{"id":"https://openalex.org/W2118917780","doi":"https://doi.org/10.1186/1752-0509-3-91","title":"Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis","display_name":"Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis","publication_year":2009,"publication_date":"2009-09-09","ids":{"openalex":"https://openalex.org/W2118917780","doi":"https://doi.org/10.1186/1752-0509-3-91","mag":"2118917780","pmid":"https://pubmed.ncbi.nlm.nih.gov/19740440"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-3-91","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-91","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-91","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-91","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072649743","display_name":"Jacob Feala","orcid":null},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jacob D Feala","raw_affiliation_strings":["Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA"],"affiliations":[{"raw_affiliation_string":"Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021668023","display_name":"Laurence Coquin","orcid":null},"institutions":[{"id":"https://openalex.org/I40399489","display_name":"Torrey Pines Institute For Molecular Studies","ror":"https://ror.org/01grq2104","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I40399489"]},{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurence Coquin","raw_affiliation_strings":["urnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA","urnham Institute for Medical Research, La Jolla, USA"],"affiliations":[{"raw_affiliation_string":"urnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I40399489"]},{"raw_affiliation_string":"urnham Institute for Medical Research, La Jolla, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002092179","display_name":"Dan Zhou","orcid":"https://orcid.org/0000-0001-6401-9040"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Zhou","raw_affiliation_strings":["Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive 0735, La Jolla, CA, 92093, USA","Department of Pediatrics, University of California, La Jolla, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive 0735, La Jolla, CA, 92093, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pediatrics, University of California, La Jolla, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102775655","display_name":"Gabriel G. Haddad","orcid":"https://orcid.org/0000-0003-2462-6668"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel G Haddad","raw_affiliation_strings":["Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive 0735, La Jolla, CA, 92093, USA","Department of Pediatrics, University of California, La Jolla, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive 0735, La Jolla, CA, 92093, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pediatrics, University of California, La Jolla, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004265401","display_name":"Giovanni Paternostro","orcid":"https://orcid.org/0000-0003-4029-5467"},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I40399489","display_name":"Torrey Pines Institute For Molecular Studies","ror":"https://ror.org/01grq2104","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I40399489"]},{"id":"https://openalex.org/I4210133661","display_name":"La Jolla Bioengineering Institute","ror":"https://ror.org/03sgbh608","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210133661"]},{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giovanni Paternostro","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, 0412, La Jolla, CA, 92093-0412, USA","urnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA","Department of Bioengineering, University of California, La Jolla, USA","urnham Institute for Medical Research, La Jolla, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, 0412, La Jolla, CA, 92093-0412, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"urnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I40399489"]},{"raw_affiliation_string":"Department of Bioengineering, University of California, La Jolla, USA","institution_ids":["https://openalex.org/I4210133661"]},{"raw_affiliation_string":"urnham Institute for Medical Research, La Jolla, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033811596","display_name":"Andrew D. McCulloch","orcid":"https://orcid.org/0000-0002-1708-5675"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D McCulloch","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, 0412, La Jolla, CA, 92093-0412, USA","Dept. of Bioengineering, University of California, La Jolla, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, 0412, La Jolla, CA, 92093-0412, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Dept. of Bioengineering, University of California, La Jolla, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5072649743"],"corresponding_institution_ids":["https://openalex.org/I188891513"],"apc_list":null,"apc_paid":null,"fwci":2.0158,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.86425635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"91","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11968","display_name":"High Altitude and Hypoxia","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flux-balance-analysis","display_name":"Flux balance analysis","score":0.7520619630813599},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6945005655288696},{"id":"https://openalex.org/keywords/hypoxia","display_name":"Hypoxia (environmental)","score":0.693226158618927},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.6557987928390503},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.6490450501441956},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.585205078125},{"id":"https://openalex.org/keywords/metabolic-flux-analysis","display_name":"Metabolic flux