{"id":"https://openalex.org/W2076883893","doi":"https://doi.org/10.1186/1752-0509-3-88","title":"The crosstalk between EGF, IGF, and Insulin cell signaling pathways - computational and experimental analysis","display_name":"The crosstalk between EGF, IGF, and Insulin cell signaling pathways - computational and experimental analysis","publication_year":2009,"publication_date":"2009-09-04","ids":{"openalex":"https://openalex.org/W2076883893","doi":"https://doi.org/10.1186/1752-0509-3-88","mag":"2076883893","pmid":"https://pubmed.ncbi.nlm.nih.gov/19732446"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-3-88","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-88","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-88","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-88","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101864817","display_name":"Rafa\u0142 Zieli\u0144ski","orcid":"https://orcid.org/0000-0001-6510-719X"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rafal Zielinski","raw_affiliation_strings":["National Center for Biotechnology Information, National Library of Medicine National Institutes of Health Bethesda, MD, USA. zielinkir@mail.nih.gov","National Cancer Institute, National Institutes of Health,Bethesda,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Biotechnology Information, National Library of Medicine National Institutes of Health Bethesda, MD, USA. zielinkir@mail.nih.gov","institution_ids":["https://openalex.org/I4210109390","https://openalex.org/I1299303238"]},{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health,Bethesda,USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007489781","display_name":"Pawel F. Przytycki","orcid":"https://orcid.org/0000-0002-3360-6936"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pawel F Przytycki","raw_affiliation_strings":["Columbia College Columbia University, New York, NY, USA","Columbia College, Columbia University, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia College Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Columbia College, Columbia University, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014529529","display_name":"Jie Zheng","orcid":"https://orcid.org/0000-0001-6774-9786"},"institutions":[{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Zheng","raw_affiliation_strings":["National Center for Biotechnology Information, National Library of Medicine National Institutes of Health, Bethesda, MD, USA","National Center for Biotechnology Information, National Library of Medicine National Institutes of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Biotechnology Information, National Library of Medicine National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210109390","https://openalex.org/I1299303238"]},{"raw_affiliation_string":"National Center for Biotechnology Information, National Library of Medicine National Institutes of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100325058","display_name":"David Zhang","orcid":"https://orcid.org/0000-0002-5027-5286"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Zhang","raw_affiliation_strings":["Department of Electrical & Computer Engineering, University of Maryland, College Park, MD, USA","[Dept. of Electrical and Computer Engineering, University of Maryland, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical & Computer Engineering, University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"[Dept. of Electrical and Computer Engineering, University of Maryland, USA]","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089548776","display_name":"Teresa M. Przytycka","orcid":"https://orcid.org/0000-0002-6261-277X"},"institutions":[{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teresa M Przytycka","raw_affiliation_strings":["National Center for Biotechnology Information, National Library of Medicine National Institutes of Health, Bethesda, MD, USA","National Center for Biotechnology Information, National Library of Medicine National Institutes of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Biotechnology Information, National Library of Medicine National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210109390","https://openalex.org/I1299303238"]},{"raw_affiliation_string":"National Center for Biotechnology Information, National Library of Medicine National Institutes of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041336753","display_name":"Jacek Capala","orcid":"https://orcid.org/0000-0001-7631-0310"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacek Capala","raw_affiliation_strings":["National Cancer Institute National Institutes of Health, Bethesda, MD, USA","National Cancer Institute, National Institutes of Health,Bethesda,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health,Bethesda,USA","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5101864817"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210109390"],"apc_list":null,"apc_paid":null,"fwci":3.3783,"has_fulltext":true,"cited_by_count":67,"citation_normalized_percentile":{"value":0.92838732,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"88","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.19269999861717224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.19269999861717224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.09969999641180038,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.07800000160932541,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.9124549627304077},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.6505381464958191},{"id":"https://openalex.org/keywords/cell-signaling","display_name":"Cell signaling","score":0.5903553366661072},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5755146145820618},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4820593297481537},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"Insulin receptor","score":0.44066762924194336},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.4313303828239441},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4307912588119507},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.36637938022613525},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3291322588920593},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.2807338237762451},{"id":"https://openalex.org/keywords/insulin","display_name":"Insulin","score":0.2620425224304199},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.1967654526233673},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"Insulin