{"id":"https://openalex.org/W2133368815","doi":"https://doi.org/10.1186/1752-0509-3-64","title":"Stochastic simulation and analysis of biomolecular reaction networks","display_name":"Stochastic simulation and analysis of biomolecular reaction networks","publication_year":2009,"publication_date":"2009-06-17","ids":{"openalex":"https://openalex.org/W2133368815","doi":"https://doi.org/10.1186/1752-0509-3-64","mag":"2133368815","pmid":"https://pubmed.ncbi.nlm.nih.gov/19534796"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-3-64","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-64","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-64","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-64","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109848471","display_name":"John M. Frazier","orcid":null},"institutions":[{"id":"https://openalex.org/I1280414376","display_name":"United States Air Force Research Laboratory","ror":"https://ror.org/02e2egq70","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280414376","https://openalex.org/I1330347796","https://openalex.org/I4210102105","https://openalex.org/I4389425425"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John M Frazier","raw_affiliation_strings":["Human Effectiveness Directorate (AFRL/REPB), Air Force Research Laboratory, WPAFB, OH 45433-5707, USA. john.frazier@wpafb.af.mil","Human Effectiveness Directorate (AFRL/REPB), Air Force Research Laboratory, WPAFB, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Effectiveness Directorate (AFRL/REPB), Air Force Research Laboratory, WPAFB, OH 45433-5707, USA. john.frazier@wpafb.af.mil","institution_ids":["https://openalex.org/I1280414376"]},{"raw_affiliation_string":"Human Effectiveness Directorate (AFRL/REPB), Air Force Research Laboratory, WPAFB, USA","institution_ids":["https://openalex.org/I1280414376"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076350453","display_name":"Yaroslav Chushak","orcid":"https://orcid.org/0000-0002-3225-8140"},"institutions":[{"id":"https://openalex.org/I2802581893","display_name":"United States Army Medical Research and Development Command","ror":"https://ror.org/03cd02q50","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893"]},{"id":"https://openalex.org/I1304082316","display_name":"United States Department of the Army","ror":"https://ror.org/035w1gb98","country_code":"US","type":"government","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yaroslav Chushak","raw_affiliation_strings":["Biotechnology HPC Software Applications Institute, Telemedicine and Advanced Technology Research Center U.S. Army Medical Research and Materiel Command, Fort Detrick, MD, USA, 21702 and","Biotechnology HPC Software Applications Institute, Telemedicine and Advanced Technology Research Center U.S. Army Medical Research and Materiel Command, Fort Detrick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology HPC Software Applications Institute, Telemedicine and Advanced Technology Research Center U.S. Army Medical Research and Materiel Command, Fort Detrick, MD, USA, 21702 and","institution_ids":["https://openalex.org/I2802581893"]},{"raw_affiliation_string":"Biotechnology HPC Software Applications Institute, Telemedicine and Advanced Technology Research Center U.S. Army Medical Research and Materiel Command, Fort Detrick, USA","institution_ids":["https://openalex.org/I1304082316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024490424","display_name":"Brent D. Foy","orcid":"https://orcid.org/0000-0003-4480-5049"},"institutions":[{"id":"https://openalex.org/I19648265","display_name":"Wright State University","ror":"https://ror.org/04qk6pt94","country_code":"US","type":"education","lineage":["https://openalex.org/I19648265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brent Foy","raw_affiliation_strings":["Department of Physics, Wright State University, Dayton, OH, USA, 45435","Dept. of Physics, Wright State University, Dayton, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Wright State University, Dayton, OH, USA, 45435","institution_ids":["https://openalex.org/I19648265"]},{"raw_affiliation_string":"Dept. of Physics, Wright State University, Dayton, USA","institution_ids":["https://openalex.org/I19648265"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109848471"],"corresponding_institution_ids":["https://openalex.org/I1280414376"],"apc_list":null,"apc_paid":null,"fwci":0.5472,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.67656423,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"3","issue":"1","first_page":"64","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9650999903678894,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9650999903678894,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.7468819618225098},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5851481556892395},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47748303413391113},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.43418997526168823},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.43176740407943726},{"id":"https://openalex.org/keywords/modelling-biological-systems","display_name":"Modelling biological systems","score":0.4209461808204651},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.35129302740097046},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3204804062843323}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.7468819618225098},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5851481556892395},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47748303413391113},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.43418997526168823},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.43176740407943726},{"id":"https://openalex.org/C137866125","wikidata":"https://www.wikidata.org/wiki/Q4299308","display_name":"Modelling biological