{"id":"https://openalex.org/W1984873551","doi":"https://doi.org/10.1186/1752-0509-3-9","title":"Information theoretical quantification of cooperativity in signalling complexes","display_name":"Information theoretical quantification of cooperativity in signalling complexes","publication_year":2009,"publication_date":"2009-01-16","ids":{"openalex":"https://openalex.org/W1984873551","doi":"https://doi.org/10.1186/1752-0509-3-9","mag":"1984873551","pmid":"https://pubmed.ncbi.nlm.nih.gov/19149897"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-3-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003581663","display_name":"Tom Lenaerts","orcid":"https://orcid.org/0000-0003-3645-1455"},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210140355","display_name":"VIB-VUB Center for Structural Biology","ror":"https://ror.org/03e84cm85","country_code":"BE","type":"facility","lineage":["https://openalex.org/I13469542","https://openalex.org/I2802017950","https://openalex.org/I4210140355"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Tom Lenaerts","raw_affiliation_strings":["SWITCH, VIB, Brussels, Belgium. tlenaert@vub.ac.be","SWITCH, VIB, Brussels, Belgium","Vrije Universiteit Brussel, Brussels, Belgium"],"affiliations":[{"raw_affiliation_string":"SWITCH, VIB, Brussels, Belgium. tlenaert@vub.ac.be","institution_ids":["https://openalex.org/I4210140355"]},{"raw_affiliation_string":"SWITCH, VIB, Brussels, Belgium","institution_ids":[]},{"raw_affiliation_string":"Vrije Universiteit Brussel, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105833323","display_name":"Jesper Ferkinghoff\u2010Borg","orcid":null},"institutions":[{"id":"https://openalex.org/I35570632","display_name":"\u00d8rsted (Denmark)","ror":"https://ror.org/02as34v38","country_code":"DK","type":"company","lineage":["https://openalex.org/I35570632"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jesper Ferkinghoff-Borg","raw_affiliation_strings":["\u00d8rsted.DTU, Technical Uiversity of Denmark, Kgs, Lyngby, Denmark"],"affiliations":[{"raw_affiliation_string":"\u00d8rsted.DTU, Technical Uiversity of Denmark, Kgs, Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099","https://openalex.org/I35570632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031589452","display_name":"Joost Schymkowitz","orcid":"https://orcid.org/0000-0003-2020-0168"},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Joost Schymkowitz","raw_affiliation_strings":["SWITCH, VIB, Brussels, Belgium","Vrije Universiteit Brussel, Brussels, Belgium"],"affiliations":[{"raw_affiliation_string":"SWITCH, VIB, Brussels, Belgium","institution_ids":[]},{"raw_affiliation_string":"Vrije Universiteit Brussel, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008256216","display_name":"Fr\u00e9d\u00e9ric Rousseau","orcid":"https://orcid.org/0000-0002-9189-7399"},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Frederic Rousseau","raw_affiliation_strings":["SWITCH, VIB, Brussels, Belgium","Vrije Universiteit Brussel, Brussels, Belgium"],"affiliations":[{"raw_affiliation_string":"SWITCH, VIB, Brussels, Belgium","institution_ids":[]},{"raw_affiliation_string":"Vrije Universiteit Brussel, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003581663"],"corresponding_institution_ids":["https://openalex.org/I13469542","https://openalex.org/I4210140355"],"apc_list":null,"apc_paid":null,"fwci":0.5391,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.65383409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"3","issue":"1","first_page":"9","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12561","display_name":"bioluminescence and chemiluminescence research","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cooperativity","display_name":"Cooperativity","score":0.9105205535888672},{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.6642684936523438},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6140954494476318},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5447427034378052},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.5334330797195435},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.525551438331604},{"id":"https://openalex.org/keywords/affinities","display_name":"Affinities","score":0.5254444479942322},{"id":"https://openalex.org/keywords/signalling","display_name":"Signalling","score":0.5067964196205139},{"id":"https://openalex.org/keywords/macromolecule","display_name":"Macromolecule","score":0.48215314745903015},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4575440585613251},{"id":"https://openalex.org/keywords/cooperative-binding","display_name":"Cooperative binding","score":0.4437875747680664},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.42285582423210144},{"id":"https://openalex.org/keywords/mutual-information","display_name":"Mutual information","score":0.42102426290512085},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3850659132003784},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3556475043296814},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.2046414613723755},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2005443572998047},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.18102926015853882},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.17296475172042847},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.15660032629966736},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10550123453140259}],"concepts":[{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.9105205535888672},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.6642684936523438},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6140954494476318},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5447427034378052},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5334330797195435},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.525551438331604},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.5254444479942322},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.5067964196205139},{"id":"https://openalex.org/C204389451","wikidata":"https://www.wikidata.org/wiki/Q178593","display_name":"Macromolecule","level":2,"score":0.48215314745903015},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4575440585613251},{"id":"https://openalex.org/C187250156","wikidata":"https://www.wikidata.org/wiki/Q2902610","display_name":"Cooperative binding","level":3,"score":0.4437875747680664},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42285582423210144},{"id":"https://openalex.org/C152139883","wikidata":"https://www.wikidata.org/wiki/Q252973","display_name":"Mutual