resistance","score":0.10390123724937439},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.08738100528717041}],"concepts":[{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.9124549627304077},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6505381464958191},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.5903553366661072},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5755146145820618},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4820593297481537},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.44066762924194336},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.4313303828239441},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4307912588119507},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36637938022613525},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3291322588920593},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2807338237762451},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2620425224304199},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.1967654526233673},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.10390123724937439},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08738100528717041},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-3-88","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-88","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-88","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:19732446","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19732446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:drum.lib.umd.edu:1903/28167","is_oa":false,"landing_page_url":"http://hdl.handle.net/1903/28167","pdf_url":null,"source":{"id":"https://openalex.org/S4306401518","display_name":"University Libraries (University of Maryland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2751744","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2751744","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"doi:10.13016/gvsr-wmvt","is_oa":true,"landing_page_url":"https://doi.org/10.13016/gvsr-wmvt","pdf_url":null,"source":{"id":"https://openalex.org/S4306402644","display_name":"Digital Repository at the University of Maryland (University of Maryland College Park)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-3-88","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-88","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-88","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3277247684","display_name":null,"funder_award_id":"N01-CO-12400","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7504989611","display_name":null,"funder_award_id":"N01-CO-12400","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2076883893.pdf","grobid_xml":"https://content.openalex.org/works/W2076883893.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1522025508","https://openalex.org/W1607134312","https://openalex.org/W1965983806","https://openalex.org/W1968606500","https://openalex.org/W1985911638","https://openalex.org/W1989053944","https://openalex.org/W1995499011","https://openalex.org/W1995819749","https://openalex.org/W2005351906","https://openalex.org/W2010000580","https://openalex.org/W2010636476","https://openalex.org/W2010820226","https://openalex.org/W2013041603","https://openalex.org/W2023977554","https://openalex.org/W2025758028","https://openalex.org/W2036924431","https://openalex.org/W2042629507","https://openalex.org/W2046538693","https://openalex.org/W2094703210","https://openalex.org/W2107591926","https://openalex.org/W2132997183","https://openalex.org/W2134989772","https://openalex.org/W2138582489","https://openalex.org/W2144885342","https://openalex.org/W2145080853","https://openalex.org/W2145666748","https://openalex.org/W2150153992","https://openalex.org/W2150318080","https://openalex.org/W2151449559","https://openalex.org/W2151852639","https://openalex.org/W2159675211","https://openalex.org/W2752885492","https://openalex.org/W3103786587"],"related_works":["https://openalex.org/W2158714033","https://openalex.org/W4386628104","https://openalex.org/W78967844","https://openalex.org/W3213185671","https://openalex.org/W2509687359","https://openalex.org/W4206945140","https://openalex.org/W3022555688","https://openalex.org/W4385588055","https://openalex.org/W2546463226","https://openalex.org/W4212865750"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cellular":[1],"response":[2,180],"to":[3,84,185,282],"external":[4],"stimuli":[5],"requires":[6],"propagation":[7,115,246],"of":[8,29,47,71,73,87,105,113,137,165,174,181,188,199,202,208,247,294],"corresponding":[9],"signals":[10],"through":[11],"molecular":[12],"signaling":[13,16,33,38,75,135,141,183,279],"pathways.":[14,129],"However,":[15,281],"pathways":[17,39],"are":[18,40],"not":[19,252],"isolated":[20],"information":[21,126],"highways,":[22],"but":[23],"rather":[24],"interact":[25],"in":[26,37,205,226,269,277],"a":[27,203,273,284,288],"number":[28],"ways":[30],"forming":[31],"sophisticated":[32],"networks.":[34,280],"Since":[35],"defects":[36],"associated":[41],"with":[42,244],"many":[43],"serious":[44],"diseases,":[45],"understanding":[46,100],"the":[48,88,101,106,117,133,175,179,200,206,227,239,248,257],"crosstalk":[49],"between":[50],"them":[51],"is":[52],"fundamental":[53],"for":[54,99,110,224,231],"designing":[55],"molecularly":[56],"targeted":[57],"therapy.":[58],"Unfortunately,":[59],"we":[60],"still":[61],"lack":[62],"technology":[63],"that":[64,91],"would":[65,95],"allow":[66],"high":[67],"throughput":[68],"detailed":[69,111,290],"measurement":[70],"activity":[72,94],"individual":[74,295],"molecules":[76,89,184],"and":[77,153,162,191,230],"their":[78,93],"interactions.":[79],"This":[80],"necessitates":[81],"developing":[82],"methods":[83],"prioritize":[85],"selection":[86],"such":[90,128,209],"measuring":[92,178],"be":[96,298],"most":[97],"informative":[98],"crosstalk.":[102,210],"Furthermore,":[103],"absence":[104],"reaction":[107],"coefficients":[108],"necessary":[109],"modeling":[112,164,278],"signal":[114],"raises":[116],"question":[118],"whether":[119],"simple":[120,266],"parameter-free":[121],"models":[122],"could":[123],"provide":[124],"useful":[125],"about":[127],"RESULTS:":[130],"We":[131,194],"study":[132,158],"combined":[134,243],"network":[136,228,241],"three":[138],"major":[139],"pro-survival":[140],"pathways:":[142],"Epidermal":[143],"Growth":[144,149],"Factor":[145],"Receptor":[146,151,155],"(EGFR),":[147],"Insulin-like":[148],"Factor-1":[150],"(IGF-1R),":[152],"Insulin":[154],"(IR).":[156],"Our":[157,234],"involves":[159],"static":[160],"analysis":[161],"dynamic":[163],"this":[166,270],"network,":[167],"as":[168,170],"well":[169],"an":[171],"experimental":[172,232],"verification":[173],"model":[176,242,267],"by":[177,256,262],"selected":[182,223],"differential":[186],"stimulation":[187],"EGF,":[189],"IGF":[190],"insulin":[192],"receptors.":[193],"introduced":[195],"two":[196],"novel":[197],"measures":[198,214],"importance":[201],"node":[204],"context":[207],"Based":[211],"on":[212,238],"these":[213],"several":[215],"molecules,":[216],"namely":[217],"Erk1/2,":[218],"Akt1,":[219],"Jnk,":[220],"p70S6K,":[221],"were":[222],"monitoring":[225],"simulation":[229,235],"studies.":[233],"method":[236],"relies":[237],"Boolean":[240],"stochastic":[245],"signal.":[249],"Most":[250],"(although":[251],"all)":[253],"trends":[254],"suggested":[255],"simulations":[258],"have":[259],"been":[260],"confirmed":[261],"experiments.":[263],"CONCLUSION:":[264],"The":[265],"implemented":[268],"paper":[271],"provides":[272],"valuable":[274],"first":[275],"step":[276],"obtain":[283],"fully":[285],"predictive":[286],"model,":[287],"more":[289],"knowledge":[291],"regarding":[292],"parameters":[293],"interactions":[296],"might":[297],"necessary.":[299]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":10}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}
