{"id":"https://openalex.org/W1994176741","doi":"https://doi.org/10.1186/1752-0509-3-51","title":"On the functional diversity of dynamical behaviour in genetic and metabolic feedback systems","display_name":"On the functional diversity of dynamical behaviour in genetic and metabolic feedback systems","publication_year":2009,"publication_date":"2009-05-11","ids":{"openalex":"https://openalex.org/W1994176741","doi":"https://doi.org/10.1186/1752-0509-3-51","mag":"1994176741","pmid":"https://pubmed.ncbi.nlm.nih.gov/19432996"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-3-51","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-51","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-51","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-51","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040251521","display_name":"Lan K. Nguyen","orcid":"https://orcid.org/0000-0003-4040-7705"},"institutions":[{"id":"https://openalex.org/I184746854","display_name":"Lincoln University","ror":"https://ror.org/04ps1r162","country_code":"NZ","type":"education","lineage":["https://openalex.org/I184746854"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Lan K Nguyen","raw_affiliation_strings":["Centre for Advanced Computational Solutions (C-fACS), Lincoln University, Christchurch, New Zealand. Khuyen.Nguyen@lincolnuni.ac.nz","Centre for Advanced Computational Solutions (C-fACS), Lincoln University, Christchurch, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Advanced Computational Solutions (C-fACS), Lincoln University, Christchurch, New Zealand. Khuyen.Nguyen@lincolnuni.ac.nz","institution_ids":["https://openalex.org/I184746854"]},{"raw_affiliation_string":"Centre for Advanced Computational Solutions (C-fACS), Lincoln University, Christchurch, New Zealand","institution_ids":["https://openalex.org/I184746854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044216588","display_name":"Don Kulasiri","orcid":"https://orcid.org/0000-0001-8744-1578"},"institutions":[{"id":"https://openalex.org/I184746854","display_name":"Lincoln University","ror":"https://ror.org/04ps1r162","country_code":"NZ","type":"education","lineage":["https://openalex.org/I184746854"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Don Kulasiri","raw_affiliation_strings":["Centre for Advanced Computational Solutions (C-fACS), Lincoln University, Christchurch, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Advanced Computational Solutions (C-fACS), Lincoln University, Christchurch, New Zealand","institution_ids":["https://openalex.org/I184746854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040251521"],"corresponding_institution_ids":["https://openalex.org/I184746854"],"apc_list":null,"apc_paid":null,"fwci":0.5475,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.65944372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"3","issue":"1","first_page":"51","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9516000151634216,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9516000151634216,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.027400000020861626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.7665212154388428},{"id":"https://openalex.org/keywords/diversity","display_name":"Diversity (politics)","score":0.5699008107185364},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5098244547843933},{"id":"https://openalex.org/keywords/dynamical-systems-theory","display_name":"Dynamical systems theory","score":0.4907435178756714},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4743080139160156},{"id":"https://openalex.org/keywords/functional-diversity","display_name":"Functional diversity","score":0.42681872844696045},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42017436027526855},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.381669819355011},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.1494135558605194},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.14629244804382324}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.7665212154388428},{"id":"https://openalex.org/C2781316041","wikidata":"https://www.wikidata.org/wiki/Q1230584","display_name":"Diversity (politics)","level":2,"score":0.5699008107185364},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5098244547843933},{"id":"https://openalex.org/C79379906","wikidata":"https://www.wikidata.org/wiki/Q3174497","display_name":"Dynamical systems theory","level":2,"score":0.4907435178756714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4743080139160156},{"id":"https://openalex.org/C2988890453","wikidata":"https://www.wikidata.org/wiki/Q5508815","display_name":"Functional diversity","level":2,"score":0.42681872844696045},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42017436027526855},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.381669819355011},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1494135558605194},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14629244804382324},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-3-51","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-51","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-51","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:19432996","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19432996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:researcharchive.lincoln.ac.nz:10182/1654","is_oa":true,"landing_page_url":"https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=elements_prod&SrcAuth=WosAPI&KeyUT=WOS:000268144600001&DestLinkType=FullRecord&DestApp=WOS_CPL","pdf_url":"https://hdl.handle.net/10182/1654","source":{"id":"https://openalex.org/S4306400204","display_name":"Lincoln University Research Archive (Lincoln University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:28146597c8034cba8aa73ac617bcc07c","is_oa":false,"landing_page_url":"https://doaj.org/article/28146597c8034cba8aa73ac617bcc07c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 3, Iss 1, p 51 (2009)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2705352","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2705352","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-3-51","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-51","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-51","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.7099999785423279,"display_name":"Life in Land"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310144","display_name":"Tertiary Education Commission","ror":"https://ror.org/05xhe5a74"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1994176741.pdf","grobid_xml":"https://content.openalex.org/works/W1994176741.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W38710637","https://openalex.org/W165850321","https://openalex.org/W567006062","https://openalex.org/W985433685","https://openalex.org/W1499659548","https://openalex.org/W1570584660","https://openalex.org/W1599969036","https://openalex.org/W1641228030","https://openalex.org/W1864361319","https://openalex.org/W1899277959","https://openalex.org/W1965738187","https://openalex.org/W1971327350","https://openalex.org/W1972200266","https://openalex.org/W1973021296","https://openalex.org/W1979833590","https://openalex.org/W1981560281","https://openalex.org/W1981862895","https://openalex.org/W1992382711","https://openalex.org/W1993445719","https://openalex.org/W1993592538","https://openalex.org/W2005486846","https://openalex.org/W2021766626","https://openalex.org/W2026985605","https://openalex.org/W2030101409","https://openalex.org/W2038763999","https://openalex.org/W2043186887","https://openalex.org/W2043791622","https://openalex.org/W2049874728","https://openalex.org/W2051497876","https://openalex.org/W2057805759","https://openalex.org/W2059108896","https://openalex.org/W2065269411","https://openalex.org/W2067160012","https://openalex.org/W2069500900","https://openalex.org/W2070974284","https://openalex.org/W2072285397","https://openalex.org/W2080757588","https://openalex.org/W2083354279","https://openalex.org/W2083561802","https://openalex.org/W2088907143","https://openalex.org/W2094305273","https://openalex.org/W2095259027","https://openalex.org/W2098272219","https://openalex.org/W2107242170","https://openalex.org/W2130841219","https://openalex.org/W2136340808","https://openalex.org/W2157005274","https://openalex.org/W2158469604","https://openalex.org/W2164143390","https://openalex.org/W2170494099","https://openalex.org/W2170744949","https://openalex.org/W2299769372","https://openalex.org/W4231550443","https