{"id":"https://openalex.org/W1971985527","doi":"https://doi.org/10.1186/1752-0509-3-84","title":"Specialized or flexible feed-forward loop motifs: a question of topology","display_name":"Specialized or flexible feed-forward loop motifs: a question of topology","publication_year":2009,"publication_date":"2009-08-31","ids":{"openalex":"https://openalex.org/W1971985527","doi":"https://doi.org/10.1186/1752-0509-3-84","mag":"1971985527","pmid":"https://pubmed.ncbi.nlm.nih.gov/19719842"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-3-84","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-84","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-84","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-84","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080642556","display_name":"Javier Mac\u00eda","orcid":"https://orcid.org/0000-0002-6705-5554"},"institutions":[{"id":"https://openalex.org/I2801864671","display_name":"Barcelona Biomedical Research Park","ror":"https://ror.org/05sajct49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801864671"]},{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Javier Mac\u00eda","raw_affiliation_strings":["Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), 08003 Barcelona, Spain. javier.macia@upf.edu","Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), 08003 Barcelona, Spain. javier.macia@upf.edu","institution_ids":["https://openalex.org/I2801864671"]},{"raw_affiliation_string":"Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Barcelona, Spain","institution_ids":["https://openalex.org/I2801864671","https://openalex.org/I11932220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073288820","display_name":"Stefanie Widder","orcid":"https://orcid.org/0000-0003-0733-5666"},"institutions":[{"id":"https://openalex.org/I2801864671","display_name":"Barcelona Biomedical Research Park","ror":"https://ror.org/05sajct49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801864671"]},{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Stefanie Widder","raw_affiliation_strings":["Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Dr. Aiguader 88, 08003 Barcelona, Spain and","Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Dr. Aiguader 88, 08003 Barcelona, Spain and","institution_ids":["https://openalex.org/I2801864671"]},{"raw_affiliation_string":"Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Barcelona, Spain","institution_ids":["https://openalex.org/I2801864671","https://openalex.org/I11932220"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046878011","display_name":"Ricard V. Sol\u00e9","orcid":"https://orcid.org/0000-0001-6974-1008"},"institutions":[{"id":"https://openalex.org/I1308548392","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35","country_code":"US","type":"funder","lineage":["https://openalex.org/I1308548392"]},{"id":"https://openalex.org/I2801864671","display_name":"Barcelona Biomedical Research Park","ror":"https://ror.org/05sajct49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801864671"]},{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Ricard Sol\u00e9","raw_affiliation_strings":["Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Barcelona, Spain","Santa Fe Institute, Santa Fe, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Barcelona, Spain","institution_ids":["https://openalex.org/I2801864671","https://openalex.org/I11932220"]},{"raw_affiliation_string":"Santa Fe Institute, Santa Fe, USA","institution_ids":["https://openalex.org/I1308548392"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080642556"],"corresponding_institution_ids":["https://openalex.org/I11932220","https://openalex.org/I2801864671"],"apc_list":null,"apc_paid":null,"fwci":1.3513,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.79031102,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"3","issue":"1","first_page":"84","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7008000016212463,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7008000016212463,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11187","display_name":"Nonlinear Dynamics and Pattern Formation","score":0.09080000221729279,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.6823965907096863},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6501983404159546},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.6401889324188232},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5528606176376343},{"id":"https://openalex.org/keywords/network-motif","display_name":"Network motif","score":0.5524060130119324},{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.5037083029747009},{"id":"https://openalex.org/keywords/dynamical-systems-theory","display_name":"Dynamical systems theory","score":0.49959444999694824},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.47300583124160767},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.41228774189949036},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.34867483377456665},{"id":"https://openalex.org/keywords/complex-network","display_name":"Complex network","score":0.2821013927459717},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.26908600330352783},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1181555688381195},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10002648830413818}],"concepts":[{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.6823965907096863},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6501983404159546},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.6401889324188232},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5528606176376343},{"id":"https://openalex.org/C60723933","wikidata":"https://www.wikidata.org/wiki/Q7001080","display_name":"Network motif","level":3,"score":0.5524060130119324},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.5037083029747009},{"id":"https://openalex.org/C79379906","wikidata":"https://www.wikidata.org/wiki/Q3174497","display_name":"Dynamical systems theory","level":2,"score":0.49959444999694824},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.47300583124160767},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.41228774189949036},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.34867483377456665},{"id":"https://openalex.org/C34947359","wikidata":"https://www.wikidata.org/wiki/Q665189","display_name":"Complex