{"id":"https://openalex.org/W2091627140","doi":"https://doi.org/10.1186/1752-0509-4-112","title":"Systems analysis of iron metabolism: the network of iron pools and fluxes","display_name":"Systems analysis of iron metabolism: the network of iron pools and fluxes","publication_year":2010,"publication_date":"2010-08-13","ids":{"openalex":"https://openalex.org/W2091627140","doi":"https://doi.org/10.1186/1752-0509-4-112","mag":"2091627140","pmid":"https://pubmed.ncbi.nlm.nih.gov/20704761"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-112","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-112","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-112","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-112","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037557478","display_name":"Tiago J. S. Lopes","orcid":"https://orcid.org/0000-0001-9605-5177"},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Tiago JS Lopes","raw_affiliation_strings":["Max-Delbrueck-Centrum of Molecular Medicine, Berlin-Buch, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Delbrueck-Centrum of Molecular Medicine, Berlin-Buch, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014667479","display_name":"Tatyana Luganskaja","orcid":null},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tatyana Luganskaja","raw_affiliation_strings":["Max-Delbrueck-Centrum of Molecular Medicine, D-13092, Berlin-Buch, Germany","Max-Delbrueck-Centrum of Molecular Medicine, Berlin-Buch, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Delbrueck-Centrum of Molecular Medicine, D-13092, Berlin-Buch, Germany","institution_ids":["https://openalex.org/I205582932"]},{"raw_affiliation_string":"Max-Delbrueck-Centrum of Molecular Medicine, Berlin-Buch, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038858663","display_name":"Maja Vuji\u0107 Spasi\u0107","orcid":"https://orcid.org/0000-0002-0297-0014"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maja Vuji\u0107 Spasi\u0107","raw_affiliation_strings":["Molecular Medicine, University of Heidelberg, Im Neuenheimer Feld 153, D-69120, Heidelberg, Germany","Molecular Medicine, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine, University of Heidelberg, Im Neuenheimer Feld 153, D-69120, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Molecular Medicine, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000270755","display_name":"Matthias W. Hentze","orcid":"https://orcid.org/0000-0002-4023-7876"},"institutions":[{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias W Hentze","raw_affiliation_strings":["European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, D-69117, Heidelberg, Germany","European Molecular Biology laboratory (EMBL), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, D-69117, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210153543"]},{"raw_affiliation_string":"European Molecular Biology laboratory (EMBL), Heidelberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060970793","display_name":"Martina U. Muckenthaler","orcid":"https://orcid.org/0000-0002-3778-510X"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martina U Muckenthaler","raw_affiliation_strings":["Molecular Medicine, University of Heidelberg, Im Neuenheimer Feld 153, D-69120, Heidelberg, Germany","Molecular Medicine, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine, University of Heidelberg, Im Neuenheimer Feld 153, D-69120, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Molecular Medicine, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103688750","display_name":"Klaus Sch\u00fcmann","orcid":null},"institutions":[{"id":"https://openalex.org/I309496635","display_name":"Weihenstephan-Triesdorf University of Applied Sciences","ror":"https://ror.org/00gzkxz88","country_code":"DE","type":"education","lineage":["https://openalex.org/I309496635"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus Sch\u00fcmann","raw_affiliation_strings":["Research Center for Nutrition and Food Sciences, Am Forum 5, D-85350, Freising-Weihenstephan, Germany","Research Center for Nutrition and Food Sciences, Freising-Weihenstephan, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Nutrition and Food Sciences, Am Forum 5, D-85350, Freising-Weihenstephan, Germany","institution_ids":[]},{"raw_affiliation_string":"Research Center for Nutrition and Food Sciences, Freising-Weihenstephan, Germany","institution_ids":["https://openalex.org/I309496635"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020823464","display_name":"J. Reich","orcid":"https://orcid.org/0000-0002-2657-4040"},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jens G Reich","raw_affiliation_strings":["Max-Delbrueck-Centrum of Molecular Medicine, D-13092, Berlin-Buch, Germany","Max-Delbrueck-Centrum of Molecular Medicine, Berlin-Buch, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Delbrueck-Centrum