systems","level":3,"score":0.4209461808204651},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.35129302740097046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3204804062843323}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-3-64","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-64","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-64","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:19534796","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19534796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:corescholar.libraries.wright.edu:physics-1264","is_oa":false,"landing_page_url":"https://corescholar.libraries.wright.edu/physics/219","pdf_url":null,"source":{"id":"https://openalex.org/S2737205702","display_name":"Journal of Bioresource Management","issn_l":"2309-3854","issn":["2309-3854"],"is_oa":false,"is_in_doaj":true,"is_core":false,"host_organization":"https://openalex.org/P4310316536","host_organization_name":"Bioresource Research Center (BRC), Islamabad","host_organization_lineage":["https://openalex.org/P4310316536"],"host_organization_lineage_names":["Bioresource Research Center (BRC), Islamabad"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Physics Faculty Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:5bd988357c8c4f4b9910db91cdb081a5","is_oa":false,"landing_page_url":"https://doaj.org/article/5bd988357c8c4f4b9910db91cdb081a5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 3, Iss 1, p 64 (2009)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2708125","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2708125","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:works.bepress.com:brent_foy-1000","is_oa":false,"landing_page_url":"https://works.bepress.com/brent_foy/1","pdf_url":null,"source":{"id":"https://openalex.org/S2737205702","display_name":"Journal of Bioresource Management","issn_l":"2309-3854","issn":["2309-3854"],"is_oa":false,"is_in_doaj":true,"is_core":false,"host_organization":"https://openalex.org/P4310316536","host_organization_name":"Bioresource Research Center (BRC), Islamabad","host_organization_lineage":["https://openalex.org/P4310316536"],"host_organization_lineage_names":["Bioresource Research Center (BRC), Islamabad"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brent Foy","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-3-64","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-64","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-64","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332467","display_name":"U.S. Air Force","ror":"https://ror.org/006gmme17"},{"id":"https://openalex.org/F4320338279","display_name":"Air Force Office of Scientific Research","ror":"https://ror.org/011e9bt93"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2133368815.pdf","grobid_xml":"https://content.openalex.org/works/W2133368815.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1509581155","https://openalex.org/W1759632117","https://openalex.org/W1964287788","https://openalex.org/W1965710067","https://openalex.org/W1967139808","https://openalex.org/W1970618289","https://openalex.org/W2033473419","https://openalex.org/W2054048544","https://openalex.org/W2058652191","https://openalex.org/W2065219357","https://openalex.org/W2072670807","https://openalex.org/W2084924279","https://openalex.org/W2091198609","https://openalex.org/W2129388048","https://openalex.org/W2133773224","https://openalex.org/W2150908245","https://openalex.org/W2155418451","https://openalex.org/W2170543954","https://openalex.org/W2171280873","https://openalex.org/W4205597578"],"related_works":["https://openalex.org/W2057769265","https://openalex.org/W4212865750","https://openalex.org/W1987445442","https://openalex.org/W2158714033","https://openalex.org/W4210989272","https://openalex.org/W2211443823","https://openalex.org/W1975586684","https://openalex.org/W4206945140","https://openalex.org/W2063941210","https://openalex.org/W4386628104"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,53],"recent":[2],"years,":[3],"several":[4],"stochastic":[5,33,101,172,186],"simulation":[6,34,127],"algorithms":[7],"have":[8,48],"been":[9],"developed":[10,65],"to":[11,55,74,103,195,208],"generate":[12],"Monte":[13],"Carlo":[14],"trajectories":[15],"that":[16,109],"describe":[17],"the":[18,22,29,40,78,98,107,111,122,133,183,190,203,210],"time":[19,136,150,193],"evolution":[20],"of":[21,24,31,43,80,85,106,115,126,135,144,149,159,161,165,171,185,192,205],"behavior":[23,79,84],"biomolecular":[25,45],"reaction":[26,46,93,154],"networks.":[27],"However,":[28],"effects":[30],"various":[32],"and":[35,76,113,124,141,168,201],"data":[36,128,139],"analysis":[37,112,123,184],"conditions":[38],"on":[39,138,153,163,174],"observed":[41],"dynamics":[42],"complex":[44],"networks":[47],"not":[49],"received":[50],"much":[51],"attention.":[52],"order":[54],"investigate":[56],"these":[57,116],"issues,":[58],"we":[59],"employed":[60],"a":[61,62,86],"software":[63],"package":[64],"in":[66,90],"out":[67],"group,":[68],"called":[69],"Biomolecular":[70],"Network":[71],"Simulator":[72],"(BNS),":[73],"simulate":[75],"analyze":[77],"such":[81],"systems.":[82],"The":[83,178],"hypothetical":[87],"two":[88,179],"gene":[89],"vitro":[91],"transcription-translation":[92],"network":[94],"is":[95],"investigated":[96],"using":[97],"Gillespie":[99],"exact":[100],"algorithm":[102],"illustrate":[104],"some":[105],"factors":[108,181],"influence":[110],"interpretation":[114,125],"data.":[117],"RESULTS:":[118],"Specific":[119],"issues":[120],"affecting":[121,182],"are":[129],"investigated,":[130],"including:":[131],"(1)":[132,189],"effect":[134,148,158],"interval":[137,152],"presentation":[140],"time-weighted":[142],"averaging":[143,151],"molecule":[145],"numbers,":[146],"(2)":[147,202],"rate":[155],"analysis,":[156],"(3)":[157],"number":[160,204],"simulations":[162,173,187,206],"precision":[164],"model":[166],"predictions,":[167],"(4)":[169],"implications":[170],"optimization":[175],"procedures.":[176],"CONCLUSION:":[177],"main":[180],"are:":[188],"selection":[191],"intervals":[194],"compute":[196],"or":[197],"average":[198],"state":[199],"variables":[200],"generated":[207],"evaluate":[209],"system":[211],"behavior.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
