{"id":"https://openalex.org/W1988562314","doi":"https://doi.org/10.1186/1752-0509-3-73","title":"An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules","display_name":"An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules","publication_year":2009,"publication_date":"2009-07-17","ids":{"openalex":"https://openalex.org/W1988562314","doi":"https://doi.org/10.1186/1752-0509-3-73","mag":"1988562314","pmid":"https://pubmed.ncbi.nlm.nih.gov/19615063"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-3-73","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-73","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-73","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-73","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091072862","display_name":"Huaxia Qin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210145812","display_name":"Cancer Genetics (United States)","ror":"https://ror.org/05feyya22","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145812"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Huaxia Qin","raw_affiliation_strings":["Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA. huaxia.qin@gmail.com","Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA. huaxia.qin@gmail.com","institution_ids":["https://openalex.org/I4210145812"]},{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111953042","display_name":"Michael WY Chan","orcid":null},"institutions":[{"id":"https://openalex.org/I148099254","display_name":"National Chung Cheng University","ror":"https://ror.org/0028v3876","country_code":"TW","type":"education","lineage":["https://openalex.org/I148099254"]},{"id":"https://openalex.org/I4210145812","display_name":"Cancer Genetics (United States)","ror":"https://ror.org/05feyya22","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145812"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Michael WY Chan","raw_affiliation_strings":["Department of Life Science and Institute of Molecular Biology, National Chung Cheng University, Min-Hsiung, Chia-Yi 621, Taiwan, Republic of China,","Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA","Department of Life Science and Institute of Molecular Biology, National Chung Cheng University, Min-Hsiung, Chia-Yi 621, Taiwan, Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science and Institute of Molecular Biology, National Chung Cheng University, Min-Hsiung, Chia-Yi 621, Taiwan, Republic of China,","institution_ids":["https://openalex.org/I148099254"]},{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","institution_ids":["https://openalex.org/I4210145812"]},{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I4210145812","https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Life Science and Institute of Molecular Biology, National Chung Cheng University, Min-Hsiung, Chia-Yi 621, Taiwan, Republic of China","institution_ids":["https://openalex.org/I148099254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072858554","display_name":"Sandya Liyanarachchi","orcid":"https://orcid.org/0000-0002-1857-5246"},"institutions":[{"id":"https://openalex.org/I4210145812","display_name":"Cancer Genetics (United States)","ror":"https://ror.org/05feyya22","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145812"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandya Liyanarachchi","raw_affiliation_strings":["Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","institution_ids":["https://openalex.org/I4210145812"]},{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004086660","display_name":"Curtis Balch","orcid":null},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curtis Balch","raw_affiliation_strings":["Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA,","Medical Sciences, Indiana University School of Medicine, Bloomington-USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA,","institution_ids":["https://openalex.org/I4210119109"]},{"raw_affiliation_string":"Medical Sciences, Indiana University School of Medicine, Bloomington-USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000357133","display_name":"Dustin Potter","orcid":null},"institutions":[{"id":"https://openalex.org/I4210145812","display_name":"Cancer Genetics (United States)","ror":"https://ror.org/05feyya22","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145812"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dustin Potter","raw_affiliation_strings":["Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","institution_ids":["https://openalex.org/I4210145812"]},{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091426030","display_name":"Irene J Souriraj","orcid":null},"institutions":[{"id":"https://openalex.org/I4210145812","display_name":"Cancer Genetics (United States)","ror":"https://ror.org/05feyya22","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145812"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene J Souriraj","raw_affiliation_strings":["Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","institution_ids":["https://openalex.org/I4210145812"]},{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055538725","display_name":"Alfred S.L. Cheng","orcid":"https://orcid.org/0000-0003-2345-6951"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210145812","display_name":"Cancer Genetics (United States)","ror":"https://ror.org/05feyya22","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145812"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["HK","US"],"is_corresponding":false,"raw_author_name":"Alfred SL