{"id":"https://openalex.org/W2070509973","doi":"https://doi.org/10.1186/1752-0509-3-35","title":"Information processing in the transcriptional regulatory network of yeast: Functional robustness","display_name":"Information processing in the transcriptional regulatory network of yeast: Functional robustness","publication_year":2009,"publication_date":"2009-03-19","ids":{"openalex":"https://openalex.org/W2070509973","doi":"https://doi.org/10.1186/1752-0509-3-35","mag":"2070509973","pmid":"https://pubmed.ncbi.nlm.nih.gov/19298671"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-3-35","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-35","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-35","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-35","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057625030","display_name":"Frank Emmert\u2010Streib","orcid":"https://orcid.org/0000-0003-0745-5641"},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Frank Emmert-Streib","raw_affiliation_strings":["Computational Biology and Machine Learning, Center for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast, UK. v@bio-complexity.com","Computational Biology and Machine Learning, Center for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology and Machine Learning, Center for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast, UK. v@bio-complexity.com","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"Computational Biology and Machine Learning, Center for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044244385","display_name":"Matthias Dehmer","orcid":"https://orcid.org/0000-0001-8454-5857"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Matthias Dehmer","raw_affiliation_strings":["Center for Mathematics, Probability and Statistics, University of Coimbra, Apartado 3008, Coimbra, 3001-454, Portugal","Center for Mathematics, Probability and Statistics, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Mathematics, Probability and Statistics, University of Coimbra, Apartado 3008, Coimbra, 3001-454, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Center for Mathematics, Probability and Statistics, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057625030"],"corresponding_institution_ids":["https://openalex.org/I126231945"],"apc_list":null,"apc_paid":null,"fwci":1.8919,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.85216479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"3","issue":"1","first_page":"35","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.4885999858379364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.4885999858379364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.42640000581741333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.7811164855957031},{"id":"https://openalex.org/keywords/betweenness-centrality","display_name":"Betweenness centrality","score":0.7472912073135376},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6036826968193054},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5880752205848694},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5834490656852722},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5495879650115967},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5464292168617249},{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.5414860248565674},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5171146392822266},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38542798161506653},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3712165355682373},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.14986008405685425},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.13896113634109497}],"concepts":[{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.7811164855957031},{"id":"https://openalex.org/C117045392","wikidata":"https://www.wikidata.org/wiki/Q4899215","display_name":"Betweenness centrality","level":3,"score":0.7472912073135376},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6036826968193054},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5880752205848694},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5834490656852722},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5495879650115967},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5464292168617249},{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.5414860248565674},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5171146392822266},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38542798161506653},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3712165355682373},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14986008405685425},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13896113634109497},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-3-35","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-35","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-35","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:19298671","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19298671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:estudogeral.uc.pt:10316/110376","is_oa":true,"landing_page_url":"https://hdl.handle.net/10316/110376","pdf_url":null,"source":{"id":"https://openalex.org/S4306402070","display_name":"Estudo Geral (Universidad de Coimbra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I76903346","host_organization_name":"University of Coimbra","host_organization_lineage":["https://openalex.org/I76903346"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2679710","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2679710","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:pure.qub.ac.uk/portal:publications/103ddea6-6553-4dca-9715-c8136d84c05b","is_oa":false,"landing_page_url":"https://pure.qub.ac.uk/en/publications/103ddea6-6553-4dca-9715-c8136d84c05b","pdf_url":null,"source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Emmert-Streib , F & Dehmer , M 2009 , ' Information processing in the transcriptional regulatory network of yeast: Functional robustness ' , BMC Systems Biology , vol. 3 , 35 , pp. x1-y1 . https://doi.org/10.1186/1752-0509-3-35","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-3-35","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-35","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-35","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2070509973.pdf","grobid_xml":"https://content.openalex.org/works/W2070509973.