network","level":2,"score":0.2821013927459717},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.26908600330352783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1181555688381195},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10002648830413818},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-3-84","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-84","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-84","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:19719842","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19719842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:repositori.upf.edu:10230/23138","is_oa":true,"landing_page_url":"http://hdl.handle.net/10230/23138","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2749051","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2749051","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-3-84","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-84","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-84","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306183","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19"},{"id":"https://openalex.org/F4320312777","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1971985527.pdf","grobid_xml":"https://content.openalex.org/works/W1971985527.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1488862788","https://openalex.org/W1513851163","https://openalex.org/W1592356192","https://openalex.org/W1644749979","https://openalex.org/W1660272337","https://openalex.org/W1808967201","https://openalex.org/W1966638085","https://openalex.org/W1987815409","https://openalex.org/W1995991050","https://openalex.org/W1999611553","https://openalex.org/W2007334358","https://openalex.org/W2008855387","https://openalex.org/W2024088550","https://openalex.org/W2037992356","https://openalex.org/W2041988645","https://openalex.org/W2049797028","https://openalex.org/W2057680921","https://openalex.org/W2059044327","https://openalex.org/W2062851353","https://openalex.org/W2071495240","https://openalex.org/W2075851722","https://openalex.org/W2083284116","https://openalex.org/W2088988616","https://openalex.org/W2094438648","https://openalex.org/W2096011929","https://openalex.org/W2104123948","https://openalex.org/W2109110326","https://openalex.org/W2109339694","https://openalex.org/W2110699703","https://openalex.org/W2112262143","https://openalex.org/W2115708039","https://openalex.org/W2122261310","https://openalex.org/W2126602684","https://openalex.org/W2130130653","https://openalex.org/W2134427620","https://openalex.org/W2143186346","https://openalex.org/W2143258942","https://openalex.org/W2146206624","https://openalex.org/W2151480825","https://openalex.org/W2153624566","https://openalex.org/W2162884852","https://openalex.org/W2163480486","https://openalex.org/W2164845193","https://openalex.org/W2171109336","https://openalex.org/W2414846929","https://openalex.org/W2899266716","https://openalex.org/W3099251374"],"related_works":["https://openalex.org/W2796517744","https://openalex.org/W2008014943","https://openalex.org/W15348386","https://openalex.org/W2807926763","https://openalex.org/W2951915565","https://openalex.org/W2090574217","https://openalex.org/W2143557297","https://openalex.org/W1976722121","https://openalex.org/W1982032334","https://openalex.org/W2985827561"],"abstract_inverted_index":{"BACKGROUND:":[0],"Network":[1],"motifs":[2],"are":[3,8,48,193,219],"recurrent":[4],"interaction":[5,15],"patterns,":[6],"which":[7],"significantly":[9],"more":[10],"often":[11],"encountered":[12],"in":[13,56,115,216],"biological":[14],"graphs":[16],"than":[17],"expected":[18],"from":[19],"random":[20],"nets.":[21],"Their":[22],"existence":[23],"raises":[24],"questions":[25],"concerning":[26],"their":[27],"emergence":[28,139,211],"and":[29,75,135,182],"functional":[30],"capacities.":[31],"In":[32],"this":[33,91],"context,":[34],"it":[35],"has":[36,80,87],"been":[37,81,88],"shown":[38],"that":[39,127],"feed":[40],"forward":[41],"loops":[42],"(FFL)":[43],"composed":[44],"of":[45,50,108,137,157,166,185,198,202,212],"three":[46],"genes":[47],"capable":[49],"processing":[51],"external":[52,118],"signals":[53],"by":[54,162],"responding":[55],"a":[57,70,109,112,141,150],"very":[58],"specific,":[59],"robust":[60],"manner,":[61],"either":[62],"accelerating":[63],"or":[64,200],"delaying":[65],"responses.":[66],"Early":[67],"studies":[68],"suggested":[69],"one-to-one":[71],"mapping":[72],"between":[73,179],"topology":[74,181],"dynamics":[76],"but":[77,153],"such":[78],"view":[79],"repeatedly":[82],"questioned.":[83],"The":[84,145,189,207],"FFL's":[85],"function":[86],"attributed":[89],"to":[90,117,130,174,195],"specific":[92,142],"response.":[93,144],"A":[94],"general":[95],"response":[96,116,168],"analysis":[97,156,172],"is":[98,102,147],"difficult,":[99],"because":[100],"one":[101],"dealing":[103],"with":[104],"the":[105,133,138,158,167,177,183,196,203,210],"dynamical":[106,143],"trajectory":[107],"system":[110],"towards":[111],"new":[113],"regime":[114],"signals.":[119],"RESULTS:":[120],"We":[121],"have":[122],"developed":[123],"an":[124,163],"analytical":[125],"method":[126,146],"allows":[128,173],"us":[129],"systematically":[131],"explore":[132],"patterns":[134],"probabilities":[136],"for":[140,209],"based":[148],"on":[149],"rather":[151],"simple,":[152],"powerful":[154],"geometrical":[155],"system's":[159],"nullclines":[160],"complemented":[161],"appropriate":[164],"formalization":[165],"probability.":[169],"CONCLUSION:":[170],"Our":[171],"determine":[175],"unambiguously":[176],"relationship":[178],"motif":[180,214],"set":[184],"potentially":[186],"implementable":[187],"functions.":[188],"distribution":[190],"probability":[191],"distributions":[192],"linked":[194],"degree":[197],"specialization":[199],"flexibility":[201],"given":[204],"network":[205],"topology.":[206],"implications":[208],"different":[213],"topologies":[215],"complex":[217],"networks":[218],"outlined.":[220]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}