analysis","score":0.5848057270050049},{"id":"https://openalex.org/keywords/glycolysis","display_name":"Glycolysis","score":0.5761754512786865},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.5487462282180786},{"id":"https://openalex.org/keywords/metabolic-control-analysis","display_name":"Metabolic control analysis","score":0.5111017823219299},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.5055031776428223},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.4293272793292999},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.42528122663497925},{"id":"https://openalex.org/keywords/oxygen","display_name":"Oxygen","score":0.29107630252838135},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2790941596031189},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.21644192934036255},{"id":"https://openalex.org/keywords/biotechnology","display_name":"Biotechnology","score":0.12158313393592834},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.08711186051368713}],"concepts":[{"id":"https://openalex.org/C167091322","wikidata":"https://www.wikidata.org/wiki/Q5463029","display_name":"Flux balance analysis","level":2,"score":0.7520619630813599},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6945005655288696},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.693226158618927},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.6557987928390503},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.6490450501441956},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.585205078125},{"id":"https://openalex.org/C160941953","wikidata":"https://www.wikidata.org/wiki/Q6822342","display_name":"Metabolic flux analysis","level":3,"score":0.5848057270050049},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.5761754512786865},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.5487462282180786},{"id":"https://openalex.org/C70818257","wikidata":"https://www.wikidata.org/wiki/Q502671","display_name":"Metabolic control analysis","level":3,"score":0.5111017823219299},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5055031776428223},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4293272793292999},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42528122663497925},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.29107630252838135},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2790941596031189},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21644192934036255},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.12158313393592834},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08711186051368713},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004735","descriptor_name":"Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004735","descriptor_name":"Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004735","descriptor_name":"Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-3-91","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-91","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-91","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:19740440","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19740440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2749811","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2749811","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-3-91","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-91","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-91","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118917780.pdf","grobid_xml":"https://content.openalex.org/works/W2118917780.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W620042932","https://openalex.org/W655201810","https://openalex.org/W1543833632","https://openalex.org/W1561767438","https://openalex.org/W1604984248","https://openalex.org/W1900310992","https://openalex.org/W1963878813","https://openalex.org/W1967573306","https://openalex.org/W1999312292","https://openalex.org/W2009940763","https://openalex.org/W2017951535","https://openalex.org/W2036337660","https://openalex.org/W2046155446","https://openalex.org/W2047635265","https://openalex.org/W2048004251","https://openalex.org/W2051366884","https://openalex.org/W2068120924","https://openalex.org/W2070951720","https://openalex.org/W2095488878","https://openalex.org/W2096731539","https://openalex.org/W2099348997","https://openalex.org/W2106421836","https://openalex.org/W2108723074","https://openalex.org/W2129553536","https://openalex.org/W2147472054","https://openalex.org/W2151406110","https://openalex.org/W2156182405","https://openalex.org/W2157938678","https://openalex.org/W2163879682","https://openalex.org/W2164298308","https://openalex.org/W2166977259","https://openalex.org/W3022194922","https://openalex.org/W4232242901","https://openalex.org/W4238101851","https://openalex.org/W4388360685"],"related_works":["https://openalex.org/W1999460937","https://openalex.org/W2113329733","https://openalex.org/W2133150343","https://openalex.org/W1984242440","https://openalex.org/W1983989854","https://openalex.org/W2070388085","https://openalex.org/W2341681417","https://openalex.org/W2047334633","https://openalex.org/W2909696795","https://openalex.org/W2350881169"],"abstract_inverted_index":{"We":[0],"suggest":[1,46],"a":[2],"network-level":[3],"hypothesis":[4],"of":[5,16,29,37],"metabolic":[6],"regulation":[7],"in":[8,11,18,26],"hypoxia-adapted":[9],"flies,":[10],"which":[12,50],"lower":[13,27],"baseline":[14],"rates":[15,28],"biosynthesis":[17],"adapted":[19],"flies":[20],"draws":[21],"less":[22,31],"anaplerotic":[23],"flux,":[24],"resulting":[25],"glycolysis,":[30],"acidosis,":[32],"and":[33],"more":[34],"efficient":[35],"use":[36],"substrate":[38],"during":[39],"acute":[40],"hypoxic":[41],"stress.":[42],"In":[43],"addition":[44],"we":[45],"new":[47],"specific":[48],"hypothesis,":[49],"were":[51],"found":[52],"to":[53],"be":[54],"consistent":[55],"with":[56],"existing":[57],"data.":[58]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