of Molecular Medicine, D-13092, Berlin-Buch, Germany","institution_ids":["https://openalex.org/I205582932"]},{"raw_affiliation_string":"Max-Delbrueck-Centrum of Molecular Medicine, Berlin-Buch, Germany","institution_ids":["https://openalex.org/I205582932"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5037557478"],"corresponding_institution_ids":["https://openalex.org/I205582932"],"apc_list":null,"apc_paid":null,"fwci":1.604,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.83803421,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"4","issue":"1","first_page":"112","last_page":"112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.4652999937534332,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.4652999937534332,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.10559999942779541,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/organism","display_name":"Organism","score":0.6834632158279419},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.6401465535163879},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.5586225986480713},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.43445801734924316},{"id":"https://openalex.org/keywords/compartment","display_name":"Compartment (ship)","score":0.43163543939590454},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.42842137813568115},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4272763133049011},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4246668815612793},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.40260106325149536},{"id":"https://openalex.org/keywords/physiology","display_name":"Physiology","score":0.3553420305252075},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3353242874145508},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14629486203193665}],"concepts":[{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.6834632158279419},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.6401465535163879},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5586225986480713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43445801734924316},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.43163543939590454},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.42842137813568115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4272763133049011},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4246668815612793},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40260106325149536},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3553420305252075},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3353242874145508},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14629486203193665},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-4-112","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-112","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-112","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20704761","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20704761","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:edoc.mdc-berlin.de:11156","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:617c828ff7ab4b92bee4be28d3f51b8f","is_oa":false,"landing_page_url":"https://doaj.org/article/617c828ff7ab4b92bee4be28d3f51b8f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 4, Iss 1, p 112 (2010)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2942822","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2942822","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-112","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-112","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-112","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2091627140.pdf","grobid_xml":"https://content.openalex.org/works/W2091627140.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1677338","https://openalex.org/W68541498","https://openalex.org/W138034579","https://openalex.org/W1488199919","https://openalex.org/W1491958585","https://openalex.org/W1519020669","https://openalex.org/W1536774035","https://openalex.org/W1558857728","https://openalex.org/W1568912715","https://openalex.org/W1586156156","https://openalex.org/W1608904542","https://openalex.org/W1618001767","https://openalex.org/W1846308052","https://openalex.org/W1914216711","https://openalex.org/W1964193402","https://openalex.org/W1964692676","https://openalex.org/W1966580120","https://openalex.org/W1970631907","https://openalex.org/W1971503180","https://openalex.org/W1982258483","https://openalex.org/W1982300107","https://openalex.org/W1987113388","https://openalex.org/W1989971434","https://openalex.org/W1990330893","https://openalex.org/W2003724282","https://openalex.org/W2005316756","https://openalex.org/W2008860022","https://openalex.org/W2009011779","https://openalex.org/W2016358751","https://openalex.org/W2025435405","https://openalex.org/W2030410388","