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W234963275","https://openalex.org/W385108639","https://openalex.org/W587005977","https://openalex.org/W1486817521","https://openalex.org/W1554851690","https://openalex.org/W1592356192","https://openalex.org/W1599969036","https://openalex.org/W1607198972","https://openalex.org/W1965555277","https://openalex.org/W1971224531","https://openalex.org/W1978319180","https://openalex.org/W1979833590","https://openalex.org/W1989008275","https://openalex.org/W1992242907","https://openalex.org/W1995875735","https://openalex.org/W1999611553","https://openalex.org/W2000163865","https://openalex.org/W2009543464","https://openalex.org/W2018045523","https://openalex.org/W2019789576","https://openalex.org/W2026781624","https://openalex.org/W2053961182","https://openalex.org/W2065769502","https://openalex.org/W2070672503","https://openalex.org/W2082383308","https://openalex.org/W2082720245","https://openalex.org/W2099069868","https://openalex.org/W2108020239","https://openalex.org/W2112090702","https://openalex.org/W2112609377","https://openalex.org/W2121477676","https://openalex.org/W2123838014","https://openalex.org/W2124637492","https://openalex.org/W2125631472","https://openalex.org/W2128150566","https://openalex.org/W2131255911","https://openalex.org/W2134923619","https://openalex.org/W2142072523","https://openalex.org/W2142437744","https://openalex.org/W2142901448","https://openalex.org/W2144455456","https://openalex.org/W2144885342","https://openalex.org/W2148606196","https://openalex.org/W2150318080","https://openalex.org/W2155205047","https://openalex.org/W2163296115","https://openalex.org/W2163480486","https://openalex.org/W2164904029","https://openalex.org/W2169528473","https://openalex.org/W2293732938","https://openalex.org/W2296679604","https://openalex.org/W2569570762","https://openalex.org/W2769133055","https://openalex.org/W2944782266","https://openalex.org/W2993383518","https://openalex.org/W3099289621","https://openalex.org/W3103071483","https://openalex.org/W3103786587","https://openalex.org/W3140968660","https://openalex.org/W4211017114","https://openalex.org/W4254962106","https://openalex.org/W4256259619","https://openalex.org/W4298982457","https://openalex.org/W4299328967","https://openalex.org/W4388252848"],"related_works":["https://openalex.org/W1973509935","https://openalex.org/W4389076551","https://openalex.org/W2097992793","https://openalex.org/W2107855069","https://openalex.org/W2611574733","https://openalex.org/W2241641394","https://openalex.org/W2140653560","https://openalex.org/W2348831795","https://openalex.org/W2514739320","https://openalex.org/W4312461432"],"abstract_inverted_index":{"BACKGROUND:":[0],"Gene":[1],"networks":[2,211],"are":[3,109,138,160],"considered":[4,36],"to":[5,39,105,113,141,144,195,205],"represent":[6],"various":[7],"aspects":[8],"of":[9,21,30,44,56,61,82,124,132,152,186,213],"molecular":[10,22],"biological":[11,197],"systems":[12,19],"meaningfully":[13],"because":[14],"they":[15],"naturally":[16],"provide":[17],"a":[18,73,128,149,171,184],"perspective":[20],"interactions.":[23],"In":[24,48],"this":[25,49],"respect,":[26],"the":[27,31,41,53,57,66,70,80,87,95,121,153],"functional":[28,42,54],"understanding":[29],"transcriptional":[32,58,154],"regulatory":[33,59,155],"network":[34,60,71,156],"is":[35,97],"as":[37,72],"key":[38],"elucidate":[40],"organization":[43],"an":[45,100],"organism.":[46],"RESULTS:":[47],"paper":[50],"we":[51],"study":[52,79,178,206],"robustness":[55],"S.":[62],"cerevisiae.":[63],"We":[64],"model":[65],"information":[67,101,189,207],"processing":[68,208],"in":[69,94,209],"first":[74],"order":[75],"Markov":[76],"chain":[77],"and":[78,168,191],"influence":[81],"single":[83,114],"gene":[84,115,210],"perturbations":[85],"on":[86],"global,":[88],"asymptotic":[89],"communication":[90,96],"among":[91],"genes.":[92],"Modification":[93],"measured":[98],"by":[99],"theoretic":[102],"measure":[103],"allowing":[104],"predict":[106],"genes":[107,126,136,167,169],"that":[108,120,137,158,183,201],"'fragile'":[110],"with":[111,170],"respect":[112],"knockouts.":[116],"Our":[117,177],"results":[118,198],"demonstrate":[119,182],"predicted":[122],"set":[123],"fragile":[125,164],"contains":[127],"statistically":[129],"significant":[130,161],"enrichment":[131],"so":[133],"called":[134],"essential":[135],"experimentally":[139],"found":[140],"be":[142],"necessary":[143],"ensure":[145],"vital":[146],"yeast.":[147],"Further,":[148],"structural":[150,216],"analysis":[151],"reveals":[157],"there":[159],"differences":[162],"between":[163],"genes,":[165],"hub":[166],"high":[172],"betweenness":[173],"centrality":[174],"value.":[175],"CONCLUSION:":[176],"does":[179],"not":[180],"only":[181],"combination":[185],"graph":[187],"theoretical,":[188],"theoretical":[190],"statistical":[192],"methods":[193,203],"leads":[194],"meaningful":[196],"but":[199],"also":[200],"such":[202],"allow":[204],"instead":[212],"just":[214],"their":[215],"properties.":[217]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}