Cheng","raw_affiliation_strings":["Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, PR China","Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","institution_ids":["https://openalex.org/I4210145812"]},{"raw_affiliation_string":"Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, PR China","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I4210145812","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057503428","display_name":"Francisco Agosto-Perez","orcid":null},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francisco J Agosto-Perez","raw_affiliation_strings":["Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024926540","display_name":"Elena Nikonova","orcid":"https://orcid.org/0009-0003-2153-8790"},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I4210145812","display_name":"Cancer Genetics (United States)","ror":"https://ror.org/05feyya22","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena V Nikonova","raw_affiliation_strings":["Center for Systems and Computational Biology, Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA","Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","Center for Systems and Computational Biology, Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems and Computational Biology, Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","institution_ids":["https://openalex.org/I4210145812"]},{"raw_affiliation_string":"Center for Systems and Computational Biology, Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, USA","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019710145","display_name":"Pearlly S. Yan","orcid":"https://orcid.org/0000-0003-1965-4920"},"institutions":[{"id":"https://openalex.org/I4210145812","display_name":"Cancer Genetics (United States)","ror":"https://ror.org/05feyya22","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145812"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pearlly S Yan","raw_affiliation_strings":["Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","institution_ids":["https://openalex.org/I4210145812"]},{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087822712","display_name":"Huey\u2010Jen Lin","orcid":"https://orcid.org/0000-0003-1726-6385"},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huey-Jen Lin","raw_affiliation_strings":["Division of Medical Technology, School of Allied Medical Professions, The Ohio State University, Columbus, OH 43210, USA,","Division of Medical Technology, School of Allied Medical Professions, The Ohio State University, Columbus, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Technology, School of Allied Medical Professions, The Ohio State University, Columbus, OH 43210, USA,","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Division of Medical Technology, School of Allied Medical Professions, The Ohio State University, Columbus, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061888144","display_name":"Kenneth P. Nephew","orcid":"https://orcid.org/0000-0003-2192-1346"},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth P Nephew","raw_affiliation_strings":["Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA,","Medical Sciences, Indiana University School of Medicine, Bloomington-USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA,","institution_ids":["https://openalex.org/I4210119109"]},{"raw_affiliation_string":"Medical Sciences, Indiana University School of Medicine, Bloomington-USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105466808","display_name":"Joel H. Saltz","orcid":null},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel H Saltz","raw_affiliation_strings":["Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA,","Department of Biomedical Informatics, The Ohio State University, Columbus, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA,","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Biomedical Informatics, The Ohio State University, Columbus, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001480754","display_name":"Louise C. Showe","orcid":"https://orcid.org/0000-0002-7818-4220"},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louise C Showe","raw_affiliation_strings":["Center for Systems and Computational Biology, Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA","Center for Systems and Computational Biology, Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems and Computational Biology, Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"Center for Systems and Computational Biology, Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, USA","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110259719","display_name":"Tim H-M. Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210145812","display_name":"Cancer Genetics (United States)","ror":"https://ror.org/05feyya22","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145812"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tim HM Huang","raw_affiliation_strings":["Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","institution_ids":["https://openalex.org/I4210145812"]},{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017429478","display_name":"Ramana V. Davuluri","orcid":"https://orcid.org/0000-0002-7053-1064"},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I4210145812","display_name":"Cancer Genetics (United States)","ror":"https://ror.org/05feyya22","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145812"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramana V Davuluri","raw_affiliation_strings":["Center