://openalex.org/W4233890999","https://openalex.org/W4237997615","https://openalex.org/W4252465488","https://openalex.org/W4256020451"],"related_works":["https://openalex.org/W4236583520","https://openalex.org/W2734736160","https://openalex.org/W2409468626","https://openalex.org/W4206863193","https://openalex.org/W2914540327","https://openalex.org/W2230606337","https://openalex.org/W4205351689","https://openalex.org/W4283518176","https://openalex.org/W4240802788","https://openalex.org/W2322261865"],"abstract_inverted_index":{"BACKGROUND:":[0],"Feedback":[1],"regulation":[2],"plays":[3],"crucial":[4],"roles":[5,190],"in":[6,74,140,191,220,336],"the":[7,31,58,75,87,90,111,143,149,171,176,184,193,198,202,227,235,239,245,249,255,260,263,265,279,289,300,313,329],"robust":[8],"control":[9],"and":[10,24,51,63,69,89,99,165,217],"maintenance":[11],"of":[12,34,49,102,110,114,145,226,248,262,278,309,315,321],"many":[13],"cellular":[14],"systems.":[15,77],"Negative":[16],"feedbacks":[17],"are":[18],"found":[19,206],"to":[20,119,131,142,152,210,259,305],"underline":[21],"both":[22],"stable":[23,286],"unstable,":[25],"often":[26],"oscillatory,":[27],"behaviours.":[28,122],"We":[29,79,105,135,168],"explore":[30],"dynamical":[32,121,316],"characteristics":[33],"systems":[35],"with":[36],"single":[37],"as":[38,40,207],"well":[39],"coupled":[41],"negative":[42,96,126],"feedback":[43,97,112,127,195,228],"loops":[44,72,116,128,163,310,333],"using":[45],"a":[46,94,100,153,208],"combined":[47],"approach":[48],"analytical":[50,82,215],"numerical":[52],"techniques.":[53],"Particularly,":[54],"we":[55],"emphasise":[56],"how":[57,70],"loop's":[59],"characterising":[60],"factors":[61],"(strength":[62],"cooperativity":[64],"levels)":[65],"affect":[66,175],"system":[67,98,133,203,236,282,301],"dynamics":[68],"individual":[71,115],"interact":[73],"coupled-loop":[76],"RESULTS:":[78],"develop":[80],"an":[81],"bifurcation":[83,317],"analysis":[84],"based":[85],"on":[86],"stability":[88],"Routh-Hurwitz":[91],"theorem":[92],"for":[93,158,180,269],"common":[95],"variety":[101],"its":[103],"variants.":[104],"demonstrate":[106,223],"that":[107,137,170,224],"different":[108,120],"combinations":[109],"strengths":[113],"give":[117],"rise":[118],"Moreover,":[123],"incorporating":[124],"more":[125,188,237,285,303],"always":[129,334],"tend":[130],"enhance":[132],"stability.":[134,212],"show":[136],"two":[138],"mechanisms,":[139],"addition":[141],"lengthening":[144],"pathway,":[146,264],"can":[147],"lower":[148],"Hill":[150,178,267],"coefficient":[151,179,268],"biologically":[154],"plausible":[155],"level":[156],"required":[157],"sustained":[159,181],"oscillations.":[160],"These":[161],"include":[162],"coupling":[164,308],"end-product":[166],"utilisation.":[167],"find":[169],"degradation":[172,199,246,280],"rates":[173,186,200,247],"solely":[174],"threshold":[177,194],"oscillation,":[182],"while":[183],"synthesis":[185],"have":[187],"significant":[189],"determining":[192],"strength.":[196],"Unbalancing":[197],"between":[201],"species":[204,291],"is":[205,242,271,296,302,325],"way":[209],"improve":[211],"CONCLUSION:":[213],"The":[214,307,319],"methods":[216],"insights":[218],"presented":[219],"this":[221],"study":[222],"reallocation":[225],"loop":[229,256],"may":[230,232],"or":[231],"not":[233],"make":[234],"stable;":[238],"specific":[240],"effect":[241],"determined":[243,327],"by":[244,328],"newly":[250],"inhibited":[251],"molecular":[252],"species.":[253],"As":[254],"moves":[257],"closer":[258],"end":[261],"minimum":[266],"oscillation":[270],"reduced.":[272],"Furthermore,":[273],"under":[274],"general":[275],"(unequal)":[276],"values":[277],"rates,":[281],"extension":[283],"becomes":[284],"only":[287],"when":[288],"added":[290],"degrades":[292],"slower":[293],"than":[294],"it":[295],"being":[297],"produced;":[298],"otherwise":[299],"prone":[304],"oscillation.":[306],"significantly":[311],"increases":[312],"richness":[314],"characteristics.":[318],"likelihood":[320],"having":[322],"oscillatory":[323,338],"behaviour":[324],"directly":[326],"loops'":[330],"strength:":[331],"stronger":[332],"result":[335],"smaller":[337],"regions.":[339]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-05-19T08:33:51.333923","created_date":"2025-10-10T00:00:00"}
