{"id":"https://openalex.org/W2092501057","doi":"https://doi.org/10.1186/1752-0509-4-10","title":"A Novel microRNA and transcription factor mediated regulatory network in schizophrenia","display_name":"A Novel microRNA and transcription factor mediated regulatory network in schizophrenia","publication_year":2010,"publication_date":"2010-02-15","ids":{"openalex":"https://openalex.org/W2092501057","doi":"https://doi.org/10.1186/1752-0509-4-10","mag":"2092501057","pmid":"https://pubmed.ncbi.nlm.nih.gov/20156358"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-4-10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-10","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-10","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-10","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113570922","display_name":"An Yuan Guo","orcid":null},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"An-Yuan Guo","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA","Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA#TAB#","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052779340","display_name":"Jingchun Sun","orcid":"https://orcid.org/0000-0002-3284-7973"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingchun Sun","raw_affiliation_strings":["Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, USA"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056121087","display_name":"Peilin Jia","orcid":"https://orcid.org/0000-0003-4523-4153"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peilin Jia","raw_affiliation_strings":["Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, USA"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006688612","display_name":"Zhongming Zhao","orcid":"https://orcid.org/0000-0002-3477-0914"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhongming Zhao","raw_affiliation_strings":["Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, USA"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, USA","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5113570922"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":6.4466,"has_fulltext":true,"cited_by_count":161,"citation_normalized_percentile":{"value":0.96637844,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"4","issue":"1","first_page":"10","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8091728687286377},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.7274024486541748},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.670824408531189},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.6553902626037598},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6185300350189209},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6065245866775513},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.5460600256919861},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"Schizophrenia (object-oriented programming)","score":0.5354257822036743},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.49445104598999023},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.44293487071990967},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.430003821849823},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.13218486309051514},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.06510260701179504}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8091728687286377},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.7274024486541748},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.670824408531189},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6553902626037598},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6185300350189209},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6065245866775513},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5460600256919861},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.5354257822036743},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49445104598999023},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44293487071990967},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.430003821849823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13218486309051514},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.06510260701179504}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-4-10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-10","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-10","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20156358","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20156358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2834616","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2834616","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-4-10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-4-10","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-4-10","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309424","display_name":"Thomas F. and Kate Miller Jeffress Memorial Trust","ror":"https://ror.org/006tvg625"},{"id":"https://openalex.org/F4320311440","display_name":"National Alliance for Research on Schizophrenia and Depression","ror":"https://ror.org/03a63f080"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2092501057.pdf","grobid_xml":"https://content.openalex.org/works/W2092501057.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W1553587640","https://openalex.org/W1971624220","https://openalex.org/W1974666828","https://openalex.org/W1979268646","https://openalex.org/W1980389572","https://openalex.org/W1984203471","https://openalex.org/W1986624071","https://openalex.org/W1986782449","https://openalex.org/W1988163167","https://openalex.org/W1990841485","https://openalex.org/W2012790217","https://openalex.org/W2013499487","https://openalex.org/W2016425872","https://openalex.org/W2016717347","https://openalex.org/W2017270642","https://openalex.org/W2019028138","https://openalex.org/W2037553038","https://openalex.org/W2038303173","https://openalex.org/W2041415111","https://openalex.org/W2042027879","https://openalex.org/W2044570331","https://openalex.org/W2050359514","https://openalex.org/W2059668070","https://openalex.org/W2060466339","https://openalex.org/W2060913442","https://openalex.org/W2062408585","https://openalex.org/W2063619823","https://openalex.org/W2065566217","https://openalex.org/W2067110557","https://openalex.org/W2070571588","https://openalex.org/W2072329780","https://openalex.org/W2073544062","https://openalex.org/W2077897416","https://openalex.org/W2080270890","https://openalex.org/W2087962734","https://openalex.org/W2089843122","https://openalex.org/W2094137970","https://openalex.org/W2095390867","https://openalex.org/W2099782860","https://openalex.org/W2102060609","https://openalex.org/W2109110326","https://openalex.org/W2112666597","https://openalex.org/W2112944159","https://openalex.org/W2121900484","https://openalex.org/W2124307069","https://openalex.org/W2124696614","https://openalex.org/W2126671780","https://openalex.org/W2136751299","https://openalex.org/W2137231271","https://openalex.org/W2139505730","https://openalex.org/W2140884549","https://openalex.org/W2143758110","https://openalex.org/W2145926386","https://openalex.org/W2147028713","https://openalex.org/W2148945289","https://openalex.org/W2149146453","https://openalex.org/W2151955797","https://openalex.org/W2153068303","https://openalex.org/W2156977058","https://openalex.org/W2157456513","https://openalex.org/W2157851293","https://openalex.org/W2159266018","https://openalex.org/W2159675211","https://openalex.org/W2161149887","https://openalex.org/W2162591320","https://openalex.org/W2166686883","https://openalex.org/W2169110289","https://openalex.org/W2170139221","https://openalex.org/W2171230529","https://openalex.org/W2171520215","https://openalex.org/W2338205519","https://openalex.org/W2597331575"],"related_works":["https://openalex.org/W2049907435","https://openalex.org/W2135896045","https://openalex.org/W2010571965","https://openalex.org/W2034377088","https://openalex.org/W2032799661","https://openalex.org/W2002709996","https://openalex.org/W2884256268","https://openalex.org/W2131025197","https://openalex.org/W3128451840","https://openalex.org/W4387092964"],"abstract_inverted_index":{"This":[0],"study":[1],"provides":[2],"many":[3],"insights":[4],"on":[5],"the":[6,16],"regulatory":[7,22],"mechanisms":[8],"of":[9,19],"genes":[10],"involved":[11],"in":[12,30],"schizophrenia.":[13,31],"It":[14],"represents":[15],"first":[17],"investigation":[18],"a":[20,25],"miRNA-TF":[21],"network":[23],"for":[24],"complex":[26],"disease,":[27],"as":[28],"demonstrated":[29]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":16}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
