"id":"https://openalex.org/I4210120325","display_name":"Biobase (Germany)","ror":"https://ror.org/0325nt175","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210120325"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nico Voss","raw_affiliation_strings":["BIOBASE GmbH, Halchtersche Strasse 33, D-38304 Wolfenbttel, Germany","BIOBASE GmbH, Halchtersche Strasse 33, D-38304, Wolfenb\u00fcttel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOBASE GmbH, Halchtersche Strasse 33, D-38304 Wolfenbttel, Germany","institution_ids":["https://openalex.org/I4210120325"]},{"raw_affiliation_string":"BIOBASE GmbH, Halchtersche Strasse 33, D-38304, Wolfenb\u00fcttel, Germany","institution_ids":["https://openalex.org/I4210120325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016954113","display_name":"Alexander Kel","orcid":"https://orcid.org/0000-0001-6775-2467"},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander E Kel","raw_affiliation_strings":["Institute of Chemical Biology and Fundamental Medicine, Lavrentiev Ave.8, 630090, Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine, Lavrentiev Ave.8, 630090, Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210091979"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029172959","display_name":"Edgar Wingender","orcid":"https://orcid.org/0000-0002-7729-8453"},"institutions":[{"id":"https://openalex.org/I4210120325","display_name":"Biobase (Germany)","ror":"https://ror.org/0325nt175","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210120325"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Edgar Wingender","raw_affiliation_strings":["BIOBASE GmbH, Halchtersche Strasse 33, D-38304, Wolfenb\u00fcttel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOBASE GmbH, Halchtersche Strasse 33, D-38304, Wolfenb\u00fcttel, Germany","institution_ids":["https://openalex.org/I4210120325"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5077363176"],"corresponding_institution_ids":["https://openalex.org/I4210120325"],"apc_list":null,"apc_paid":null,"fwci":0.5444,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.6735045,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"4","issue":"1","first_page":"124","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.492900013923645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.492900013923645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.16169999539852142,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0502999983727932,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.8125791549682617},{"id":"https://openalex.org/keywords/clinical-phenotype","display_name":"Clinical phenotype","score":0.47350719571113586},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.43191900849342346},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.41009122133255005},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.36369919776916504},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3595666289329529},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35557276010513306},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3010316789150238},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2779384255409241},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.19684278964996338},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.1631891131401062},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.14382803440093994},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.10122710466384888}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.8125791549682617},{"id":"https://openalex.org/C3020646490","wikidata":"https://www.wikidata.org/wiki/Q25203551","display_name":"Clinical phenotype","level":4,"score":0.47350719571113586},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.43191900849342346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41009122133255005},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36369919776916504},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3595666289329529},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35557276010513306},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3010316789150238},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2779384255409241},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.19684278964996338},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1631891131401062},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14382803440093994},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.10122710466384888}],"mesh":[{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-4-124","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-124","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-124","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20815942","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20815942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:publications.goettingen-research-online.de:2/18956","is_oa":false,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/18956","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"journal_article"},{"id":"pmh:oai:doaj.org/article:6939153351ed45bba99c6d85d55b1a37","is_oa":false,"landing_page_url":"https://doaj.org/article/6939153351ed45bba99c6d85d55b1a37","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 4, Iss 1, p 124 (2010)","raw_type":"article"},{"id":"pmh:oai:goescholar:1/6022","is_oa":true,"landing_page_url":"http://resolver.sub.uni-goettingen.de/purl?gs-1/6022","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journalArticle"},{"id":"pmh:oai:pubmedcentral.nih.gov:2946303","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2946303","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-124","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-124","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-124","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2956492175","display_name":null,"funder_award_id":"LSHM-CT-2006-518153","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6401217413","display_name":null,"funder_award_id":"200754","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2151730690.pdf","grobid_xml":"https://content.openalex.org/works/W2151730690.