for Systems and Computational Biology, Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA","Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA","Center for Systems and Computational Biology, Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems and Computational Biology, Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA,","institution_ids":["https://openalex.org/I4210145812"]},{"raw_affiliation_string":"Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Center for Systems and Computational Biology, Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, USA","institution_ids":["https://openalex.org/I102322052"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5091072862"],"corresponding_institution_ids":["https://openalex.org/I4210145812","https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":2.1906,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.87005409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"73","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.34209999442100525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.34209999442100525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.2630000114440918,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.16769999265670776,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/smad","display_name":"SMAD","score":0.933059811592102},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.6705935001373291},{"id":"https://openalex.org/keywords/chromatin-immunoprecipitation","display_name":"Chromatin immunoprecipitation","score":0.6436567902565002},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5474810600280762},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.45876258611679077},{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.4564630091190338},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.44893819093704224},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"Transcriptional regulation","score":0.44628921151161194},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4403075575828552},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4133506417274475},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.39822497963905334},{"id":"https://openalex.org/keywords/promoter","display_name":"Promoter","score":0.3616553544998169},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3233991265296936},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.29337167739868164},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2925528585910797}],"concepts":[{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.933059811592102},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6705935001373291},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.6436567902565002},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5474810600280762},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.45876258611679077},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.4564630091190338},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.44893819093704224},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.44628921151161194},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4403075575828552},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4133506417274475},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.39822497963905334},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.3616553544998169},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3233991265296936},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.29337167739868164},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2925528585910797},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-3-73","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-73","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-73","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:19615063","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19615063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2724489","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2724489","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-3-73","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-73","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-73","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7099999785423279,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320314457","display_name":"Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1988562314.pdf","grobid_xml":"https://content.openalex.org/works/W1988562314.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W1530689820","https://openalex.org/W1539593569","https://openalex.org/W1547242410","https://openalex.org/W1553713556","https://openalex.org/W1565561072","https://openalex.org/W1594031697","https://openalex.org/W1595424060","https://openalex.org/W1718902928","https://openalex.org/W1965068333","https://openalex.org/W1965425054","https://openalex.org/W1966647849","https://openalex.org/W1967695492","https://openalex.org/W1968926018","https://openalex.org/W1969798346","https://openalex.org/W1979079848","https://openalex.org/W1982147469","https://openalex.org/W1988498329","https://openalex.org/W1992105713","https://openalex.org/W1994185571","https://openalex.org/W1995194065","https://openalex.org/W1998415342","https://openalex.org/W1999299866","https://openalex.org/W2010488399","https://openalex.org/W2014406863","https://openalex.org/W2015979443","https://openalex.org/W2016959368","https://openalex.org/W2018183560","https://openalex.org/W2018631055","https://openalex.org/W2018867485","https://