information","level":2,"score":0.42102426290512085},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3850659132003784},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3556475043296814},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2046414613723755},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2005443572998047},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.18102926015853882},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17296475172042847},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.15660032629966736},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10550123453140259}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007257","descriptor_name":"Information Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007257","descriptor_name":"Information Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007257","descriptor_name":"Information Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044786","descriptor_name":"S-Phase Kinase-Associated Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D044786","descriptor_name":"S-Phase Kinase-Associated Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D044786","descriptor_name":"S-Phase Kinase-Associated Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D044786","descriptor_name":"S-Phase Kinase-Associated Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044786","descriptor_name":"S-Phase Kinase-Associated Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044786","descriptor_name":"S-Phase Kinase-Associated Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055592","descriptor_name":"Biophysical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055592","descriptor_name":"Biophysical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055592","descriptor_name":"Biophysical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1752-0509-3-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:19149897","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19149897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:499a89e92c1548e2b8ed215cb0e360e4","is_oa":true,"landing_page_url":"https://doaj.org/article/499a89e92c1548e2b8ed215cb0e360e4","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 3, Iss 1, p 9 (2009)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2637831","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2637831","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/8b437d6d-4612-473e-9df7-2a088f9aea53","is_oa":true,"landing_page_url":"https://orbit.dtu.dk/en/publications/8b437d6d-4612-473e-9df7-2a088f9aea53","pdf_url":null,"source":{"id":"https://openalex.org/S4306400705","display_name":"Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I96673099","host_organization_name":"Technical University of Denmark","host_organization_lineage":["https://openalex.org/I96673099"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lenaerts , T , Ferkinghoff-Borg , J , Schymkowitz , J & Rousseau , F 2009 , ' Information theoretical quantification of cooperativity in signalling complexes ' , BMC Systems Biology , vol. 3 , pp. 9 . https://doi.org/10.1186/1752-0509-3-9","raw_type":"article"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:150789","is_oa":false,"landing_page_url":"https://biblio.vub.ac.be/vubir/information-theoretical-quantification-of-cooperativity-in-signalling-complexes(e5d1798b-b239-40dd-a0a9-a4036513adeb).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:218295","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-3-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1984873551.pdf","grobid_xml":"https://content.openalex.org/works/W1984873551.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W65694556","https://openalex.org/W1542245192","https://openalex.org/W1573825647","https://openalex.org/W1581129475","https://openalex.org/W1607198972","https://openalex.org/W1636086261","https://openalex.org/W1965049479","https://openalex.org/W1966034229","https://openalex.org/W1983659508","https://openalex.org/W1986123070","https://openalex.org/W1988050069","https://openalex.org/W1988088522","https://openalex.org/W1995875735","https://openalex.org/W2000434788","https://openalex.org/W2009931826","https://openalex.org/W2046298465","https://openalex.org/W2048287651","https://openalex.org/W2053579714","https://openalex.org/W2056234356","https://openalex.org/W2066873261","https://openalex.org/W2077927147","https://openalex.org/W2103620774","https://openalex.org/W2107651677","https://openalex.org/W2122748438","https://openalex.org/W2142547111","https://openalex.org/W2152495216","https://openalex.org/W2887002214","https://openalex.org/W2914679068","https://openalex.org/W3140968660"],"related_works":["https://openalex.org/W1997135566","https://openalex.org/W1004292963","https://openalex.org/W2067253151","https://openalex.org/W2078068721","https://openalex.org/W1986169335","https://openalex.org/W2075856071","https://openalex.org/W4205106225","https://openalex.org/W2092615839","https://openalex.org/W1965064962","https://openalex.org/W2022546465"],"abstract_inverted_index":{"The":[0],"proposed":[1],"framework":[2,46,94],"provides":[3],"a":[4,32,81],"new":[5],"and":[6],"original":[7],"approach":[8],"to":[9],"analyse":[10],"the":[11,16,23,27,40,48],"effects":[12],"of":[13,18,50,64,83,88],"cooperativity":[14,98],"in":[15,62,86,101],"assembly":[17],"macromolecular":[19],"complexes.":[20],"It":[21],"shows":[22],"conditions,":[24],"provided":[25],"by":[26],"protein":[28],"concentrations,":[29],"for":[30,95],"which":[31],"particular":[33],"system":[34,56],"acts":[35],"most":[36,41],"effectively,":[37],"i.e.":[38],"exchanges":[39],"information.":[42],"As":[43],"such":[44,54],"this":[45],"opens":[47],"possibility":[49],"grasping":[51],"biological":[52,84],"qualities":[53],"as":[55],"sensitivity,":[57],"robustness":[58],"or":[59],"plasticity":[60],"directly":[61],"terms":[63,87],"their":[65],"effect":[66],"on":[67],"information":[68,89],"exchange.":[69],"Although":[70],"these":[71],"parameters":[72],"might":[73,100],"also":[74],"be":[75,104],"derived":[76],"using":[77],"classical":[78],"thermodynamic":[79],"parameters,":[80],"recasting":[82],"signalling":[85],"exchange":[90],"offers":[91],"an":[92],"alternative":[93],"visualising":[96],"network":[97],"that":[99],"some":[102],"cases":[103],"more":[105],"intuitive.":[106]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}