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W140228277","https://openalex.org/W1635638240","https://openalex.org/W1971430873","https://openalex.org/W1980914397","https://openalex.org/W1995442662","https://openalex.org/W1997031720","https://openalex.org/W2001537654","https://openalex.org/W2003585722","https://openalex.org/W2007820472","https://openalex.org/W2012196772","https://openalex.org/W2016183056","https://openalex.org/W2027816595","https://openalex.org/W2027916530","https://openalex.org/W2027926303","https://openalex.org/W2037010452","https://openalex.org/W2044340941","https://openalex.org/W2047252564","https://openalex.org/W2047814129","https://openalex.org/W2055197018","https://openalex.org/W2062596469","https://openalex.org/W2064013116","https://openalex.org/W2075155461","https://openalex.org/W2080007652","https://openalex.org/W2080010210","https://openalex.org/W2080255605","https://openalex.org/W2082019409","https://openalex.org/W2083045667","https://openalex.org/W2091286894","https://openalex.org/W2094802773","https://openalex.org/W2097498614","https://openalex.org/W2103017472","https://openalex.org/W2104261859","https://openalex.org/W2107638877","https://openalex.org/W2108869871","https://openalex.org/W2112735398","https://openalex.org/W2112947018","https://openalex.org/W2113561514","https://openalex.org/W2117088067","https://openalex.org/W2119220491","https://openalex.org/W2119595824","https://openalex.org/W2119943416","https://openalex.org/W2120051475","https://openalex.org/W2121926780","https://openalex.org/W2122683221","https://openalex.org/W2123229219","https://openalex.org/W2130790725","https://openalex.org/W2132992030","https://openalex.org/W2134711219","https://openalex.org/W2138183717","https://openalex.org/W2142414392","https://openalex.org/W2142635246","https://openalex.org/W2146895097","https://openalex.org/W2153866356","https://openalex.org/W2154150778","https://openalex.org/W2154654747","https://openalex.org/W2155699197","https://openalex.org/W2158116492","https://openalex.org/W2158217645","https://openalex.org/W2159413587","https://openalex.org/W2163485494","https://openalex.org/W2165043719","https://openalex.org/W2165253681","https://openalex.org/W2168301815","https://openalex.org/W2169376102","https://openalex.org/W2171537806","https://openalex.org/W2481042206","https://openalex.org/W2785468108","https://openalex.org/W2902900172","https://openalex.org/W2917375902","https://openalex.org/W3149745985","https://openalex.org/W4247937483","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2055243143","https://openalex.org/W4321636575","https://openalex.org/W2357796999","https://openalex.org/W2045526782","https://openalex.org/W2741131631","https://openalex.org/W1986418932","https://openalex.org/W2156919374","https://openalex.org/W35446969","https://openalex.org/W1984019423","https://openalex.org/W4280588203"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,68],"study":[2,204],"of":[3,39,90,96,101,113,123,148,167,173,180,205,219,223],"relationships":[4,133],"between":[5,65],"human":[6,17,40,66],"diseases":[7,19,41],"provides":[8],"new":[9],"possibilities":[10],"for":[11,111,163,202],"biomedical":[12],"research.":[13,151],"Recent":[14],"achievements":[15],"on":[16],"genetic":[18,194,232],"have":[20],"stimulated":[21],"interest":[22],"to":[23,26,32,43,61,119,135,160,177,193,214],"derive":[24,161],"methods":[25,162],"identify":[27],"disease":[28,45,87,98,102,114,132,144,164,174,182],"associations":[29,64,103,138],"in":[30,185],"order":[31],"gain":[33],"further":[34,105],"insight":[35],"into":[36,85],"the":[37,121,178,203],"network":[38],"and":[42,73,82,139,141,171,225],"predict":[44],"genes.":[46,115,175],"RESULTS:":[47],"Using":[48],"about":[49],"10000":[50],"manually":[51],"collected":[52],"causal":[53,181],"disease/gene":[54,195],"associations,":[55,170],"we":[56],"developed":[57],"a":[58,108,157],"statistical":[59],"approach":[60],"infer":[62],"meaningful":[63],"morbidities.":[67],"derived":[69],"method":[70],"clustered":[71],"cardiometabolic":[72],"endocrine":[74],"disorders,":[75],"immune":[76],"system-related":[77],"diseases,":[78],"solid":[79],"tissue":[80],"neoplasms":[81],"neurodegenerative":[83],"pathologies":[84],"prominent":[86],"groups.":[88],"Analysis":[89],"biological":[91],"functions":[92],"confirmed":[93],"characteristic":[94],"features":[95],"corresponding":[97],"clusters.":[99],"Inference":[100],"was":[104],"employed":[106],"as":[107,217],"starting":[109],"point":[110],"prediction":[112,172],"Efforts":[116],"were":[117,146],"made":[118],"underpin":[120],"validity":[122],"results":[124,189],"by":[125,231],"relevant":[126],"literature":[127],"evidence.":[128],"Interestingly,":[129],"many":[130],"inferred":[131],"correspond":[134],"known":[136],"clinical":[137,168],"comorbidities,":[140],"several":[142],"predicted":[143],"genes":[145,183],"subjects":[147],"therapeutic":[149],"target":[150],"CONCLUSIONS:":[152],"Causal":[153],"molecular":[154],"mechanisms":[155],"present":[156],"unifying":[158],"principle":[159],"classification,":[165],"analysis":[166],"disorder":[169],"According":[176],"definition":[179],"applied":[184],"this":[186],"study,":[187],"these":[188],"are":[190],"not":[191,227],"restricted":[192],"relationships.":[196],"This":[197],"may":[198,226],"be":[199,228],"particularly":[200],"useful":[201],"long-term":[206],"or":[207,216],"chronic":[208],"illnesses,":[209],"where":[210],"pathological":[211],"derangement":[212],"due":[213],"environmental":[215],"part":[218],"sequel":[220],"conditions":[221],"is":[222],"importance":[224],"fully":[229],"explained":[230],"background.":[233]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}