https://openalex.org/W2030748132","https://openalex.org/W2041686980","https://openalex.org/W2056044240","https://openalex.org/W2065838703","https://openalex.org/W2067204454","https://openalex.org/W2072374090","https://openalex.org/W2086567353","https://openalex.org/W2088089367","https://openalex.org/W2088487864","https://openalex.org/W2114015514","https://openalex.org/W2126489810","https://openalex.org/W2128021554","https://openalex.org/W2128782793","https://openalex.org/W2130191588","https://openalex.org/W2142411057","https://openalex.org/W2153145418","https://openalex.org/W2159316975","https://openalex.org/W2165603655","https://openalex.org/W2166071821","https://openalex.org/W2177456910","https://openalex.org/W2257697934","https://openalex.org/W2259040121","https://openalex.org/W2268395224","https://openalex.org/W2319038150","https://openalex.org/W2322276456","https://openalex.org/W2340206296","https://openalex.org/W2398573122","https://openalex.org/W2400472059","https://openalex.org/W2474482597","https://openalex.org/W2616076389","https://openalex.org/W4205507656","https://openalex.org/W4213134081","https://openalex.org/W4232450315","https://openalex.org/W4247423476"],"related_works":["https://openalex.org/W24843447","https://openalex.org/W94193318","https://openalex.org/W4206762368","https://openalex.org/W2073808674","https://openalex.org/W322176015","https://openalex.org/W2028140658","https://openalex.org/W2173289516","https://openalex.org/W2037306065","https://openalex.org/W2468061618","https://openalex.org/W2966529883"],"abstract_inverted_index":{"BACKGROUND:":[0],"Every":[1],"cell":[2,73],"of":[3,23,28,41,62,89,116,120,168,176,183,189,194,197,208,224,240,246,253],"the":[4,39,51,104,117,181,200,212],"mammalian":[5,54],"organism":[6,55,105],"needs":[7],"iron":[8,30,63,90,121,147,184,198,232,241,254],"as":[9,16,18,85,87,106],"trace":[10],"element":[11],"in":[12,50,71,134,149,164,180,199,203,256,272],"numerous":[13],"oxido-reductive":[14],"processes":[15],"well":[17,86],"for":[19,158],"transport":[20],"and":[21,47,66,93,123,131,152,193,251,270],"storage":[22,255],"oxygen.":[24],"The":[25,53,145,161,172,234],"very":[26],"versatility":[27],"ionic":[29],"makes":[31],"it":[32],"a":[33,58,78,107,113,165,220],"toxic":[34],"entity":[35],"which":[36,263],"can":[37,98],"catalyze":[38],"production":[40],"radicals":[42],"that":[43],"damage":[44],"vital":[45],"membranous":[46],"macromolecular":[48],"assemblies":[49],"cell.":[52],"maintains":[56],"therefore":[57],"complex":[59],"regulatory":[60],"network":[61],"uptake,":[64],"excretion":[65],"intra-body":[67],"distribution.":[68],"Intracellular":[69],"regulation":[70],"different":[72,187,201,228],"types":[74],"is":[75,126],"intertwined":[76],"with":[77,230],"global":[79],"hormonal":[80],"signalling":[81],"structure.":[82],"Iron":[83],"deficiency":[84],"excess":[88],"are":[91],"frequent":[92],"serious":[94],"human":[95],"disorders.":[96],"They":[97],"affect":[99],"every":[100],"cell,":[101],"but":[102],"also":[103],"whole.":[108],"RESULTS:":[109],"Here,":[110],"we":[111,260],"present":[112],"kinematic":[114],"model":[115,167,218],"dynamic":[118,243],"system":[119],"pools":[122],"fluxes.":[124],"It":[125],"based":[127],"on":[128,139],"ferrokinetic":[129],"data":[130],"chemical":[132],"measurements":[133],"C57BL6":[135],"wild-type":[136],"mice":[137,225],"maintained":[138],"iron-deficient,":[140],"iron-adequate,":[141],"or":[142],"iron-loaded":[143],"diet.":[144],"tracer":[146],"levels":[148],"major":[150],"tissues":[151],"organs":[153],"(16":[154],"compartment)":[155],"were":[156],"followed":[157],"28":[159],"days.":[160],"evaluation":[162],"resulted":[163],"whole-body":[166],"fractional":[169],"clearance":[170],"rates.":[171],"analysis":[173],"permits":[174],"calculation":[175],"absolute":[177],"flux":[178],"rates":[179],"steady-state,":[182],"distribution":[185],"into":[186],"organs,":[188],"tracer-accessible":[190],"pool":[191],"sizes":[192],"residence":[195],"times":[196],"compartments":[202],"response":[204,250],"to":[205],"three":[206,227],"states":[207],"iron-repletion":[209],"induced":[210],"by":[211],"dietary":[213,268],"regime.":[214],"CONCLUSIONS:":[215],"This":[216],"mathematical":[217],"presents":[219],"comprehensive":[221],"physiological":[222],"picture":[223],"under":[226,267],"diets":[229],"varying":[231],"contents.":[233],"quantitative":[235,273],"results":[236],"reflect":[237],"systemic":[238],"properties":[239],"metabolism:":[242],"closedness,":[244],"hierarchy":[245],"time":[247],"scales,":[248],"switch-over":[249],"dynamics":[252],"parenchymal":[257],"organs.":[258],"Therefore,":[259],"could":[261],"assess":[262],"parameters":[264],"will":[265],"change":[266],"perturbations":[269],"study":[271],"terms":[274],"when":[275],"those":[276],"changes":[277],"take":[278],"place.":[279]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}