openalex.org/W2019474025","https://openalex.org/W2024805424","https://openalex.org/W2029222496","https://openalex.org/W2032924726","https://openalex.org/W2042515526","https://openalex.org/W2047535279","https://openalex.org/W2050410270","https://openalex.org/W2059030354","https://openalex.org/W2063076489","https://openalex.org/W2065634403","https://openalex.org/W2067434109","https://openalex.org/W2069414088","https://openalex.org/W2069678729","https://openalex.org/W2072363222","https://openalex.org/W2078928513","https://openalex.org/W2079596996","https://openalex.org/W2080915541","https://openalex.org/W2082867992","https://openalex.org/W2084770265","https://openalex.org/W2086099578","https://openalex.org/W2088685468","https://openalex.org/W2089956843","https://openalex.org/W2093762155","https://openalex.org/W2094036688","https://openalex.org/W2094298080","https://openalex.org/W2095605427","https://openalex.org/W2095708380","https://openalex.org/W2100668965","https://openalex.org/W2100999453","https://openalex.org/W2102165807","https://openalex.org/W2102223833","https://openalex.org/W2107575419","https://openalex.org/W2107577013","https://openalex.org/W2109972881","https://openalex.org/W2112762570","https://openalex.org/W2114066176","https://openalex.org/W2116765712","https://openalex.org/W2117200840","https://openalex.org/W2118628540","https://openalex.org/W2119104284","https://openalex.org/W2124659501","https://openalex.org/W2125604855","https://openalex.org/W2126432272","https://openalex.org/W2127597058","https://openalex.org/W2129061533","https://openalex.org/W2133193835","https://openalex.org/W2138784667","https://openalex.org/W2140275562","https://openalex.org/W2145190346","https://openalex.org/W2146264532","https://openalex.org/W2148664347","https://openalex.org/W2150926065","https://openalex.org/W2153424791","https://openalex.org/W2154022964","https://openalex.org/W2154568166","https://openalex.org/W2155812032","https://openalex.org/W2159248478","https://openalex.org/W2162305823","https://openalex.org/W2162929030","https://openalex.org/W2164615751","https://openalex.org/W2165118109","https://openalex.org/W2165198231","https://openalex.org/W2165680633","https://openalex.org/W2167627996","https://openalex.org/W2169318796","https://openalex.org/W2313962533","https://openalex.org/W2911964244","https://openalex.org/W3085162807","https://openalex.org/W4248318091"],"related_works":["https://openalex.org/W1975375876","https://openalex.org/W2359293140","https://openalex.org/W957133499","https://openalex.org/W83225612","https://openalex.org/W2014288528","https://openalex.org/W34983834","https://openalex.org/W2066972031","https://openalex.org/W3130139893","https://openalex.org/W1973260612","https://openalex.org/W2620422757"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,39,166],"TGF-beta/SMAD":[2,22,98],"pathway":[3,24],"is":[4],"part":[5],"of":[6,21,34,42,120,178,201,223],"a":[7,76,148],"broader":[8],"signaling":[9,23],"network":[10],"in":[11,28,50,66,105,141,162],"which":[12,51,121],"crosstalk":[13],"between":[14,204],"pathways":[15],"occurs.":[16],"While":[17],"the":[18,30,52,110,153,163,195,199,202,216,224],"molecular":[19],"mechanisms":[20],"have":[25],"been":[26],"studied":[27],"detail,":[29],"global":[31],"networks":[32],"downstream":[33],"SMAD":[35,43,53,80,159,168,171,205],"remain":[36],"largely":[37],"unknown.":[38],"regulatory":[40],"effect":[41],"complex":[44],"likely":[45],"depends":[46],"on":[47,137],"transcriptional":[48,160],"modules,":[49,81],"binding":[54,60,172,183],"elements":[55],"and":[56,74,92,100,112,134,174,191,206,214],"partner":[57],"transcription":[58,181,208],"factor":[59,182],"sites":[61,184],"(SMAD":[62],"modules)":[63],"are":[64],"present":[65],"specific":[67,211],"context.":[68],"RESULTS:":[69],"To":[70],"address":[71],"this":[72],"question":[73],"develop":[75],"computational":[77,196],"model":[78,158],"for":[79,218],"we":[82],"simultaneously":[83],"performed":[84],"chromatin":[85],"immunoprecipitation":[86],"followed":[87],"by":[88,152],"microarray":[89],"analysis":[90],"(ChIP-chip)":[91],"mRNA":[93],"expression":[94,114,142],"profiling":[95],"to":[96,157,176],"identify":[97],"regulated":[99],"synchronously":[101],"coexpressed":[102],"gene":[103,113,128],"sets":[104,129],"ovarian":[106],"surface":[107],"epithelium.":[108],"Intersecting":[109],"ChIP-chip":[111],"data":[115],"yielded":[116],"150":[117],"direct":[118],"targets,":[119],"141":[122],"were":[123],"grouped":[124],"into":[125],"3":[126],"co-expressed":[127],"(sustained":[130],"up-regulated,":[131],"transient":[132],"up-regulated":[133],"down-regulated),":[135],"based":[136],"their":[138],"temporal":[139],"changes":[140],"after":[143],"TGF-beta":[144],"activation.":[145],"We":[146],"developed":[147],"data-mining":[149],"method":[150],"driven":[151],"Random":[154],"Forest":[155],"algorithm":[156],"modules":[161,169],"target":[164,212],"sequences.":[165],"predicted":[167],"contain":[170],"element":[173],"up":[175],"2":[177],"7":[179],"other":[180,207],"(E2F,":[185],"P53,":[186],"LEF1,":[187],"ELK1,":[188],"COUPTF,":[189],"PAX4":[190],"DR1).":[192],"CONCLUSION:":[193],"Together,":[194],"results":[197],"further":[198],"understanding":[200],"interactions":[203],"factors":[209],"at":[210],"promoters,":[213],"provide":[215],"basis":[217],"more":[219],"targeted":[220],"experimental":[221],"verification":[222],"co-regulatory":[225],"modules.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-05-07T13:39:58.223016","created_date":"2025-10-10T00:00:00"}